{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T11:06:59Z","timestamp":1778929619472,"version":"3.51.4"},"reference-count":60,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T00:00:00Z","timestamp":1729728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170181"],"award-info":[{"award-number":["82170181"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["7222027"],"award-info":[{"award-number":["7222027"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFF1502000"],"award-info":[{"award-number":["2022YFF1502000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the National Cancer Center"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.jncc.2024.10.001","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T04:33:53Z","timestamp":1730262833000},"page":"57-74","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Overexpression of ornithine decarboxylase 1 mediates the immune-deserted microenvironment and poor prognosis in diffuse large B-cell lymphoma"],"prefix":"10.1016","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4135-3155","authenticated-orcid":false,"given":"Xiaojie","family":"Liang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baiwei","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruiying","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihao","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaoran","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aimin","family":"Zang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youchao","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5158-3862","authenticated-orcid":false,"given":"Lin","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6140-914X","authenticated-orcid":false,"given":"Liang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jncc.2024.10.001_bib0001","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.cell.2018.03.034","article-title":"Machine learning identifies stemness features associated with oncogenic dedifferentiation","volume":"173","author":"Malta","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.jncc.2024.10.001_bib0002","doi-asserted-by":"crossref","first-page":"bbaa211","DOI":"10.1093\/bib\/bbaa211","article-title":"Depiction of tumor stemlike features and underlying relationships with hazard immune infiltrations based on large prostate cancer cohorts","volume":"22","author":"Zhang","year":"2021","journal-title":"Brief Bioinform"},{"key":"10.1016\/j.jncc.2024.10.001_bib0003","doi-asserted-by":"crossref","first-page":"9020","DOI":"10.1073\/pnas.1818210116","article-title":"Cancer stemness, intratumoral heterogeneity, and immune response across cancers","volume":"116","author":"Miranda","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jncc.2024.10.001_bib0004","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1002\/1878-0261.12557","article-title":"Integrative analysis of gene expression and DNA methylation through one-class logistic regression machine learning identifies stemness features in medulloblastoma","volume":"13","author":"Lian","year":"2019","journal-title":"Mol Oncol"},{"key":"10.1016\/j.jncc.2024.10.001_bib0005","doi-asserted-by":"crossref","first-page":"142","DOI":"10.7150\/jca.35000","article-title":"Cancer stem cells of diffuse large B cell lymphoma are not enriched in the CD45+CD19- cells but in the ALDH high cells","volume":"11","author":"Song","year":"2020","journal-title":"J Cancer"},{"key":"10.1016\/j.jncc.2024.10.001_bib0006","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.7150\/thno.41362","article-title":"PI3K\/AKT inhibition reverses R-CHOP resistance by destabilizing SOX2 in diffuse large B cell lymphoma","volume":"10","author":"Chen","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.jncc.2024.10.001_bib0007","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.0105-2896.2006.00373.x","article-title":"A library of gene expression signatures to illuminate normal and pathological lymphoid biology","volume":"210","author":"Shaffer","year":"2006","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jncc.2024.10.001_bib0008","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.ccell.2021.04.014","article-title":"Conserved pan-cancer microenvironment subtypes predict response to immunotherapy","volume":"39","author":"Bagaev","year":"2021","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jncc.2024.10.001_bib0009","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.celrep.2016.12.019","article-title":"Pan-cancer immunogenomic analyses reveal genotype-immunophenotype relationships and predictors of response to checkpoint blockade","volume":"18","author":"Charoentong","year":"2017","journal-title":"Cell Rep"},{"key":"10.1016\/j.jncc.2024.10.001_bib0010","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.jncc.2024.10.001_bib0011","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/ng.127","article-title":"An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors","volume":"40","author":"Ben-Porath","year":"2008","journal-title":"Nat Genet"},{"key":"10.1016\/j.jncc.2024.10.001_bib0012","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.cell.2010.09.010","article-title":"A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs","volume":"143","author":"Kim","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.jncc.2024.10.001_bib0013","doi-asserted-by":"crossref","first-page":"22745","DOI":"10.1073\/pnas.1017001108","article-title":"Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures","volume":"107","author":"Mizuno","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jncc.2024.10.001_bib0014","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1158\/0008-5472.CAN-10-1735","article-title":"Using a stem cell-based signature to guide therapeutic selection in cancer","volume":"71","author":"Shats","year":"2011","journal-title":"Cancer Res"},{"key":"10.1016\/j.jncc.2024.10.001_bib0015","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.stem.2008.02.009","article-title":"Module map of stem cell genes guides creation of epithelial cancer stem cells","volume":"2","author":"Wong","year":"2008","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jncc.2024.10.001_bib0016","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/35000501","article-title":"Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling","volume":"403","author":"Alizadeh","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.jncc.2024.10.001_bib0017","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1056\/NEJMoa012914","article-title":"The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma","volume":"346","author":"Rosenwald","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jncc.2024.10.001_bib0018","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1056\/NEJMoa0802885","article-title":"Stromal gene signatures in large-B-cell lymphomas","volume":"359","author":"Lenz","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jncc.2024.10.001_bib0019","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1158\/2159-8290.CD-20-0839","article-title":"Clinical and Biological Subtypes of B-cell Lymphoma Revealed by Microenvironmental Signatures","volume":"11","author":"Kotlov","year":"2021","journal-title":"Cancer Discov"},{"key":"10.1016\/j.jncc.2024.10.001_bib0020","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1182\/blood-2012-03-415380","article-title":"Identification of human germinal center light and dark zone cells and their relationship to human B-cell lymphomas","volume":"120","author":"Victora","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.jncc.2024.10.001_bib0021","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/j.cell.2017.11.013","article-title":"Myc cooperates with ras by programming inflammation and immune suppression","volume":"171","author":"Kortlever","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.jncc.2024.10.001_bib0022","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/nature11378","article-title":"Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics","volume":"490","author":"Schmitz","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.jncc.2024.10.001_bib0023","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1038\/ng.2468","article-title":"The genetic landscape of mutations in Burkitt lymphoma","volume":"44","author":"Love","year":"2012","journal-title":"Nat Genet"},{"issue":"4","key":"10.1016\/j.jncc.2024.10.001_bib0024","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.jncc.2024.10.001_bib0025","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s13045-020-00990-3","article-title":"Targeting the Wnt\/\u03b2-catenin signaling pathway in cancer","volume":"13","author":"Zhang","year":"2020","journal-title":"Journal of Hematology & Oncology"},{"issue":"6282","key":"10.1016\/j.jncc.2024.10.001_bib0026","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1126\/science.aac9935","article-title":"MYC regulates the antitumor immune response through CD47 and PD-L1","volume":"352","author":"Casey","year":"2016","journal-title":"Science"},{"issue":"10","key":"10.1016\/j.jncc.2024.10.001_bib0027","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1016\/j.ccell.2021.08.011","article-title":"The landscape of tumor cell states and ecosystems in diffuse large B cell lymphoma","volume":"39","author":"Steen","year":"2021","journal-title":"Cancer Cell"},{"issue":"7","key":"10.1016\/j.jncc.2024.10.001_bib0028","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1038\/s41556-020-0532-x","article-title":"Dissecting intratumour heterogeneity of nodal B-cell lymphomas at the transcriptional, genetic and drug-response levels","volume":"22","author":"Roider","year":"2020","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jncc.2024.10.001_bib0029","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cytogfr.2022.01.004","article-title":"Revisiting IRF1-mediated antiviral innate immunity","volume":"64","author":"Zhou","year":"2022","journal-title":"Cytokine Growth Factor Rev"},{"issue":"3","key":"10.1016\/j.jncc.2024.10.001_bib0030","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.immuni.2019.07.007","article-title":"Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and Type III Interferons","volume":"51","author":"Forero","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.jncc.2024.10.001_bib0031","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2023.1222265","article-title":"JunB: a paradigm for Jun family in immune response and cancer","volume":"13","author":"Ren","year":"2023","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.jncc.2024.10.001_bib0032","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1016\/j.stem.2021.07.001","article-title":"Establishment, maintenance, and recall of inflammatory memory","volume":"28","author":"Larsen","year":"2021","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jncc.2024.10.001_bib0033","doi-asserted-by":"crossref","first-page":"i109","DOI":"10.1136\/ard.2010.140533","article-title":"Targeting inflammation by modulating the Jun\/AP-1 pathway","volume":"70","author":"Schonthaler","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jncc.2024.10.001_bib0034","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.smim.2017.12.002","article-title":"Dendritic cells in the regulation of immunity and inflammation","volume":"35","author":"Qian","year":"2018","journal-title":"Semin Immunol"},{"key":"10.1016\/j.jncc.2024.10.001_bib0035","doi-asserted-by":"crossref","first-page":"5184","DOI":"10.1038\/s41467-022-32849-1","article-title":"Distinct metabolic states guide maturation of inflammatory and tolerogenic dendritic cells","volume":"13","author":"Adamik","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.jncc.2024.10.001_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110609","article-title":"Metabolism drives macrophage heterogeneity in the tumor microenvironment","volume":"39","author":"Li","year":"2022","journal-title":"Cell Rep"},{"key":"10.1016\/j.jncc.2024.10.001_bib0037","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.immuni.2023.01.011","article-title":"Oxidative phosphorylation selectively orchestrates tissue macrophage homeostasis","volume":"56","author":"Wculek","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.jncc.2024.10.001_bib0038","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/nature25501","article-title":"TGF\u03b2 attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells","volume":"554","author":"Mariathasan","year":"2018","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.jncc.2024.10.001_bib0039","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.cell.2016.02.065","article-title":"Genomic and transcriptomic features of response to anti-PD-1 therapy in metastatic melanoma","volume":"165","author":"Hugo","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.jncc.2024.10.001_bib0040","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1158\/2159-8290.CD-19-0813","article-title":"Impaired death receptor signaling in leukemia causes antigen-independent resistance by inducing CAR T-cell dysfunction","volume":"10","author":"Singh","year":"2020","journal-title":"Cancer Discov"},{"key":"10.1016\/j.jncc.2024.10.001_bib0041","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1182\/blood-2003-05-1545","article-title":"Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray","volume":"103","author":"Hans","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.jncc.2024.10.001_bib0042","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1093\/annonc\/mdy450","article-title":"Dissection of DLBCL microenvironment provides a gene expression-based predictor of survival applicable to formalin-fixed paraffin-embedded tissue","volume":"29","author":"Ciavarella","year":"2018","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jncc.2024.10.001_bib0043","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1200\/JCO.2010.32.8385","article-title":"The gray zone between Burkitt's lymphoma and diffuse large B-cell lymphoma from a genetics perspective","volume":"29","author":"Salaverria","year":"2011","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jncc.2024.10.001_bib0044","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1200\/JCO.18.01314","article-title":"Molecular high-grade B-Cell lymphoma: defining a poor-risk group that requires different approaches to therapy","volume":"37","author":"Sha","year":"2019","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jncc.2024.10.001_bib0045","doi-asserted-by":"crossref","first-page":"5606","DOI":"10.1038\/s41467-021-25894-9","article-title":"9p21 loss confers a cold tumor immune microenvironment and primary resistance to immune checkpoint therapy","volume":"12","author":"Han","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.jncc.2024.10.001_bib0046","doi-asserted-by":"crossref","first-page":"6995","DOI":"10.3390\/ijms22136995","article-title":"Macrophage polarization states in the tumor microenvironment","volume":"22","author":"Boutilier","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jncc.2024.10.001_bib0047","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13045-024-01559-0","article-title":"Deciphering the performance of macrophages in tumour microenvironment: a call for precision immunotherapy","volume":"17","author":"Toledo","year":"2024","journal-title":"J Hematol Oncol"},{"key":"10.1016\/j.jncc.2024.10.001_bib0048","article-title":"Metabolic reprogramming induces macrophage polarization in the tumor microenvironment","volume":"13","author":"Wang","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.jncc.2024.10.001_bib0049","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/s41568-022-00473-2","article-title":"Polyamines in cancer: integrating organismal metabolism and antitumour immunity","volume":"22","author":"Holbert","year":"2022","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.jncc.2024.10.001_bib0050","doi-asserted-by":"crossref","first-page":"e27360","DOI":"10.4161\/onci.27360","article-title":"Polyamine blockade promotes antitumor immunity","volume":"3","author":"Hayes","year":"2014","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.jncc.2024.10.001_bib0051","doi-asserted-by":"crossref","first-page":"5839","DOI":"10.1158\/0008-5472.CAN-04-0465","article-title":"Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses","volume":"64","author":"Rodriguez","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.jncc.2024.10.001_bib0052","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.cell.2016.09.031","article-title":"l-Arginine modulates T cell metabolism and enhances survival and anti-tumor activity","volume":"167","author":"Geiger","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.jncc.2024.10.001_bib0053","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/nri1668","article-title":"Regulation of immune responses by l-arginine metabolism","volume":"5","author":"Bronte","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jncc.2024.10.001_bib0054","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/s41568-018-0050-3","article-title":"Polyamine metabolism and cancer: treatments, challenges and opportunities","volume":"18","author":"Casero","year":"2018","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.jncc.2024.10.001_bib0055","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1126\/science.6775372","article-title":"Polyamine metabolism: a potential therapeutic target in trypanosomes","volume":"210","author":"Bacchi","year":"1980","journal-title":"Science"},{"key":"10.1016\/j.jncc.2024.10.001_bib0056","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nrd2243","article-title":"Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases","volume":"6","author":"Casero","year":"2007","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jncc.2024.10.001_bib0057","doi-asserted-by":"crossref","first-page":"eaau1099","DOI":"10.1126\/scitranslmed.aau1099","article-title":"Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma","volume":"11","author":"Gamble","year":"2019","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jncc.2024.10.001_bib0058","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/s41467-021-20896-z","article-title":"Dual targeting of polyamine synthesis and uptake in diffuse intrinsic pontine gliomas","volume":"12","author":"Khan","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.jncc.2024.10.001_bib0059","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1002\/ijc.2910430632","article-title":"Microbial flora in the gastrointestinal tract abolishes cytostatic effects of alpha-difluoromethylornithine in vivo","volume":"43","author":"Hessels","year":"1989","journal-title":"Int J Cancer"},{"key":"10.1016\/j.jncc.2024.10.001_bib0060","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1200\/JCO.22.02875","article-title":"Eflornithine as postimmunotherapy maintenance in high-risk neuroblastoma: externally controlled, propensity score-matched survival outcome comparisons","volume":"42","author":"Oesterheld","year":"2024","journal-title":"J Clin Oncol"}],"container-title":["Journal of the National Cancer Center"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667005424000875?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667005424000875?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T10:14:28Z","timestamp":1778926468000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2667005424000875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":60,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["S2667005424000875"],"URL":"https:\/\/doi.org\/10.1016\/j.jncc.2024.10.001","relation":{},"ISSN":["2667-0054"],"issn-type":[{"value":"2667-0054","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Overexpression of ornithine decarboxylase 1 mediates the immune-deserted microenvironment and poor prognosis in diffuse large B-cell lymphoma","name":"articletitle","label":"Article Title"},{"value":"Journal of the National Cancer Center","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jncc.2024.10.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Chinese National Cancer Center. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}