{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T02:17:15Z","timestamp":1789179435488,"version":"build-2803163510"},"reference-count":26,"publisher":"Stanford University Press","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T00:00:00Z","timestamp":1653004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Mass Spectrometry and Advances in the Clinical Lab"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.jmsacl.2022.05.002","type":"journal-article","created":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T12:07:12Z","timestamp":1653134832000},"page":"1-11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Quantitation of non-derivatized free amino acids for detecting inborn errors of metabolism by incorporating mixed-mode chromatography with tandem mass spectrometry"],"prefix":"10.21627","volume":"25","author":[{"given":"Patrick D.","family":"DeArmond","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dustin R.","family":"Bunch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4811","reference":[{"key":"10.1016\/j.jmsacl.2022.05.002_b0005","series-title":"Contemporary Practice in Clinical Chemistry","first-page":"865","article-title":"Newborn screening and inborn errors of metabolism","author":"Patel","year":"2020"},{"key":"10.1016\/j.jmsacl.2022.05.002_b0010","series-title":"Physician's Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases","first-page":"749","article-title":"Amino acids","author":"Pasquali","year":"2014"},{"key":"10.1016\/j.jmsacl.2022.05.002_b0015","first-page":"177","article-title":"The change in Gibbs free energy for hydrophobic association: Derivation and evaluation by means of inverse temperature transitions","volume":"399","author":"Urry","year":"2004","journal-title":"Chem. Phys. Lett."},{"key":"10.1016\/j.jmsacl.2022.05.002_b0020","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1016\/j.jchromb.2011.07.030","article-title":"Quantitative urine amino acid analysis using liquid chromatography tandem mass spectrometry and aTRAQ reagents","volume":"879","author":"Held","year":"2011","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jmsacl.2022.05.002_b0025","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1007\/s12161-016-0463-0","article-title":"Sensitive analysis of 33 free amino acids in serum, milk, and muscle by ultra-high performance liquid chromatography-quadrupole-orbitrap high resolution mass spectrometry","volume":"9","author":"Yin","year":"2016","journal-title":"Food Anal. Method"},{"key":"10.1016\/j.jmsacl.2022.05.002_b0030","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jchromb.2013.06.026","article-title":"Analysis of chloroformate-derivatised amino acids, dipeptides and polyamines by LC-MS\/MS","volume":"934","author":"Ubhi","year":"2013","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jmsacl.2022.05.002_b0035","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1002\/rcm.1054","article-title":"ESI-MS\/MS analysis of underivatised amino acids: a new tool for the diagnosis of inherited disorders of amino acid metabolism. Fragmentation study of 79 molecules of biological interest in positive and negative ionisation mode","volume":"17","author":"Piraud","year":"2003","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.jmsacl.2022.05.002_b0040","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.1002\/rcm.2197","article-title":"A new reversed-phase liquid chromatographic\/tandem mass spectrometric method for analysis of underivatised amino acids: evaluation for the diagnosis and the management of inherited disorders of amino acid metabolism","volume":"19","author":"Piraud","year":"2005","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.jmsacl.2022.05.002_b0045","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/jms.1287","article-title":"Analysis of native amino acids by liquid chromatography\/electrospray ionization mass spectrometry: comparative study between two sources and interfaces","volume":"43","author":"de Person","year":"2008","journal-title":"J. Mass Spectrom."},{"key":"10.1016\/j.jmsacl.2022.05.002_b0050","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.jpba.2015.06.001","article-title":"Amino acid analysis using chromatography\u2013mass spectrometry: an inter platform comparison study","volume":"114","author":"Krumpochova","year":"2015","journal-title":"J. Pharmaceut. Biomed."},{"issue":"5","key":"10.1016\/j.jmsacl.2022.05.002_b0055","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/s10545-016-9935-z","article-title":"Rapid quantification of underivatized amino acids in plasma by hydrophilic interaction liquid chromatography (HILIC) coupled with tandem mass-spectrometry","volume":"39","author":"Prinsen","year":"2016","journal-title":"J. Inherit. Metab. Dis."},{"issue":"5","key":"10.1016\/j.jmsacl.2022.05.002_b0060","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1007\/s00726-013-1463-7","article-title":"Hydrophilic interaction ultra-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry for highly rapid and sensitive analysis of underivatized amino acids in functional foods","volume":"44","author":"Zhou","year":"2013","journal-title":"Amino Acids"},{"key":"10.1016\/j.jmsacl.2022.05.002_b0065","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jchromb.2013.11.017","article-title":"A rapid, sensitive method for quantitative analysis of underivatized amino acids by liquid chromatography\u2013tandem mass spectrometry (LC\u2013MS\/MS)","volume":"944","author":"Le","year":"2014","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jmsacl.2022.05.002_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2019.121819","article-title":"Analytical strategies for the determination of amino acids: Past, present and future trends","volume":"1132","author":"Ferr\u00e9","year":"2019","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jmsacl.2022.05.002_b0075","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jpba.2017.06.040","article-title":"Development of a mixed-mode chromatography with tandem mass spectrometry method for the quantitative analysis of 23 underivatized amino acids in human serum","volume":"145","author":"Choi","year":"2017","journal-title":"J. Pharmaceut. Biomed."},{"issue":"8","key":"10.1016\/j.jmsacl.2022.05.002_b0080","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1002\/bkcs.11816","article-title":"The performance investigation of bimodal cation exchange\/hydrophilic interaction liquid chromatography\u2013electrospray ionization mass spectrometry by modifying mobile phase composition in amino acid separation","volume":"40","author":"Lee","year":"2019","journal-title":"Bull. Korean Chem. Soc."},{"key":"10.1016\/j.jmsacl.2022.05.002_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2019.121786","article-title":"Rapid quantification of underivatized alloisoleucine and argininosuccinate using mixed-mode chromatography with tandem mass spectrometry","volume":"1128","author":"Griffin","year":"2019","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jmsacl.2022.05.002_b0090","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3390\/ijns7030044","article-title":"Development of second-tier liquid chromatography-tandem mass spectrometry analysis for expanded newborn screening in Japan","volume":"7","author":"Shigematsu","year":"2021","journal-title":"Int. J. Neonatal Screen"},{"key":"10.1016\/j.jmsacl.2022.05.002_b0095","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1002\/jssc.201601097","article-title":"Direct analysis of free amino acids by mixed-mode chromatography with tandem mass spectrometry","volume":"40","author":"Vilches","year":"2017","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.jmsacl.2022.05.002_b0100","first-page":"30","article-title":"Direct quantitation of amino acids in human serum using a stepwise-dilution strategy and a mixed-mode liquid chromatography-tandem mass spectrometry method","volume":"9","author":"Lee","year":"2018","journal-title":"Mass Spectrom. Lett."},{"key":"10.1016\/j.jmsacl.2022.05.002_b0105","doi-asserted-by":"crossref","unstructured":"Hage DS. Chromatography. In: Rifai N, Horvath AR, Wittwer CT, eds. Principles and Applications of Clinical Mass Spectrometry: Elsevier, 2018:1\u201332.","DOI":"10.1016\/B978-0-12-816063-3.00001-3"},{"key":"10.1016\/j.jmsacl.2022.05.002_b0110","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1042\/bj0770135","article-title":"Argininosuccinic aciduria: identification and reactions of the abnormal metabolite in a newly described form of mental disease, with some preliminary metabolic studies","volume":"77","author":"Westall","year":"1960","journal-title":"J. Biochem."},{"key":"10.1016\/j.jmsacl.2022.05.002_b0115","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.cca.2016.01.026","article-title":"The effects of pre-analysis sample handling on human plasma amino acid concentrations","volume":"455","author":"Takehana","year":"2016","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.jmsacl.2022.05.002_b0120","doi-asserted-by":"crossref","first-page":"12802","DOI":"10.3390\/ijms222312802","article-title":"Erythrocytes prevent degradation of carnosine by human serum carnosinase","volume":"22","author":"Oppermann","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jmsacl.2022.05.002_b0125","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1373\/clinchem.2007.098434","article-title":"Second-tier test for quantification of alloisoleucine and branched-chain amino acids in dried blood spots to improve newborn screening for maple syrup urine disease (MSUD)","volume":"54","author":"Oglesbee","year":"2008","journal-title":"Clin. Chem."},{"key":"10.1016\/j.jmsacl.2022.05.002_b0130","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1258\/acb.2011.010283","article-title":"An improved ultra performance liquid chromatography-tandem mass spectrometry method for the determination of alloisoleucine and branched chain amino acids in dried blood samples","volume":"48","author":"Alodaib","year":"2011","journal-title":"Ann. Clin. Biochem."}],"container-title":["Journal of Mass Spectrometry and Advances in the Clinical Lab"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667145X22000153?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667145X22000153?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T07:22:27Z","timestamp":1767770547000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2667145X22000153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":26,"alternative-id":["S2667145X22000153"],"URL":"https:\/\/doi.org\/10.1016\/j.jmsacl.2022.05.002","relation":{},"ISSN":["2667-145X"],"issn-type":[{"value":"2667-145X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantitation of non-derivatized free amino acids for detecting inborn errors of metabolism by incorporating mixed-mode chromatography with tandem mass spectrometry","name":"articletitle","label":"Article Title"},{"value":"Journal of Mass Spectrometry and Advances in the Clinical Lab","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmsacl.2022.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 THE AUTHORS. Publishing services by ELSEVIER B.V. on behalf of MSACL.","name":"copyright","label":"Copyright"}]}}