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Primiparous women (N = 139) were randomly assigned to an intervention group (HAase injection, n = 71) or to a control group (no injection, n = 68). Significant differences were noted between the two groups in frequency of perineal trauma (intervention, 39.4%; control, 76.5%), degree of spontaneous laceration (intervention, 0.0%; control, 82.4%), and laceration located in the posterior region of the perineum (intervention, 54.2%; control, 84.3%). When episiotomy and second\u2010degree lacerations were considered together and women with intact perineum were excluded from the analysis, the difference between the groups was no longer significant. With the use of the HAase enzyme, the relative risk was 0.5 for perineal trauma and 0.0 for second\u2010degree lacerations. The present findings suggest that perineal injection of HAase prevented perineal trauma. These findings provide strong rationale for a larger follow\u2010up study.<\/jats:p>","DOI":"10.1016\/j.jmwh.2008.02.015","type":"journal-article","created":{"date-parts":[[2008,6,28]],"date-time":"2008-06-28T09:41:32Z","timestamp":1214646092000},"page":"353-361","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Use of Hyaluronidase to Prevent Perineal Trauma During Spontaneous Delivery: A Pilot Study"],"prefix":"10.1111","volume":"53","author":[{"given":"Leila Barreto","family":"Scarabotto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Luiza Gonzalez","family":"Riesco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,12,24]]},"reference":[{"key":"e_1_2_8_2_2","volume-title":"DATASUS. Nascidos vivos. Brasil. 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