{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:46:47Z","timestamp":1790894807575,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Magnetic Resonance"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1016\/j.jmr.2011.05.007","type":"journal-article","created":{"date-parts":[[2011,5,24]],"date-time":"2011-05-24T18:11:07Z","timestamp":1306260667000},"page":"170-177","source":"Crossref","is-referenced-by-count":25,"title":["The evaluation of new and isotopically labeled isoindoline nitroxides and an azaphenalene nitroxide for EPR oximetry"],"prefix":"10.1016","volume":"211","author":[{"given":"Nadeem","family":"Khan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Blinco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven E.","family":"Bottle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyuki","family":"Hosokawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold M.","family":"Swartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron S.","family":"Micallef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmr.2011.05.007_b0005","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1016\/j.freeradbiomed.2007.02.030","article-title":"The chemistry and biology of nitroxide compounds","volume":"42","author":"Soule","year":"2007","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.jmr.2011.05.007_b0010","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1002\/mrm.1910360507","article-title":"Noninvasive measurement of the pH inside the gut by using pH-sensitive nitroxides. An in vivo EPR study","volume":"36","author":"Gallez","year":"1996","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.jmr.2011.05.007_b0015","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1115\/1.2795959","article-title":"The measurement of temperature with electron paramagnetic resonance spectroscopy","volume":"118","author":"Eckburg","year":"1996","journal-title":"J. Biomech. Eng."},{"key":"10.1016\/j.jmr.2011.05.007_b0020","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/mrm.1910350113","article-title":"Use of nitroxides for assessing perfusion, oxygenation, and viability of tissues: in vivo EPR and MRI studies","volume":"35","author":"Gallez","year":"1996","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.jmr.2011.05.007_b0025","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/mrm.1910290105","article-title":"Simultaneous measurement of intracellular and extracellular oxygen concentrations using a nitroxide-liposome system","volume":"29","author":"Glockner","year":"1993","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.jmr.2011.05.007_b0030","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.freeradbiomed.2008.04.019","article-title":"In vivo EPR measurement of glutathione in tumor-bearing mice using improved disulfide biradical probe","volume":"45","author":"Roshchupkina","year":"2008","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.jmr.2011.05.007_b0035","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1089\/ars.2007.1722","article-title":"Therapeutic and clinical applications of nitroxide compounds","volume":"9","author":"Soule","year":"2007","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.jmr.2011.05.007_b0040","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1089\/ars.2007.1718","article-title":"Use of electron paramagnetic resonance spectroscopy to evaluate the redox state in vivo","volume":"9","author":"Swartz","year":"2007","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.jmr.2011.05.007_b0045","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1034\/j.1600-0455.2002.430418.x","article-title":"Feasibility and assessment of non-invasive in vivo redox status using electron paramagnetic resonance imaging","volume":"43","author":"Yamada","year":"2002","journal-title":"Acta Radiol."},{"key":"10.1016\/j.jmr.2011.05.007_b0050","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1211\/jpp.60.8.0011","article-title":"Assessment of tissue redox status using metabolic responsive contrast agents and magnetic resonance imaging","volume":"60","author":"Hyodo","year":"2008","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jmr.2011.05.007_b0055","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1158\/1078-0432.CCR-05-2747","article-title":"High-resolution mapping of tumor redox status by Magnetic Resonance Imaging using nitroxides as redox-sensitive contrast agents","volume":"12","author":"Matsumoto","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jmr.2011.05.007_b0060","series-title":"Advances in Magnetic Resonance Imaging","first-page":"49","article-title":"Metabolically responsive contrast agents","author":"Swartz","year":"1989"},{"key":"10.1016\/j.jmr.2011.05.007_b0065","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1089\/ars.2007.1620","article-title":"Measurements of oxygen in vivo: overview and perspectives on methods to measure oxygen within cells and tissues","volume":"9","author":"Springett","year":"2007","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.jmr.2011.05.007_b0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/jmre.1998.1438","article-title":"EPR and DNP properties of certain novel single electron contrast agents intended for oximetric imaging","volume":"133","author":"Ardenkj\u00e6r-Larsen","year":"1998","journal-title":"J. Magn. Reson."},{"key":"10.1016\/j.jmr.2011.05.007_b0075","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jmr.2008.12.013","article-title":"Nano-emulsions of fluorinated trityl radicals as sensors for EPR oximetry","volume":"197","author":"Charlier","year":"2009","journal-title":"J. Magn. Reson."},{"key":"10.1016\/j.jmr.2011.05.007_b0080","doi-asserted-by":"crossref","first-page":"3298","DOI":"10.1021\/jp0682356","article-title":"Encapsulation of a highly sensitive EPR active oxygen probe into sonochemically prepared microspheres","volume":"111","author":"Sostaric","year":"2007","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.jmr.2011.05.007_b0085","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.freeradbiomed.2008.12.011","article-title":"Esterified trityl radicals as intracellular oxygen probes","volume":"46","author":"Liu","year":"2009","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.jmr.2011.05.007_b0090","doi-asserted-by":"crossref","first-page":"7240","DOI":"10.1021\/ja071515u","article-title":"Trityl radicals as persistent dual function pH and oxygen probes for in vivo electron paramagnetic resonance spectroscopy and imaging: concept and experiment","volume":"129","author":"Bobko","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jmr.2011.05.007_b0095","doi-asserted-by":"crossref","first-page":"10780","DOI":"10.1021\/ja803083z","article-title":"Synthesis and characterization of amino derivatives of persistent trityl radicals as dual function pH and oxygen paramagnetic probes","volume":"130","author":"Dhimitruka","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jmr.2011.05.007_b0100","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0730-725X(94)92353-1","article-title":"Spin labelled arabinogalactan as MRI contrast agent","volume":"12","author":"Gallez","year":"1994","journal-title":"Magn. Reson. Imaging"},{"key":"10.1016\/j.jmr.2011.05.007_b0105","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1002\/mrm.1910300510","article-title":"Evaluation of a nitroxyl fatty acid as liver contrast agent for magnetic resonance imaging","volume":"30","author":"Gallez","year":"1993","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.jmr.2011.05.007_b0110","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/0730-725X(92)90516-3","article-title":"Evaluation of nonionic nitroxyl lipids as potential organ-specific contrast agents for magnetic resonance imaging","volume":"10","author":"Gallez","year":"1992","journal-title":"Magn. Reson. Imaging"},{"key":"10.1016\/j.jmr.2011.05.007_b0115","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/S0891-5849(00)00184-2","article-title":"A new nitroxyl-probe with high retention in the brain and its application for brain imaging","volume":"28","author":"Sano","year":"2000","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.jmr.2011.05.007_b0120","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/S0076-6879(02)52043-7","article-title":"Nitroxyl probes for brain research and their application to brain imaging","volume":"352","author":"Utsumi","year":"2002","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.jmr.2011.05.007_b0125","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1039\/b310467b","article-title":"Esterase-assisted accumulation of 3-carboxy-2,2,5,5-tetramethyl-1-pyrrolidinyloxyl into lymphocytes","volume":"2","author":"Kao","year":"2004","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.jmr.2011.05.007_b0130","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1039\/b415586f","article-title":"Synthesis and biological testing of aminoxyls designed for long-term retention by living cells","volume":"3","author":"Rosen","year":"2005","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.jmr.2011.05.007_b0135","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1124\/jpet.106.106245","article-title":"Acetoxymethoxycarbonyl nitroxides as electron paramagnetic resonance proimaging agents to measure O2 levels in mouse brain: a pharmacokinetic and pharmacodynamic study","volume":"318","author":"Miyake","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.jmr.2011.05.007_b0140","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1002\/mrm.20894","article-title":"Use of 3-acetoxymethoxycarbonyl-2,2,5,5-tetramethyl-1-pyrrolidinyloxyl as an EPR oximetry probe: potential for in vivo measurement of tissue oxygenation in mouse brain","volume":"55","author":"Shen","year":"2006","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.jmr.2011.05.007_b0145","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/BF03166117","article-title":"Development of isoindoline nitroxides for EPR oximetry in viable systems","volume":"22","author":"Shen","year":"2002","journal-title":"Appl. Magn. Reson."},{"key":"10.1016\/j.jmr.2011.05.007_b0150","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1021\/jo00029a036","article-title":"Trapping of cyclopentanediyl and trimethylenemethane triplet diradicals with the nitroxide 1,1,3,3-tetramethyl-1,3-dihydroisoindolin-2-yloxyl","volume":"57","author":"Adam","year":"1992","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.jmr.2011.05.007_b0155","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1021\/ma00231a042","article-title":"Selectivity of the reaction of free radicals with styrene","volume":"15","author":"Moad","year":"1982","journal-title":"Macromolecules"},{"key":"10.1016\/j.jmr.2011.05.007_b0160","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/S0040-4039(00)87091-4","article-title":"Quantitative studies on free radical reactions with the scavenger 1,1,3,3-tetramethylisoindolinyl-2-oxy","volume":"23","author":"Griffiths","year":"1982","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.jmr.2011.05.007_b0165","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1039\/b300642e","article-title":"Synthesis and EPR spin trapping properties of a new isoindole-based nitrone: 1,1,3-trimethylisoindole N-oxide (TMINO)","volume":"1","author":"Bottle","year":"2003","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.jmr.2011.05.007_b0170","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1039\/p29930002049","article-title":"An EPR and NMR study of some tetramethylisoindolin-2-yloxyl free radicals","volume":"2","author":"Bolton","year":"1993","journal-title":"J. Chem. Soc. Perkin Trans."},{"key":"10.1016\/j.jmr.2011.05.007_b0175","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1039\/ft9949002345","article-title":"NMR determination of EPR hyperfine coupling constants of some 5-(n-alkyl)-1,1,3,3-tetrakis(trideuteriomethyl)isoindolin-2-yloxyls","volume":"90","author":"Gillies","year":"1994","journal-title":"J. Chem. Soc. Faraday Trans."},{"key":"10.1016\/j.jmr.2011.05.007_b0180","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/(SICI)1097-458X(199910)37:10<730::AID-MRC530>3.0.CO;2-E","article-title":"ESR measurements of the partitioning of some new spin probes in n-octanol-water","volume":"37","author":"Bottle","year":"1999","journal-title":"Magn. Reson. Chem."},{"key":"10.1016\/j.jmr.2011.05.007_b0185","doi-asserted-by":"crossref","first-page":"4638","DOI":"10.1002\/ejoc.200700545","article-title":"The first example of an azaphenalene pro-fluorescent nitroxide","author":"Blinco","year":"2007","journal-title":"Eur. J. Org. Chem."},{"key":"10.1016\/j.jmr.2011.05.007_b0190","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.freeradbiomed.2004.06.035","article-title":"The impact of carboxy nitroxide antioxidants on irradiated ataxia telangiectasia cells","volume":"37","author":"Hosokawa","year":"2004","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.jmr.2011.05.007_b0195","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1039\/b002497j","article-title":"Synthesis, single crystal X-ray structure and W-band (95 GHz) EPR spectroscopy of a new anionic isoindoline aminoxyl: synthesis and characterization of some derivatives","volume":"2","author":"Bottle","year":"2000","journal-title":"J. Chem. Soc. Perkin Trans."},{"key":"10.1016\/j.jmr.2011.05.007_b0200","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1071\/CH9830397","article-title":"Synthesis of the radical scavenger 1,1,3,3-tetramethylisoindolin-2-yloxyl","volume":"36","author":"Griffiths","year":"1983","journal-title":"Aust. J. Chem."},{"key":"10.1016\/j.jmr.2011.05.007_b0205","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1039\/a805228j","article-title":"The synthesis of water soluble isoindoline nitroxides and a pronitroxide hydroxylamine hydrochloride UV\u2013VIS probe for free radicals","author":"Reid","year":"1998","journal-title":"Chem. Commun. (Cambridge, UK)"},{"key":"10.1016\/j.jmr.2011.05.007_b0210","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/mrm.1910200113","article-title":"In vivo oximetry using a nitroxide-liposome system","volume":"20","author":"Glockner","year":"1991","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.jmr.2011.05.007_b0215","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0006-3495(94)80551-X","article-title":"In vivo measurement of oxygen concentration using sonochemically synthesized microspheres","volume":"67","author":"Liu","year":"1994","journal-title":"Biophys. J."},{"key":"10.1016\/j.jmr.2011.05.007_b0220","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1063\/1.555680","article-title":"The solubility of oxygen and ozone in liquids","volume":"12","author":"Battino","year":"1983","journal-title":"J. Phys. Chem. Ref. Data"},{"key":"10.1016\/j.jmr.2011.05.007_b0225","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1073\/pnas.0510670103","article-title":"Simultaneous molecular imaging of redox reactions monitored by Overhauser-enhanced MRI with 14N- and 15N-labeled nitroxyl radicals","volume":"103","author":"Utsumi","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jmr.2011.05.007_b0230","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.jmr.2006.06.025","article-title":"Dynamic nuclear polarization properties of nitroxyl radicals used in Overhauser-enhanced MRI for simultaneous molecular imaging","volume":"182","author":"Benial","year":"2006","journal-title":"J. Magn. Reson."},{"key":"10.1016\/j.jmr.2011.05.007_b0235","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jmr.2010.02.016","article-title":"Dynamic nuclear polarization studies of redox-sensitive nitroxyl spin probes in liposomal solution","volume":"204","author":"Benial","year":"2010","journal-title":"J. Magn. Reson."},{"key":"10.1016\/j.jmr.2011.05.007_b0240","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.freeradbiomed.2006.06.018","article-title":"Dramatic extension of tumor latency and correction of neurobehavioral phenotype in Atm-mutant mice with a nitroxide antioxidant","volume":"41","author":"Gueven","year":"2006","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.jmr.2011.05.007_b0245","doi-asserted-by":"crossref","first-page":"11453","DOI":"10.1523\/JNEUROSCI.23-36-11453.2003","article-title":"Oxidative stress is responsible for deficient survival and dendritogenesis in Purkinje neurons from ataxia-telangiectasia mutated mutant mice","volume":"23","author":"Chen","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jmr.2011.05.007_b0250","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1002\/jlcr.2580340711","article-title":"Synthesis of isotopically-labeled nitroxyl radicals for use as spin probes","volume":"34","author":"Bolton","year":"1994","journal-title":"J. Labelled Compd. Radiopharm."},{"key":"10.1016\/j.jmr.2011.05.007_b0255","doi-asserted-by":"crossref","first-page":"6252","DOI":"10.1021\/ja048713v","article-title":"A tetrahedrally coordinated L3Fe\u2013Nx platform that accommodates terminal nitride (FeIVN) and dinitrogen (FeI\u2013N2\u2013FeI) ligands","volume":"126","author":"Betley","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jmr.2011.05.007_b0260","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.jinorgbio.2004.02.003","article-title":"XSophe-Sophe-XeprView. A computer simulation software suite (v. 1.1.3) for the analysis of continuous wave EPR spectra","volume":"98","author":"Hanson","year":"2004","journal-title":"J. Inorg. Biochem."}],"container-title":["Journal of Magnetic Resonance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090780711001649?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090780711001649?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T00:03:07Z","timestamp":1560211387000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1090780711001649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["S1090780711001649"],"URL":"https:\/\/doi.org\/10.1016\/j.jmr.2011.05.007","relation":{},"ISSN":["1090-7807"],"issn-type":[{"value":"1090-7807","type":"print"}],"subject":[],"published":{"date-parts":[[2011,8]]}}}