{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:45:47Z","timestamp":1777445147276,"version":"3.51.4"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroscience Methods"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1016\/j.jneumeth.2014.04.005","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T08:32:46Z","timestamp":1397809966000},"page":"30-36","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Validation of a neuropathology score using quantitative methods to evaluate brain injury in a pig model of hypoxia ischaemia"],"prefix":"10.1016","volume":"230","author":[{"given":"Nicholas","family":"Hoque","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hemmen","family":"Sabir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elke","family":"Maes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Bishop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Thoresen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jneumeth.2014.04.005_bib0005","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1203\/01.PDR.0000072783.22373.FF","article-title":"Hypothermia for 24hours after asphyxic cardiac arrest in piglets provides striatal neuroprotection that is sustained 10 days after rewarming","volume":"54","author":"Agnew","year":"2003","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jneumeth.2014.04.005_bib0010","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1113\/jphysiol.2006.119602","article-title":"The effect of cerebral hypothermia on white and grey matter injury induced by severe hypoxia in preterm fetal sheep","volume":"578","author":"Bennet","year":"2007","journal-title":"J Physiol"},{"key":"10.1016\/j.jneumeth.2014.04.005_bib0015","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/ana.22016","article-title":"Xenon enhances hypothermic neuroprotection in asphyxiated newborn pigs","volume":"68","author":"Chakkarapani","year":"2010","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jneumeth.2014.04.005_bib0020","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.neuroscience.2006.06.066","article-title":"Endogenous alpha2-adrenergic receptor-mediated neuroprotection after severe hypoxia in preterm fetal sheep","volume":"142","author":"Dean","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.jneumeth.2014.04.005_bib0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0361-9230(99)00012-X","article-title":"Stereotaxic atlas of the pig brain","volume":"49","author":"Felix","year":"1999","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.jneumeth.2014.04.005_bib0030","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.expneurol.2006.07.024","article-title":"Induced cerebral hypothermia reduces post-hypoxic loss of phenotypic striatal neurons in preterm fetal sheep","volume":"203","author":"George","year":"2007","journal-title":"Exp Neurol"},{"key":"10.1016\/j.jneumeth.2014.04.005_bib0035","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1750-3639.2007.00095.x","article-title":"Analysis of neuronal, glial, endothelial, axonal and apoptotic markers following moderate therapeutic hypothermia and anesthesia in the developing piglet brain","volume":"18","author":"Gressens","year":"2008","journal-title":"Brain Pathol (Zurich, Switzerland)"},{"key":"10.1016\/j.jneumeth.2014.04.005_bib0040","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1172\/JCI119153","article-title":"Dramatic neuronal rescue with prolonged selective head cooling after ischemia in fetal lambs","volume":"99","author":"Gunn","year":"1997","journal-title":"J Clin Investig"},{"key":"10.1016\/j.jneumeth.2014.04.005_bib0045","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1203\/00006450-199704000-00009","article-title":"Posthypoxic hypothermia in newborn piglets","volume":"41","author":"Haaland","year":"1997","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jneumeth.2014.04.005_bib0050","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1203\/PDR.0b013e318174efdd","article-title":"Delayed hypothermia as selective head cooling or whole body cooling does not protect brain or body in newborn pig subjected to hypoxia-ischemia","volume":"64","author":"Karlsson","year":"2008","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jneumeth.2014.04.005_bib0055","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1542\/peds.108.5.1103","article-title":"Differences in brain temperature and cerebral blood flow during selective head versus whole-body cooling","volume":"108","author":"Laptook","year":"2001","journal-title":"Pediatrics"},{"key":"10.1016\/j.jneumeth.2014.04.005_bib0060","series-title":"Fetal and neonatal brain injury. Mechanisms, management and the risks of practice","article-title":"Mechanisms of neurodegeneration and therapeutics in animal models of neonatal hypoxic\u2013ischaemic encephalopathy","author":"Martin","year":"2009"},{"key":"10.1016\/j.jneumeth.2014.04.005_bib0065","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/ana.410420310","article-title":"Hypoxia-ischemia causes abnormalities in glutamate transporters and death of astroglia and neurons in newborn striatum","volume":"42","author":"Martin","year":"1997","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jneumeth.2014.04.005_bib0070","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1006\/nbdi.2000.0282","article-title":"Neuronal death in newborn striatum after hypoxia-ischemia is necrosis and evolves with oxidative stress","volume":"7","author":"Martin","year":"2000","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.jneumeth.2014.04.005_bib0075","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1126\/science.3975601","article-title":"Limits of neurogenesis in primates","volume":"227","author":"Rakic","year":"1985","journal-title":"Science (New York, NY)"},{"key":"10.1016\/j.jneumeth.2014.04.005_bib0080","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S1474-4422(09)70295-9","article-title":"Assessment of brain tissue injury after moderate hypothermia in neonates with hypoxic\u2013ischaemic encephalopathy: a nested substudy of a randomised controlled trial","volume":"9","author":"Rutherford","year":"2010","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jneumeth.2014.04.005_bib0085","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1542\/peds.102.2.323","article-title":"Abnormal magnetic resonance signal in the internal capsule predicts poor neurodevelopmental outcome in infants with hypoxic\u2013ischemic encephalopathy","volume":"102","author":"Rutherford","year":"1998","journal-title":"Pediatrics"},{"key":"10.1016\/j.jneumeth.2014.04.005_bib0090","doi-asserted-by":"crossref","first-page":"F3","DOI":"10.1136\/fn.74.1.F3","article-title":"Posthypoxic cooling of neonatal rats provides protection against brain injury","volume":"74","author":"Thoresen","year":"1996","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.jneumeth.2014.04.005_bib0095","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1203\/00006450-199611000-00014","article-title":"A piglet survival model of posthypoxic encephalopathy","volume":"40","author":"Thoresen","year":"1996","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jneumeth.2014.04.005_bib0100","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1203\/00006450-200109000-00017","article-title":"Twenty-four hours of mild hypothermia in unsedated newborn pigs starting after a severe global hypoxic\u2013ischemic insult is not neuroprotective","volume":"50","author":"Thoresen","year":"2001","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jneumeth.2014.04.005_bib0105","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1203\/00006450-200104000-00024","article-title":"Effective selective head cooling during posthypoxic hypothermia in newborn piglets","volume":"49","author":"Thoresen","year":"2001","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jneumeth.2014.04.005_bib0110","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/ana.10402","article-title":"Head cooling with mild systemic hypothermia in anesthetized piglets is neuroprotective","volume":"53","author":"Tooley","year":"2003","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jneumeth.2014.04.005_bib0115","series-title":"Hypoxic\u2013ischemic encephalopathy. Neurology of the newborn","first-page":"347","author":"Volpe","year":"2008"},{"key":"10.1016\/j.jneumeth.2014.04.005_bib0120","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1146\/annurev.ne.11.030188.002231","article-title":"The control of neuron number","volume":"11","author":"Williams","year":"1988","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.jneumeth.2014.04.005_bib0125","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1038\/jcbfm.2013.117","article-title":"Adenosine A2A receptor contributes to ischemic brain damage in newborn piglet","volume":"33","author":"Yang","year":"2013","journal-title":"J Cereb Blood Flow Metab"}],"container-title":["Journal of Neuroscience Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165027014001216?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165027014001216?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T00:32:33Z","timestamp":1759019553000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165027014001216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":25,"alternative-id":["S0165027014001216"],"URL":"https:\/\/doi.org\/10.1016\/j.jneumeth.2014.04.005","relation":{},"ISSN":["0165-0270"],"issn-type":[{"value":"0165-0270","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Validation of a neuropathology score using quantitative methods to evaluate brain injury in a pig model of hypoxia ischaemia","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroscience Methods","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneumeth.2014.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}