{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T17:25:02Z","timestamp":1783617902487,"version":"3.55.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,4,11]],"date-time":"2016-04-11T00:00:00Z","timestamp":1460332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","journals.elsevierhealth.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Molecular Diagnostics"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.jmoldx.2016.03.004","type":"journal-article","created":{"date-parts":[[2016,5,7]],"date-time":"2016-05-07T20:13:44Z","timestamp":1462652024000},"page":"595-603","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Genome-Wide Single-Nucleotide Polymorphism Array Analysis Improves Prognostication of Acute Lymphoblastic Leukemia\/Lymphoma"],"prefix":"10.1016","volume":"18","author":[{"given":"Yunhong","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Roulston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale","family":"Bixby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmoldx.2016.03.004_bib1","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1056\/NEJMra052603","article-title":"Treatment of acute lymphoblastic leukemia","volume":"354","author":"Pui","year":"2006","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jmoldx.2016.03.004_bib2","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S1470-2045(10)70066-8","article-title":"Prognostic effect of chromosomal abnormalities in childhood B-cell precursor acute lymphoblastic leukaemia: results from the UK Medical Research Council ALL97\/99 randomised trial","volume":"11","author":"Moorman","year":"2010","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.jmoldx.2016.03.004_bib3","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/ejh.12097","article-title":"Risk group assignment differs for children and adults 1-45 yr with acute lymphoblastic leukemia treated by the NOPHO ALL-2008 protocol","volume":"90","author":"Toft","year":"2013","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.jmoldx.2016.03.004_bib4","doi-asserted-by":"crossref","first-page":"5136","DOI":"10.1182\/blood-2009-08-231217","article-title":"T-cell acute lymphoblastic leukemia in adults: clinical features, immunophenotype, cytogenetics, and outcome from the large randomized prospective trial (UKALL XII\/ECOG 2993)","volume":"114","author":"Marks","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.jmoldx.2016.03.004_bib5","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1182\/blood-2006-10-051912","article-title":"Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII\/Eastern Cooperative Oncology Group (ECOG) 2993 trial","volume":"109","author":"Moorman","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.jmoldx.2016.03.004_bib6","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1182\/blood-2007-10-116186","article-title":"Impact of cytogenetics on the outcome of adult acute lymphoblastic leukemia: results of Southwest Oncology Group 9400 study","volume":"111","author":"Pullarkat","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.jmoldx.2016.03.004_bib7","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.blre.2012.01.001","article-title":"The clinical relevance of chromosomal and genomic abnormalities in B-cell precursor acute lymphoblastic leukaemia","volume":"26","author":"Moorman","year":"2012","journal-title":"Blood Rev"},{"key":"10.1016\/j.jmoldx.2016.03.004_bib8","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1182\/asheducation.V2012.1.389.3798360","article-title":"The molecular genetic makeup of acute lymphoblastic leukemia","volume":"2012","author":"Mullighan","year":"2012","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"10.1016\/j.jmoldx.2016.03.004_bib9","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/nature05690","article-title":"Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia","volume":"446","author":"Mullighan","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.jmoldx.2016.03.004_bib10","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.3324\/haematol.2013.085175","article-title":"Genes commonly deleted in childhood B-cell precursor acute lymphoblastic leukemia: association with cytogenetics and clinical features","volume":"98","author":"Schwab","year":"2013","journal-title":"Haematologica"},{"key":"10.1016\/j.jmoldx.2016.03.004_bib11","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1182\/blood-2014-03-562918","article-title":"A novel integrated cytogenetic and genomic classification refines risk stratification in pediatric acute lymphoblastic leukemia","volume":"124","author":"Moorman","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.jmoldx.2016.03.004_bib12","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1056\/NEJMoa0808253","article-title":"Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia","volume":"360","author":"Mullighan","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jmoldx.2016.03.004_bib13","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/leu.2013.206","article-title":"Deletions of IKZF1 and SPRED1 are associated with poor prognosis in a population-based series of pediatric B-cell precursor acute lymphoblastic leukemia diagnosed between 1992 and 2011","volume":"28","author":"Olsson","year":"2014","journal-title":"Leukemia"},{"key":"10.1016\/j.jmoldx.2016.03.004_bib14","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1182\/blood-2007-05-088310","article-title":"Molecular allelokaryotyping of pediatric acute lymphoblastic leukemias by high-resolution single nucleotide polymorphism oligonucleotide genomic microarray","volume":"111","author":"Kawamata","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.jmoldx.2016.03.004_bib15","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.cancergen.2015.04.006","article-title":"Cytogenetic, fluorescence in situ hybridization, and genomic array characterization of chronic myeloid leukemia with cryptic BCR-ABL1 fusions","volume":"208","author":"Shao","year":"2015","journal-title":"Cancer Genet"},{"key":"10.1016\/j.jmoldx.2016.03.004_bib16","doi-asserted-by":"crossref","first-page":"8167","DOI":"10.1073\/pnas.0602360103","article-title":"Complex genomic alterations and gene expression in acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21","volume":"103","author":"Strefford","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jmoldx.2016.03.004_bib17","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/leu.2008.278","article-title":"Heterogeneous patterns of amplification of the NUP214-ABL1 fusion gene in T-cell acute lymphoblastic leukemia","volume":"23","author":"Graux","year":"2009","journal-title":"Leukemia"},{"key":"10.1016\/j.jmoldx.2016.03.004_bib18","doi-asserted-by":"crossref","first-page":"19594","DOI":"10.1074\/jbc.M000254200","article-title":"Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity","volume":"275","author":"Koipally","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jmoldx.2016.03.004_bib19","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/bjh.13342","article-title":"Ikaros and leukaemia","volume":"169","author":"Olsson","year":"2015","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jmoldx.2016.03.004_bib20","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nature06866","article-title":"BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros","volume":"453","author":"Mullighan","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.jmoldx.2016.03.004_bib21","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1182\/blood-2008-08-173963","volume":"114","author":"Iacobucci","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.jmoldx.2016.03.004_bib22","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1182\/blood-2013-06-509794","article-title":"IKZF1 status as a prognostic feature in BCR-ABL1-positive childhood ALL","volume":"123","author":"van der Veer","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.jmoldx.2016.03.004_bib23","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1038\/leu.2015.134","article-title":"IKZF1 deletion is an independent prognostic marker in childhood B-cell precursor acute lymphoblastic leukemia, and distinguishes patients benefiting from pulses during maintenance therapy: results of the EORTC Children's Leukemia Group study 58951","volume":"29","author":"Clappier","year":"2015","journal-title":"Leukemia"},{"key":"10.1016\/j.jmoldx.2016.03.004_bib24","doi-asserted-by":"crossref","first-page":"5202","DOI":"10.1200\/JCO.2008.21.6408","article-title":"IKZF1 (Ikaros) deletions in BCR-ABL1-positive acute lymphoblastic leukemia are associated with short disease-free survival and high rate of cumulative incidence of relapse: a GIMEMA AL WP report","volume":"27","author":"Martinelli","year":"2009","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jmoldx.2016.03.004_bib25","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1182\/blood-2012-10-462358","article-title":"Independent prognostic value of BCR-ABL1-like signature and IKZF1 deletion, but not high CRLF2 expression, in children with B-cell precursor ALL","volume":"122","author":"van der Veer","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.jmoldx.2016.03.004_bib26","first-page":"1","article-title":"Prognostic value of rare IKZF1 deletion in childhood B-cell precursor acute lymphoblastic leukemia: an international collaborative study","volume":"29","author":"Boer","year":"2015","journal-title":"Leukemia"},{"key":"10.1016\/j.jmoldx.2016.03.004_bib27","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S1470-2045(08)70339-5","article-title":"A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study","volume":"10","author":"Den Boer","year":"2009","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.jmoldx.2016.03.004_bib28","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ccr.2012.06.005","article-title":"Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia","volume":"22","author":"Roberts","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jmoldx.2016.03.004_bib29","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1111\/bjh.13757","article-title":"Identification of novel kinase fusion transcripts in paediatric B cell precursor acute lymphoblastic leukaemia with IKZF1 deletion","volume":"171","author":"Yano","year":"2015","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jmoldx.2016.03.004_bib30","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1056\/NEJMoa1403088","article-title":"Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia","volume":"371","author":"Roberts","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jmoldx.2016.03.004_bib31","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1002\/gcc.22163","article-title":"Acute lymphoblastic leukemia with low hypodiploid\/near triploid karyotype is a specific clinical entity and exhibits a very high TP53 mutation frequency of 93%","volume":"53","author":"Muhlbacher","year":"2014","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.jmoldx.2016.03.004_bib32","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.1365-2141.2010.08314.x","article-title":"Detection of prognostically relevant genetic abnormalities in childhood B-cell precursor acute lymphoblastic leukaemia: recommendations from the Biology and Diagnosis Committee of the International Berlin-Frankfurt-Munster study group","volume":"151","author":"Harrison","year":"2010","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jmoldx.2016.03.004_bib33","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1038\/leu.2013.317","article-title":"An international study of intrachromosomal amplification of chromosome 21 (iAMP21): cytogenetic characterization and outcome","volume":"28","author":"Harrison","year":"2014","journal-title":"Leukemia"},{"key":"10.1016\/j.jmoldx.2016.03.004_bib34","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1182\/blood-2014-08-569228","article-title":"Blood spotlight on iAMP21 acute lymphoblastic leukemia (ALL), a high-risk pediatric disease","volume":"125","author":"Harrison","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.jmoldx.2016.03.004_bib35","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.leukres.2015.06.005","article-title":"Next-generation-sequencing of recurrent childhood high hyperdiploid acute lymphoblastic leukemia reveals mutations typically associated with high risk patients","volume":"39","author":"Chen","year":"2015","journal-title":"Leuk Res"},{"key":"10.1016\/j.jmoldx.2016.03.004_bib36","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1038\/leu.2015.107","article-title":"KRAS and CREBBP mutations: a relapse-linked malicious liaison in childhood high hyperdiploid acute lymphoblastic leukemia","volume":"29","author":"Malinowska-Ozdowy","year":"2015","journal-title":"Leukemia"},{"key":"10.1016\/j.jmoldx.2016.03.004_bib37","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/leu.2008.318","article-title":"Rapid complete cytogenetic remission after upfront dasatinib monotherapy in a patient with a NUP214-ABL1-positive T-cell acute lymphoblastic leukemia","volume":"23","author":"Deenik","year":"2009","journal-title":"Leukemia"},{"key":"10.1016\/j.jmoldx.2016.03.004_bib38","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1182\/blood-2013-08-521518","article-title":"SET-NUP214 is a recurrent gammadelta lineage-specific fusion transcript associated with corticosteroid\/chemotherapy resistance in adult T-ALL","volume":"123","author":"Ben Abdelali","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.jmoldx.2016.03.004_bib39","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.6004\/jnccn.2015.0153","article-title":"Acute lymphoblastic leukemia, version 2.2015","volume":"13","author":"Alvarnas","year":"2015","journal-title":"J Natl Compr Canc Netw"}],"container-title":["The Journal of Molecular Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525157816300216?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525157816300216?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,19]],"date-time":"2020-09-19T15:12:46Z","timestamp":1600528366000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525157816300216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["S1525157816300216"],"URL":"https:\/\/doi.org\/10.1016\/j.jmoldx.2016.03.004","relation":{},"ISSN":["1525-1578"],"issn-type":[{"value":"1525-1578","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genome-Wide Single-Nucleotide Polymorphism Array Analysis Improves Prognostication of Acute Lymphoblastic Leukemia\/Lymphoma","name":"articletitle","label":"Article Title"},{"value":"The Journal of Molecular Diagnostics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmoldx.2016.03.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc. on behalf of the American Society for Investigative Pathology and the Association for Molecular Pathology.","name":"copyright","label":"Copyright"}]}}