{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T14:14:12Z","timestamp":1789740852675,"version":"4.0.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroscience Methods"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1016\/j.jneumeth.2009.10.007","type":"journal-article","created":{"date-parts":[[2009,10,16]],"date-time":"2009-10-16T04:19:39Z","timestamp":1255666779000},"page":"246-256","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Development of multi-electrode array screening for anticonvulsants in acute rat brain slices"],"prefix":"10.1016","volume":"185","author":[{"given":"Andrew J.","family":"Hill","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas A.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire M.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary J.","family":"Stephens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin J.","family":"Whalley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jneumeth.2009.10.007_bib1","first-page":"36","article-title":"Image processing with imageJ","volume":"11","author":"Abramoff","year":"2004","journal-title":"Biophotonics Int"},{"key":"10.1016\/j.jneumeth.2009.10.007_bib2","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1113\/jphysiol.1996.sp021416","article-title":"Extracellular free potassium and calcium during synchronous activity induced by 4-aminopyridine in the juvenile rat hippocampus","volume":"493","author":"Avoli","year":"1996","journal-title":"J Physiol"},{"key":"10.1016\/j.jneumeth.2009.10.007_bib3","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/0006-8993(96)00376-9","article-title":"Synchronization of rat hippocampal neurons in the absence of excitatory amino acid-mediated transmission","volume":"735","author":"Avoli","year":"1996","journal-title":"Brain Res"},{"issue":"3","key":"10.1016\/j.jneumeth.2009.10.007_bib4","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1124\/jpet.105.100354","article-title":"Activation of the cannabinoid Type-1 receptor mediates the anticonvulsant properties of cannabinoids in the hippocampal neuronal culture models of acquired epilepsy and status epilepticus","volume":"317","author":"Blair","year":"2006","journal-title":"JPET"},{"issue":"24","key":"10.1016\/j.jneumeth.2009.10.007_bib5","doi-asserted-by":"crossref","first-page":"5623","DOI":"10.1523\/JNEUROSCI.0918-04.2004","article-title":"Endocannabinoids inhibit transmission at granule cell to Purkinje cell synapses by modulating three types of presynaptic calcium channels","volume":"24","author":"Brown","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.jneumeth.2009.10.007_bib6","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0006-8993(99)02348-3","article-title":"Effects of standard anticonvulsant drugs on different patterns of epileptiform discharges induced by 4-aminopyridine in combined entorhinal cortex-hippocampal slices","volume":"859","author":"Bruckner","year":"2000","journal-title":"Brain Res"},{"issue":"Suppl. 9","key":"10.1016\/j.jneumeth.2009.10.007_bib7","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1528-1167.2008.01930.x","article-title":"When drugs and surgery don\u2019t work","volume":"49","author":"Cascino","year":"2008","journal-title":"Epilepsia"},{"issue":"2","key":"10.1016\/j.jneumeth.2009.10.007_bib8","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jneumeth.2008.04.019","article-title":"The pilocarpine model of temporal lobe epilepsy","volume":"172","author":"Curia","year":"2008","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.jneumeth.2009.10.007_bib9","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.neuropharm.2007.01.008","article-title":"Antiepileptic drugs and muscarinic receptor-dependent excitation in the rat subiculum","volume":"52","author":"D\u2019Antuono","year":"2007","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jneumeth.2009.10.007_bib10","doi-asserted-by":"crossref","first-page":"PL391","DOI":"10.1016\/0024-3205(96)00251-2","article-title":"Effects of felbamate, kynurenic acid derivatives and nmda antagonists on in vitro kainate-induced epileptiform activity","volume":"58","author":"Domenici","year":"1996","journal-title":"Life Sci"},{"key":"10.1016\/j.jneumeth.2009.10.007_bib11","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0014-2999(94)90782-X","article-title":"Felbamate displays in vitro antiepileptic effects as a broad spectrum excitatory amino acid receptor antagonist","volume":"271","author":"Domenici","year":"1994","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jneumeth.2009.10.007_bib12","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1007\/s00221-001-0932-5","article-title":"Two-dimensional monitoring of spiking networks in acute brain slices. Experimental brain research","volume":"142","author":"Egert","year":"2002","journal-title":"Experimentelle Hirnforschung"},{"key":"10.1016\/j.jneumeth.2009.10.007_bib13","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0165-0270(02)00045-6","article-title":"MEA-tools: an open source toolbox for the analysis of multi-electrode data with","volume":"117","author":"Egert","year":"2002","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.jneumeth.2009.10.007_bib14","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S0006-8993(98)01102-0","article-title":"Epileptiform activity induced by low Mg2+ in cultured rat hippocampal slices","volume":"815","author":"Gutierrez","year":"1999","journal-title":"Brain Res"},{"key":"10.1016\/j.jneumeth.2009.10.007_bib15","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0079-6123(02)35019-2","article-title":"Cell death and metabolic activity during epileptiform discharges and status epilepticus in the hippocampus","volume":"135","author":"Heinemann","year":"2002","journal-title":"Prog Brain Res"},{"issue":"Suppl. 5","key":"10.1016\/j.jneumeth.2009.10.007_bib16","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1046\/j.1528-1157.43.s.5.15.x","article-title":"Coupling of electrical and metabolic activity during epileptiform discharges","volume":"43","author":"Heinemann","year":"2002","journal-title":"Epilepsia"},{"key":"10.1016\/j.jneumeth.2009.10.007_bib17","unstructured":"Jones NA, Hill AJ, Smith I, Bevan S, William CM, Whalley BJ, et al. Cannabidiol displays anti-epileptiform and anti-seizure properties in vitro and in vivo; in press."},{"key":"10.1016\/j.jneumeth.2009.10.007_bib18","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S0306-4522(01)00222-6","article-title":"Prolonged epileptiform bursting induced by 0-Mg2+ in rat hippocampal slices depends on gap junctional coupling","volume":"105","author":"Kohling","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.jneumeth.2009.10.007_bib19","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1152\/jn.1987.57.1.325","article-title":"Epileptiform burst activity induced by potassium in the hippocampus and its regulation by GABA-mediated inhibition","volume":"57","author":"Korn","year":"1987","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.jneumeth.2009.10.007_bib20","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1097\/00001756-199902050-00002","article-title":"Acute cell damage after low Mg2+-induced epileptiform activity in organotypic hippocampal slice cultures","volume":"10","author":"Kovacs","year":"1999","journal-title":"Neuroreport"},{"issue":"17","key":"10.1016\/j.jneumeth.2009.10.007_bib21","doi-asserted-by":"crossref","first-page":"4260","DOI":"10.1523\/JNEUROSCI.4000-04.2005","article-title":"Mitochondrial calcium ion and membrane potential transients follow the pattern of epileptiform discharges in hippocampal slice cultures","volume":"25","author":"Kovacs","year":"2005","journal-title":"J Neuorsci"},{"key":"10.1016\/j.jneumeth.2009.10.007_bib22","doi-asserted-by":"crossref","first-page":"8565","DOI":"10.1523\/JNEUROSCI.5698-08.2009","article-title":"Endogenous nitric oxide is a key promoting factor for initiation of seizure-like events in hippocampal and entorhinal cortex slices","volume":"29","author":"Kovacs","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.jneumeth.2009.10.007_bib23","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1046\/j.1460-9568.2000.00156.x","article-title":"Generation and propagation of 4-AP-induced epileptiform activity in neonatal intact limbic structures in vitro","volume":"12","author":"Luhmann","year":"2000","journal-title":"Eur J Neurosci"},{"issue":"1","key":"10.1016\/j.jneumeth.2009.10.007_bib24","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/bjp.2008.57","article-title":"The phytocannabinoid Delta(9)-tetrahydrocannabivarin modulates inhibitory neurotransmission in the cerebellum","volume":"154","author":"Ma","year":"2008","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jneumeth.2009.10.007_bib25","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1523\/JNEUROSCI.4873-06.2007","article-title":"The spatial organization of long-term synaptic plasticity at the input stage of cerebellum","volume":"27","author":"Mapelli","year":"2007","journal-title":"J Neurosci"},{"issue":"5","key":"10.1016\/j.jneumeth.2009.10.007_bib26","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1111\/j.1460-9568.2009.06648.x","article-title":"Age matters","volume":"29","author":"McCutcheon","year":"2009","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.jneumeth.2009.10.007_bib27","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1152\/jn.1997.78.5.2467","article-title":"Ca2+ current in rabbit carotid body glomus cells is conducted by multiple types of high-voltage-activated Ca2+ channels","volume":"78","author":"Overholt","year":"1997","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.jneumeth.2009.10.007_bib28","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1528-1167.2008.01779.x","article-title":"Epileptiform synchronization in the cingulate cortex","volume":"50","author":"Panuccio","year":"2009","journal-title":"Epilepsia"},{"issue":"1","key":"10.1016\/j.jneumeth.2009.10.007_bib29","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1523\/JNEUROSCI.12-01-00104.1992","article-title":"4-Aminopyridine-induced epileptiform activity and a GABA-mediated long-lasting depolarization in the rat hippocampus","volume":"12","author":"Perreault","year":"1992","journal-title":"J Neurosci"},{"issue":"4","key":"10.1016\/j.jneumeth.2009.10.007_bib30","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1152\/jn.1991.65.4.771","article-title":"Physiology and pharmacology of epileptiform activity induced by 4-aminopyridine in rat hippocampal slices","volume":"65","author":"Perreault","year":"1991","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.jneumeth.2009.10.007_bib31","series-title":"Models of seizures and epilepsy","year":"2006"},{"key":"10.1016\/j.jneumeth.2009.10.007_bib32","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.eplepsyres.2004.03.002","article-title":"Hyperoxia is not an essential condition for status epilepticus induced cell death in organotypic hippocampal slice cultures","volume":"59","author":"Pomper","year":"2004","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.jneumeth.2009.10.007_bib33","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0306-3623(97)00266-8","article-title":"Characterization of the in vitro antiepileptic activity of new and old anticonvulsant drugs","volume":"30","author":"Sagratella","year":"1998","journal-title":"Gen Pharmacol-Vasc S"},{"key":"10.1016\/j.jneumeth.2009.10.007_bib34","first-page":"344","article-title":"The treatment of epilepsy in developing countries: where do we go from here?","volume":"79","author":"Scott","year":"2001","journal-title":"Bull World Health Organ"},{"key":"10.1016\/j.jneumeth.2009.10.007_bib35","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.brainres.2006.04.034","article-title":"The adult rat hippocampal slice revisited with multi-electrode arrays","volume":"1096","author":"Steidl","year":"2006","journal-title":"Brain Res"},{"key":"10.1016\/j.jneumeth.2009.10.007_bib36","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/0006-8993(90)90173-9","article-title":"Low magnesium epileptogenesis in the rat hippocampal slice: electrophysiological and pharmacological features","volume":"511","author":"Tancredi","year":"1990","journal-title":"Brain Res"},{"issue":"478 Pt 3","key":"10.1016\/j.jneumeth.2009.10.007_bib37","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1113\/jphysiol.1994.sp020259","article-title":"Enhanced NMDA conductance can account for epileptiform activity induced by low Mg2+ in the rat hippocampal slice","author":"Traub","year":"1994","journal-title":"J Physiol"},{"issue":"13","key":"10.1016\/j.jneumeth.2009.10.007_bib38","doi-asserted-by":"crossref","first-page":"3383","DOI":"10.1523\/JNEUROSCI.0145-07.2007","article-title":"Feedforward inhibition contributes to the control of epileptiform propagation speed","volume":"27","author":"Trevelyan","year":"2007","journal-title":"J Neurosci"}],"container-title":["Journal of Neuroscience Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165027009005639?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165027009005639?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T00:19:32Z","timestamp":1759018772000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165027009005639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["S0165027009005639"],"URL":"https:\/\/doi.org\/10.1016\/j.jneumeth.2009.10.007","relation":{},"ISSN":["0165-0270"],"issn-type":[{"value":"0165-0270","type":"print"}],"subject":[],"published":{"date-parts":[[2010,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of multi-electrode array screening for anticonvulsants in acute rat brain slices","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroscience Methods","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneumeth.2009.10.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}