{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:04:25Z","timestamp":1777392265016,"version":"3.51.4"},"reference-count":49,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019714","name":"Foundation Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019714","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmdjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Molecular Diagnostics"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.jmoldx.2025.06.002","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T15:15:20Z","timestamp":1753283720000},"page":"920-935","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["FoundationOne CDx and FoundationOne Heme Detect Epstein-Barr Virus with High Sensitivity and Specificity"],"prefix":"10.1016","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1592-7023","authenticated-orcid":false,"given":"Julius","family":"Honecker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Paffenholz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Jungmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Wieland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela A.","family":"Kou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo-Ryum","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8114-0237","authenticated-orcid":false,"given":"Chad M.","family":"Vanderbilt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vignesh","family":"Shanmugam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9155-556X","authenticated-orcid":false,"given":"Meagan","family":"Montesion","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8065-4148","authenticated-orcid":false,"given":"Ryon P.","family":"Graf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee A.","family":"Albacker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0105-9760","authenticated-orcid":false,"given":"Douglas I.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Heilmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sotirios","family":"Lakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8329-6083","authenticated-orcid":false,"given":"Richard A.","family":"Hickman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brennan","family":"Decker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren L.","family":"Ritterhouse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8059-8668","authenticated-orcid":false,"given":"Douglas A.","family":"Mata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmoldx.2025.06.002_bib1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jcv.2018.03.001","article-title":"Primary Epstein-Barr virus infection","volume":"102","author":"Dunmire","year":"2018","journal-title":"J Clin Virol"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib2","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S1470-2045(12)70137-7","article-title":"Global burden of cancers attributable to infections in 2008: a review and synthetic analysis","volume":"13","author":"de Martel","year":"2012","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib3","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/nrc.2016.92","article-title":"Epstein-Barr virus: more than 50 years old and still providing surprises","volume":"16","author":"Young","year":"2016","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib4","doi-asserted-by":"crossref","first-page":"226","DOI":"10.3390\/pathogens9030226","article-title":"Recent advances in diagnostic approaches for Epstein-Barr virus","volume":"9","author":"AbuSalah","year":"2020","journal-title":"Pathogens"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib5","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1200\/JCO.21.02767","article-title":"Somatic genomic testing in patients with metastatic or advanced cancer: ASCO provisional clinical opinion","volume":"40","author":"Chakravarty","year":"2022","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib6","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jmoldx.2021.10.009","article-title":"Quantitative off-target detection of Epstein-Barr virus-derived DNA in routine molecular profiling of hematopoietic neoplasms by panel-based hybrid-capture next-generation sequencing","volume":"24","author":"Petrova-Drus","year":"2022","journal-title":"J Mol Diagn"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib7","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2020.38.15_suppl.e15576","article-title":"Targeted PCR vs NGS for molecular diagnostic in solid tumors and liquid biopsies. How to choose in real-life","volume":"38","author":"Merlin","year":"2020","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib8","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1158\/2159-8290.CD-20-0672","article-title":"Somatic HLA class I loss is a widespread mechanism of immune evasion which refines the use of tumor mutational burden as a biomarker of checkpoint inhibitor response","volume":"11","author":"Montesion","year":"2021","journal-title":"Cancer Discov"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib9","article-title":"Epstein-Barr virus positive diffuse large B-cell lymphoma predict poor outcome, regardless of the age","volume":"5","author":"Lu","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib10","author":"Shibusawa"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib11","doi-asserted-by":"crossref","first-page":"6339","DOI":"10.1182\/bloodadvances.2023010330","article-title":"Targeted therapy with nanatinostat and valganciclovir in recurrent EBV-positive lymphoid malignancies: a phase 1b\/2 study","volume":"7","author":"Haverkos","year":"2023","journal-title":"Blood Adv"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0264138","article-title":"Clinical and analytical validation of FoundationOne\u00aeCDx, a comprehensive genomic profiling assay for solid tumors","volume":"17","author":"Milbury","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib13","doi-asserted-by":"crossref","first-page":"3004","DOI":"10.1182\/blood-2015-08-664649","article-title":"Integrated genomic DNA\/RNA profiling of hematologic malignancies in the clinical setting","volume":"127","author":"He","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib14","article-title":"STARD 2015: an updated list of essential items for reporting diagnostic accuracy studies","volume":"351","author":"Bossuyt","year":"2015","journal-title":"BMJ"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib15","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/S0140-6736(07)61602-X","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"370","author":"von Elm","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib16","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1200\/CCI.20.00108","article-title":"OncoTree: a cancer classification system for precision oncology","volume":"5","author":"Kundra","year":"2021","journal-title":"JCO Clin Cancer Inform"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib17","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1056\/NEJMc2213457","article-title":"Disparities according to genetic ancestry in the use of precision oncology assays","volume":"388","author":"Mata","year":"2023","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib18","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/S0140-6736(15)00055-0","article-title":"Nasopharyngeal carcinoma","volume":"387","author":"Chua","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib19","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/s41588-023-01333-x","article-title":"Multiancestry genomic and transcriptomic analysis of gastric cancer","volume":"55","author":"Totoki","year":"2023","journal-title":"Nat Genet"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib20","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1038\/nbt.2696","article-title":"Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing","volume":"31","author":"Frampton","year":"2013","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib21","doi-asserted-by":"crossref","first-page":"338","DOI":"10.5858\/arpa.2021-0313-OA","article-title":"Method of tissue acquisition affects success of comprehensive genomic profiling in lung cancer","volume":"147","author":"Mata","year":"2023","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib22","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.ccell.2023.03.017","article-title":"Not all TMB assays are the same: clinical validity of robust algorithmic germline filtering","volume":"41","author":"Huang","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib23","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/s41698-024-00679-7","article-title":"Pan-tumor validation of a NGS fraction-based MSI analysis as a predictor of response to pembrolizumab","volume":"8","author":"Lin","year":"2024","journal-title":"NPJ Precis Oncol"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib24","doi-asserted-by":"crossref","first-page":"e224","DOI":"10.1093\/oncolo\/oyad251","article-title":"Insights of clinical significance from 109 695 solid tumor tissue-based comprehensive genomic profiles","volume":"29","author":"Heilmann","year":"2023","journal-title":"Oncologist"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib25","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3","article-title":"Index for rating diagnostic tests","volume":"3","author":"Youden","year":"1950","journal-title":"Cancer"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib26","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/nature02168","article-title":"The International HapMap Project","volume":"426","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib27","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.3390\/v13122344","article-title":"Molecular basis of Epstein-Barr virus latency establishment and lytic reactivation","volume":"13","author":"Murata","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib28","doi-asserted-by":"crossref","first-page":"D20","DOI":"10.1093\/nar\/gkae979","article-title":"Database resources of the national center for biotechnology information in 2025","volume":"53","author":"Sayers","year":"2025","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib29","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1097\/PAS.0000000000001862","article-title":"HPV51-associated leiomyosarcoma: a novel class of TP53\/RB1-wildtype tumor with predilection for the female lower reproductive tract","volume":"46","author":"Williams","year":"2022","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib30","article-title":"Genetic landscape and PD-L1 expression in Epstein-Barr virus-associated gastric cancer according to the histological pattern","volume":"13","author":"Park","year":"2023","journal-title":"Sci Rep"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib31","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/nature13480","article-title":"Comprehensive molecular characterization of gastric adenocarcinoma","volume":"513","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.583463","article-title":"EBV-positive gastric cancer: current knowledge and future perspectives","volume":"10","author":"Sun","year":"2020","journal-title":"Front Oncol"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib33","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/CJI.0000000000000316","article-title":"Positive status of Epstein-Barr virus as a biomarker for gastric cancer immunotherapy: a prospective observational study","volume":"43","author":"Xie","year":"2020","journal-title":"J Immunother"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib34","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1093\/annonc\/mdx047","article-title":"Epstein-Barr virus-associated gastric cancer reveals intratumoral heterogeneity of PIK3CA mutations","volume":"28","author":"B\u00f6ger","year":"2017","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib35","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S1470-2045(15)70126-9","article-title":"Chemotherapy and radiotherapy in nasopharyngeal carcinoma: an update of the MAC-NPC meta-analysis","volume":"16","author":"Blanchard","year":"2015","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib36","doi-asserted-by":"crossref","first-page":"6078","DOI":"10.3390\/cancers13236078","article-title":"Multimodality management of EBV-associated nasopharyngeal carcinoma","volume":"13","author":"Yu","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib37","doi-asserted-by":"crossref","first-page":"210","DOI":"10.3390\/cancers10070210","article-title":"Genomic landscapes of EBV-associated nasopharyngeal carcinoma vs. HPV-associated head and neck cancer","volume":"10","author":"Ngan","year":"2018","journal-title":"Cancers"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib38","article-title":"Exome and genome sequencing of nasopharynx cancer identifies NF-\u03baB pathway activating mutations","volume":"8","author":"Li","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib39","doi-asserted-by":"crossref","first-page":"3346","DOI":"10.1200\/JCO.2015.60.7846","article-title":"Nasopharyngeal cancer: molecular landscape","volume":"33","author":"Bruce","year":"2015","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib40","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1038\/ng.3006","article-title":"The genomic landscape of nasopharyngeal carcinoma","volume":"46","author":"Lin","year":"2014","journal-title":"Nat Genet"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib41","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/s41375-022-01804-w","article-title":"Molecular profiling of EBV associated diffuse large B-cell lymphoma","volume":"37","author":"Frontzek","year":"2023","journal-title":"Leukemia"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib42","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41408-021-00493-5","article-title":"Genomic insights into the pathogenesis of Epstein-Barr virus-associated diffuse large B-cell lymphoma by whole-genome and targeted amplicon sequencing","volume":"11","author":"Gebauer","year":"2021","journal-title":"Blood Cancer J"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib43","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1182\/blood.2020007507","article-title":"Mutational landscape of gray zone lymphoma","volume":"137","author":"Sarkozy","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib44","doi-asserted-by":"crossref","first-page":"683","DOI":"10.3389\/fonc.2019.00683","article-title":"Comprehensive genomic profiling of EBV-positive diffuse large B-cell lymphoma and the expression and clinicopathological correlations of some related genes","volume":"9","author":"Zhou","year":"2019","journal-title":"Front Oncol"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib45","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/ajh.25760","article-title":"EBV-positive diffuse large B-cell lymphoma, not otherwise specified: 2020 update on diagnosis, risk-stratification and management","volume":"95","author":"Beltran","year":"2020","journal-title":"Am J Hematol"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib46","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3390\/cancers10060167","article-title":"Clinical importance of Epstein-Barr virus-associated gastric cancer","volume":"10","author":"Nishikawa","year":"2018","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib47","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s12672-022-00479-0","article-title":"PD-L1 expression in EBV associated gastric cancer: a systematic review and meta-analysis","volume":"13","author":"Lima","year":"2022","journal-title":"Discov Oncol"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib48","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1001\/jama.2023.20181","article-title":"Toripalimab plus chemotherapy for recurrent or metastatic nasopharyngeal carcinoma: the JUPITER-02 randomized clinical trial","volume":"330","author":"Mai","year":"2023","journal-title":"JAMA"},{"key":"10.1016\/j.jmoldx.2025.06.002_bib49","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1200\/PO.20.00272","article-title":"Hyperprogressive disease after pembrolizumab treatment in advanced Epstein-Barr virus-associated gastric adenocarcinoma with ERBB2 amplification","volume":"5","author":"Watson","year":"2021","journal-title":"JCO Precis Oncol"}],"container-title":["The Journal of Molecular Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525157825001679?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525157825001679?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T01:09:50Z","timestamp":1772759390000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525157825001679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":49,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S1525157825001679"],"URL":"https:\/\/doi.org\/10.1016\/j.jmoldx.2025.06.002","relation":{},"ISSN":["1525-1578"],"issn-type":[{"value":"1525-1578","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"FoundationOne CDx and FoundationOne Heme Detect Epstein-Barr Virus with High Sensitivity and Specificity","name":"articletitle","label":"Article Title"},{"value":"The Journal of Molecular Diagnostics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmoldx.2025.06.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Association for Molecular Pathology and American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}