{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T11:04:34Z","timestamp":1784804674706,"version":"3.55.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmdjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Molecular Diagnostics"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.jmoldx.2026.05.004","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T07:07:38Z","timestamp":1779952058000},"page":"605-614","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rapid On-Site Next-Generation Sequencing"],"prefix":"10.1016","volume":"28","author":[{"given":"Ossama","family":"Tawfik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Thomason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4720-7178","authenticated-orcid":false,"given":"Samuel","family":"Caughron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Aboudara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0004-6225","authenticated-orcid":false,"given":"Ambra","family":"Isenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmoldx.2026.05.004_bib1","first-page":"17","article-title":"Cancer statistics, 2023","volume":"73","author":"Siegel","year":"2023","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.jmoldx.2026.05.004_bib2","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nature13385","article-title":"Comprehensive molecular profiling of lung adenocarcinoma","volume":"511","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.jmoldx.2026.05.004_bib3","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nature11252","article-title":"Comprehensive molecular characterization of human colon and rectal cancer","volume":"487","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.jmoldx.2026.05.004_bib4","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1200\/JCO.21.01626","article-title":"Targeted therapies for lung cancer patients with oncogenic driver molecular alterations","volume":"40","author":"Tan","year":"2022","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jmoldx.2026.05.004_bib5","doi-asserted-by":"crossref","first-page":"321","DOI":"10.5858\/arpa.2017-0388-CP","volume":"142","author":"Lindeman","year":"2018","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.jmoldx.2026.05.004_bib6","year":"2024"},{"key":"10.1016\/j.jmoldx.2026.05.004_bib7","year":"2024"},{"key":"10.1016\/j.jmoldx.2026.05.004_bib8","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.jmoldx.2017.01.011","article-title":"Guidelines for validation of next-generation sequencing\u2013based oncology panels: a joint Consensus Recommendation of the Association for Molecular Pathology and College of American Pathologists","volume":"19","author":"Jennings","year":"2017","journal-title":"J Mol Diagn"},{"key":"10.1016\/j.jmoldx.2026.05.004_bib9","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.5858\/arpa.2016-0117-RA","article-title":"Preanalytic variables in cytology: lessons learned from next-generation sequencing\u2014the MD Anderson experience","volume":"140","author":"Roy-Chowdhuri","year":"2016","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.jmoldx.2026.05.004_bib10","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1093\/annonc\/mdw018","article-title":"Incidental germline variants in 1000 advanced cancers on a prospective somatic genomic profiling protocol","volume":"27","author":"Meric-Bernstam","year":"2016","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jmoldx.2026.05.004_bib11","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1001\/jama.2018.9824","article-title":"Association of broad-based genomic sequencing with survival among patients with advanced non\u2013small cell lung cancer in the community oncology setting","volume":"320","author":"Presley","year":"2018","journal-title":"JAMA"},{"key":"10.1016\/j.jmoldx.2026.05.004_bib12","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.cllc.2017.04.004","article-title":"Genomic profiling of advanced non-small cell lung cancer in community settings: gaps and opportunities","volume":"18","author":"Gutierrez","year":"2017","journal-title":"Clin Lung Cancer"},{"key":"10.1016\/j.jmoldx.2026.05.004_bib13","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1001\/jama.2019.3241","article-title":"Association of patient characteristics and tumor genomics with clinical outcomes among patients with non\u2013small cell lung cancer using a clinicogenomic database","volume":"321","author":"Singal","year":"2019","journal-title":"JAMA"},{"key":"10.1016\/j.jmoldx.2026.05.004_bib14","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1093\/jnci\/djy156","article-title":"A prospective study of circulating tumor DNA to guide matched targeted therapy in lung cancers","volume":"111","author":"Sabari","year":"2019","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.jmoldx.2026.05.004_bib15","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1001\/jamaoncol.2018.4305","article-title":"Clinical implications of plasma-based genotyping","volume":"5","author":"Aggarwal","year":"2019","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.jmoldx.2026.05.004_bib16","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1200\/EDBK_237863","article-title":"Biomarker testing for patients with advanced non-small cell lung cancer: real-world issues and touch choices","volume":"39","author":"Pennell","year":"2019","journal-title":"Am Soc Clin Oncol Educ Book"},{"key":"10.1016\/j.jmoldx.2026.05.004_bib17","doi-asserted-by":"crossref","first-page":"505","DOI":"10.21037\/tlcr.2016.10.08","article-title":"Next-generation sequencing techniques in liquid biopsy: focus on non\u2013small cell lung cancer patients","volume":"5","author":"Malapelle","year":"2016","journal-title":"Transl Lung Cancer Res"},{"key":"10.1016\/j.jmoldx.2026.05.004_bib18","doi-asserted-by":"crossref","first-page":"513","DOI":"10.5858\/arpa.2025-0181-OA","article-title":"Retrospective comparison of operational metrics across diagnostic approaches for molecular testing in lung and colon cancers in a community-based setting","volume":"150","author":"Tawfik","year":"2026","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.jmoldx.2026.05.004_bib19","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S1470-2045(10)70087-5","article-title":"New driver mutations in non-small-cell lung cancer","volume":"12","author":"Pao","year":"2011","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.jmoldx.2026.05.004_bib20","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1158\/2159-8290.CD-18-1321","article-title":"Targeting alterations in the RAF\u2013MEK pathway in colorectal cancer","volume":"9","author":"Yaeger","year":"2019","journal-title":"Cancer Discov"},{"key":"10.1016\/j.jmoldx.2026.05.004_bib21","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1126\/science.aan6733","article-title":"Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade","volume":"357","author":"Le","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.jmoldx.2026.05.004_bib22","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1200\/JCO.2016.71.9807","article-title":"Molecular biomarkers for the evaluation of colorectal cancer: guideline from the American Society for Clinical Pathology, College of American Pathologists, Association for Molecular Pathology, and American Society of Clinical Oncology","volume":"35","author":"Sepulveda","year":"2017","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jmoldx.2026.05.004_bib23","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1200\/JCO.21.02767","article-title":"Somatic genomic testing in patients with metastatic or advanced cancer: ASCO provisional clinical opinion","volume":"40","author":"Chakravarty","year":"2022","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jmoldx.2026.05.004_bib24","article-title":"Impact of clinical practice gaps on the implementation of personalized medicine in advanced non-small-cell lung cancer","volume":"6","author":"Sadik","year":"2022","journal-title":"JCO Precis Oncol"}],"container-title":["The Journal of Molecular Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525157826000887?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525157826000887?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T10:35:12Z","timestamp":1784802912000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525157826000887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":24,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S1525157826000887"],"URL":"https:\/\/doi.org\/10.1016\/j.jmoldx.2026.05.004","relation":{},"ISSN":["1525-1578"],"issn-type":[{"value":"1525-1578","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rapid On-Site Next-Generation Sequencing","name":"articletitle","label":"Article Title"},{"value":"The Journal of Molecular Diagnostics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmoldx.2026.05.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Association for Molecular Pathology and American Society for Investigative Pathology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}