{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:18:24Z","timestamp":1761502704812,"version":"build-2065373602"},"reference-count":44,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000871","name":"Mayo Clinic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015537","name":"Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015537","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmdjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Molecular Diagnostics"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.jmoldx.2020.12.006","type":"journal-article","created":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T20:38:50Z","timestamp":1609360730000},"page":"375-388","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Chromosomal Junction Detection from Whole-Genome Sequencing on Formalin-Fixed, Paraffin-Embedded Tumors"],"prefix":"10.1016","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8630-5897","authenticated-orcid":false,"given":"Stephen","family":"Murphy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8902-0950","authenticated-orcid":false,"given":"James","family":"Smadbeck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Eckloff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yean","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7412-5322","authenticated-orcid":false,"given":"Sarah","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giannoula","family":"Karagouga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishnu","family":"Serla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4341-9613","authenticated-orcid":false,"given":"Anurag","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Sikkink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesse","family":"Voss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faye","family":"Harris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet Schaefer","family":"Kline","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farhad","family":"Kosari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5009-4808","authenticated-orcid":false,"given":"Andrew","family":"Feldman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Wieben","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie Christine","family":"Aubry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Kipp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Jen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8202-6268","authenticated-orcid":false,"given":"John","family":"Cheville","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Vasmatzis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmoldx.2020.12.006_bib1","doi-asserted-by":"crossref","first-page":"19096","DOI":"10.1073\/pnas.0910672106","article-title":"Genetic diagnosis by whole exome capture and massively parallel DNA sequencing","volume":"106","author":"Choi","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jmoldx.2020.12.006_bib2","doi-asserted-by":"crossref","first-page":"e1002384","DOI":"10.1371\/journal.pgen.1002384","article-title":"Repetitive elements may comprise over two-thirds of the human genome","volume":"7","author":"de Koning","year":"2011","journal-title":"PLoS Genet"},{"key":"10.1016\/j.jmoldx.2020.12.006_bib3","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1136\/jmedgenet-2018-105272","article-title":"Whole-genome sequencing analysis of CNV using low-coverage and paired-end strategies is efficient and outperforms array-based CNV analysis","volume":"55","author":"Zhou","year":"2018","journal-title":"J Med Genet"},{"key":"10.1016\/j.jmoldx.2020.12.006_bib4","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1093\/annonc\/mdw405","article-title":"Chromoplectic TPM3-ALK rearrangement in a patient with inflammatory myofibroblastic tumor who responded to ceritinib after progression on crizotinib","volume":"27","author":"Mansfield","year":"2016","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jmoldx.2020.12.006_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cancergen.2017.11.009","article-title":"SVAtools for junction detection of genome-wide chromosomal rearrangements by mate-pair sequencing (MPseq)","volume":"221","author":"Johnson","year":"2018","journal-title":"Cancer Genet"},{"key":"10.1016\/j.jmoldx.2020.12.006_bib6","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1093\/bioinformatics\/btx829","article-title":"Genome U-Plot: a whole genome visualization","volume":"34","author":"Gaitatzes","year":"2018","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jmoldx.2020.12.006_bib7","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/gcc.5","article-title":"Copy number variant analysis using genome-wide mate-pair sequencing","volume":"57","author":"Smadbeck","year":"2018","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.jmoldx.2020.12.006_bib8","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/s41408-019-0255-z","article-title":"Mate pair sequencing outperforms fluorescence in situ hybridization in the genomic characterization of multiple myeloma","volume":"9","author":"Smadbeck","year":"2019","journal-title":"Blood Cancer J"},{"key":"10.1016\/j.jmoldx.2020.12.006_bib9","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.celrep.2018.03.050","article-title":"Driver fusions and their implications in the development and treatment of human cancers","volume":"23","author":"Gao","year":"2018","journal-title":"Cell Rep"},{"key":"10.1016\/j.jmoldx.2020.12.006_bib10","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.lungcan.2019.06.004","article-title":"Sensitivity of next-generation sequencing assays detecting oncogenic fusions in plasma cell-free DNA","volume":"134","author":"Supplee","year":"2019","journal-title":"Lung Cancer"},{"key":"10.1016\/j.jmoldx.2020.12.006_bib11","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1200\/EDBK_199765","article-title":"Liquid biopsy to identify actionable genomic alterations","volume":"38","author":"Ou","year":"2018","journal-title":"Am Soc Clin Oncol Educ Book"},{"key":"10.1016\/j.jmoldx.2020.12.006_bib12","doi-asserted-by":"crossref","first-page":"e248","DOI":"10.3324\/haematol.2018.207290","article-title":"False-negative rates for MYC fluorescence in situ hybridization probes in B-cell neoplasms","volume":"104","author":"King","year":"2019","journal-title":"Haematologica"},{"key":"10.1016\/j.jmoldx.2020.12.006_bib13","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.humpath.2018.09.010","article-title":"Use of mate-pair sequencing to characterize a complex cryptic BCR\/ABL1 rearrangement observed in a newly diagnosed case of chronic myeloid leukemia","volume":"89","author":"Peterson","year":"2019","journal-title":"Hum Pathol"},{"key":"10.1016\/j.jmoldx.2020.12.006_bib14","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cancergen.2018.11.005","article-title":"Constitutional chromosome rearrangements that mimic the 2017 World Health Organization \"acute myeloid leukemia with recurrent genetic abnormalities\": a study of three cases and review of the literature","volume":"230","author":"Peterson","year":"2019","journal-title":"Cancer Genet"},{"key":"10.1016\/j.jmoldx.2020.12.006_bib15","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/ejh.13179","article-title":"Mate pair sequencing improves detection of genomic abnormalities in acute myeloid leukemia","volume":"102","author":"Aypar","year":"2019","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.jmoldx.2020.12.006_bib16","doi-asserted-by":"crossref","first-page":"29087","DOI":"10.18632\/oncotarget.4900","article-title":"Chromosomal catastrophe is a frequent event in clinically insignificant prostate cancer","volume":"6","author":"Kovtun","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.jmoldx.2020.12.006_bib17","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jcv.2013.12.006","article-title":"Mate pair sequencing of oropharyngeal squamous cell carcinomas reveals that HPV integration occurs much less frequently than in cervical cancer","volume":"59","author":"Gao","year":"2014","journal-title":"J Clin Virol"},{"key":"10.1016\/j.jmoldx.2020.12.006_bib18","doi-asserted-by":"crossref","first-page":"29831","DOI":"10.1038\/srep29831","article-title":"Quantification of somatic chromosomal rearrangements in circulating cell-free DNA from ovarian cancers","volume":"6","author":"Harris","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.jmoldx.2020.12.006_bib19","doi-asserted-by":"crossref","first-page":"4050","DOI":"10.1200\/JCO.2014.56.7644","article-title":"Identification of independent primary tumors and intrapulmonary metastases using DNA rearrangements in non-small-cell lung cancer","volume":"32","author":"Murphy","year":"2014","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jmoldx.2020.12.006_bib20","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jtho.2018.10.001","article-title":"Neoantigenic potential of complex chromosomal rearrangements in mesothelioma","volume":"14","author":"Mansfield","year":"2019","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.jmoldx.2020.12.006_bib21","doi-asserted-by":"crossref","first-page":"546","DOI":"10.18632\/oncotarget.503","article-title":"Dramatic reduction of sequence artefacts from DNA isolated from formalin-fixed cancer biopsies by treatment with uracil- DNA glycosylase","volume":"3","author":"Do","year":"2012","journal-title":"Oncotarget"},{"key":"10.1016\/j.jmoldx.2020.12.006_bib22","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.pathol.2016.01.001","article-title":"Comparison of whole-exome sequencing of matched fresh and formalin fixed paraffin embedded melanoma tumours: implications for clinical decision making","volume":"48","author":"De Paoli-Iseppi","year":"2016","journal-title":"Pathology"},{"key":"10.1016\/j.jmoldx.2020.12.006_bib23","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1038\/gim.2017.241","article-title":"Clinical whole-genome sequencing from routine formalin-fixed, paraffin-embedded specimens: pilot study for the 100,000 Genomes Project","volume":"20","author":"Robbe","year":"2018","journal-title":"Genet Med"},{"key":"10.1016\/j.jmoldx.2020.12.006_bib24","doi-asserted-by":"crossref","first-page":"e98187","DOI":"10.1371\/journal.pone.0098187","article-title":"Next-generation sequencing of RNA and DNA isolated from paired fresh-frozen and formalin-fixed paraffin-embedded samples of human cancer and normal tissue","volume":"9","author":"Hedegaard","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jmoldx.2020.12.006_bib25","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1186\/s12864-015-1982-6","article-title":"Whole exome sequencing (WES) on formalin-fixed, paraffin-embedded (FFPE) tumor tissue in gastrointestinal stromal tumors (GIST)","volume":"16","author":"Astolfi","year":"2015","journal-title":"BMC Genomics"},{"key":"10.1016\/j.jmoldx.2020.12.006_bib26","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.jmoldx.2013.05.004","article-title":"Comparison of clinical targeted next-generation sequence data from formalin-fixed and fresh-frozen tissue specimens","volume":"15","author":"Spencer","year":"2013","journal-title":"J Mol Diagn"},{"key":"10.1016\/j.jmoldx.2020.12.006_bib27","doi-asserted-by":"crossref","first-page":"25943","DOI":"10.18632\/oncotarget.4671","article-title":"Targeted or whole genome sequencing of formalin fixed tissue samples: potential applications in cancer genomics","volume":"6","author":"Munchel","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.jmoldx.2020.12.006_bib28","doi-asserted-by":"crossref","first-page":"e0178706","DOI":"10.1371\/journal.pone.0178706","article-title":"Automated high throughput nucleic acid purification from formalin-fixed paraffin-embedded tissue samples for next generation sequence analysis","volume":"12","author":"Haile","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jmoldx.2020.12.006_bib29","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1097\/PAS.0000000000000961","article-title":"Feasibility of prostate PAXgene fixation for molecular research and diagnostic surgical pathology: comparison of matched fresh frozen, FFPE, and PFPE tissues","volume":"42","author":"Hognas","year":"2018","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.jmoldx.2020.12.006_bib30","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1038\/s41374-018-0066-z","article-title":"Mutation screening using formalin-fixed paraffin-embedded tissues: a stratified approach according to DNA quality","volume":"98","author":"Cucco","year":"2018","journal-title":"Lab Invest"},{"key":"10.1016\/j.jmoldx.2020.12.006_bib31","doi-asserted-by":"crossref","first-page":"e0212801","DOI":"10.1371\/journal.pone.0212801","article-title":"Integrated routine workflow using next-generation sequencing and a fully-automated platform for the detection of KRAS, NRAS and BRAF mutations in formalin-fixed paraffin embedded samples with poor DNA quality in patients with colorectal carcinoma","volume":"14","author":"Franczak","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.jmoldx.2020.12.006_bib32","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.nbt.2019.07.005","article-title":"Standardization of the preanalytical phase of DNA extraction from fixed tissue for next-generation sequencing analyses","volume":"54","author":"Kofanova","year":"2020","journal-title":"N Biotechnol"},{"key":"10.1016\/j.jmoldx.2020.12.006_bib33","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1097\/PAI.0000000000000535","article-title":"Evaluation of a DNA extraction and purification protocol using archived formalin-fixed paraffin-embedded tissues for BRAF mutations analysis in papillary thyroid microcarcinomas","volume":"27","author":"Nechifor-Boil\u0103","year":"2019","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"10.1016\/j.jmoldx.2020.12.006_bib34","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1002\/ar.24002","article-title":"An improved NGS library construction approach using DNA isolated from human cancer formalin-fixed paraffin-embedded samples","volume":"302","author":"Zhang","year":"2019","journal-title":"Anat Rec (Hoboken)"},{"key":"10.1016\/j.jmoldx.2020.12.006_bib35","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jmoldx.2017.11.010","article-title":"Assessment of capture and amplicon-based approaches for the development of a targeted next-generation sequencing pipeline to personalize lymphoma management","volume":"20","author":"Hung","year":"2018","journal-title":"J Mol Diagn"},{"key":"10.1016\/j.jmoldx.2020.12.006_bib36","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s13073-016-0375-z","article-title":"Copy number analysis by low coverage whole genome sequencing using ultra low-input DNA from formalin-fixed paraffin embedded tumor tissue","volume":"8","author":"Kader","year":"2016","journal-title":"Genome Med"},{"key":"10.1016\/j.jmoldx.2020.12.006_bib37","doi-asserted-by":"crossref","first-page":"e5548","DOI":"10.1371\/journal.pone.0005548","article-title":"Genome-wide massively parallel sequencing of formaldehyde fixed-paraffin embedded (FFPE) tumor tissues for copy-number- and mutation-analysis","volume":"4","author":"Schweiger","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.jmoldx.2020.12.006_bib38","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1093\/bioinformatics\/btu078","article-title":"BIMA V3: an aligner customized for mate pair library sequencing","volume":"30","author":"Drucker","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jmoldx.2020.12.006_bib39","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00428-011-1184-9","article-title":"Nucleic acids from long-term preserved FFPE tissues are suitable for downstream analyses","volume":"460","author":"Ludyga","year":"2012","journal-title":"Virchows Arch"},{"key":"10.1016\/j.jmoldx.2020.12.006_bib40","doi-asserted-by":"crossref","first-page":"e0144162","DOI":"10.1371\/journal.pone.0144162","article-title":"Comparison of accuracy of whole-exome sequencing with formalin-fixed paraffin-embedded and fresh frozen tissue samples","volume":"10","author":"Oh","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jmoldx.2020.12.006_bib41","doi-asserted-by":"crossref","first-page":"e151","DOI":"10.1093\/nar\/gkq510","article-title":"Using next-generation sequencing for high resolution multiplex analysis of copy number variation from nanogram quantities of DNA from formalin-fixed paraffin-embedded specimens","volume":"38","author":"Wood","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jmoldx.2020.12.006_bib42","doi-asserted-by":"crossref","first-page":"241","DOI":"10.5858\/arpa.2013-0953-SA","article-title":"Recommendations for human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology\/College of American Pathologists clinical practice guideline update","volume":"138","author":"Wolff","year":"2014","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.jmoldx.2020.12.006_bib43","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1002\/cncy.21897","article-title":"Next-generation sequencing of cytologic preparations: an analysis of quality metrics","volume":"125","author":"Hwang","year":"2017","journal-title":"Cancer Cytopathol"},{"key":"10.1016\/j.jmoldx.2020.12.006_bib44","doi-asserted-by":"crossref","first-page":"e86","DOI":"10.1002\/cphg.86","article-title":"Best practices for Illumina library preparation","volume":"102","author":"Bronner","year":"2019","journal-title":"Curr Protoc Hum Genet"}],"container-title":["The Journal of Molecular Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525157820306140?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525157820306140?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:14:50Z","timestamp":1761502490000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525157820306140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["S1525157820306140"],"URL":"https:\/\/doi.org\/10.1016\/j.jmoldx.2020.12.006","relation":{},"ISSN":["1525-1578"],"issn-type":[{"type":"print","value":"1525-1578"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chromosomal Junction Detection from Whole-Genome Sequencing on Formalin-Fixed, Paraffin-Embedded Tumors","name":"articletitle","label":"Article Title"},{"value":"The Journal of Molecular Diagnostics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmoldx.2020.12.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Association for Molecular Pathology and American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}