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This report examines the clinical course of an RhD\u2010negative woman who developed a high anti\u2010D antibody titer during her pregnancy while carrying an RhD\u2010positive female fetus yet had a negative antibody screen at the time she gave birth. Although she delivered a healthy newborn unaffected by hemolytic disease, subsequent pregnancies will be treated as though she is RhD alloimmunized. The discussion below includes possible causes for the abrupt rise in this woman's anti\u2010D antibody titer, a review of the complex Rh system and cellular anamnestic response, and current fetal surveillance for hemolytic disease of the fetus and newborn.<\/jats:p>","DOI":"10.1016\/j.jmwh.2009.08.006","type":"journal-article","created":{"date-parts":[[2009,10,30]],"date-time":"2009-10-30T08:43:41Z","timestamp":1256892221000},"page":"497-502","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Curious Case of Anti\u2010D Antibody Titer"],"prefix":"10.1111","volume":"54","author":[{"given":"Jennifer G.","family":"Hensley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine P.","family":"Coughlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura L.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,12,24]]},"reference":[{"key":"e_1_2_8_2_2","volume-title":"Technical manual","author":"Roback JD","year":"2008"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200608000-00044"},{"key":"e_1_2_8_4_2","volume-title":"Obstetrics: Normal and problem pregnancies","author":"Moise KJ.","year":"2005"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6909.2001.tb00006.x"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(99)90000-0"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1986.tb01958.x"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00924_1.x"},{"key":"e_1_2_8_9_2","first-page":"491","volume-title":"Maternal, fetal & neonatal physiology: A clinical perspective","author":"Blackburn S.","year":"2007"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1991.03460240066029"},{"key":"e_1_2_8_11_2","first-page":"1","article-title":"Births: Final data for 2003","volume":"54","author":"Martin JA","year":"2005","journal-title":"Natl Vital Stat Rep"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1999.39299154731.x"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200001063420102"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2002.01314.x"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31817d453c"}],"container-title":["Journal of Midwifery &amp; Women's Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.jmwh.2009.08.006","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.jmwh.2009.08.006","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.jmwh.2009.08.006","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.jmwh.2009.08.006","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.jmwh.2009.08.006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T23:16:01Z","timestamp":1693955761000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/j.jmwh.2009.08.006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11,12]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,11,12]]}},"alternative-id":["10.1016\/j.jmwh.2009.08.006"],"URL":"https:\/\/doi.org\/10.1016\/j.jmwh.2009.08.006","archive":["Portico"],"relation":{},"ISSN":["1526-9523","1542-2011"],"issn-type":[{"value":"1526-9523","type":"print"},{"value":"1542-2011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11,12]]},"assertion":[{"value":"2010-12-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}