{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:42:21Z","timestamp":1792651341051,"version":"4.5.0"},"reference-count":124,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":1841,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100000095","name":"Savoy Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000095","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-8109"],"award-info":[{"award-number":["MOP-8109"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004229","name":"Fondazione Pierfranco e Luisa Mariani","doi-asserted-by":"publisher","award":["PRIER 2007\/09"],"award-info":[{"award-number":["PRIER 2007\/09"]}],"id":[{"id":"10.13039\/501100004229","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["CHRPJ323272-06"],"award-info":[{"award-number":["CHRPJ323272-06"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroscience Methods"],"published-print":{"date-parts":[[2008,7]]},"DOI":"10.1016\/j.jneumeth.2008.04.019","type":"journal-article","created":{"date-parts":[[2008,4,27]],"date-time":"2008-04-27T07:58:42Z","timestamp":1209283122000},"page":"143-157","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":956,"title":["The pilocarpine model of temporal lobe epilepsy"],"prefix":"10.1016","volume":"172","author":[{"given":"Giulia","family":"Curia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Longo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Biagini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland S.G.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Avoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jneumeth.2008.04.019_bib1","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/S0920-1211(98)00057-6","article-title":"Hormonal and gestational parameters in female rats submitted to the pilocarpine model of epilepsy","volume":"32","author":"Amado","year":"1998","journal-title":"Epilepsy Res"},{"issue":"Suppl 5","key":"10.1016\/j.jneumeth.2008.04.019_bib2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1528-1167.2007.01288.x","article-title":"Pathogenesis and pharmacology of epilepsy in the lithium\u2013pilocarpine model","volume":"48","author":"Andr\u00e9","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib3","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0920-1211(98)00092-8","article-title":"The course of untreated seizures in the pilocarpine model of epilepsy","volume":"34","author":"Arida","year":"1999","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib4","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0301-0082(02)00077-1","article-title":"Network and pharmacological mechanisms leading to epileptiform synchronization in the limbic system in vitro","volume":"68","author":"Avoli","year":"2002","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib5","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1111\/j.1528-1167.2005.43804.x","article-title":"Entorhinal cortex involvement in human mesial temporal lobe epilepsy: an electrophysiologic and volumetric study","volume":"46","author":"Bartolomei","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib6","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1212\/01.wnl.0000169066.46912.fa","article-title":"Progression in temporal lobe epilepsy: differential atrophy in mesial temporal structures","volume":"65","author":"Bernasconi","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib7","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1046\/j.1471-4159.2001.00163.x","article-title":"Brain-derived neurotrophic factor superinduction parallels anti-epileptic\u2014neuroprotective treatment in the pilocarpine epilepsy model","volume":"76","author":"Biagini","year":"2001","journal-title":"J Neurochem"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib8","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1097\/NEN.0b013e318181b8ae","article-title":"Proepileptic influence of a focal vascular lesion affecting entorhinal cortex-CA3 connections after status epilepticus","volume":"67","author":"Biagini","year":"2008","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib9","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.expneurol.2006.04.029","article-title":"Endogenous neurosteroids modulate epileptogenesis in a model of temporal lobe epilepsy","volume":"201","author":"Biagini","year":"2006","journal-title":"Exp Neurol"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib10","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1385\/NMM:7:4:325","article-title":"Impaired activation of CA3 pyramidal neurons in the epileptic hippocampus","volume":"7","author":"Biagini","year":"2005","journal-title":"Neuromol Med"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib11","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.neuroimage.2006.05.038","article-title":"Gray matter atrophy associated with duration of temporal lobe epilepsy","volume":"32","author":"Bonilha","year":"2006","journal-title":"Neuroimage"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib12","series-title":"The neuropathology of temporal lobe epilepsy","author":"Bruton","year":"1988"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib13","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1111\/j.1528-1157.1991.tb05533.x","article-title":"Long-term effects of pilocarpine in rats: structural damage of the brain triggers kindling and spontaneous recurrent seizures","volume":"32","author":"Cavalheiro","year":"1991","journal-title":"Epilepsia"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib14","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1111\/j.1528-1157.1996.tb00541.x","article-title":"The pilocarpine model of epilepsy in mice","volume":"37","author":"Cavalheiro","year":"1996","journal-title":"Epilepsia"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib15","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0165-3806(87)90227-6","article-title":"The susceptibility of rats to pilocarpine-induced seizures is age-dependent","volume":"37","author":"Cavalheiro","year":"1987","journal-title":"Dev Brain Res"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib16","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.brainresbull.2006.08.009","article-title":"Drug resistance and hippocampal damage after delayed treatment of pilocarpine-induced epilepsy in the rat","volume":"71","author":"Chakir","year":"2006","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib17","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.neulet.2004.11.008","article-title":"Expression analysis of metabotropic glutamate receptors I and III in mouse strains with different susceptibility to experimental temporal lobe epilepsy","volume":"375","author":"Chen","year":"2005","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib18","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/0306-4522(87)90171-0","article-title":"The functional anatomy and pathology of lithium-pilocarpine and high-dose pilocarpine seizures","volume":"23","author":"Clifford","year":"1987","journal-title":"Neuroscience"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib19","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0920-1211(99)00119-9","article-title":"Temporal profile of neuronal injury following pilocarpine or kainic acid-induced status epilepticus","volume":"39","author":"Covolan","year":"2000","journal-title":"Epilepsy Res"},{"issue":"Suppl 5","key":"10.1016\/j.jneumeth.2008.04.019_bib20","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1528-1167.2005.01003.x","article-title":"Disruption of cortical development as a consequence of repetitive pilocarpine-induced status epilepticus in rats","volume":"46","author":"da Silva","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib21","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1111\/j.1528-1167.2005.31604.x","article-title":"Neocortical and hippocampal changes after multiple pilocarpine-induced status epilepticus in rats","volume":"46","author":"da Silva","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib22","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/00019052-200104000-00009","article-title":"The process of epileptogenesis: a pathophysiological approach","volume":"14","author":"Dalby","year":"2001","journal-title":"Curr Opin Neurol"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib23","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1002\/hipo.20215","article-title":"Subiculum network excitability is increased in a rodent model of temporal lobe epilepsy","volume":"16","author":"de Guzman","year":"2006","journal-title":"Hippocampus"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib24","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1038\/sj.bjp.0704606","article-title":"A comparison of the efficacy of carbamazepine and the novel anti-epileptic drug levetiracetam in the tetanus toxin model of focal complex partial epilepsy","volume":"135","author":"Doheny","year":"2002","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib25","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0165-0173(99)00089-2","article-title":"Epileptogenesis in immature rats following recurrent status epilepticus.","volume":"32","author":"Dos Santos","year":"2000","journal-title":"Brain Res Rev"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib26","doi-asserted-by":"crossref","first-page":"6301","DOI":"10.1523\/JNEUROSCI.15-10-06301.1995","article-title":"Preferential neuronal loss in layer III of the medial entorhinal cortex in rat models of temporal lobe epilepsy","volume":"15","author":"Du","year":"1995","journal-title":"J Neurosci"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib27","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1006\/exnr.2000.7561","article-title":"Relationship between neuronal loss and interictal glucose metabolism during the chronic phase of the lithium-pilocarpine model of epilepsy in the immature and adult rat","volume":"167","author":"Dub\u00e9","year":"2001","journal-title":"Exp Neurol"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib28","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/(SICI)1096-9861(19990614)408:4<449::AID-CNE1>3.0.CO;2-R","article-title":"Newly formed excitatory pathways provide a substrate for hyperexcitability in experimental temporal lobe epilepsy","volume":"408","author":"Esclapez","year":"1999","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib29","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1590\/S0100-879X2003001200010","article-title":"Absence-like seizures in adult rats following pilocarpine-induced status epilepticus early in life","volume":"36","author":"Ferreira","year":"2003","journal-title":"Braz J Med Biol Res"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib30","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/28179","article-title":"Cholinergic induction of network oscillations at 40Hz in the hippocampus in vitro","volume":"394","author":"Fisahn","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib31","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/ana.10509","article-title":"Hippocampal sclerosis is a progressive disorder: a longitudinal volumetric MRI study","volume":"53","author":"Fuerst","year":"2003","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib32","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0006-8993(96)00203-X","article-title":"The temporal evolution of neuronal damage from pilocarpine-induced status epilepticus","volume":"725","author":"Fujikawa","year":"1996","journal-title":"Brain Res"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib33","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1046\/j.1460-9568.1999.00573.x","article-title":"Lithium-pilocarpine-induced status epilepticus produces necrotic neurons with internucleosomal DNA fragmentation in adult rats","volume":"11","author":"Fujikawa","year":"1999","journal-title":"Eur J Neurosci"},{"issue":"Suppl 5","key":"10.1016\/j.jneumeth.2008.04.019_bib34","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1046\/j.1528-1157.43.s.5.41.x","article-title":"Behavioral, morphologic, and electroencephalographic evaluation of seizures induced by intrahippocampal microinjection of pilocarpine","volume":"43","author":"Furtado","year":"2002","journal-title":"Epilepsia"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib35","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0304-3940(03)00282-9","article-title":"Estradiol reduces seizures-induced hippocampal injury in ovariectomized female but not in male rats","volume":"342","author":"Galanopoulou","year":"2003","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib36","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1046\/j.1528-1157.2002.18101.x","article-title":"Effects of the novel antiepileptic drug levetiracetam on spontaneous recurrent seizures in the rat pilocarpine model of temporal lobe epilepsy","volume":"43","author":"Glien","year":"2002","journal-title":"Epilepsia"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib37","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0920-1211(01)00272-8","article-title":"Repeated low-dose treatment of rats with pilocarpine: low mortality but high proportion of rats developed epilepsy","volume":"46","author":"Glien","year":"2001","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib38","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.expneurol.2007.03.008","article-title":"Cyclicity of spontaneous recurrent seizures in pilocarpine model of temporal lobe epilepsy in rat","volume":"205","author":"Goffin","year":"2007","journal-title":"Exp Neurol"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib39","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0006-8993(99)01924-1","article-title":"Mossy fiber sprouting induced by repeated electroconvulsive shock seizures","volume":"844","author":"Gombos","year":"1999","journal-title":"Brain Res"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib40","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0306-4530(01)00045-2","article-title":"Social regulation of the cortisol levels in early human development","volume":"27","author":"Gunnar","year":"2002","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib41","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0920-1211(97)00030-2","article-title":"Status epilepticus induced by pilocarpine and picrotoxin","volume":"28","author":"Hamani","year":"1997","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib42","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1179\/016164102101199611","article-title":"Spontaneous recurrent seizures and neurophatology in the chronic phase of the pilocarpine and picrotoxin model epilepsy","volume":"24","author":"Hamani","year":"2002","journal-title":"Neurol Res"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib43","doi-asserted-by":"crossref","first-page":"13311","DOI":"10.1073\/pnas.94.24.13311","article-title":"Disruption of the m1 receptor gene ablates muscarinic receptor-dependent M current regulation and seizure activity in mice","volume":"94","author":"Hamilton","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib44","doi-asserted-by":"crossref","first-page":"576","DOI":"10.4065\/71.6.576","article-title":"Descriptive epidemiology of epilepsy: contributions of population-based studies from Rochester, Minnesota","volume":"71","author":"Hauser","year":"1996","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib45","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/S0006-8993(10)80015-0","article-title":"Ontogenic study of lithium-pilocarpine-induced status epilepticus in rats","volume":"583","author":"Hirsch","year":"1992","journal-title":"Brain Res"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib46","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1126\/science.6301005","article-title":"Systemic cholinergic agents induce seizures and brain damage in lithium-treated rats","volume":"220","author":"Honchar","year":"1983","journal-title":"Science"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib47","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0166-4328(00)00163-7","article-title":"Interstrain differences in cognitive functions in rats in relation to status epilepticus","volume":"112","author":"Hort","year":"2000","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib48","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1097\/00001756-199303000-00022","article-title":"MK-801 sensitizes rats to pilocarpine induced limbic seizures and status epilepticus","volume":"4","author":"Hughes","year":"1993","journal-title":"Neuroreport"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib49","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0920-1211(02)00085-2","article-title":"Characterization of pharmacoresistance to benzodiazepines in the rat Li-pilocarpine model of status epilepticus","volume":"50","author":"Jones","year":"2002","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib50","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/0014-4886(86)90045-2","article-title":"Characterization of lithium potentiation of pilocarpine-induced status epilepticus in rats","volume":"91","author":"Jope","year":"1986","journal-title":"Exp Neurol"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib51","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0920-1211(02)00099-2","article-title":"Pilocarpine-induced epileptogenesis in the rat: impact of initial duration of status epilepticus on electrophysiological and neuropathological alterations","volume":"51","author":"Klitgaard","year":"2002","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib52","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/cne.20460","article-title":"Cellular and network properties of the subiculum in the pilocarpine model of temporal lobe epilepsy","volume":"483","author":"Knopp","year":"2005","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib53","doi-asserted-by":"crossref","first-page":"8471","DOI":"10.1523\/JNEUROSCI.23-24-08471.2003","article-title":"Reduced inhibition and increased output of layer II neurons in the medial entorhinal cortex in a model of temporal lobe epilepsy","volume":"23","author":"Kobayashi","year":"2003","journal-title":"J Neurosci"},{"issue":"Suppl 5","key":"10.1016\/j.jneumeth.2008.04.019_bib54","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1528-1167.2005.01005.x","article-title":"Outcome of status epilepticus in immature rats varies according to the paraldehyde treatment","volume":"46","author":"Kubov\u00e1","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib55","first-page":"4613","article-title":"Hyperexcitability, interneurons, and loss of GABAergic synapses in entorhinal cortex in a model of temporal lobe epilepsy","volume":"26","author":"Kumar","year":"2006","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib56","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.brainres.2006.07.082","article-title":"Differential paired-pulse responses between the CA1 region and the dentate gyrus are related to altered CLC-2 immunoreactivity in the pilocarpine-induced rat epilepsy model","volume":"1115","author":"Kwak","year":"2006","journal-title":"Brain Res"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib57","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.eplepsyres.2005.10.005","article-title":"Effect of neonatal isolation on outcome following neonatal seizures in rats\u2014the role of corticosterone","volume":"68","author":"Lai","year":"2006","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib58","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1046\/j.0953-816x.2001.01632.x","article-title":"Fluorescent tracer in pilocarpine-treated rats shows widespread aberrant hippocampal neuronal connectivity","volume":"14","author":"Lehmann","year":"2001","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib59","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0149-7634(05)80076-4","article-title":"Spontaneous recurrent seizures in rats: an experimental model of partial epilepsy","volume":"14","author":"Leite","year":"1990","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib60","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0920-1211(94)00070-D","article-title":"Effects of conventional antiepileptic drugs in a model of spontaneous recurrent seizures in rats","volume":"20","author":"Leite","year":"1995","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib61","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0920-1211(02)00072-4","article-title":"New insights from the use of pilocarpine and kainate models","volume":"50","author":"Leite","year":"2002","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib62","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/BF00230647","article-title":"Suppression of pilocarpine-induced status epilepticus and the late development of epilepsy in rats","volume":"102","author":"Lemos","year":"1995","journal-title":"Exp Brain Res"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib63","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0920-1211(94)90062-0","article-title":"Long-term behavioral deficits following pilocarpine seizures in immature rats","volume":"19","author":"Liu","year":"1994","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib64","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0920-1211(94)90054-X","article-title":"Quantitative evaluation of neuronal loss in the dorsal hippocampus in rats with long-term pilocarpine seizures","volume":"17","author":"Liu","year":"1994","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib65","unstructured":"Longo D. Characterization of pharmacoresistance in a model of temporal lobe epilepsy, Thesis. Modena: University of Modena and Reggio Emilia, 2005, p. 74."},{"key":"10.1016\/j.jneumeth.2008.04.019_bib66","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0304-3940(97)00267-X","article-title":"Blockade of pilocarpine- or kainate-induced mossy fiber sprouting by cycloheximide does not prevent subsequent epileptogenesis in rats","volume":"226","author":"Longo","year":"1997","journal-title":"Neurosci Lett"},{"issue":"Suppl 5","key":"10.1016\/j.jneumeth.2008.04.019_bib67","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1046\/j.1528-1157.43.s.5.4.x","article-title":"Electrophysiologic abnormalities of the hippocampus in the pilocarpine\/cycloheximide model of chronic spontaneous seizures","volume":"43","author":"Longo","year":"2002","journal-title":"Epilepsia"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib68","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0920-1211(02)00073-6","article-title":"Animal models of epilepsy for the development of antiepileptogenic and disease-modifying drugs. A comparison of the pharmacology of kindling and post-status epilepticus models of temporal lobe epilepsy","volume":"50","author":"Loscher","year":"2002","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib69","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1111\/j.1528-1167.2007.01185.x","article-title":"In vivo and in vitro effects of pilocarpine: relevance to ictogenesis","volume":"48","author":"Marchi","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib70","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0079-6123(02)35023-4","article-title":"Hippocampal neuron damage in human epilepsy: Meyer's hypothesis revisited","volume":"135","author":"Mathern","year":"2002","journal-title":"Prog Brain Res"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib71","series-title":"Epilepsy: a comprehensive textbook","first-page":"133","article-title":"Hippocampal sclerosis","author":"Mathern","year":"1997"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib72","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/00005072-199702000-00011","article-title":"Human fascia dentata anatomy and hippocampal neuron densities differ depending on the epileptic syndrome and age at first seizure","volume":"56","author":"Mathern","year":"1997","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib73","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S0006-8993(02)02691-4","article-title":"Sex differences in models of temporal lobe epilepsy: role of testosterone","volume":"944","author":"Mej\u00ecas-Aponte","year":"2002","journal-title":"Brain Res"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib74","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0920-1211(96)00048-4","article-title":"Spontaneous seizures preferentially injure interneurons in the pilocarpine model of chronic spontaneous seizures","volume":"26","author":"Mello","year":"1996","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib75","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2004.03.009","article-title":"Kindling and status epilepticus models of epilepsy: rewiring the brain","volume":"73","author":"Morimoto","year":"2004","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib76","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0014-4886(87)90293-7","article-title":"Effects of drugs on the initiation and maintenance of status epilepticus induced by administration of pilocarpine to lithium-pretreated rats","volume":"97","author":"Morrisett","year":"1987","journal-title":"Exp Neurol"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib77","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/0306-4522(95)00534-X","article-title":"Epileptiform activity induced by pilocarpine in the rat hippocampal-entorhinal slice preparation","volume":"72","author":"Nagao","year":"1996","journal-title":"Neuroscience"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib78","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/301520a0","article-title":"Seizure-related brain damage induced by cholinergic agents","volume":"301","author":"Olney","year":"1983","journal-title":"Nature"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib79","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0166-4328(88)90019-8","article-title":"Susceptibility to pilocarpine-induced seizures in rats increases with age","volume":"31","author":"Patel","year":"1988","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib80","series-title":"Models of seizures and epilepsy","author":"Pitk\u00e4nen","year":"2006"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib81","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S1474-4422(02)00073-X","article-title":"Is epilepsy a progressive disorder? Prospects for new therapeutic approaches in temporal-lobe epilepsy","volume":"1","author":"Pitk\u00e4nen","year":"2002","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib82","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0306-4522(00)00026-9","article-title":"Differential progression of Dark Neuron and Fluoro-Jade labelling in the rat hippocampus following pilocarpine-induced status epilepticus","volume":"97","author":"Poirier","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib83","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0006-8993(02)03009-3","article-title":"Pilocarpine-induced seizure-like activity with increased BNDF and neuropeptide Y expression in organotypic hippocampal slice cultures","volume":"950","author":"Poulsen","year":"2002","journal-title":"Brain Res"},{"issue":"Suppl 5","key":"10.1016\/j.jneumeth.2008.04.019_bib84","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1046\/j.1528-1157.43.s.5.18.x","article-title":"Short-term effect of pilocarpine on rat hippocampal neurons in culture","volume":"43","author":"Priel","year":"2002","journal-title":"Epilepsia"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib85","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0920-1211(96)00047-2","article-title":"Developmental aspects of the pilocarpine model of epilepsy","volume":"26","author":"Priel","year":"1996","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib86","series-title":"Experimental models of epilepsy\u2014a manual for the laboratory worker","author":"Purpura","year":"1972"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib87","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0013-4694(72)90177-0","article-title":"Modification of seizure activity by electrical stimulation. II. Motor seizure","volume":"32","author":"Racine","year":"1972","journal-title":"Electroenceph Clin Neurophysiol"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib88","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1111\/j.1528-1167.2007.01175.x","article-title":"The epidemiology of convulsive status epilepticus in children: a critical review","volume":"48","author":"Raspall-Chaure","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib89","series-title":"Animal behavior and drug action","first-page":"410","article-title":"Extrapolation from animals to man","author":"Russell","year":"1964"},{"issue":"Suppl 5","key":"10.1016\/j.jneumeth.2008.04.019_bib90","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1046\/j.1528-1157.43.s.5.31.x","article-title":"Damage, reorganization, and abnormal neocortical hyperexcitability in the pilocarpine model of temporal lobe epilepsy","volume":"43","author":"Sanabria","year":"2002","journal-title":"Epilepsia"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib91","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1001\/archpsyc.57.10.925","article-title":"Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders","volume":"57","author":"Sapolsky","year":"2000","journal-title":"Arch Gen Psychiat"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib92","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/0165-0173(86)90010-X","article-title":"Maturation of the adrenocortical stress response: neuroendocrine control mechanisms and the stress hyporesponsive period","volume":"396","author":"Sapolsky","year":"1986","journal-title":"Brain Res"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib93","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/S0306-4522(01)00132-4","article-title":"Survival of dentate hilar mossy cells after pilocarpine-induced seizures and their synchronized burst discharges with area CA3 pyramidal cells","volume":"3","author":"Scharfman","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib94","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/S0306-4522(03)00481-0","article-title":"Perforant path activation of ectopic granule cells that are born after pilocarpine-induced seizures","volume":"121","author":"Scharfman","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib95","series-title":"Epilepsy: models mechanisms and concepts","author":"Schwartzkroin","year":"1983"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib96","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0920-1211(02)00012-8","article-title":"Pilocarpine-induced status epilepticus results in mossy fiber sprouting and spontaneous seizures in C57BL\/6 and CD-1 mice","volume":"49","author":"Shibley","year":"2002","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib97","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0361-9230(02)00811-0","article-title":"Alterations of the neocortical GABAergic system in the pilocarpine model of temporal lobe epilepsy: neuronal damage and immunocytochemical changes in chronic epileptic rats","volume":"58","author":"Silva","year":"2002","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib98","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.crvi.2004.10.010","article-title":"The neurobiology of temporal lobe epilepsy: too much information, not enough knowledge","volume":"328","author":"Sloviter","year":"2005","journal-title":"C R Biol"},{"issue":"Suppl 8","key":"10.1016\/j.jneumeth.2008.04.019_bib99","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1528-1167.2007.01335.x","article-title":"On the relevance of prolonged convulsive status epilepticus in animals to the etiology and neurobiology of human temporal lobe epilepsy","volume":"48","author":"Sloviter","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib100","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1097\/00004647-199607000-00008","article-title":"Metyrapone, an inhibitor of glucocorticoid production, reduces brain injury induced by focal and global ischemia and seizures","volume":"16","author":"Smith-Swintosky","year":"1996","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib101","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1038\/sj.bjp.0701231","article-title":"NMDA receptor-mediated pilocarpine-induced seizures: characterization in freely moving rats by microdialysis","volume":"121","author":"Smolders","year":"1997","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib102","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S1474-4422(02)00163-1","article-title":"When should temporal-lobe epilepsy be treated surgically?","volume":"1","author":"Spencer","year":"2002","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib103","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0091-3057(93)90246-P","article-title":"Paradoxical facilitation of pilocarpine-induced seizures in the mouse by MK-801 and the nitric oxide synthesis inhibitor L-NAME","volume":"45","author":"Starr","year":"1993","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib104","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-3806(96)00209-X","article-title":"Lithium-pilocarpine status epilepticus in the immature rabbit","volume":"100","author":"Thompson","year":"1997","journal-title":"Dev Brain Res"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib105","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1159\/000098515","article-title":"Depression of glutamate and GABA release by presynaptic GABAB receptors in the entorhinal cortex in normal and chronically epileptic rats","volume":"15","author":"Thompson","year":"2007","journal-title":"Neurosignals"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib106","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.devbrainres.2004.06.009","article-title":"Neuropathology of seizures in the immature rabbit","volume":"152","author":"Towfighi","year":"2004","journal-title":"Dev Brain Res"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib107","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0006-8993(84)90177-X","article-title":"Seizures produced by pilocarpine in mice: a behavioral, electroencephalographic and morphological analysis","volume":"32","author":"Turski","year":"1984","journal-title":"Brain Res"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib108","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0166-4328(83)90136-5","article-title":"Limbic seizures produced by pilocarpine I rats: behavioral, electroencephalographic and neuropathological study","volume":"9","author":"Turski","year":"1983","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib109","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1007\/BF01990130","article-title":"Cholinomimetics produce seizures and brain damage in rats","volume":"39","author":"Turski","year":"1983","journal-title":"Experientia"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib110","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/syn.890030207","article-title":"Review: cholinergic mechanisms and epileptogenesis. The seizures induced by pilocarpine: a novel experimental model of intractable epilepsy","volume":"3","author":"Turski","year":"1989","journal-title":"Synapse"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib111","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.neuroscience.2007.10.037","article-title":"Acute induction of epileptiform discharges by pilocarpine in the in vitro isolated guinea-pig brain requires enhancement of blood-brain barrier permeability","volume":"151","author":"Uva","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib112","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0920-1211(02)00024-4","article-title":"Castration in female rats modifies the development of the pilocarpine model of epilepsy","volume":"49","author":"Valente","year":"2002","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib113","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1152\/jn.1999.82.5.2441","article-title":"Carbachol induces fast oscillations in the medial but not in the lateral enthorinal cortex of the isolated guinea pig brain","volume":"82","author":"Van der Linden","year":"1999","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib114","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1093\/brain\/awl318","article-title":"Blood-brain barrier leakage may lead to progression of temporal lobe epilepsy","volume":"130","author":"van Vliet","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib115","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0306-4530(98)00029-8","article-title":"Stress and the developing limbic-hypothalamic pituitary-adrenal axis","volume":"23","author":"Vazquez","year":"1998","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib116","series-title":"Models of seizures and epilepsy","first-page":"601","article-title":"Behavioral characterization of seizures in rats","author":"Veliskova","year":"2006"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib117","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.nbd.2005.09.006","article-title":"Antiepileptic drug-resistant rats differ from drug-responsive rats in hippocampal neurodegeneration and GABAA receptor ligand binding in a model of temporal lobe epilepsy","volume":"21","author":"Volk","year":"2006","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib118","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1254\/jphs.CRJ05009X","article-title":"Lithium: potential therapeutics against acute brain injuries and chronic neurodegenerative disease","volume":"99","author":"Wada","year":"2005","journal-title":"J Pharmacol Sci"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib119","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.0013-9580.2004.09004.x","article-title":"ILAE Commission on Neurosurgery of Epilepsy. ILAE Commission Report. Mesial temporal lobe epilepsy with hippocampal sclerosis","volume":"45","author":"Wieser","year":"2004","journal-title":"Epilepsia"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib120","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1152\/jn.2002.88.4.2075","article-title":"Reassessment of the effects of cycloheximide on mossy fiber sprouting and epileptogenesis in the pilocarpine model of temporal lobe epilepsy","volume":"88","author":"Williams","year":"2002","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib121","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.neuroscience.2007.06.009","article-title":"Acute and chronic responses to the convulsant pilocarpine in DBA\/2J and A\/J mice","volume":"149","author":"Winawer","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib122","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.nbd.2005.01.016","article-title":"Entorhinal cortex entrains epileptiform activity in CA1 in pilocarpine-treated rats","volume":"19","author":"Wozny","year":"2005","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib123","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1523\/JNEUROSCI.4413-05.2006","article-title":"Tonic facilitation of glutamate release by presynaptic NR2B-containing NMDA receptors is increased in the entorhinal cortex of chronically epileptic rats","volume":"26","author":"Yang","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.jneumeth.2008.04.019_bib124","doi-asserted-by":"crossref","first-page":"6052","DOI":"10.1523\/JNEUROSCI.22-14-06052.2002","article-title":"Relations between brain pathology and temporal lobe epilepsy","volume":"22","author":"Zhang","year":"2002","journal-title":"J Neurosci"}],"container-title":["Journal of Neuroscience Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165027008002550?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165027008002550?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T00:15:33Z","timestamp":1759018533000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165027008002550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":124,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["S0165027008002550"],"URL":"https:\/\/doi.org\/10.1016\/j.jneumeth.2008.04.019","relation":{},"ISSN":["0165-0270"],"issn-type":[{"value":"0165-0270","type":"print"}],"subject":[],"published":{"date-parts":[[2008,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The pilocarpine model of temporal lobe epilepsy","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroscience Methods","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneumeth.2008.04.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}