{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:21:06Z","timestamp":1761502866826,"version":"build-2065373602"},"reference-count":34,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmdjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Molecular Diagnostics"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.jmoldx.2020.06.009","type":"journal-article","created":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T11:43:33Z","timestamp":1593431013000},"page":"1189-1198","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["A Role for Chromosomal Microarray Testing in the Workup of Male Infertility"],"prefix":"10.1016","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0798-9232","authenticated-orcid":false,"given":"Kelsey J.","family":"McIntyre","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0888-8705","authenticated-orcid":false,"given":"Elissa","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Mertens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian M.","family":"Dubuc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5527-5496","authenticated-orcid":false,"given":"Ruth A.","family":"Heim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0146-4881","authenticated-orcid":false,"given":"Heather","family":"Mason-Suares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmoldx.2020.06.009_bib1","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S0015-0282(02)03105-9","article-title":"Best practice policies for male infertility","volume":"77","author":"Sharlip","year":"2002","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jmoldx.2020.06.009_bib2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12958-015-0032-1","article-title":"A unique view on male infertility around the globe","volume":"13","author":"Agarwal","year":"2015","journal-title":"Reprod Biol Endocrinol"},{"year":"2000","series-title":"Clinical Management of Male Infertility: Endotext","author":"Barak","key":"10.1016\/j.jmoldx.2020.06.009_bib3"},{"key":"10.1016\/j.jmoldx.2020.06.009_bib4","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.ucl.2013.08.004","article-title":"Azoospermia due to spermatogenic failure","volume":"41","author":"Berookhim","year":"2014","journal-title":"Urol Clin North Am"},{"year":"2010","series-title":"Andrology: Male Reproductive Health and Dysfunction","author":"Nieschlag","key":"10.1016\/j.jmoldx.2020.06.009_bib5"},{"key":"10.1016\/j.jmoldx.2020.06.009_bib6","first-page":"s41","article-title":"Genetic dissection of mammalian fertility pathways","volume":"4 Suppl","author":"Matzuk","year":"2002","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jmoldx.2020.06.009_bib7","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1258\/0007142001903436","article-title":"Lifestyle and environmental contribution to male infertility","volume":"56","author":"Sharpe","year":"2000","journal-title":"Br Med Bull"},{"key":"10.1016\/j.jmoldx.2020.06.009_bib8","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1159\/000030280","article-title":"Cytogenetic study in 102 infertile men","volume":"61","author":"Gunduz","year":"1998","journal-title":"Urol Int"},{"key":"10.1016\/j.jmoldx.2020.06.009_bib9","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/BF00278879","article-title":"Localization of factors controlling spermatogenesis in the nonfluorescent portion of the human Y chromosome long arm","volume":"34","author":"Tiepolo","year":"1976","journal-title":"Hum Genet"},{"key":"10.1016\/j.jmoldx.2020.06.009_bib10","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1093\/humrep\/16.8.1543","article-title":"Prognostic value of Y deletion analysis: the role of current methods","volume":"16","author":"Foresta","year":"2001","journal-title":"Hum Reprod"},{"key":"10.1016\/j.jmoldx.2020.06.009_bib11","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1093\/hmg\/5.7.933","article-title":"Human Y chromosome azoospermia factors (AZF) mapped to different subregions in Yq11","volume":"5","author":"Vogt","year":"1996","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jmoldx.2020.06.009_bib12","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.ajhg.2012.09.003","article-title":"AZFc deletions and spermatogenic failure: a population-based survey of 20,000 Y chromosomes","volume":"91","author":"Rozen","year":"2012","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jmoldx.2020.06.009_bib13","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1136\/jmg.2004.025833","article-title":"Association of partial AZFc region deletions with spermatogenic impairment and male infertility","volume":"42","author":"Ferlin","year":"2005","journal-title":"J Med Genet"},{"key":"10.1016\/j.jmoldx.2020.06.009_bib14","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.bpobgyn.2017.05.002","article-title":"Genetic diagnostics of male infertility in clinical practice","volume":"44","author":"Flannigan","year":"2017","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"10.1016\/j.jmoldx.2020.06.009_bib15","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1093\/humrep\/15.7.1431","article-title":"Prognostic value of Y deletion analysis: what is the clinical prognostic value of Y chromosome microdeletion analysis?","volume":"15","author":"Krausz","year":"2000","journal-title":"Hum Reprod"},{"key":"10.1016\/j.jmoldx.2020.06.009_bib16","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1016\/j.fertnstert.2009.09.006","article-title":"A decade of experience emphasizes that testing for Y microdeletions is essential in American men with azoospermia and severe oligozoospermia","volume":"94","author":"Stahl","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jmoldx.2020.06.009_bib17","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/nrg.2017.36","article-title":"Human Y-chromosome variation in the genome-sequencing era","volume":"18","author":"Jobling","year":"2017","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.jmoldx.2020.06.009_bib18","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/ng1754","article-title":"High mutation rates have driven extensive structural polymorphism among human Y chromosomes","volume":"38","author":"Repping","year":"2006","journal-title":"Nat Genet"},{"key":"10.1016\/j.jmoldx.2020.06.009_bib19","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1159\/000184715","article-title":"Copy number variation on the human Y chromosome","volume":"123","author":"Jobling","year":"2008","journal-title":"Cytogenet Genome Res"},{"key":"10.1016\/j.jmoldx.2020.06.009_bib20","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/ng.3559","article-title":"Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences","volume":"48","author":"Poznik","year":"2016","journal-title":"Nat Genet"},{"key":"10.1016\/j.jmoldx.2020.06.009_bib21","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1534\/g3.113.006577","article-title":"A dynamic database of microarray-characterized cell lines with various cytogenetic and genomic backgrounds","volume":"3","author":"Tang","year":"2013","journal-title":"G3 (Bethesda)"},{"key":"10.1016\/j.jmoldx.2020.06.009_bib22","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1086\/342928","article-title":"Recombination between palindromes P5 and P1 on the human Y chromosome causes massive deletions and spermatogenic failure","volume":"71","author":"Repping","year":"2002","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jmoldx.2020.06.009_bib23","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/gim.2013.36","article-title":"Density matters: comparison of array platforms for detection of copy-number variation and copy-neutral abnormalities","volume":"15","author":"Mason-Suares","year":"2013","journal-title":"Genet Med"},{"key":"10.1016\/j.jmoldx.2020.06.009_bib24","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/humu.22912","article-title":"Targeted droplet-digital PCR as a tool for novel deletion discovery at the DFNB1 locus","volume":"37","author":"Tayoun","year":"2016","journal-title":"Hum Mutat"},{"key":"10.1016\/j.jmoldx.2020.06.009_bib25","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1093\/hmg\/6.11.1985","article-title":"Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females","volume":"6","author":"Schiebel","year":"1997","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jmoldx.2020.06.009_bib26","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1097\/GIM.0b013e3182217a3a","article-title":"American College of Medical Genetics standards and guidelines for interpretation and reporting of postnatal constitutional copy number variants","volume":"13","author":"Kearney","year":"2011","journal-title":"Genet Med"},{"key":"10.1016\/j.jmoldx.2020.06.009_bib27","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.fertnstert.2005.09.060","article-title":"Reevaluation of azoospermic factor c microdeletions using sequence-tagged site markers with confirmed physical positions from the GenBank database","volume":"85","author":"Fukushima","year":"2006","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jmoldx.2020.06.009_bib28","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/S0090-4295(00)00846-3","article-title":"Y-chromosome microdeletion and its effect on reproductive decisions in Taiwanese patients presenting with nonobstructive azoospermia","volume":"56","author":"Lin","year":"2000","journal-title":"Urology"},{"key":"10.1016\/j.jmoldx.2020.06.009_bib29","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1136\/jmg.34.11.881","article-title":"Clustering of Y chromosome deletions in subinterval E of interval 6 supports the existence of an oligozoospermia critical region outside the DAZ gene","volume":"34","author":"Stuppia","year":"1997","journal-title":"J Med Genet"},{"key":"10.1016\/j.jmoldx.2020.06.009_bib30","first-page":"226","article-title":"Y chromosome microdeletions and alterations of spermatogenesis","volume":"22","author":"Foresta","year":"2001","journal-title":"Endocr Rev"},{"key":"10.1016\/j.jmoldx.2020.06.009_bib31","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/s41585-018-0003-3","article-title":"Genetics of male infertility","volume":"15","author":"Krausz","year":"2018","journal-title":"Nat Rev Urol"},{"key":"10.1016\/j.jmoldx.2020.06.009_bib32","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1080\/14737159.2019.1633917","article-title":"Contemporary genetics-based diagnostics of male infertility","volume":"19","author":"Ferlin","year":"2019","journal-title":"Expert Rev Mol Diagn"},{"key":"10.1016\/j.jmoldx.2020.06.009_bib33","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1007\/s10815-018-1204-7","article-title":"Comprehensive genetic testing for female and male infertility using next-generation sequencing","volume":"35","author":"Patel","year":"2018","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.jmoldx.2020.06.009_bib34","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s40142-016-0091-4","article-title":"Detecting copy number variants via next generation sequencing technologies","volume":"4","author":"Mason-Suares","year":"2016","journal-title":"Curr Genet Med Rep"}],"container-title":["The Journal of Molecular Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152515782030372X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152515782030372X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:14:02Z","timestamp":1761502442000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S152515782030372X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":34,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["S152515782030372X"],"URL":"https:\/\/doi.org\/10.1016\/j.jmoldx.2020.06.009","relation":{},"ISSN":["1525-1578"],"issn-type":[{"type":"print","value":"1525-1578"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Role for Chromosomal Microarray Testing in the Workup of Male Infertility","name":"articletitle","label":"Article Title"},{"value":"The Journal of Molecular Diagnostics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmoldx.2020.06.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Association for Molecular Pathology and American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}