{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T23:57:52Z","timestamp":1783727872289,"version":"3.55.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,16]],"date-time":"2025-03-16T00:00:00Z","timestamp":1742083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Microbiology, Immunology and Infection"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.jmii.2025.03.005","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T17:38:30Z","timestamp":1742233110000},"page":"422-428","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["High bacterial coinfection rates and associated mortality among hospitalized older adults with laboratory-confirmed respiratory syncytial virus infection"],"prefix":"10.1016","volume":"58","author":[{"given":"Yu-Chang","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-wei","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Hua","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chao","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Yen","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chieh-Lung","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Ren","family":"Hsueh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmii.2025.03.005_bib1","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/S0140-6736(10)60206-1","article-title":"Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis","volume":"375","author":"Nair","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.jmii.2025.03.005_bib2","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1128\/CMR.13.3.371","article-title":"Respiratory syncytial virus infection in adults","volume":"13","author":"Falsey","year":"2000","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.jmii.2025.03.005_bib3","doi-asserted-by":"crossref","first-page":"S577","DOI":"10.1093\/infdis\/jiz059","article-title":"Global disease burden estimates of respiratory syncytial virus-associated acute respiratory infection in older adults in 2015: a systematic review and meta-analysis","volume":"222","author":"Shi","year":"2020","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jmii.2025.03.005_bib4","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1093\/cid\/ciab595","article-title":"Incidence of respiratory syncytial virus infection among hospitalized adults, 2017-2020","volume":"74","author":"Branche","year":"2022","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jmii.2025.03.005_bib5","doi-asserted-by":"crossref","DOI":"10.1093\/infdis\/jiae314","article-title":"Incidence of RSV in adults: a comprehensive review of observational studies and critical gaps in information","author":"Doty","year":"2024","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jmii.2025.03.005_bib6","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s10096-018-3407-3","article-title":"Microorganisms associated with respiratory syncytial virus pneumonia in the adult population","volume":"38","author":"Jeanno\u00ebl","year":"2019","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.jmii.2025.03.005_bib7","article-title":"Epidemiology and characteristics of respiratory syncytial virus pneumonia in critically ill adults","volume":"10","author":"Kim","year":"2023","journal-title":"Open Forum Infect Dis"},{"key":"10.1016\/j.jmii.2025.03.005_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinf.2024.106180","article-title":"Clinical characteristics and outcomes of respiratory syncytial virus-associated ARF in immunocompetent patients: a seven-year experience at a tertiary hospital in France","volume":"89","author":"Mokrani","year":"2024","journal-title":"J Infect"},{"key":"10.1016\/j.jmii.2025.03.005_bib9","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jmii.2023.12.005","article-title":"High mortality of patients with severe pneumonia caused by respiratory syncytial virus, August 2021-June 2023, Taiwan","volume":"57","author":"Chen","year":"2024","journal-title":"J Microbiol Immunol Infect"},{"key":"10.1016\/j.jmii.2025.03.005_bib10","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1056\/NEJMc2216153","article-title":"Viral lineages in the 2022 RSV surge in the United States","volume":"388","author":"Adams","year":"2023","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jmii.2025.03.005_bib11","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1093\/cid\/civ486","article-title":"Community surveillance of respiratory viruses among families in the Utah better identification of germs-longitudinal viral epidemiology (BIG-LoVE) study","volume":"61","author":"Byington","year":"2015","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jmii.2025.03.005_bib12","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1177\/0033354920976353","article-title":"Increase in detection of respiratory syncytial virus among older adults in Arizona : an association with changes in testing practices","volume":"136","author":"Bridge","year":"2021","journal-title":"Publ Health Rep"},{"key":"10.1016\/j.jmii.2025.03.005_bib13","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S1473-3099(22)00544-8","article-title":"Quantifying the RSV immunity debt following COVID-19: a public health matter","volume":"23","author":"Billard","year":"2023","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.jmii.2025.03.005_bib14","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.1038\/s41467-022-30485-3","article-title":"Off-season RSV epidemics in Australia after easing of COVID-19 restrictions","volume":"13","author":"Eden","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.jmii.2025.03.005_bib15","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1093\/cid\/ciad031","article-title":"Prevalence and clinical outcomes of respiratory syncytial virus vs influenza in adults hospitalized with acute respiratory illness from a prospective multicenter study","volume":"76","author":"Begley","year":"2023","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jmii.2025.03.005_bib16","doi-asserted-by":"crossref","DOI":"10.1111\/irv.13031","article-title":"Respiratory syncytial virus disease burden in adults aged 60 years and older in high-income countries: a systematic literature review and meta-analysis","volume":"17","author":"Savic","year":"2023","journal-title":"Influenza Other Respir Viruses"},{"key":"10.1016\/j.jmii.2025.03.005_bib17","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1186\/s12879-014-0544-x","article-title":"Social, economic, and health impact of the respiratory syncytial virus: a systematic search","volume":"14","author":"D\u00edez-Domingo","year":"2014","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.jmii.2025.03.005_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcv.2023.105635","article-title":"Respiratory syncytial virus-related hospital stays in adults in France from 2012 to 2021: a national hospital database study","volume":"171","author":"Loubet","year":"2024","journal-title":"J Clin Virol"},{"key":"10.1016\/j.jmii.2025.03.005_bib19","doi-asserted-by":"crossref","first-page":"793","DOI":"10.15585\/mmwr.mm7229a4","article-title":"Use of respiratory syncytial virus vaccines in older adults: recommendations of the Advisory Committee on Immunization Practices - United States, 2023","volume":"72","author":"Melgar","year":"2023","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.jmii.2025.03.005_bib20","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.jmii.2024.05.009","article-title":"Burden of respiratory syncytial virus in older adults in Taiwan: an expert perspective on knowledge gaps","volume":"57","author":"Lee","year":"2024","journal-title":"J Microbiol Immunol Infect"},{"key":"10.1016\/j.jmii.2025.03.005_bib21","doi-asserted-by":"crossref","DOI":"10.1002\/rmv.70003","article-title":"An overview on disease burden and management of respiratory syncytial virus infections in older adults in the Asia-Pacific region","volume":"34","author":"Lai","year":"2024","journal-title":"Rev Med Virol"},{"key":"10.1016\/j.jmii.2025.03.005_bib22","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1164\/rccm.201908-1581ST","article-title":"Diagnosis and treatment of adults with community-acquired pneumonia. An official clinical practice guideline of the American Thoracic Society and Infectious Diseases Society of America","volume":"200","author":"Metlay","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jmii.2025.03.005_bib23","doi-asserted-by":"crossref","first-page":"e61","DOI":"10.1093\/cid\/ciw353","article-title":"Management of adults with hospital-acquired and ventilator-associated pneumonia: 2016 clinical practice guidelines by the Infectious Diseases Society of America and the American Thoracic Society","volume":"63","author":"Kalil","year":"2016","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jmii.2025.03.005_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0182321","article-title":"The epidemiology of medically attended respiratory syncytial virus in older adults in the United States: a systematic review","volume":"12","author":"Colosia","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jmii.2025.03.005_bib25","doi-asserted-by":"crossref","DOI":"10.1093\/ofid\/ofy316","article-title":"Clinical features, severity, and incidence of RSV illness during 12 consecutive seasons in a community cohort of adults \u226560 years old","volume":"5","author":"Belongia","year":"2018","journal-title":"Open Forum Infect Dis"},{"key":"10.1016\/j.jmii.2025.03.005_bib26","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jcv.2017.09.001","article-title":"Respiratory syncytial virus hospitalization in middle-aged and older adults","volume":"96","author":"Malosh","year":"2017","journal-title":"J Clin Virol"},{"key":"10.1016\/j.jmii.2025.03.005_bib27","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1093\/cid\/cit767","article-title":"Medically attended respiratory syncytial virus infections in adults aged \u2265 50 years: clinical characteristics and outcomes","volume":"58","author":"Sundaram","year":"2014","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jmii.2025.03.005_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0102586","article-title":"Seasonal incidence of medically attended respiratory syncytial virus infection in a community cohort of adults \u226550 years old","volume":"9","author":"McClure","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jmii.2025.03.005_bib29","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1001\/jamainternmed.2024.0212","article-title":"Acute cardiac events in hospitalized older adults with respiratory syncytial virus infection","volume":"184","author":"Woodruff","year":"2024","journal-title":"JAMA Intern Med"},{"key":"10.1016\/j.jmii.2025.03.005_bib30","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1093\/infdis\/jit839","article-title":"Respiratory syncytial virus and other respiratory viral infections in older adults with moderate to severe influenza-like illness","volume":"209","author":"Falsey","year":"2014","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jmii.2025.03.005_bib31","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jcv.2019.07.001","article-title":"Clinical manifestations and outcomes of respiratory syncytial virus infection in adult hospitalized patients","volume":"117","author":"Chuaychoo","year":"2019","journal-title":"J Clin Virol"},{"key":"10.1016\/j.jmii.2025.03.005_bib32","doi-asserted-by":"crossref","first-page":"e158","DOI":"10.1093\/cid\/ciaa730","article-title":"Respiratory syncytial virus-associated hospitalizations among adults with chronic medical conditions","volume":"73","author":"Prasad","year":"2021","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jmii.2025.03.005_bib33","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.3389\/fimmu.2020.01205","article-title":"Mechanisms of virus-induced airway immunity dysfunction in the pathogenesis of COPD disease, progression, and exacerbation","volume":"11","author":"Guo-Parke","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.jmii.2025.03.005_bib34","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1093\/cid\/cit471","article-title":"High morbidity and mortality in adults hospitalized for respiratory syncytial virus infections","volume":"57","author":"Lee","year":"2013","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jmii.2025.03.005_bib35","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.15585\/mmwr.mm7240a1","article-title":"Characteristics and outcomes among adults aged \u226560 years hospitalized with laboratory-confirmed respiratory syncytial virus - RSV-NET, 12 States, July 2022-June 2023","volume":"72","author":"Havers","year":"2023","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.jmii.2025.03.005_bib36","doi-asserted-by":"crossref","DOI":"10.1093\/ofid\/ofaa546","article-title":"Respiratory syncytial virus infection: its propensity for bacterial coinfection and related mortality in elderly adults","volume":"7","author":"Godefroy","year":"2020","journal-title":"Open Forum Infect Dis"},{"key":"10.1016\/j.jmii.2025.03.005_bib37","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.jfma.2023.12.004","article-title":"Epidemiology and clinical characteristics of hospitalized adults with respiratory syncytial virus infection at a medical center in northern Taiwan","volume":"123","author":"Chang","year":"2023","journal-title":"J Formos Med Assoc"}],"container-title":["Journal of Microbiology, Immunology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1684118225000672?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1684118225000672?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T11:32:25Z","timestamp":1749209545000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1684118225000672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S1684118225000672"],"URL":"https:\/\/doi.org\/10.1016\/j.jmii.2025.03.005","relation":{},"ISSN":["1684-1182"],"issn-type":[{"value":"1684-1182","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High bacterial coinfection rates and associated mortality among hospitalized older adults with laboratory-confirmed respiratory syncytial virus infection","name":"articletitle","label":"Article Title"},{"value":"Journal of Microbiology, Immunology and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmii.2025.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}