{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T09:10:14Z","timestamp":1784797814058,"version":"3.55.0"},"reference-count":30,"publisher":"National University of Health Sciences","issue":"6","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Manipulative and Physiological Therapeutics"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1016\/j.jmpt.2013.05.018","type":"journal-article","created":{"date-parts":[[2013,7,26]],"date-time":"2013-07-26T13:09:23Z","timestamp":1374844163000},"page":"385-393","source":"Crossref","is-referenced-by-count":15,"title":["Itch Sensation Through Transient Receptor Potential Channels: A Systematic Review and Relevance to Manual Therapy"],"prefix":"10.67400","volume":"36","author":[{"given":"Octavian C.","family":"Lucaciu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaelan P.","family":"Connell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"57152","reference":[{"key":"10.1016\/j.jmpt.2013.05.018_bb0020","series-title":"Textbook of medical physiology","author":"Guyton","year":"2011"},{"key":"10.1016\/j.jmpt.2013.05.018_bb0025","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.bbadis.2007.03.002","article-title":"TRP channels as novel players in the pathogenesis and therapy of itch","volume":"1772","author":"Biro","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jmpt.2013.05.018_bb0005","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1152\/physrev.00021.2006","article-title":"Transient receptor potential cation channels in disease","volume":"87","author":"Nilius","year":"2007","journal-title":"Physiology Rev"},{"key":"10.1016\/j.jmpt.2013.05.018_bb0010","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nrd2280","article-title":"The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept","volume":"6","author":"Szallasi","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.jmpt.2013.05.018_bb0015","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1186\/gb-2011-12-3-218","article-title":"The transient receptor potential family of ion channels","volume":"12","author":"Nilius","year":"2011","journal-title":"Genome Biol"},{"key":"10.1016\/j.jmpt.2013.05.018_bb0030","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/ar3305","article-title":"Update on peripheral mechanisms of pain: beyond prostaglandins and cytokines","volume":"13","author":"Shaible","year":"2011","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jmpt.2013.05.018_bb0035","doi-asserted-by":"crossref","first-page":"e17387","DOI":"10.1371\/journal.pone.0017387","article-title":"Transient receptor potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients","volume":"6","author":"Binder","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jmpt.2013.05.018_bb0040","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/nn.2789","article-title":"TRPA1 is required for histamine-independent, Mas-related G protein\u2013coupled receptor-mediated itch","volume":"14","author":"Wilson","year":"2011","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.jmpt.2013.05.018_bb0045","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.neulet.2011.02.009","article-title":"Role of transient receptor potential ankyrin subfamily member 1 in pruritus induced by endothelin-1","volume":"492","author":"Liang","year":"2011","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jmpt.2013.05.018_bb0050","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.1073\/pnas.1019755108","article-title":"Analysis of cellular and behavioral responses to imiquimod reveals a unique itch pathway in transient receptor potential vanilloid 1 (TRPV1)\u2013expressing neurons","volume":"108","author":"Kim","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jmpt.2013.05.018_bb0055","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.neuron.2010.09.016","article-title":"VGLUT2-dependent sensory neurons in the TRPV1 population regulate pain and itch","volume":"68","author":"Lagerstr\u00f6m","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.jmpt.2013.05.018_bb0060","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.npep.2009.10.002","article-title":"Differential effects of substance P or hemokinin-1 on transient receptor potential channels, TRPV1, TRPA1 and TRPM8, in the rat","volume":"44","author":"Naono-Nakayama","year":"2010","journal-title":"Neuropeptides"},{"key":"10.1016\/j.jmpt.2013.05.018_bb0065","doi-asserted-by":"crossref","first-page":"11330","DOI":"10.1073\/pnas.0905605106","article-title":"TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms","volume":"106","author":"Imamachi","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jmpt.2013.05.018_bb0070","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1111\/j.1398-9995.2009.01937.x","article-title":"TRPV1-mediated itch in seasonal allergic rhinitis","volume":"64","author":"Alenmyr","year":"2009","journal-title":"Allergy"},{"key":"10.1016\/j.jmpt.2013.05.018_bb0075","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/jid.2008.245","article-title":"Impact of the Gly573Ser substitution in TRPV3 on the development of allergic and pruritic dermatitis in mice","volume":"129","author":"Yoshioka","year":"2009","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jmpt.2013.05.018_bb0080","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1523\/JNEUROSCI.4643-06.2007","article-title":"TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase","volume":"27","author":"Shim","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.jmpt.2013.05.018_bb0085","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1136\/jech.52.6.377","article-title":"The feasibility of creating a checklist for the assessment of the methodological quality of both of randomised and non-randomised studies of health care interventions","volume":"52","author":"Downs","year":"1998","journal-title":"J Epidemiol Community Health"},{"key":"10.1016\/j.jmpt.2013.05.018_bb0090","series-title":"Reducing racial\/ethnic disparities in reproductive and perinatal outcomes: the evidence from population-based interventions","author":"Handler","year":"2011"},{"key":"10.1016\/j.jmpt.2013.05.018_bb0095","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/82924","article-title":"Spinothalamic lamina I neurons selectively sensitive to histamine: a central neural pathway for itch","volume":"4","author":"Andrew","year":"2001","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.jmpt.2013.05.018_bb0100","doi-asserted-by":"crossref","first-page":"8003","DOI":"10.1523\/JNEUROSCI.17-20-08003.1997","article-title":"Specific C-receptors for itch in human skin","volume":"17","author":"Schmelz","year":"1997","journal-title":"J Neurosci"},{"key":"10.1016\/j.jmpt.2013.05.018_bb0105","series-title":"BARR's the human nervous system: an anatomical viewpoint","author":"Kiernan","year":"2009"},{"key":"10.1016\/j.jmpt.2013.05.018_bb0110","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0079-6123(03)46021-4","article-title":"Expression of nerve growth factor in the airways and its possible role in asthma","volume":"146","author":"Freund","year":"2004","journal-title":"Prog Brain Res"},{"key":"10.1016\/j.jmpt.2013.05.018_bb0115","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1111\/j.1365-2133.1987.tb07359.x","article-title":"Effect of acupuncture on experimentally induced itch","volume":"117","author":"Lundeberg","year":"1987","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jmpt.2013.05.018_bb0120","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0304-3959(95)00080-1","article-title":"A comparison of the effects of noxious and innocuous counterstimuli on experimentally induced itch and pain","volume":"64","author":"Ward","year":"1996","journal-title":"Pain"},{"key":"10.1016\/j.jmpt.2013.05.018_bb0125","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/ncpneuro0807","article-title":"A case of neuropathic brachioradial pruritus caused by cervical disc herniation","volume":"4","author":"Binder","year":"2008","journal-title":"Nat Clin Pract Neurol"},{"key":"10.1016\/j.jmpt.2013.05.018_bb0130","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0304-3940(99)00257-8","article-title":"Potentiation and suppression of the histamine response by raising and lowering the temperature in canine visceral polymodal receptors in vitro","volume":"266","author":"Mizumura","year":"1999","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jmpt.2013.05.018_bb0135","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3171\/2009.9.JNS09620","article-title":"A C-fiber\u2013mediated neuropathic brachioradial pruritus","volume":"113","author":"De Ridder","year":"2010","journal-title":"J Neurosurg"},{"key":"10.1016\/j.jmpt.2013.05.018_bb0140","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1529-8019.2008.00167.x","article-title":"Neuropathic and psychogenic itch","volume":"21","author":"Yosipovitch","year":"2008","journal-title":"Dermatol Ther"},{"key":"10.1016\/j.jmpt.2013.05.018_bb0145","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1346-8138.2007.00279.x","article-title":"Transcutaneous electrical nerve stimulation offers partial relief in notalgia paresthetica patients with a relevant spinal pathology","volume":"32","author":"Savk","year":"2007","journal-title":"J Dermatol"},{"key":"10.1016\/j.jmpt.2013.05.018_bb0150","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0304-3959(97)03339-3","article-title":"Cutaneous field stimulation (CFS): a new powerful method to combat itch","volume":"71","author":"Nilsson","year":"1997","journal-title":"Pain"}],"container-title":["Journal of Manipulative and Physiological Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161475413001024?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161475413001024?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T08:55:16Z","timestamp":1784796916000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmpt.kglmeridian.com\/doi\/10.1016\/j.jmpt.2013.05.018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["S0161475413001024"],"URL":"https:\/\/doi.org\/10.1016\/j.jmpt.2013.05.018","relation":{},"ISSN":["0161-4754"],"issn-type":[{"value":"0161-4754","type":"print"}],"subject":[],"published":{"date-parts":[[2013,7]]}}}