{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T20:30:41Z","timestamp":1761165041627,"version":"build-2065373602"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T00:00:00Z","timestamp":1633737600000},"content-version":"am","delay-in-days":342,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100012645","name":"University of Texas at Dallas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012645","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000928","name":"Welch Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000928","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000090","name":"Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Magnetic Resonance"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.jmr.2020.106837","type":"journal-article","created":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T19:06:10Z","timestamp":1601406370000},"page":"106837","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Hyperpolarized 89Y-EDTMP complex as a chemical shift-based NMR sensor for pH at the physiological range"],"prefix":"10.1016","volume":"320","author":[{"given":"Qing","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Parish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0528-2508","authenticated-orcid":false,"given":"Peter","family":"Niedbalski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Ratnakar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoltan","family":"Kovacs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lloyd","family":"Lumata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"year":"2008","series-title":"Spin Dynamics: Basics of Nuclear Magnetic Resonance","author":"Levitt","key":"10.1016\/j.jmr.2020.106837_b0005"},{"year":"1990","series-title":"Principles of Magnetic Resonance","author":"Slichter","key":"10.1016\/j.jmr.2020.106837_b0010"},{"year":"1961","series-title":"The Principles of Nuclear Magnetism","author":"Abragam","key":"10.1016\/j.jmr.2020.106837_b0015"},{"key":"10.1016\/j.jmr.2020.106837_b0020","doi-asserted-by":"crossref","first-page":"10158","DOI":"10.1073\/pnas.1733835100","article-title":"Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMR","volume":"100","author":"Ardenkjaer-Larsen","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jmr.2020.106837_b0025","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1088\/0034-4885\/41\/3\/002","article-title":"Principles of dynamic nuclear polarisation","volume":"41","author":"Abragam","year":"1978","journal-title":"Rep. Prog. Phys."},{"key":"10.1016\/j.jmr.2020.106837_b0030","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1146\/annurev.nucl.47.1.67","article-title":"Solid polarized targets for nuclear and particle physics experiments","volume":"47","author":"Crabb","year":"1997","journal-title":"Annu. Rev. Nucl. Part. Sci."},{"key":"10.1016\/j.jmr.2020.106837_b0035","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jmr.2008.12.016","article-title":"Dynamic Nuclear Polarization of [1-13C]pyruvic acid at 4.6 tesla","volume":"197","author":"Johannesson","year":"2009","journal-title":"J. Magn. Reson"},{"key":"10.1016\/j.jmr.2020.106837_b0040","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/bs.mie.2015.04.006","article-title":"Hyperpolarized (13)C magnetic resonance and its use in metabolic assessment of cultured cells and perfused organs","volume":"561","author":"Lumata","year":"2015","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.jmr.2020.106837_b0045","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1002\/mrc.4597","article-title":"Construction and 13C hyperpolarization efficiency of a 180 GHz dissolution dynamic nuclear polarization system","volume":"55","author":"Kiswandhi","year":"2017","journal-title":"Magn. Reson. Chem."},{"key":"10.1016\/j.jmr.2020.106837_b0050","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1002\/mrc.4624","article-title":"Assembly and performance of a 6.4 T cryogen-free dynamic nuclear polarization system","volume":"55","author":"Kiswandhi","year":"2017","journal-title":"Magn. Reson. Chem."},{"key":"10.1016\/j.jmr.2020.106837_b0055","doi-asserted-by":"crossref","first-page":"5481","DOI":"10.1021\/acs.jpclett.8b01687","article-title":"NMR spectroscopy unchained: attaining the highest signal enhancements in dissolution dynamic nuclear polarization","volume":"9","author":"Niedbalski","year":"2018","journal-title":"J. Phys. Chem. Lett."},{"key":"10.1016\/j.jmr.2020.106837_b0060","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s10334-014-0455-2","article-title":"Development and performance of a 129-GHz dynamic nuclear polarizer in an ultra-wide bore superconducting magnet","volume":"28","author":"Lumata","year":"2015","journal-title":"Magn. Reson. Mater. Phys. Biol. Med."},{"key":"10.1016\/j.jmr.2020.106837_b0065","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1039\/C3CS60124B","article-title":"Chemistry and biochemistry of 13C hyperpolarized magnetic resonance using dynamic nuclear polarization","volume":"43","author":"Keshari","year":"2014","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.jmr.2020.106837_b0070","doi-asserted-by":"crossref","first-page":"8673","DOI":"10.1021\/ja201880y","article-title":"DNP by thermal mixing under optimized conditions yields >60 000-fold enhancement of 89Y NMR signal","volume":"133","author":"Lumata","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jmr.2020.106837_b0075","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s00723-012-0335-8","article-title":"Fast Dissolution Dynamic Nuclear Polarization NMR of 13C-Enriched 89Y-DOTA Complex: Experimental and Theoretical Considerations","volume":"43","author":"Lumata","year":"2012","journal-title":"Appl. Magn. Reson."},{"key":"10.1016\/j.jmr.2020.106837_b0080","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/anie.201106073","article-title":"Production and NMR characterization of hyperpolarized (107,109)Ag complexes","volume":"51","author":"Lumata","year":"2012","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jmr.2020.106837_b0085","doi-asserted-by":"crossref","first-page":"6418","DOI":"10.1021\/jacs.5b03300","article-title":"Imaging Metabolism with Hyperpolarized 13C-Labeled Cell Substrates","volume":"137","author":"Brindle","year":"2015","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jmr.2020.106837_b0090","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/mrm.25419","article-title":"Hyperpolarized 13C NMR detects rapid drug-induced changes in cardiac metabolism","volume":"74","author":"Khemtong","year":"2015","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.jmr.2020.106837_b0095","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1593\/neo.101102","article-title":"Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research","volume":"13","author":"Kurhanewicz","year":"2011","journal-title":"Neoplasia"},{"key":"10.1016\/j.jmr.2020.106837_b0100","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.molcel.2014.09.025","article-title":"Glutamine Oxidation Maintains the TCA Cycle and Cell Survival during Impaired Mitochondrial Pyruvate Transport","volume":"56","author":"Yang","year":"2014","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jmr.2020.106837_b0105","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1109\/MEMB.2004.1360409","article-title":"pH imaging. A review of pH measurement methods and applications in cancers","volume":"23","author":"Gillies","year":"2004","journal-title":"IEEE Eng. Med. Biol. Mag."},{"key":"10.1016\/j.jmr.2020.106837_b0110","first-page":"4373","article-title":"Acid pH in tumors and its potential for therapeutic exploitation","volume":"49","author":"Tannock","year":"1989","journal-title":"Cancer Res."},{"key":"10.1016\/j.jmr.2020.106837_b0115","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1056\/NEJM199801013380106","article-title":"Management of life-threatening acid-base disorders. First of two parts","volume":"338","author":"Adrogu\u00e9","year":"1998","journal-title":"N. Eng. J. Med."},{"key":"10.1016\/j.jmr.2020.106837_b0120","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/nmat3819","article-title":"A nanoparticle-based strategy for the imaging of a broad range of tumours by nonlinear amplification of microenvironment signals","volume":"13","author":"Wang","year":"2014","journal-title":"Nat. Mater."},{"key":"10.1016\/j.jmr.2020.106837_b0125","doi-asserted-by":"crossref","unstructured":"F.A. Gallagher, M.I. Kettunen, S.E. Day, D.-E. Hu, J.H. Ardenkj\u00e6r-Larsen, R.i.t. Zandt, P.R. Jensen, M. Karlsson, K. Golman, M.H. Lerche, K.M. Brindle, Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate, Nature 453 (2008) 940-943.","DOI":"10.1038\/nature07017"},{"key":"10.1016\/j.jmr.2020.106837_b0130","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.1039\/C5CC09724J","article-title":"Dynamic nuclear polarization of biocompatible 13C-enriched carbonates for in vivo pH imaging","volume":"52","author":"Korenchan","year":"2016","journal-title":"Chem. Commun."},{"key":"10.1016\/j.jmr.2020.106837_b0135","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1021\/acssensors.8b01097","article-title":"Esterase-Catalyzed Production of Hyperpolarized 13C-Enriched Carbon Dioxide in Tissues for Measuring pH","volume":"3","author":"Maptue","year":"2018","journal-title":"ACS Sens."},{"key":"10.1016\/j.jmr.2020.106837_b0140","doi-asserted-by":"crossref","first-page":"15126","DOI":"10.1038\/ncomms15126","article-title":"Imaging of pH in vivo using hyperpolarized 13C-labelled zymonic acid","volume":"8","author":"D\u00fcwel","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jmr.2020.106837_b0145","doi-asserted-by":"crossref","first-page":"14119","DOI":"10.1039\/C5CC05348J","article-title":"Application of Good's buffers to pH imaging using hyperpolarized (13)C MRI","volume":"51","author":"Flavell","year":"2015","journal-title":"Chem. Commun."},{"key":"10.1016\/j.jmr.2020.106837_b0150","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1039\/C7AN00076F","article-title":"Dicarboxylic acids as pH sensors for hyperpolarized (13)C magnetic resonance spectroscopic imaging","volume":"142","author":"Korenchan","year":"2017","journal-title":"Analyst"},{"key":"10.1016\/j.jmr.2020.106837_b0155","doi-asserted-by":"crossref","DOI":"10.3390\/s18020600","article-title":"Hyperpolarized Amino Acid Derivatives as Multivalent Magnetic Resonance pH Sensor Molecules","volume":"18","author":"Hundshammer","year":"2018","journal-title":"Sensors"},{"key":"10.1016\/j.jmr.2020.106837_b0160","doi-asserted-by":"crossref","first-page":"9104","DOI":"10.1038\/srep09104","article-title":"Hyperpolarized 15N-pyridine derivatives as pH-sensitive MRI agents","volume":"5","author":"Jiang","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jmr.2020.106837_b0165","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1021\/acssensors.6b00231","article-title":"(15)N Hyperpolarization of Imidazole-(15)N(2) for Magnetic Resonance pH Sensing via SABRE-SHEATH","volume":"1","author":"Shchepin","year":"2016","journal-title":"ACS Sens."},{"key":"10.1016\/j.jmr.2020.106837_b0170","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1021\/ja910278e","article-title":"Hyperpolarized 89Y complexes as pH sensitive NMR probes","volume":"132","author":"Jindal","year":"2010","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.jmr.2020.106837_b0175","doi-asserted-by":"crossref","unstructured":"R. Ramasamy, M.M.C.A. Castro, D.M.d. Freitas, C.F.G.C. Geraldes, Lanthanide complexes of aminophosphonates as shift reagents for 7Li and 23Na NMR studies in biological systems, Biochimie 74 (1992) 777-783.","DOI":"10.1016\/0300-9084(92)90060-R"},{"key":"10.1016\/j.jmr.2020.106837_b0180","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0020-1693(98)06083-6","article-title":"Potentiometric and computer studies of yttrium-EDTMP","volume":"275\u2013276","author":"de Witt","year":"1998","journal-title":"Inorganica Chimica Acta"},{"key":"10.1016\/j.jmr.2020.106837_b0185","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1023\/A:1019943319341","article-title":"Lanthanide complexes of ethylenediaminotetramethylene-phosphonic acid","volume":"69","author":"Princz","year":"2002","journal-title":"J. Thermal Anal. Calorimetry"},{"key":"10.1016\/j.jmr.2020.106837_b0190","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1006\/jmre.1997.1159","article-title":"Longitudinal relaxation and diffusion measurements using magnetic resonance signals from laser-hyperpolarized 129Xe nuclei","volume":"126","author":"Patyal","year":"1997","journal-title":"J. Magn. Reson."},{"key":"10.1016\/j.jmr.2020.106837_b0195","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1021\/cr980440x","article-title":"Gadolinium(III) Chelates as MRI Contrast Agents: Structure, Dynamics, and Applications","volume":"99","author":"Caravan","year":"1999","journal-title":"Chem. Rev."},{"year":"2013","series-title":"The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging","author":"Merbach","key":"10.1016\/j.jmr.2020.106837_b0200"},{"key":"10.1016\/j.jmr.2020.106837_b0205","doi-asserted-by":"crossref","unstructured":"B. J. Tickner, G. J. Stasiuk, S. B. Duckett, G. Angelovski, The use of yttrium in medical imaging and therapy: historical background and future perspectives, Chem. Soc. Rev. (2020), Advance Article. https:\/\/doi.org\/10.1039\/C9CS00840C","DOI":"10.1039\/C9CS00840C"},{"key":"10.1016\/j.jmr.2020.106837_b0210","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10967-005-0920-5","article-title":"Radionuclides used for therapy and suggestion for new candidates","volume":"266","author":"Neves","year":"2005","journal-title":"J. Radioanal. Nucl. Chem."},{"key":"10.1016\/j.jmr.2020.106837_b0215","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.talanta.2003.10.007","article-title":"Accurate determination of low pK values by (1)H NMR titration","volume":"62","author":"Szak\u00e1cs","year":"2004","journal-title":"Talanta"},{"key":"10.1016\/j.jmr.2020.106837_b0220","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/s11306-016-1101-y","article-title":"Modelling the acid\/base (1)H NMR chemical shift limits of metabolites in human urine","volume":"12","author":"Tredwell","year":"2016","journal-title":"Metabolomics"},{"key":"10.1016\/j.jmr.2020.106837_b0225","doi-asserted-by":"crossref","first-page":"21351","DOI":"10.1039\/C6CP03954E","article-title":"Impact of Ho3+-doping on 13C dynamic nuclear polarization using trityl OX063 free radical","volume":"18","author":"Kiswandhi","year":"2016","journal-title":"Phys. Chem. Chem. Phys."},{"key":"10.1016\/j.jmr.2020.106837_b0230","doi-asserted-by":"crossref","first-page":"5129","DOI":"10.1021\/jp302399f","article-title":"Impact of Gd3+ on DNP of [1-13C]Pyruvate Doped with Trityl OX063, BDPA, or 4-Oxo-TEMPO","volume":"116","author":"Lumata","year":"2012","journal-title":"J. Phys. Chem. A"},{"key":"10.1016\/j.jmr.2020.106837_b0235","doi-asserted-by":"crossref","DOI":"10.1063\/1.4973317","article-title":"Influence of Dy(3+) and Tb(3+) doping on (13)C dynamic nuclear polarization","volume":"146","author":"Niedbalski","year":"2017","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.jmr.2020.106837_b0240","doi-asserted-by":"crossref","first-page":"7032","DOI":"10.1039\/c3cp50750e","article-title":"Influence of deuteration in the glassing matrix on 13C dynamic nuclear polarization","volume":"15","author":"Lumata","year":"2013","journal-title":"Phys. Chem. Chem. Phys."},{"key":"10.1016\/j.jmr.2020.106837_b0245","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nm.3416","article-title":"Magnetic resonance imaging of tumor glycolysis using hyperpolarized 13C-labeled glucose","volume":"20","author":"Rodrigues","year":"2014","journal-title":"Nat. Med."}],"container-title":["Journal of Magnetic Resonance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090780720301555?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090780720301555?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T18:59:53Z","timestamp":1761073193000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1090780720301555"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":49,"alternative-id":["S1090780720301555"],"URL":"https:\/\/doi.org\/10.1016\/j.jmr.2020.106837","relation":{},"ISSN":["1090-7807"],"issn-type":[{"type":"print","value":"1090-7807"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hyperpolarized 89Y-EDTMP complex as a chemical shift-based NMR sensor for pH at the physiological range","name":"articletitle","label":"Article Title"},{"value":"Journal of Magnetic Resonance","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmr.2020.106837","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106837"}}