{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T22:56:43Z","timestamp":1785020203251,"version":"3.55.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006303","name":"Associa\u00e7\u00e3o Fundo de Incentivo \u00e0 Pesquisa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006303","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2021\/05920-7"],"award-info":[{"award-number":["2021\/05920-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2021\/09089-0"],"award-info":[{"award-number":["2021\/09089-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2020\/13467-8"],"award-info":[{"award-number":["2020\/13467-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the National Cancer Center"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.jncc.2025.11.004","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T23:40:06Z","timestamp":1770507606000},"page":"204-210","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the genetic overlap between obstructive sleep apnea and prostate cancer"],"prefix":"10.1016","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0133-9036","authenticated-orcid":false,"given":"Allan Saj","family":"Porcacchia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Moyses-Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Natan","family":"Pires","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica Levy","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Tufik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jncc.2025.11.004_bib0001","series-title":"Cancer","author":"Roser","year":"2015"},{"issue":"1","key":"10.1016\/j.jncc.2025.11.004_bib0002","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","article-title":"The hallmarks of cancer","volume":"100","author":"Hanahan","year":"2000","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.jncc.2025.11.004_bib0003","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.jncc.2025.11.004_bib0004","first-page":"7","article-title":"Cancer statistics, 2019","volume":"69","author":"Siegel","year":"2019","journal-title":"CA Cancer J Clin"},{"issue":"4","key":"10.1016\/j.jncc.2025.11.004_bib0005","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S1470-2045(09)70096-8","article-title":"A review of human carcinogens\u2014part B: biological agents","volume":"10","author":"Bouvard","year":"2009","journal-title":"Lancet Oncol"},{"issue":"10159","key":"10.1016\/j.jncc.2025.11.004_bib0006","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1016\/S0140-6736(18)32225-6","volume":"392","author":"Stanaway","year":"2018","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.jncc.2025.11.004_bib0007","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.sleep.2009.10.005","article-title":"Obstructive sleep apnea syndrome in the sao paulo epidemiologic sleep study","volume":"11","author":"Tufik","year":"2010","journal-title":"Sleep Med"},{"key":"10.1016\/j.jncc.2025.11.004_bib39","doi-asserted-by":"crossref","DOI":"10.1111\/jsr.70255","article-title":"Prevalence and Risk Factors for Obstructive Sleep Apnea in S\u00e3o Paulo: Findings From the 4th Edition of the EPISONO Study","author":"Tufik","year":"2026","journal-title":"J Sleep Res"},{"key":"10.1016\/j.jncc.2025.11.004_bib0008","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.sleep.2021.05.029","article-title":"Obstructive sleep apnea and incidence of malignant tumors: a meta-analysis","volume":"84","author":"Cheng","year":"2021","journal-title":"Sleep Med"},{"key":"10.1016\/j.jncc.2025.11.004_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.canep.2021.102057","article-title":"Sleep problems and risk of cancer incidence and mortality in an older cohort: the Cardiovascular Health Study (CHS)","volume":"76","author":"Sillah","year":"2022","journal-title":"Cancer Epidemiol"},{"issue":"6","key":"10.1016\/j.jncc.2025.11.004_bib0010","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000024659","article-title":"The incidence of prostate cancer is increased in patients with obstructive sleep apnea: results from the national insurance claim data 2007-2014","volume":"100","author":"Lee","year":"2021","journal-title":"Medicine (Baltimore)"},{"issue":"1","key":"10.1016\/j.jncc.2025.11.004_bib0011","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1159\/000486577","article-title":"Increased risk for cancer in young patients with severe obstructive Sleep apnea","volume":"97","author":"Brenner","year":"2018","journal-title":"Respiration"},{"key":"10.1016\/j.jncc.2025.11.004_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.smrv.2020.101409","article-title":"Sleep disorders and cancer: State of the art and future perspectives","volume":"56","author":"Mogavero","year":"2021","journal-title":"Sleep Med Rev"},{"key":"10.1016\/j.jncc.2025.11.004_bib0013","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.smrv.2015.05.006","article-title":"Obstructive sleep apnea and cancer: epidemiologic links and theoretical biological constructs","volume":"27","author":"Gozal","year":"2016","journal-title":"Sleep Med Rev"},{"key":"10.1016\/j.jncc.2025.11.004_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.smrv.2024.102010","article-title":"A narrative review of the relationship between head and neck cancer and obstructive sleep apnea: clinical studies and statistical analysis","volume":"78","author":"Le","year":"2024","journal-title":"Sleep Med Rev"},{"issue":"6","key":"10.1016\/j.jncc.2025.11.004_bib0015","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.3390\/genes13061039","article-title":"Correlation between genomic variants and worldwide epidemiology of prostate cancer","volume":"13","author":"Vieira","year":"2022","journal-title":"Genes (Basel)"},{"issue":"4","key":"10.1016\/j.jncc.2025.11.004_bib0016","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1001\/jamaoncol.2018.6760","article-title":"Prevalence of germline variants in prostate cancer and implications for current genetic testing guidelines","volume":"5","author":"Nicolosi","year":"2019","journal-title":"JAMA Oncol"},{"issue":"7","key":"10.1016\/j.jncc.2025.11.004_bib0017","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1038\/s41588-018-0142-8","article-title":"Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci","volume":"50","author":"Schumacher","year":"2018","journal-title":"Nat Genet"},{"issue":"6","key":"10.1016\/j.jncc.2025.11.004_bib0018","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/s41443-023-00795-1","article-title":"Lipid metabolism and neuromuscular junction as common pathways underlying the genetic basis of erectile dysfunction and obstructive sleep apnea","volume":"36","author":"Adami","year":"2024","journal-title":"Int J Impot Res"},{"issue":"10","key":"10.1016\/j.jncc.2025.11.004_bib0019","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.5664\/jcsm.8682","article-title":"Patients with obstructive sleep apnea present with chronic upregulation of serum HIF-1\u03b1 protein","volume":"6","author":"Gabryelska","year":"2020","journal-title":"J Clin Sleep Med"},{"issue":"4","key":"10.1016\/j.jncc.2025.11.004_bib0020","doi-asserted-by":"crossref","first-page":"3873","DOI":"10.1007\/s11033-023-08251-5","article-title":"The role of hypoxia on prostate cancer progression and metastasis","volume":"50","author":"Mohamed","year":"2023","journal-title":"Mol Biol Rep"},{"key":"10.1016\/j.jncc.2025.11.004_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.114168","article-title":"STAT3 signaling in prostate cancer progression and therapy resistance: an oncogenic pathway with diverse functions","volume":"158","author":"Sadrkhanloo","year":"2023","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"10.1016\/j.jncc.2025.11.004_bib0022","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/s41591-021-01672-4","article-title":"A roadmap to increase diversity in genomic studies","volume":"28","author":"Fatumo","year":"2022","journal-title":"Nat Med"},{"issue":"7","key":"10.1016\/j.jncc.2025.11.004_bib40","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1093\/carcin\/bgs150","article-title":"Gene variants in the angiogenesis pathway and prostate cancer","volume":"33","author":"Amankwah","year":"2012","journal-title":"Carcinogenesis"},{"issue":"8","key":"10.1016\/j.jncc.2025.11.004_bib41","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1158\/1055-9965.EPI-16-1046","article-title":"A Review of Prostate Cancer Genome-Wide Association Studies (GWAS)","volume":"27","author":"Benafif","year":"2018","journal-title":"Cancer Epidemiol, Biomark Prevent"},{"issue":"4","key":"10.1016\/j.jncc.2025.11.004_bib42","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/sj.pcan.4501024","article-title":"Variants in circadian genes and prostate cancer risk: a population-based study in China","volume":"11","author":"Chu","year":"2008","journal-title":"Prost Cancer Prostat Dis"},{"issue":"1","key":"10.1016\/j.jncc.2025.11.004_bib43","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/s41588-020-00748-0","article-title":"Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction","volume":"53","author":"Conti","year":"2021","journal-title":"Nat Genet"},{"issue":"4","key":"10.1016\/j.jncc.2025.11.004_bib44","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.eururo.2017.10.036","article-title":"Genomic Markers in Prostate Cancer Decision Making","volume":"73","author":"Cucchiara","year":"2018","journal-title":"Eur Urol"},{"issue":"5","key":"10.1016\/j.jncc.2025.11.004_bib45","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1093\/jnci\/djaa132","article-title":"Germline Sequencing DNA Repair Genes in 5545 Men With Aggressive and Nonaggressive Prostate Cancer","volume":"113","author":"Darst","year":"2021","journal-title":"JNCI: J Nat Cancer Institute"},{"issue":"4","key":"10.1016\/j.jncc.2025.11.004_bib46","article-title":"An expanded variant list and assembly annotation identifies multiple novel coding and noncoding genes for prostate cancer risk using a normal prostate tissue eQTL data set","volume":"14","author":"DeRycke","year":"2019","journal-title":"Ahmad A, ed. PLoS One."},{"issue":"10","key":"10.1016\/j.jncc.2025.11.004_bib47","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1038\/ng.3094","article-title":"A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer","volume":"46","author":"Al Olama","year":"2014","journal-title":"Nat Genet"},{"issue":"13","key":"10.1016\/j.jncc.2025.11.004_bib48","doi-asserted-by":"crossref","first-page":"3192","DOI":"10.1158\/0008-5472.CAN-18-3536","article-title":"Identification of Novel Susceptibility Loci and Genes for Prostate Cancer Risk: A Transcriptome-Wide Association Study in Over 140,000 European Descendants","volume":"79","author":"Wu","year":"2019","journal-title":"Cancer Res"},{"issue":"12","key":"10.1016\/j.jncc.2025.11.004_bib0024","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.23545","article-title":"Plasma expression of HIF-1\u03b1 as novel biomarker for the diagnosis of obstructive sleep apnea-hypopnea syndrome","volume":"34","author":"Liu","year":"2020","journal-title":"J Clin Lab Anal"},{"issue":"6","key":"10.1016\/j.jncc.2025.11.004_bib0025","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.02456-2016","article-title":"Monocytes inhibit NK activity via TGF-\u03b2 in patients with obstructive sleep apnoea","volume":"49","author":"Hern\u00e1ndez-Jim\u00e9nez","year":"2017","journal-title":"Eur Respir J"},{"issue":"6","key":"10.1016\/j.jncc.2025.11.004_bib0026","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.2353\/ajpath.2008.071054","article-title":"Stat3 promotes metastatic progression of prostate cancer","volume":"172","author":"Abdulghani","year":"2008","journal-title":"Am J Pathol"},{"issue":"5","key":"10.1016\/j.jncc.2025.11.004_bib0027","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1111\/cas.13586","article-title":"Tumor necrosis factor-\u03b1 induces prostate cancer cell migration in lymphatic metastasis through CCR7 upregulation","volume":"109","author":"Maolake","year":"2018","journal-title":"Cancer Sci"},{"issue":"9","key":"10.1016\/j.jncc.2025.11.004_bib0028","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1002\/emmm.201202367","article-title":"Targeting the androgen receptor with siRNA promotes prostate cancer metastasis through enhanced macrophage recruitment via CCL2\/CCR2-induced STAT3 activation","volume":"5","author":"Izumi","year":"2013","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.jncc.2025.11.004_bib0029","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.bbi.2016.09.005","article-title":"The relationship between sleep apnea, metabolic dysfunction and inflammation: The gender influence","volume":"59","author":"Hirotsu","year":"2017","journal-title":"Brain Behav Immun"},{"issue":"1","key":"10.1016\/j.jncc.2025.11.004_bib0030","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/s12890-020-01253-0","article-title":"Association between tumor necrosis factor alpha and obstructive sleep apnea in adults: a meta-analysis update","volume":"20","author":"Cao","year":"2020","journal-title":"BMC Pulm Med"},{"issue":"8","key":"10.1016\/j.jncc.2025.11.004_bib0031","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1161\/01.CIR.0000052627.99976.18","article-title":"Elevated levels of C-reactive protein and interleukin-6 in patients with obstructive sleep apnea syndrome are decreased by nasal continuous positive airway pressure","volume":"107","author":"Yokoe","year":"2003","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.jncc.2025.11.004_bib0032","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1158\/0008-5472.CAN-10-1791","article-title":"PrLZ protects prostate cancer cells from apoptosis induced by androgen deprivation via the activation of Stat3\/Bcl-2 pathway","volume":"71","author":"Zhang","year":"2011","journal-title":"Cancer Res"},{"issue":"4","key":"10.1016\/j.jncc.2025.11.004_bib0033","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nrm3546","article-title":"The ATM protein kinase: regulating the cellular response to genotoxic stress, and more","volume":"14","author":"Shiloh","year":"2013","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jncc.2025.11.004_bib0034","article-title":"Identification and validation of ferroptosis-related hub genes in obstructive sleep apnea syndrome","volume":"14","author":"Liu","year":"2023","journal-title":"Front Neurol"},{"issue":"18","key":"10.1016\/j.jncc.2025.11.004_bib0035","doi-asserted-by":"crossref","first-page":"4869","DOI":"10.1158\/1078-0432.CCR-20-0764","article-title":"Genomic and clinicopathologic characterization of ATM-deficient prostate cancer","volume":"26","author":"Kaur","year":"2020","journal-title":"Clin Cancer Res"},{"issue":"5","key":"10.1016\/j.jncc.2025.11.004_bib0036","first-page":"7045","article-title":"ATM-JAK-PD-L1 signaling pathway inhibition decreases EMT and metastasis of androgen-independent prostate cancer","volume":"17","author":"Zhang","year":"2018","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.jncc.2025.11.004_bib0037","unstructured":"U.S. Food & Drug Administration. Precision Medicine. Published 2018. Accessed September 17, 2025. https:\/\/www.fda.gov\/medical-devices\/in-vitro-diagnostics\/precision-medicine."},{"key":"10.1016\/j.jncc.2025.11.004_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.smrv.2024.102031","article-title":"Circadian immunometabolism: a future insight for targeted therapy in cancer","volume":"80","author":"Tomar","year":"2025","journal-title":"Sleep Med Rev"}],"container-title":["Journal of the National Cancer Center"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667005426000086?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667005426000086?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T10:15:09Z","timestamp":1778926509000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2667005426000086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S2667005426000086"],"URL":"https:\/\/doi.org\/10.1016\/j.jncc.2025.11.004","relation":{},"ISSN":["2667-0054"],"issn-type":[{"value":"2667-0054","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring the genetic overlap between obstructive sleep apnea and prostate cancer","name":"articletitle","label":"Article Title"},{"value":"Journal of the National Cancer Center","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jncc.2025.11.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Chinese National Cancer Center. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}