{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T12:42:02Z","timestamp":1767789722552,"version":"3.49.0"},"reference-count":23,"publisher":"Stanford University Press","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Mass Spectrometry and Advances in the Clinical Lab"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.jmsacl.2025.11.004","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:18:01Z","timestamp":1764173881000},"page":"88-96","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A non-affinity-dependent high-resolution mass spectrometry method for detecting and typing monoclonal free light immunoglobulin chains"],"prefix":"10.21627","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6762-3443","authenticated-orcid":false,"given":"Per","family":"Bengtson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9227-744X","authenticated-orcid":false,"given":"Magnus","family":"F\u00f6rnvik Jonsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4811","reference":[{"key":"10.1016\/j.jmsacl.2025.11.004_b0005","doi-asserted-by":"crossref","first-page":"e538","DOI":"10.1016\/S1470-2045(14)70442-5","article-title":"International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma","volume":"15","author":"Rajkumar","year":"2014","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.jmsacl.2025.11.004_b0010","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.clinbiochem.2021.05.006","article-title":"Monoclonal free light chain detection and quantification: performances and limits of available laboratory assays","volume":"95","author":"Sarto","year":"2021","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.jmsacl.2025.11.004_b0015","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1093\/labmed\/lmz007","article-title":"Serum free light chain assay in monoclonal gammopathic manifestations","volume":"50","author":"Lee","year":"2019","journal-title":"Lab. Med."},{"key":"10.1016\/j.jmsacl.2025.11.004_b0020","doi-asserted-by":"crossref","first-page":"4954","DOI":"10.1182\/blood-2009-06-224832","article-title":"Abnormal serum free light chain ratio in patients with multiple myeloma in complete remission has strong association with the presence of oligoclonal bands: implications for stringent complete remission definition","volume":"114","author":"de Larrea","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.jmsacl.2025.11.004_b0025","doi-asserted-by":"crossref","first-page":"447","DOI":"10.3109\/00365517609054462","article-title":"Polymeric forms of free light chains in serum from normal individuals and from patients with renal diseases","volume":"36","author":"S\u00f6lling","year":"1976","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"10.1016\/j.jmsacl.2025.11.004_b0030","doi-asserted-by":"crossref","first-page":"7807","DOI":"10.1038\/s41467-023-43443-4","article-title":"Structural and thermodynamic insights into antibody light chain tetramer formation through 3D domain swapping","volume":"14","author":"Sakai","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jmsacl.2025.11.004_b0035","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1002\/ajh.23773","article-title":"Immunoglobulin-free light chain monomer-dimer patterns help to distinguish malignant from premalignant monoclonal gammopathies: a pilot study","volume":"89","author":"Kaplan","year":"2014","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.jmsacl.2025.11.004_b0040","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1038\/s41375-020-0940-8","article-title":"N-glycosylation of monoclonal light chains on routine MASS-FIX testing is a risk factor for MGUS progression","volume":"34","author":"Dispenzieri","year":"2020","journal-title":"Leukemia"},{"key":"10.1016\/j.jmsacl.2025.11.004_b0045","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1038\/s41375-022-01599-w","article-title":"An N-glycosylation hotspot in immunoglobulin \u03ba light chains is associated with AL amyloidosis","volume":"36","author":"Nevone","year":"2022","journal-title":"Leukemia"},{"key":"10.1016\/j.jmsacl.2025.11.004_b0050","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1111\/trf.16279","article-title":"In from the cold: M-protein light chain glycosylation is positively associated with cold agglutinin titer levels","volume":"61","author":"Juskewitch","year":"2021","journal-title":"Transfusion"},{"key":"10.1016\/j.jmsacl.2025.11.004_b0055","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1021\/pr400985k","article-title":"Using mass spectrometry to monitor monoclonal immunoglobulins in patients with a monoclonal gammopathy","volume":"13","author":"Barnidge","year":"2014","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.jmsacl.2025.11.004_b0060","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1515\/cclm-2015-0917","article-title":"Monitoring free light chains in serum using mass spectrometry","volume":"54","author":"Barnidge","year":"2016","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.jmsacl.2025.11.004_b0065","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1002\/rcm.7314","article-title":"Using matrix-assisted laser desorption\/ionization time-of-flight mass spectrometry to detect monoclonal immunoglobulin light chains in serum and urine","volume":"29","author":"Barnidge","year":"2015","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.jmsacl.2025.11.004_b0070","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1373\/clinchem.2015.253740","article-title":"Comprehensive Assessment of M-Proteins using Nanobody Enrichment coupled to MALDI-TOF Mass Spectrometry","volume":"62","author":"Mills","year":"2016","journal-title":"Clin. Chem."},{"issue":"10","key":"10.1016\/j.jmsacl.2025.11.004_b0075","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1373\/clinchem.2015.253781","article-title":"Screening Method for M-Proteins in Serum using Nanobody Enrichment coupled to MALDI-TOF Mass Spectrometry","volume":"62","author":"Kohlhagen","year":"2016","journal-title":"Clin. Chem."},{"key":"10.1016\/j.jmsacl.2025.11.004_b0080","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1002\/ajh.24772","article-title":"The utility of MASS-FIX to detect and monitor monoclonal proteins in the clinic","volume":"92","author":"Milani","year":"2017","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.jmsacl.2025.11.004_b0085","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1373\/clinchem.2018.299461","article-title":"Direct detection of monoclonal free light chains in serum by use of immunoenrichment-coupled MALDI-TOF mass spectrometry","volume":"65","author":"Sepiashvili","year":"2019","journal-title":"Clin. Chem."},{"key":"10.1016\/j.jmsacl.2025.11.004_b0090","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s41408-021-00408-4","article-title":"Mass spectrometry for the evaluation of monoclonal proteins in multiple myeloma and related disorders: an International Myeloma Working Group Mass Spectrometry Committee Report","volume":"11","author":"Murray","year":"2021","journal-title":"Blood Cancer J."},{"key":"10.1016\/j.jmsacl.2025.11.004_b0095","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.1002253","article-title":"Localized light chain amyloidosis: a self-limited plasmacytic B-cell lymphoproliferative disorder","volume":"12","author":"Mart\u00ednez","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.jmsacl.2025.11.004_b0100","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1093\/clinchem\/hvae130","article-title":"Clonality Determination by Detecting Unmodified Monoclonal Serum Free Light Chains using On-Probe Extraction coupled with Liquid Chromatography-High-Resolution Mass Spectrometry","volume":"70","author":"Yeung","year":"2024","journal-title":"Clin. Chem."},{"key":"10.1016\/j.jmsacl.2025.11.004_b0105","series-title":"Methods of Immunological Analysis Volume 1: Fundamentals","first-page":"656","article-title":"Data analysis, mathematical modeling","author":"Baud","year":"1993"},{"key":"10.1016\/j.jmsacl.2025.11.004_b0110","unstructured":"N Latex FLC kappa and lambda, rev 12 (Package Inserts), Siemens Healthineers, Erlangen, Germany."},{"key":"10.1016\/j.jmsacl.2025.11.004_b0115","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.jpba.2011.03.033","article-title":"Validation of immunoassay for protein biomarkers: bioanalytical study plan implementation to support pre-clinical and clinical studies","volume":"55","author":"Valentin","year":"2011","journal-title":"J. Pharm. Biomed. Anal."}],"container-title":["Journal of Mass Spectrometry and Advances in the Clinical Lab"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667145X25000331?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667145X25000331?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T07:22:52Z","timestamp":1767770572000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2667145X25000331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":23,"alternative-id":["S2667145X25000331"],"URL":"https:\/\/doi.org\/10.1016\/j.jmsacl.2025.11.004","relation":{},"ISSN":["2667-145X"],"issn-type":[{"value":"2667-145X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A non-affinity-dependent high-resolution mass spectrometry method for detecting and typing monoclonal free light immunoglobulin chains","name":"articletitle","label":"Article Title"},{"value":"Journal of Mass Spectrometry and Advances in the Clinical Lab","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmsacl.2025.11.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 THE AUTHORS. Publishing services by ELSEVIER B.V. on behalf of MSACL.","name":"copyright","label":"Copyright"}]}}