{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T02:49:48Z","timestamp":1790131788393,"version":"4.0.1"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,12,24]],"date-time":"2010-12-24T00:00:00Z","timestamp":1293148800000},"content-version":"vor","delay-in-days":660,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Midwife Womens Health"],"published-print":{"date-parts":[[2009,3,4]]},"abstract":"<jats:p>The objective of this study was to compare a Tibetan traditional medicine (the uterotonic <jats:italic>Zhi Byed 11<\/jats:italic> [<jats:italic>ZB11<\/jats:italic>]) to oral misoprostol for prophylaxis of postpartum hemorrhage (PPH). We conducted a double\u2010blind randomized controlled trial at three hospitals in Lhasa, Tibet, People's Republic of China. Women (N = 967) were randomized to either <jats:italic>ZB11<\/jats:italic> or misoprostol groups. Postpartum blood loss was measured in a calibrated blood collection drape. The primary combined outcome was incidence of PPH, defined as measured blood loss (MBL) \u2265 500 mL, administration of open label uterotonics, or maternal death. We found that the rate of the combined outcome was lower among the misoprostol group (16.1% versus 21.8% for <jats:italic>ZB11; P<\/jats:italic> = .02). Frequency of PPH was lower with misoprostol (12.4% versus 17.4%; <jats:italic>P<\/jats:italic> = .02). There were no significant differences in MBL &gt; 1000 mL or mean or median MBL. Fever was significantly more common in the misoprostol group (<jats:italic>P<\/jats:italic> = .03). The rate of combined outcome was significantly lower among women receiving misoprostol. However, other indices of obstetric hemorrhage were not significantly different.<\/jats:p>","DOI":"10.1016\/j.jmwh.2008.09.010","type":"journal-article","created":{"date-parts":[[2009,3,4]],"date-time":"2009-03-04T10:23:35Z","timestamp":1236162215000},"page":"133-141","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Randomized Double Masked Trial of <i>Zhi Byed 11<\/i>, a Tibetan Traditional Medicine, Versus Misoprostol to Prevent Postpartum Hemorrhage in Lhasa, Tibet"],"prefix":"10.1111","volume":"54","author":[{"given":"Suellen","family":"Miller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie","family":"Tudor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Thorsten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Nyima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Kalyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Sonam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Lhakpen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Droyoung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karma","family":"Quzong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsering","family":"Dekyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ty","family":"Hartwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda L.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Varner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,12,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1596\/978-0-8213-6133-7"},{"key":"e_1_2_6_3_2","first-page":"258","article-title":"Maternal mortality in rural areas of China","volume":"35","author":"Liang J","year":"2004","journal-title":"Sichuan Da Xue Xue Bao Yi Xue Ban"},{"key":"e_1_2_6_4_2","unstructured":"TshomoM.Knowledge of pregnancy and delivery and obstetrical diseases and treatments from a Tibetan medical perspective[master's thesis]. Lhasa Tibet:Tibetan Medical College 2004."},{"key":"e_1_2_6_5_2","unstructured":"DukeJ.Phytochemical and ethnobotanical databases. Available from:www.ars\u2010grin.govduke. [Accessed August 1 2007]."},{"key":"e_1_2_6_6_2","volume-title":"Solid material sample; analysis consultant case CC\u201020\u201303","author":"University of Utah Center for Human Toxicology.","year":"2003"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(06)60017-9"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1969.49.1.122"},{"key":"e_1_2_6_9_2","first-page":"51","article-title":"Physiological roles of the prostaglandins","author":"Horton EW.","year":"1970","journal-title":"Sci Basis Med Annu Rev"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-80642-1_1"},{"key":"e_1_2_6_11_2","first-page":"531","article-title":"A study on the effect of cortisol and progesterone on cytosolic arachidonic and palmitic acid concentrations in cultured human myometrial cells","volume":"47","author":"Otsuki T","year":"1995","journal-title":"Nippon Sanka Fujinka Gakkai Zasshi"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/107155769400100206"},{"key":"e_1_2_6_13_2","volume-title":"Herbal medicines: A guide for health care professionals","author":"Barnes J","year":"2007"},{"key":"e_1_2_6_14_2","volume-title":"The physiomedical dispensatory","author":"Cook W.","year":"1869"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/07399330500230920"},{"key":"e_1_2_6_16_2","unstructured":"Lhasa Municipality Health Bureau 2003."},{"key":"e_1_2_6_17_2","unstructured":"International Confederation of Midwives Web site.International Confederation of Midwives and the International Federation of Gynecology and Obstetrics. Joint statement: Management of the third stage of labour to prevent post\u2010partum haemorrhage. Available from:www.internationalmidwives.orgmodulesContentExpressimg_repositoryfinal20joint20statement20active20manangement\u2010eng20with20logo.pdf. [Accessed October 13 2008]."},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)05835-4"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2005.00711.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69522-6"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1998.tb10259.x"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.331.7519.723"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(99)00271-9"},{"key":"e_1_2_6_24_2","unstructured":"International Federation of Gynecology and Obstetrics Web site.International Confederation of Midwives and the International Federation of Gynecology and Obstetrics. Joint statement: Prevention and treatment of post\u2010partum haemorrhage. New advances for low resource settings. Available from:www.figo.orgdocsPPH20Joint20Statement20220English.pdf. [Accessed October 13 2008]."},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2005.10.019"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-4-16"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1999.tb08266.x"},{"key":"e_1_2_6_28_2","unstructured":"Tibetan Centre for Human Rights and Democracy Web site.Behind bars: Prison conditions in Tibet. Impoverishing Tibetans. II. Poverty in TibetAvailable from:www.tchrd.orgpublicationstopical_reportsimpoverishing_tibetans\u201020002_poverty.html. [Accessed August 1 2007]."},{"key":"e_1_2_6_29_2","unstructured":"Xinhua News Agency Web site.Facts & figures: Tibet's populationAvailable from:http:news.xinhuanet.comenglish20080411content_7960090.htm. [Accessed October 13 2008]."},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1525\/maq.2005.19.3.267"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11013-007-9070-2"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2007.03.033"},{"key":"e_1_2_6_33_2","first-page":"7","article-title":"How to make consent informed: Possible lessons from Tibet","volume":"29","author":"Miller S","year":"2007","journal-title":"IRB"},{"key":"e_1_2_6_34_2","unstructured":"US Food and Drug Administration Web site.Misoprostol (marketed as Cytotec) informationAvailable from:http:www.fda.govcderdruginfopagemisoprostoldefault.htm. [Accessed October 13 2008]."},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1054\/ijoa.1999.0371"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-7-13"},{"key":"e_1_2_6_37_2","volume-title":"Pill capsules; placebo, ZB 11; analysis, consultant case CC\u201030\u201304","author":"University of Utah Center for Human Toxicology.","year":"2004"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2006.02.014"},{"key":"e_1_2_6_39_2","first-page":"1011","article-title":"Evaluation of the effect of castor oil on initiating labor in term pregnancy","volume":"27","author":"Azhari S","year":"2006","journal-title":"Saudi Med J"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-2182(84)90166-6"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(96)01499-7"},{"key":"e_1_2_6_42_2","first-page":"CD003099","article-title":"Castor oil, bath and\/or enema for cervical priming and induction of labour","volume":"2","author":"Kelly AJ","year":"2001","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200202000-00025"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(81)90001-5"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19970915)16:17<1913::AID-SIM610>3.0.CO;2-Z"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.2307\/2530245"}],"container-title":["Journal of Midwifery &amp; Women's Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.jmwh.2008.09.010","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.jmwh.2008.09.010","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.jmwh.2008.09.010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T22:54:51Z","timestamp":1694818491000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/j.jmwh.2008.09.010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3,4]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,3,4]]}},"alternative-id":["10.1016\/j.jmwh.2008.09.010"],"URL":"https:\/\/doi.org\/10.1016\/j.jmwh.2008.09.010","archive":["Portico"],"relation":{},"ISSN":["1526-9523","1542-2011"],"issn-type":[{"value":"1526-9523","type":"print"},{"value":"1542-2011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3,4]]},"assertion":[{"value":"2010-12-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}