{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T11:11:25Z","timestamp":1777461085021,"version":"3.51.4"},"reference-count":22,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroscience Methods"],"published-print":{"date-parts":[[2006,9]]},"DOI":"10.1016\/j.jneumeth.2006.03.005","type":"journal-article","created":{"date-parts":[[2006,4,19]],"date-time":"2006-04-19T13:42:46Z","timestamp":1145454166000},"page":"305-309","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Methods for the diagnosis of creatine deficiency syndromes: A comparative study"],"prefix":"10.1016","volume":"156","author":[{"given":"Angela","family":"Arias","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aida","family":"Ormazabal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernardino","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Antonia","family":"Vilaseca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judit","family":"Garc\u00eda-Villoria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"P\u00e0mpols","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paz","family":"Briones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Artuch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonia","family":"Ribes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jneumeth.2006.03.005_bib1","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.ymgme.2004.05.001","article-title":"Creatine and guanidinoacetate: diagnostic markers for inborn errors in creatine biosynthesis and transport","volume":"82","author":"Almeida","year":"2004","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.jneumeth.2006.03.005_bib2","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.ymgme.2004.04.009","article-title":"Guanidinoacetate and creatine\/creatinine levels in controls and patients with urea cycle defects","volume":"82","author":"Arias","year":"2004","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.jneumeth.2006.03.005_bib3","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/S1096-7192(02)00175-0","article-title":"Creatine depletion in a new case with AGAT deficiency: clinical and genetic study in a large pedigree","volume":"77","author":"Battini","year":"2002","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.jneumeth.2006.03.005_bib4","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0009-8981(01)00480-6","article-title":"Analysis of guanidinoacetate and creatine by isotope dilution electrospray tandem mass spectrometry","volume":"308","author":"Bodamer","year":"2001","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.jneumeth.2006.03.005_bib5","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0378-4347(01)00052-4","article-title":"Automated high-performance liquid chromatographic method for the determination of guanidinoacetic acid in dried blood spots: a tool for early diagnosis of guanidinoacetate methyltransferase deficiency","volume":"755","author":"Carducci","year":"2001","journal-title":"J Chromatogr B"},{"key":"10.1016\/j.jneumeth.2006.03.005_bib6","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1093\/clinchem\/48.10.1772","article-title":"Guanidinoacetate and creatine plus creatinine assessment in physiologic fluids: an effective diagnostic tool for the biochemical diagnosis of arginine:glycine amidinotransferase and guanidinoacetate methyltransferase deficiencies","volume":"48","author":"Carducci","year":"2002","journal-title":"Clin Chem"},{"key":"10.1016\/j.jneumeth.2006.03.005_bib7","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1373\/clinchem.2004.034538","article-title":"Determination of guanidinoacetate and creatine in urine and plasma by liquid chromatography\u2013tandem mass spectrometry","volume":"50","author":"Cognat","year":"2004","journal-title":"Clin Chem"},{"key":"10.1016\/j.jneumeth.2006.03.005_bib8","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.ymgme.2004.04.005","article-title":"Guanidinoacetato methyltransferase deficiency: differences of creatine uptake in human brain and muscle","volume":"82","author":"Ensenauer","year":"2004","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.jneumeth.2006.03.005_bib9","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1023\/A:1005383507547","article-title":"GC\u2013MS determination of guanidinoacetate in urine and plasma","volume":"20","author":"Hunneman","year":"1997","journal-title":"J Inherit Metab Dis"},{"key":"10.1016\/j.jneumeth.2006.03.005_bib10","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1086\/323765","article-title":"Arginine:glycine amidinotransferase deficiency: the third inborn error of creatine metabolism in humans","volume":"69","author":"Item","year":"2001","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jneumeth.2006.03.005_bib11","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1002\/humu.9238","article-title":"Characterization of seven novel mutations in seven patients with GAMT deficiency","volume":"23","author":"Item","year":"2004","journal-title":"Hum Mutat"},{"key":"10.1016\/j.jneumeth.2006.03.005_bib12","unstructured":"P\u00f3o-Arg\u00fcelles P, Arias A, Vilaseca MA, Ribes A, Artuch R, Sans-Fito A, et al. (in press). X-linked creatine transporter deficiency in two patients with severe mental retardation and autism. J Inherit Metab Dis."},{"key":"10.1016\/j.jneumeth.2006.03.005_bib13","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1086\/320595","article-title":"X-linked creatine-transporter gene (SLC6A8) defect: a new creatine-deficiency syndrome","volume":"68","author":"Salomons","year":"2001","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jneumeth.2006.03.005_bib14","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1023\/A:1024405821638","article-title":"X-linked creatine transporter defect: an overview","volume":"26","author":"Salomons","year":"2003","journal-title":"J Inherit Metab Dis"},{"key":"10.1016\/j.jneumeth.2006.03.005_bib15","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1023\/A:1022443503883","article-title":"Creatine deficiency syndromes","volume":"244","author":"Schulze","year":"2003","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.jneumeth.2006.03.005_bib16","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1006\/mgme.2001.3257","article-title":"Improving treatment of guanidinoacetate methyltransferase deficiency: reduction of guanidinoacetic acid in body fluids by arginine restriction and ornithine supplementation","volume":"74","author":"Schulze","year":"2001","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.jneumeth.2006.03.005_bib17","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1203\/00006450-199409000-00023","article-title":"Creatine deficiency in the brain: a new treatable inborn error of metabolism","volume":"36","author":"St\u00f6ckler","year":"1994","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jneumeth.2006.03.005_bib18","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1023\/A:1024453704800","article-title":"Clinical characteristics and diagnostic clues in inborn errors of creatine metabolism","volume":"26","author":"Stromberger","year":"2003","journal-title":"J Inherit Metab Dis"},{"key":"10.1016\/j.jneumeth.2006.03.005_bib19","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S0731-7085(98)00280-5","article-title":"An accurate stable isotope dilution gas chromatographic-mass spectrometric approach to the diagnosis of guanidinoacetate methyltransferase deficiency","volume":"18","author":"Struys","year":"1998","journal-title":"J Pharm Biomed Anal"},{"key":"10.1016\/j.jneumeth.2006.03.005_bib20","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.cccn.2004.05.013","article-title":"Age related reference values for urine creatine and guanidinoacetic acid concentration in children and adolescents by gas chromatography\u2013mass spectrometry","volume":"348","author":"Valongo","year":"2004","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.jneumeth.2006.03.005_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cccn.2005.04.022","article-title":"Laboratory diagnosis of defects of creatine biosynthesis and transport","volume":"361","author":"Verhoeven","year":"2005","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.jneumeth.2006.03.005_bib22","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1006\/abio.1997.2343","article-title":"Simultaneous determination of creatinine, creatine and guanidinoacetic acid in human serum and urine using liquid chromatography-atmospheric pressure chemical ionization mass spectrometry","volume":"253","author":"Yasuda","year":"1997","journal-title":"Anal Biochem"}],"container-title":["Journal of Neuroscience Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165027006001452?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165027006001452?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T00:09:58Z","timestamp":1759018198000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165027006001452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9]]},"references-count":22,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["S0165027006001452"],"URL":"https:\/\/doi.org\/10.1016\/j.jneumeth.2006.03.005","relation":{},"ISSN":["0165-0270"],"issn-type":[{"value":"0165-0270","type":"print"}],"subject":[],"published":{"date-parts":[[2006,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Methods for the diagnosis of creatine deficiency syndromes: A comparative study","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroscience Methods","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneumeth.2006.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}