{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:55:15Z","timestamp":1790733315295,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":1382,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","journals.elsevierhealth.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Molecular Diagnostics"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.jmoldx.2015.11.006","type":"journal-article","created":{"date-parts":[[2016,1,20]],"date-time":"2016-01-20T05:54:11Z","timestamp":1453269251000},"page":"299-315","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"title":["Clinical Validation and Implementation of a Targeted Next-Generation Sequencing Assay to Detect Somatic Variants in Non-Small Cell Lung, Melanoma, and Gastrointestinal Malignancies"],"prefix":"10.1016","volume":"18","author":[{"given":"Kevin E.","family":"Fisher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linsheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey H.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Newman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rathi N.","family":"Pillai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ragini R.","family":"Kudchadkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taofeek K.","family":"Owonikoko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh S.","family":"Ramalingam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Lawson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith A.","family":"Delman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bassel F.","family":"El-Rayes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malania M.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Clifford","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie S.","family":"Morrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serdar","family":"Balci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. Volkan","family":"Adsay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony A.","family":"Gal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel L.","family":"Sica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra F.","family":"Saxe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen P.","family":"Mann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles E.","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadlo R.","family":"Khuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmoldx.2015.11.006_bib1","doi-asserted-by":"crossref","first-page":"515","DOI":"10.6004\/jnccn.2015.0071","article-title":"Non-small cell lung cancer, version 6.2015","volume":"13","author":"Ettinger","year":"2015","journal-title":"J Natl Compr Canc Netw"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib2","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.jmoldx.2013.03.001","volume":"15","author":"Lindeman","year":"2013","journal-title":"J Mol Diagn"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib3","doi-asserted-by":"crossref","first-page":"395","DOI":"10.6004\/jnccn.2013.0055","article-title":"Melanoma, version 2.2013: featured updates to the NCCN guidelines","volume":"11","author":"Coit","year":"2013","journal-title":"J Natl Compr Canc Netw"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib4","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1111\/bjd.12248","article-title":"BRAF mutation testing algorithm for vemurafenib treatment in melanoma: recommendations from an expert panel","volume":"168","author":"Gonzalez","year":"2013","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib5","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.6004\/jnccn.2014.0099","article-title":"Colon cancer, version 3.2014","volume":"12","author":"Benson","year":"2014","journal-title":"J Natl Compr Canc Netw"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib6","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1136\/jclinpath-2014-202467","article-title":"RAS testing of colorectal carcinoma: a guidance document from the Association of Clinical Pathologists Molecular Pathology and Diagnostics Group","volume":"67","author":"Wong","year":"2014","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib7","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nrg2626","article-title":"Sequencing technologies: the next generation","volume":"11","author":"Metzker","year":"2010","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib8","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.canlet.2012.11.025","article-title":"Next-generation sequencing in the clinic: promises and challenges","volume":"340","author":"Xuan","year":"2013","journal-title":"Cancer Lett"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib9","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s40291-015-0140-9","article-title":"Cost effectiveness of sequencing 34 cancer-associated genes as an aid for treatment selection in patients with metastatic melanoma","volume":"19","author":"Li","year":"2015","journal-title":"Mol Diagn Ther"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib10","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1093\/annonc\/mdv184","article-title":"A new generation of cancer genome diagnostics for routine clinical use: overcoming the roadblocks to personalized cancer medicine","volume":"26","author":"Heuckmann","year":"2015","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib11","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/nbt.2198","article-title":"Performance comparison of benchtop high-throughput sequencing platforms","volume":"30","author":"Loman","year":"2012","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib12","doi-asserted-by":"crossref","first-page":"251364","DOI":"10.1155\/2012\/251364","article-title":"Comparison of next-generation sequencing systems","volume":"2012","author":"Liu","year":"2012","journal-title":"J Biomed Biotechnol"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib13","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jmoldx.2010.11.010","article-title":"A platform for rapid detection of multiple oncogenic mutations with relevance to targeted therapy in non-small-cell lung cancer","volume":"13","author":"Su","year":"2011","journal-title":"J Mol Diagn"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib14","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jss.2013.05.003","article-title":"Epidermal growth factor receptor overexpression is a marker for adverse pathologic features in papillary thyroid carcinoma","volume":"185","author":"Fisher","year":"2013","journal-title":"J Surg Res"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib15","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1097\/PDM.0b013e318182af52","article-title":"Implementation of novel pyrosequencing assays to screen for common mutations of BRAF and KRAS in a cohort of sporadic colorectal cancers","volume":"18","author":"Packham","year":"2009","journal-title":"Diagn Mol Pathol"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib16","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1016\/j.humpath.2014.07.014","article-title":"Accurate detection of BRAF p.V600E mutations in challenging melanoma specimens requires stringent immunohistochemistry scoring criteria or sensitive molecular assays","volume":"45","author":"Fisher","year":"2014","journal-title":"Hum Pathol"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib17","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1158\/1078-0432.CCR-13-3114","article-title":"High-throughput detection of clinically relevant mutations in archived tumor samples by multiplexed PCR and next-generation sequencing","volume":"20","author":"Bourgon","year":"2014","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib18","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1093\/bioinformatics\/btp698","article-title":"Fast and accurate long-read alignment with Burrows-Wheeler transform","volume":"26","author":"Li","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib19","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The Sequence Alignment\/Map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib20","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1101\/gr.129684.111","article-title":"VarScan 2: somatic mutation and copy number alteration discovery in cancer by exome sequencing","volume":"22","author":"Koboldt","year":"2012","journal-title":"Genome Res"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib21","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/ng.806","article-title":"A framework for variation discovery and genotyping using next-generation DNA sequencing data","volume":"43","author":"DePristo","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib22","doi-asserted-by":"crossref","first-page":"e164","DOI":"10.1093\/nar\/gkq603","article-title":"ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data","volume":"38","author":"Wang","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib23","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1309\/AJCPMWGWGO34EGOD","article-title":"Clinical validation of KRAS, BRAF, and EGFR mutation detection using next-generation sequencing","volume":"141","author":"Lin","year":"2014","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib24","doi-asserted-by":"crossref","first-page":"481","DOI":"10.5858\/arpa.2014-0250-CP","article-title":"College of American Pathologists' laboratory standards for next-generation sequencing clinical tests","volume":"139","author":"Aziz","year":"2015","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib25","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.currproblcancer.2014.08.004","article-title":"Section I: integrating laboratory medicine with tissue specimens","volume":"38","author":"Fisher","year":"2014","journal-title":"Curr Probl Cancer"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib26","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/modpathol.2013.134","article-title":"The estimation of tumor cell percentage for molecular testing by pathologists is not accurate","volume":"27","author":"Smits","year":"2014","journal-title":"Mod Pathol"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib27","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1093\/nar\/gks1443","article-title":"Discovery and characterization of artifactual mutations in deep coverage targeted capture sequencing data due to oxidative DNA damage during sample preparation","volume":"41","author":"Costello","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib28","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.jmoldx.2013.05.004","article-title":"Comparison of clinical targeted next-generation sequence data from formalin-fixed and fresh-frozen tissue specimens","volume":"15","author":"Spencer","year":"2013","journal-title":"J Mol Diagn"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib29","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.jmoldx.2013.05.003","article-title":"Clinical validation of a next-generation sequencing screen for mutational hotspots in 46 cancer-related genes","volume":"15","author":"Singh","year":"2013","journal-title":"J Mol Diagn"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib30","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1755-8794-7-23","article-title":"Sequence artefacts in a prospective series of formalin-fixed tumours tested for mutations in hotspot regions by massively parallel sequencing","volume":"7","author":"Wong","year":"2014","journal-title":"BMC Med Genomics"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib31","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jmoldx.2012.08.001","article-title":"Detection of FLT3 internal tandem duplication in targeted, short-read-length, next-generation sequencing data","volume":"15","author":"Spencer","year":"2013","journal-title":"J Mol Diagn"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib32","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1101\/gad.191999.112","article-title":"Melanoma: from mutations to medicine","volume":"26","author":"Tsao","year":"2012","journal-title":"Genes Dev"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib33","doi-asserted-by":"crossref","first-page":"320","DOI":"10.7150\/jca.3619","article-title":"Rare though not mutually exclusive: a report of three cases of concomitant KRAS and BRAF mutation and a review of the literature","volume":"4","author":"Sahin","year":"2013","journal-title":"J Cancer"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib34","doi-asserted-by":"crossref","first-page":"425","DOI":"10.2353\/jmoldx.2010.090188","article-title":"Comparison of Sanger sequencing, pyrosequencing, and melting curve analysis for the detection of KRAS mutations: diagnostic and clinical implications","volume":"12","author":"Tsiatis","year":"2010","journal-title":"J Mol Diagn"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib35","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jmoldx.2013.08.004","article-title":"Validation and implementation of targeted capture and sequencing for the detection of actionable mutation, copy number variation, and gene rearrangement in clinical cancer specimens","volume":"16","author":"Pritchard","year":"2014","journal-title":"J Mol Diagn"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib36","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1038\/bjc.2014.518","article-title":"Clinical massively parallel next-generation sequencing analysis of 409 cancer-related genes for mutations and copy number variations in solid tumours","volume":"111","author":"Singh","year":"2014","journal-title":"Br J Cancer"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib37","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jmoldx.2012.09.003","article-title":"Combining highly multiplexed PCR with semiconductor-based sequencing for rapid cancer genotyping","volume":"15","author":"Beadling","year":"2013","journal-title":"J Mol Diagn"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib38","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nm.2697","article-title":"Chipping away at the lung cancer genome","volume":"18","author":"Pao","year":"2012","journal-title":"Nat Med"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib39","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1056\/NEJMra1404198","article-title":"Pancreatic adenocarcinoma","volume":"371","author":"Ryan","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib40","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/jid.2014.366","article-title":"Beyond BRAF(V600): clinical mutation panel testing by next-generation sequencing in advanced melanoma","volume":"135","author":"Siroy","year":"2015","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib41","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/nrc2645","article-title":"Genetic prognostic and predictive markers in colorectal cancer","volume":"9","author":"Walther","year":"2009","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib42","doi-asserted-by":"crossref","first-page":"5477","DOI":"10.1038\/ncomms6477","article-title":"Genomic landscape and genetic heterogeneity in gastric adenocarcinoma revealed by whole-genome sequencing","volume":"5","author":"Wong","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib43","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.currproblcancer.2014.08.007","article-title":"Section IV: non-small cell lung cancer and malignant melanoma","volume":"38","author":"Fisher","year":"2014","journal-title":"Curr Probl Cancer"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib44","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.cell.2012.06.024","article-title":"A landscape of driver mutations in melanoma","volume":"150","author":"Hodis","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib45","doi-asserted-by":"crossref","first-page":"747","DOI":"10.3390\/ijms16010747","article-title":"Gene mutation analysis in EGFR wild type NSCLC responsive to erlotinib: are there features to guide patient selection?","volume":"16","author":"Ulivi","year":"2015","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib46","doi-asserted-by":"crossref","first-page":"7071","DOI":"10.1158\/0008-5472.CAN-11-0128","article-title":"P53 modulates acquired resistance to EGFR inhibitors and radiation","volume":"71","author":"Huang","year":"2011","journal-title":"Cancer Res"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib47","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.currproblcancer.2014.08.006","article-title":"Section III: molecular diagnostics in neuro-oncology","volume":"38","author":"Neill","year":"2014","journal-title":"Curr Probl Cancer"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib48","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.currproblcancer.2014.08.005","article-title":"Section II: hematolymphoid malignancies","volume":"38","author":"Zhang","year":"2014","journal-title":"Curr Probl Cancer"},{"key":"10.1016\/j.jmoldx.2015.11.006_bib49","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1158\/1078-0432.CCR-14-1998","article-title":"A translational, pharmacodynamic, and pharmacokinetic phase IB clinical study of everolimus in resectable non-small cell lung cancer","volume":"21","author":"Owonikoko","year":"2015","journal-title":"Clin Cancer Res"}],"container-title":["The Journal of Molecular Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525157815002767?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525157815002767?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T12:45:57Z","timestamp":1576241157000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525157815002767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["S1525157815002767"],"URL":"https:\/\/doi.org\/10.1016\/j.jmoldx.2015.11.006","relation":{},"ISSN":["1525-1578"],"issn-type":[{"value":"1525-1578","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical Validation and Implementation of a Targeted Next-Generation Sequencing Assay to Detect Somatic Variants in Non-Small Cell Lung, Melanoma, and Gastrointestinal Malignancies","name":"articletitle","label":"Article Title"},{"value":"The Journal of Molecular Diagnostics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmoldx.2015.11.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 American Society for Investigative Pathology and the Association for Molecular Pathology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}