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The 3 main differential diagnoses associated with vaginal bleeding are spontaneous abortion, ectopic pregnancy, and gestational trophoblastic disease. This article reviews early pregnancy development, etiologies of vaginal bleeding in the first trimester, strategies for evaluation, and recognition and management of the main diagnostic considerations. Case study examples illustrating the complexity of the assessment and management of vaginal bleeding in early pregnancy are presented.<\/jats:p>","DOI":"10.1016\/j.jmwh.2009.08.007","type":"journal-article","created":{"date-parts":[[2009,10,30]],"date-time":"2009-10-30T08:43:41Z","timestamp":1256892221000},"page":"483-491","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Assessment and Management of Bleeding in the First Trimester of Pregnancy"],"prefix":"10.1111","volume":"54","author":[{"given":"B. 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