{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T11:10:01Z","timestamp":1756120201007,"version":"3.44.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Diasorin"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmdjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Molecular Diagnostics"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.jmoldx.2025.05.009","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T02:30:20Z","timestamp":1750905020000},"page":"809-818","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Age-Stratified Epidemiology of Respiratory Pathogens and the Value of Customizable Syndromic Testing Using the LIAISON PLEX Respiratory Flex Assay"],"prefix":"10.1016","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7152-5412","authenticated-orcid":false,"given":"Kaisha","family":"Gonzalez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Amicarelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmoldx.2025.05.009_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12546-021-09271-3","article-title":"Loss of life expectancy due to respiratory infectious diseases: findings from the global burden of disease study in 195 countries and territories 1990-2017","volume":"39","author":"Huang","year":"2022","journal-title":"J Popul Res (Canberra)"},{"key":"10.1016\/j.jmoldx.2025.05.009_bib2","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.3390\/microorganisms10091856","article-title":"Respiratory tract infections and laboratory diagnostic methods: a review with a focus on syndromic panel-based assays","volume":"10","author":"Calderaro","year":"2022","journal-title":"Microorganisms"},{"key":"10.1016\/j.jmoldx.2025.05.009_bib3","article-title":"Mycoplasma pneumoniae and adenovirus coinfection cause pediatric severe community-acquired pneumonia","volume":"10","author":"Li","year":"2022","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.jmoldx.2025.05.009_bib4","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/s41579-021-00535-6","article-title":"Transmissibility and transmission of respiratory viruses","volume":"19","author":"Leung","year":"2021","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.jmoldx.2025.05.009_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.rmed.2021.106356","article-title":"COVID-19: why does disease severity vary among individuals?","volume":"180","author":"Samadizadeh","year":"2021","journal-title":"Respir Med"},{"key":"10.1016\/j.jmoldx.2025.05.009_bib6","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0266-2023","article-title":"Diverging patterns in innate immunity against respiratory viruses during a lifetime: lessons from the young and the old","volume":"33","author":"Smits","year":"2024","journal-title":"Eur Respir Rev"},{"key":"10.1016\/j.jmoldx.2025.05.009_bib7","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jpeds.2016.02.050","article-title":"Impact of multiplex polymerase chain reaction testing for respiratory pathogens on healthcare resource utilization for pediatric inpatients","volume":"173","author":"Subramony","year":"2016","journal-title":"J Pediatr"},{"key":"10.1016\/j.jmoldx.2025.05.009_bib8","doi-asserted-by":"crossref","first-page":"636","DOI":"10.5858\/arpa.2014-0257-OA","article-title":"Impact of a rapid respiratory panel test on patient outcomes","volume":"139","author":"Rogers","year":"2015","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.jmoldx.2025.05.009_bib9","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1093\/jalm\/jfae010","article-title":"ADLM guidance document on laboratory diagnosis of respiratory viruses","volume":"9","author":"Berry","year":"2024","journal-title":"J Appl Lab Med"},{"key":"10.1016\/j.jmoldx.2025.05.009_bib10","doi-asserted-by":"crossref","first-page":"2744","DOI":"10.1093\/cid\/ciaa508","article-title":"Molecular testing for acute respiratory tract infections: clinical and diagnostic recommendations from the IDSA\u2019s diagnostics committee","volume":"71","author":"Hanson","year":"2020","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jmoldx.2025.05.009_bib11","first-page":"107","article-title":"Enhancing the clinical value of medical laboratory testing","volume":"38","author":"Sikaris","year":"2017","journal-title":"Clin Biochem Rev"},{"key":"10.1016\/j.jmoldx.2025.05.009_bib12","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1056\/NEJMoa1500245","article-title":"Community-acquired pneumonia requiring hospitalization among U.S. adults","volume":"373","author":"Jain","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jmoldx.2025.05.009_bib13","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0140-6736(03)12162-9","article-title":"The common cold","volume":"361","author":"Heikkinen","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.jmoldx.2025.05.009_bib14","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1128\/JCM.02264-16","article-title":"Implementation of rapid molecular infectious disease diagnostics: the role of diagnostic and antimicrobial stewardship","volume":"55","author":"Messacar","year":"2017","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jmoldx.2025.05.009_bib15","doi-asserted-by":"crossref","DOI":"10.1128\/jcm.00960-24","article-title":"The foundation for the microbiology laboratory\u2019s essential role in diagnostic stewardship: an ASM Laboratory Practices Subcommittee report","volume":"62","author":"Dumm","year":"2024","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jmoldx.2025.05.009_bib17","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1214\/ss\/1009213286","article-title":"Interval estimation for a binomial proportion","volume":"16","author":"Brown","year":"2001","journal-title":"Stat Sci"},{"key":"10.1016\/j.jmoldx.2025.05.009_bib18","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1080\/01621459.1927.10502953","article-title":"Probable inference, the law of succession, and statistical inference","volume":"22","author":"Wilson","year":"2012","journal-title":"J Am Stat Assoc"},{"key":"10.1016\/j.jmoldx.2025.05.009_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2020.567184","article-title":"Seasonality of respiratory viral infections: will COVID-19 follow suit?","volume":"8","author":"Audi","year":"2020","journal-title":"Front Public Health"},{"key":"10.1016\/j.jmoldx.2025.05.009_bib20","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1128\/CMR.18.2.326-382.2005","article-title":"Molecular pathogenesis, epidemiology, and clinical manifestations of respiratory infections due to Bordetella pertussis and other Bordetella subspecies","volume":"18","author":"Mattoo","year":"2005","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.jmoldx.2025.05.009_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.843463","article-title":"Epidemiological study on Mycoplasma pneumoniae and Chlamydia pneumoniae infection of hospitalized children in a single center during the COVID-19 pandemic","volume":"12","author":"Cai","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.jmoldx.2025.05.009_bib22","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1146\/annurev-virology-012420-022445","article-title":"Seasonality of respiratory viral infections","volume":"7","author":"Moriyama","year":"2020","journal-title":"Annu Rev Virol"},{"key":"10.1016\/j.jmoldx.2025.05.009_bib23","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.2147\/TCRM.S87789","article-title":"Virus-induced secondary bacterial infection: a concise review","volume":"11","author":"Hendaus","year":"2015","journal-title":"Ther Clin Risk Manag"},{"key":"10.1016\/j.jmoldx.2025.05.009_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-92220-0","article-title":"Secondary bacterial infection in COVID-19 patients is a stronger predictor for death compared to influenza patients","volume":"11","author":"Shafran","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.jmoldx.2025.05.009_bib25","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/S1473-3099(10)70194-8","article-title":"Virology, epidemiology, pathogenesis, and control of enterovirus 71","volume":"10","author":"Solomon","year":"2010","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.jmoldx.2025.05.009_bib26","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1177\/0009922818809483","article-title":"The resource burden of infections with rhinovirus\/enterovirus, influenza, and respiratory syncytial virus in children","volume":"58","author":"Fine","year":"2019","journal-title":"Clin Pediatr (Phila)"},{"key":"10.1016\/j.jmoldx.2025.05.009_bib27","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3390\/v14010141","article-title":"Understanding rhinovirus circulation and impact on illness","volume":"14","author":"Esneau","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.jmoldx.2025.05.009_bib28","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0140-6736(21)02346-1","article-title":"Diagnostics for COVID-19: moving from pandemic response to control","volume":"399","author":"Peeling","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.jmoldx.2025.05.009_bib29","first-page":"1091","article-title":"Respiratory infections in the aging lung: implications for diagnosis, therapy, and prevention","volume":"14","author":"H\u00e4der","year":"2023","journal-title":"Aging Dis"},{"key":"10.1016\/j.jmoldx.2025.05.009_bib30","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1001\/jama.289.2.179","article-title":"Mortality associated with influenza and respiratory syncytial virus in the United States","volume":"289","author":"Thompson","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.jmoldx.2025.05.009_bib31","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.3201\/eid3005.231278","article-title":"Reemergence of Bordetella parapertussis, United States, 2019-2023","volume":"30","author":"Noble","year":"2024","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.jmoldx.2025.05.009_bib32","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3390\/pathogens14010060","article-title":"Description of a current outbreak of Mycoplasma pneumoniae in the United States","volume":"14","author":"Raghuram","year":"2025","journal-title":"Pathogens"}],"container-title":["The Journal of Molecular Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525157825001424?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525157825001424?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T10:44:18Z","timestamp":1756118658000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525157825001424"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":31,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S1525157825001424"],"URL":"https:\/\/doi.org\/10.1016\/j.jmoldx.2025.05.009","relation":{},"ISSN":["1525-1578"],"issn-type":[{"type":"print","value":"1525-1578"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Age-Stratified Epidemiology of Respiratory Pathogens and the Value of Customizable Syndromic Testing Using the LIAISON PLEX Respiratory Flex Assay","name":"articletitle","label":"Article Title"},{"value":"The Journal of Molecular Diagnostics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmoldx.2025.05.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Association for Molecular Pathology and American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}