{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:07:20Z","timestamp":1778818040458,"version":"3.51.4"},"reference-count":15,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100021465","name":"Department of Pathology and Laboratory Medicine, College of Medicine, Medical University of South Carolina","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100021465","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000871","name":"Mayo Clinic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmdjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Molecular Diagnostics"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jmoldx.2026.02.004","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:19:56Z","timestamp":1772151596000},"page":"439-447","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Utility of Expression Imbalance in the Idylla GeneFusion Assay for Non\u2013Small-Cell Lung Cancer"],"prefix":"10.1016","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9956-9453","authenticated-orcid":false,"given":"Michelle N.","family":"Stram","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia L.","family":"Caffes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8893-0645","authenticated-orcid":false,"given":"Ying-Chun","family":"Lo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmoldx.2026.02.004_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctrv.2021.102179","article-title":"Immunotherapy in non-small cell lung cancer harbouring driver mutations","volume":"96","author":"Addeo","year":"2021","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.jmoldx.2026.02.004_bib2","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/s41568-019-0179-8","article-title":"Co-occurring genomic alterations in non-small-cell lung cancer biology and therapy","volume":"19","author":"Skoulidis","year":"2019","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.jmoldx.2026.02.004_bib3","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1200\/JCO.21.01626","article-title":"Targeted therapies for lung cancer patients with oncogenic driver molecular alterations","volume":"40","author":"Tan","year":"2022","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jmoldx.2026.02.004_bib4","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S1470-2045(19)30690-4","article-title":"Entrectinib in ROS1 fusion-positive non-small-cell lung cancer: integrated analysis of three phase 1-2 trials","volume":"21","author":"Drilon","year":"2020","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.jmoldx.2026.02.004_bib5","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/S1470-2045(21)00247-3","article-title":"Pralsetinib for RET fusion-positive non-small-cell lung cancer (ARROW): a multi-cohort, open-label, phase 1\/2 study","volume":"22","author":"Gainor","year":"2021","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.jmoldx.2026.02.004_bib6","doi-asserted-by":"crossref","DOI":"10.7573\/dic.2022-3-1","article-title":"Non-small-cell lung cancer: how to manage ALK-ROS1- and NTRK-rearranged disease","volume":"11","author":"Marinelli","year":"2022","journal-title":"Drugs Context"},{"key":"10.1016\/j.jmoldx.2026.02.004_bib7","doi-asserted-by":"crossref","first-page":"321","DOI":"10.5858\/arpa.2017-0388-CP","volume":"142","author":"Lindeman","year":"2018","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.jmoldx.2026.02.004_bib8","article-title":"Clinical utility validation of an automated ultrarapid gene fusion assay for NSCLC","volume":"3","author":"Buglioni","year":"2022","journal-title":"JTO Clin Res Rep"},{"key":"10.1016\/j.jmoldx.2026.02.004_bib9","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.jmoldx.2022.05.004","article-title":"Multicenter evaluation of the Idylla GeneFusion in non-small-cell lung cancer","volume":"24","author":"Depoilly","year":"2022","journal-title":"J Mol Diagn"},{"key":"10.1016\/j.jmoldx.2026.02.004_bib10","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.jmoldx.2022.03.014","article-title":"NTRK gene fusion detection in a pan-cancer setting using the Idylla GeneFusion Assay","volume":"24","author":"Sorber","year":"2022","journal-title":"J Mol Diagn"},{"key":"10.1016\/j.jmoldx.2026.02.004_bib11","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.3390\/genes14081551","article-title":"Efficient lung cancer molecular diagnostics by combining next generation sequencing with reflex Idylla Genefusion Assay testing","volume":"14","author":"Nkosi","year":"2023","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.jmoldx.2026.02.004_bib12","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s00428-024-03778-9","article-title":"Multicenter evaluation of an automated, multiplex, RNA-based molecular assay for detection of ALK, ROS1, RET fusions and MET exon 14 skipping in NSCLC","volume":"484","author":"Melchior","year":"2024","journal-title":"Virchows Arch"},{"key":"10.1016\/j.jmoldx.2026.02.004_bib13","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.jmoldx.2022.03.006","article-title":"Clinical utility and performance of an ultrarapid multiplex RNA-based assay for detection of ALK, ROS1, RET, and NTRK1\/2\/3 rearrangements and MET exon 14 skipping alterations","volume":"24","author":"Chu","year":"2022","journal-title":"J Mol Diagn"},{"key":"10.1016\/j.jmoldx.2026.02.004_bib14","article-title":"Routine clinically detected increased ROS1 transcripts are related with ROS1 expression by immunohistochemistry and associated with EGFR mutations in lung adenocarcinoma","volume":"4","author":"Grenier","year":"2023","journal-title":"JTO Clin Res Rep"},{"key":"10.1016\/j.jmoldx.2026.02.004_bib15","article-title":"ALK gene rearrangements in lung adenocarcinomas: concordance of immunohistochemistry, fluorescence in situ hybridization, RNA in situ hybridization, and RNA next-generation sequencing testing","volume":"2","author":"Canterbury","year":"2021","journal-title":"JTO Clin Res Rep"}],"container-title":["The Journal of Molecular Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525157826000279?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525157826000279?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T03:12:39Z","timestamp":1778814759000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525157826000279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S1525157826000279"],"URL":"https:\/\/doi.org\/10.1016\/j.jmoldx.2026.02.004","relation":{},"ISSN":["1525-1578"],"issn-type":[{"value":"1525-1578","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diagnostic Utility of Expression Imbalance in the Idylla GeneFusion Assay for Non\u2013Small-Cell Lung Cancer","name":"articletitle","label":"Article Title"},{"value":"The Journal of Molecular Diagnostics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmoldx.2026.02.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Association for Molecular Pathology and American Society for Investigative Pathology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}