{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T12:20:31Z","timestamp":1778588431390,"version":"3.51.4"},"reference-count":40,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroscience Methods"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1016\/j.jneumeth.2012.08.002","type":"journal-article","created":{"date-parts":[[2012,8,13]],"date-time":"2012-08-13T10:06:09Z","timestamp":1344852369000},"page":"1-10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Development and validation of an automated system for detection and assessment of scratching in the rodent"],"prefix":"10.1016","volume":"211","author":[{"given":"Marc","family":"Marino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Polly","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelle","family":"Malkmus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin","family":"Robertshaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine A.","family":"Mac","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuri","family":"Shatterman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tony L.","family":"Yaksh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.jneumeth.2012.08.002_bib0005","doi-asserted-by":"crossref","first-page":"e22665","DOI":"10.1371\/journal.pone.0022665","article-title":"Transmitters and pathways mediating inhibition of spinal itch-signaling neurons by scratching and other counterstimuli","volume":"6","author":"Akiyama","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jneumeth.2012.08.002_bib0010","series-title":"2nd international workshop for the study of Itch","article-title":"\u2018Pleasure of scratch\u2019 is a complex sensation of itch and pain","author":"Aoki","year":"2003"},{"key":"10.1016\/j.jneumeth.2012.08.002_bib0015","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1001\/jama.1964.03070130023006","article-title":"The fine art of scratching","volume":"189","author":"Ayres","year":"1964","journal-title":"JAMA"},{"key":"10.1016\/j.jneumeth.2012.08.002_bib0020","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.4049\/jimmunol.128.6.2475","article-title":"Mucosal mast cells. I. Isolation and functional characteristics of rat intestinal mast cells","volume":"128","author":"Befus","year":"1982","journal-title":"J Immunol"},{"issue":"1","key":"10.1016\/j.jneumeth.2012.08.002_bib0025","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jneumeth.2004.08.001","article-title":"A repetitive movement detector used for automatic monitoring and quantification of scratching in mice","volume":"142","author":"Brash","year":"2005","journal-title":"J Neurosci Methods"},{"issue":"11","key":"10.1016\/j.jneumeth.2012.08.002_bib0030","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.jpain.2008.08.002","article-title":"Scratching the brain to understand neuropathic itch","volume":"9","author":"Carstens","year":"2008","journal-title":"J Pain"},{"key":"10.1016\/j.jneumeth.2012.08.002_bib0035","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1046\/j.1087-0024.2003.09111.x","article-title":"Self-reported skin morbidity among adults: associations with quality of life and general health in a Norwegian survey","volume":"9","author":"Dalgard","year":"2004","journal-title":"J Investig Dermatol Symp Proc"},{"issue":"12","key":"10.1016\/j.jneumeth.2012.08.002_bib0040","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.tins.2010.09.002","article-title":"The multiple pathways for itch and their interactions with pain","volume":"33","author":"Davidson","year":"2010","journal-title":"Trends Neurosci"},{"issue":"37","key":"10.1016\/j.jneumeth.2012.08.002_bib0045","doi-asserted-by":"crossref","first-page":"10007","DOI":"10.1523\/JNEUROSCI.2862-07.2007","article-title":"The itch-producing agents histamine and cowhage activate separate populations of primate spinothalamic tract neurons","volume":"27","author":"Davidson","year":"2007","journal-title":"J Neurosci"},{"issue":"5","key":"10.1016\/j.jneumeth.2012.08.002_bib0050","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/nn.2292","article-title":"Relief of itch by scratching: state-dependent inhibition of primate spinothalamic tract neurons","volume":"12","author":"Davidson","year":"2009","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.jneumeth.2012.08.002_bib0055","series-title":"Statistical methods for medical and biological students","author":"Doulborg","year":"1940"},{"issue":"3","key":"10.1016\/j.jneumeth.2012.08.002_bib0060","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S1056-8719(01)00111-3","article-title":"An automated method for registering and quantifying scratching activity in mice: use for drug evaluation","volume":"44","author":"Elliott","year":"2000","journal-title":"J Pharmacol Toxicol Methods"},{"key":"10.1016\/j.jneumeth.2012.08.002_bib0065","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/BF00220383","article-title":"Ultrastructure of mast cells in normal and compound 48\/80-treated rats","volume":"150","author":"Enerback","year":"1974","journal-title":"Cell Tissue Res"},{"issue":"4","key":"10.1016\/j.jneumeth.2012.08.002_bib0070","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1038\/jid.2010.413","article-title":"Topical cholecystokinin depresses itch-associated scratching behavior in mice","volume":"131","author":"Fukamachi","year":"2011","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jneumeth.2012.08.002_bib0075","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.1529-8019.2005.00036.x","article-title":"Itch in systemic disease: therapeutic options","volume":"18","author":"Greaves","year":"2005","journal-title":"Dermatol Ther"},{"key":"10.1016\/j.jneumeth.2012.08.002_bib0080","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.pain.2006.03.023","article-title":"Influence of genotype, dose and sex on pruritogen-induced scratching behavior in the mouse","volume":"124","author":"Green","year":"2006","journal-title":"Pain"},{"issue":"4","key":"10.1016\/j.jneumeth.2012.08.002_bib0085","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.neuron.2006.09.036","article-title":"Phospholipase Cbeta 3 mediates the scratching response activated by the histamine H1 receptor on C-fiber nociceptive neurons","volume":"52","author":"Han","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.jneumeth.2012.08.002_bib0090","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nrn1950","article-title":"The neurobiology of itch","volume":"7","author":"Ikoma","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.jneumeth.2012.08.002_bib0095","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0014-2999(98)00974-1","article-title":"Participation of histamine H1 and H2 receptors in passive cutaneous anaphylaxis-induced scratching behavior in ICR mice","volume":"367","author":"Inagaki","year":"1999","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jneumeth.2012.08.002_bib0100","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1159\/000069755","article-title":"Evaluation and characterization of mouse scratching behavior by a new apparatus, MicroAct","volume":"16","author":"Inagaki","year":"2003","journal-title":"Skin Pharmacol Appl Skin Physiol"},{"key":"10.1016\/j.jneumeth.2012.08.002_bib0105","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1007\/BF01967317","article-title":"Compound 48\/80 and substance P induced release of histamine and serotonin from peritoneal mast cells","volume":"13","author":"Irman-Florjanc","year":"1983","journal-title":"Agents Actions"},{"issue":"1","key":"10.1016\/j.jneumeth.2012.08.002_bib0110","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1109\/TASE.2007.902868","article-title":"Automatic scratching pattern detection for laboratory mice using high-speed video images","volume":"5","author":"Ishii","year":"2008","journal-title":"IEEE Trans Automat Sci Eng"},{"issue":"4","key":"10.1016\/j.jneumeth.2012.08.002_bib0115","first-page":"286","article-title":"Itch signaling in the nervous system","volume":"26","author":"Jeffry","year":"2011","journal-title":"Physiology (Bethesda)"},{"issue":"30","key":"10.1016\/j.jneumeth.2012.08.002_bib0120","doi-asserted-by":"crossref","first-page":"7659","DOI":"10.1523\/JNEUROSCI.1760-08.2008","article-title":"A role for polymodal C-fiber afferents in nonhistaminergic itch","volume":"28","author":"Johanek","year":"2008","journal-title":"J Neurosci"},{"issue":"10","key":"10.1016\/j.jneumeth.2012.08.002_bib0125","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1111\/j.1600-0625.2011.01367.x","article-title":"Mouse models of acute, chemical itch and pain in humans","volume":"20","author":"LaMotte","year":"2011","journal-title":"Exp Dermatol"},{"issue":"6","key":"10.1016\/j.jneumeth.2012.08.002_bib0130","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1172\/JCI45414","article-title":"TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice","volume":"122","author":"Liu","year":"2012","journal-title":"J Clin Invest"},{"issue":"7","key":"10.1016\/j.jneumeth.2012.08.002_bib0135","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/j.cell.2009.11.034","article-title":"Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus","volume":"139","author":"Liu","year":"2009","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.jneumeth.2012.08.002_bib0140","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/BF00216889","article-title":"Electron microscopic study of the regeneration in vivo of rat peritoneal mast cells after histamine secretion","volume":"224","author":"Nielsen","year":"1982","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.jneumeth.2012.08.002_bib0145","series-title":"Discrete-time signal processing","author":"Oppenheim","year":"1999"},{"issue":"1","key":"10.1016\/j.jneumeth.2012.08.002_bib0150","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1365-2133.2004.05744.x","article-title":"A new analytical system for quantification scratching behaviour in mice","volume":"150","author":"Orito","year":"2004","journal-title":"Br J Dermatol"},{"issue":"1","key":"10.1016\/j.jneumeth.2012.08.002_bib0155","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1159\/000324131","article-title":"The molecular mechanism of cholestatic pruritus","volume":"29","author":"Oude Elferink","year":"2011","journal-title":"Dig Dis"},{"key":"10.1016\/j.jneumeth.2012.08.002_bib0160","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1172\/JCI28553","article-title":"Frontiers in pruritus research: scratching the brain for more effective itch therapy","volume":"116","author":"Paus","year":"2006","journal-title":"J Clin Invest"},{"issue":"42","key":"10.1016\/j.jneumeth.2012.08.002_bib0165","doi-asserted-by":"crossref","first-page":"14841","DOI":"10.1523\/JNEUROSCI.3005-11.2011","article-title":"A role for nociceptive, myelinated nerve fibers in itch sensation","volume":"31","author":"Ringkamp","year":"2011","journal-title":"J Neurosci"},{"issue":"1","key":"10.1016\/j.jneumeth.2012.08.002_bib0170","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jep.2011.10.023","article-title":"Effects of Lecythis pisonis Camb. (Lecythidaceae) in a mouse model of pruritus","volume":"139","author":"Silva","year":"2012","journal-title":"J Ethnopharmacol"},{"issue":"9","key":"10.1016\/j.jneumeth.2012.08.002_bib0175","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1523\/JNEUROSCI.4643-06.2007","article-title":"TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase","volume":"27","author":"Shim","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.jneumeth.2012.08.002_bib0200","series-title":"Electronic statistics textbook","author":"StatSoft, Inc.","year":"2012"},{"issue":"1","key":"10.1016\/j.jneumeth.2012.08.002_bib0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-2999(98)00288-X","article-title":"Effects of histamine H1 receptor antagonists on compound 48\/80-induced scratching behavior in mice","volume":"351","author":"Sugimoto","year":"1998","journal-title":"Eur J Pharmacol"},{"issue":"22","key":"10.1016\/j.jneumeth.2012.08.002_bib0185","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1016\/j.lfs.2006.07.010","article-title":"A novel acoustic evaluation system of scratching in mouse dermatitis: rapid and specific detection of invisibly rapid scratch in an atopic dermatitis model mouse","volume":"79","author":"Umeda","year":"2006","journal-title":"Life Sci"},{"key":"10.1016\/j.jneumeth.2012.08.002_bib0190","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1152\/jappl.2001.90.6.2386","article-title":"An automated flinch detecting system for use in the formalin nociceptive bioassay","volume":"90","author":"Yaksh","year":"2001","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.jneumeth.2012.08.002_bib0195","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s11554-009-0111-7","article-title":"Real-time scratching behavior quantification system for laboratory mice using high-speed vision","volume":"4","author":"Yuman","year":"2009","journal-title":"J Real-Time Image Proc"}],"container-title":["Journal of Neuroscience Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165027012002919?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165027012002919?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T00:28:32Z","timestamp":1759019312000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165027012002919"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["S0165027012002919"],"URL":"https:\/\/doi.org\/10.1016\/j.jneumeth.2012.08.002","relation":{},"ISSN":["0165-0270"],"issn-type":[{"value":"0165-0270","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development and validation of an automated system for detection and assessment of scratching in the rodent","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroscience Methods","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneumeth.2012.08.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}