{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:13:33Z","timestamp":1792494813352,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["282510-BLUEPRINT"],"award-info":[{"award-number":["282510-BLUEPRINT"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["FP\/2007-2013"],"award-info":[{"award-number":["FP\/2007-2013"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004376","name":"Terry Fox Research Institute","doi-asserted-by":"publisher","award":["1079"],"award-info":[{"award-number":["1079"]}],"id":[{"id":"10.13039\/501100004376","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009812","name":"Princess Margaret Cancer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009812","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003579","name":"University of Toronto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003579","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012118","name":"Ontario Institute for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012118","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013873","name":"Government of Ontario","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013873","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmdjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Molecular Diagnostics"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.jmoldx.2021.09.002","type":"journal-article","created":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T00:20:41Z","timestamp":1632356441000},"page":"1774-1786","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["DNA Methylation-Based Classification of Small B-Cell Lymphomas"],"prefix":"10.1016","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3825-0577","authenticated-orcid":false,"given":"Daniel","family":"Xia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto Jose","family":"Leon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9292-1920","authenticated-orcid":false,"given":"Anjali","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehran","family":"Bakhtiari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8099-6546","authenticated-orcid":false,"given":"Rosemarie","family":"Tremblay-LeMay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9894-4864","authenticated-orcid":false,"given":"Shamini","family":"Selvarajah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3361-0468","authenticated-orcid":false,"given":"Peter","family":"Sabatini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phedias","family":"Diamandis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor","family":"Pugh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Kridel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5023-0689","authenticated-orcid":false,"given":"Jan","family":"Delabie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmoldx.2021.09.002_bib1","series-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Revised 4t","author":"Swerdlow","year":"2017"},{"key":"10.1016\/j.jmoldx.2021.09.002_bib2","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1309\/AJCPEMVXES72DUIF","article-title":"Clinicopathologic features of CD5-positive nodal marginal zone lymphoma","volume":"140","author":"Jaso","year":"2013","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.jmoldx.2021.09.002_bib3","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1046\/j.1365-2559.2003.01580.x","article-title":"Follicular lymphoma with marginal zone differentiation: cytogenetic findings in support of a high-risk variant of follicular lymphoma","volume":"42","author":"Goodlad","year":"2003","journal-title":"Histopathology"},{"key":"10.1016\/j.jmoldx.2021.09.002_bib4","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.3324\/haematol.2012.083386","article-title":"Recognizing nodal marginal zone lymphoma: recent advances and pitfalls: asystematic review","volume":"98","author":"van den Brand","year":"2013","journal-title":"Haematologica"},{"key":"10.1016\/j.jmoldx.2021.09.002_bib5","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/j.1365-2559.2005.02309.x","article-title":"A clinicopathological study of nodal marginal zone B-cell lymphoma: a report on 21 cases","volume":"48","author":"Traverse-Glehen","year":"2006","journal-title":"Histopathology"},{"key":"10.1016\/j.jmoldx.2021.09.002_bib6","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/path.1981","article-title":"A marginal zone phenotype in follicular lymphoma with t(14;18) is associated with secondary cytogenetic aberrations typical of marginal zone lymphoma","volume":"209","author":"Torlakovic","year":"2006","journal-title":"J Pathol"},{"key":"10.1016\/j.jmoldx.2021.09.002_bib7","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nature26000","article-title":"DNA methylation-based classification of central nervous system tumours","volume":"555","author":"Capper","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.jmoldx.2021.09.002_bib8","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/S1470-2045(17)30155-9","article-title":"DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis","volume":"18","author":"Sahm","year":"2017","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.jmoldx.2021.09.002_bib9","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1016\/S1470-2045(16)30297-2","article-title":"Epigenetic profiling to classify cancer of unknown primary: a multicentre, retrospective analysis","volume":"17","author":"Moran","year":"2016","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.jmoldx.2021.09.002_bib10","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00432-019-03093-w","article-title":"DNA methylation-based profiling of uterine neoplasms: a novel tool to improve gynecologic cancer diagnostics","volume":"146","author":"Kommoss","year":"2020","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1016\/j.jmoldx.2021.09.002_bib11","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/s41467-020-20603-4","article-title":"Sarcoma classification by DNA methylation profiling","volume":"12","author":"Koelsche","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.jmoldx.2021.09.002_bib12","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1158\/1078-0432.CCR-19-2180","article-title":"DNA methylation profiling identifies distinct clusters in angiosarcomas","volume":"26","author":"Weidema","year":"2020","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jmoldx.2021.09.002_bib13","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/s41379-019-0207-y","article-title":"DNA methylation profiling reliably distinguishes pulmonary enteric adenocarcinoma from metastatic colorectal cancer","volume":"32","author":"Jurmeister","year":"2019","journal-title":"Mod Pathol"},{"key":"10.1016\/j.jmoldx.2021.09.002_bib14","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1186\/1471-2105-11-587","article-title":"Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis","volume":"11","author":"Du","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.jmoldx.2021.09.002_bib15","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.ccell.2016.09.014","article-title":"Decoding the DNA methylome of mantle cell lymphoma in the light of the entire B cell lineage","volume":"30","author":"Queir\u00f3s","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jmoldx.2021.09.002_bib16","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/ng.2443","article-title":"Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia","volume":"44","author":"Kulis","year":"2012","journal-title":"Nat Genet"},{"key":"10.1016\/j.jmoldx.2021.09.002_bib17","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s13059-016-1143-5","article-title":"Estimating and accounting for tumor purity in the analysis of DNA methylation data from cancer studies","volume":"18","author":"Zheng","year":"2017","journal-title":"Genome Biol"},{"key":"10.1016\/j.jmoldx.2021.09.002_bib18","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.1186\/gb-2014-15-4-r54","article-title":"DNA methylome profiling of human tissues identifies global and tissue-specific methylation patterns","volume":"15","author":"Lokk","year":"2014","journal-title":"Genome Biol"},{"key":"10.1016\/j.jmoldx.2021.09.002_bib19","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1038\/s41379-020-0547-7","article-title":"Minimalist approaches to cancer tissue-of-origin classification by DNA methylation","volume":"33","author":"Xia","year":"2020","journal-title":"Mod Pathol"},{"key":"10.1016\/j.jmoldx.2021.09.002_bib20","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1182\/blood.2019000490","article-title":"Developmental subtypes assessed by DNA methylation-iPLEX forecast the natural history of chronic lymphocytic leukemia","volume":"134","author":"Giacopelli","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.jmoldx.2021.09.002_bib21","doi-asserted-by":"crossref","first-page":"4627","DOI":"10.1038\/s41467-018-06715-y","article-title":"Epigenetic profiling for the molecular classification of metastatic brain tumors","volume":"9","author":"Orozco","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.jmoldx.2021.09.002_bib22","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/leu.2014.252","article-title":"A B-cell epigenetic signature defines three biologic subgroups of chronic lymphocytic leukemia with clinical impact","volume":"29","author":"Queir\u00f3s","year":"2015","journal-title":"Leukemia"},{"key":"10.1016\/j.jmoldx.2021.09.002_bib23","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1038\/s43018-020-00131-2","article-title":"The proliferative history shapes the DNA methylome of B-cell tumors and predicts clinical outcome","volume":"1","author":"Duran-Ferrer","year":"2020","journal-title":"Nat Cancer"},{"key":"10.1016\/j.jmoldx.2021.09.002_bib24","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1182\/blood-2010-01-264275","article-title":"Genome-wide DNA profiling of marginal zone lymphomas identifies subtype-specific lesions with an impact on the clinical outcome","volume":"117","author":"Rinaldi","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jmoldx.2021.09.002_bib25","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1158\/1078-0432.CCR-0873-03","article-title":"Frequency of Chromosomal aberrations involving MALT1 in Mucosa-associated lymphoid tissue lymphoma in patients with Sj\u00f6gren\u2019s Syndrome","volume":"10","author":"Streubel","year":"2004","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jmoldx.2021.09.002_bib26","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1097\/01.pas.0000213275.60962.2a","article-title":"The incidence and anatomic site specificity of chromosomal translocations in primary extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) in North America","volume":"30","author":"Remstein","year":"2006","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.jmoldx.2021.09.002_bib27","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1182\/blood-2010-02-267476","article-title":"Cytogenetic aberrations and their prognostic value in a series of 330 splenic marginal zone B-cell lymphomas: a multicenter study of the Splenic B-Cell Lymphoma Group","volume":"116","author":"Salido","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.jmoldx.2021.09.002_bib28","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1182\/blood-2003-06-2160","article-title":"Small lymphocytic lymphoma, marginal zone B-cell lymphoma, and mantle cell lymphoma exhibit distinct gene-expression profiles allowing molecular diagnosis","volume":"103","author":"Thieblemont","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.jmoldx.2021.09.002_bib29","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/s41408-020-0322-5","article-title":"Combining gene expression profiling and machine learning to diagnose B-cell non-Hodgkin lymphoma","volume":"10","author":"Bob\u00e9e","year":"2020","journal-title":"Blood Cancer J"},{"key":"10.1016\/j.jmoldx.2021.09.002_bib30","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1111\/j.1365-2559.2012.04289.x","article-title":"IRTA1 is selectively expressed in nodal and extranodal marginal zone lymphomas","volume":"61","author":"Falini","year":"2012","journal-title":"Histopathology"},{"key":"10.1016\/j.jmoldx.2021.09.002_bib31","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1002\/cyto.b.21325","article-title":"CD180 expression in B-cell lymphomas: a multicenter GEIL study","volume":"90","author":"Mayeur-Rousse","year":"2016","journal-title":"Cytometry B Clin Cytom"},{"key":"10.1016\/j.jmoldx.2021.09.002_bib32","first-page":"292","article-title":"Diagnostic utility of lymphoid enhancer binding factor 1 immunohistochemistry in small B-cell lymphomas","volume":"147","author":"Menter","year":"2017","journal-title":"Am J Clin Pathol"}],"container-title":["The Journal of Molecular Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525157821002877?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525157821002877?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:07:29Z","timestamp":1778616449000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525157821002877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":32,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["S1525157821002877"],"URL":"https:\/\/doi.org\/10.1016\/j.jmoldx.2021.09.002","relation":{},"ISSN":["1525-1578"],"issn-type":[{"value":"1525-1578","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DNA Methylation-Based Classification of Small B-Cell Lymphomas","name":"articletitle","label":"Article Title"},{"value":"The Journal of Molecular Diagnostics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmoldx.2021.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Association for Molecular Pathology and American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}