{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:23:22Z","timestamp":1791235402151,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroscience Methods"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.jneumeth.2014.09.021","type":"journal-article","created":{"date-parts":[[2014,9,27]],"date-time":"2014-09-27T15:48:11Z","timestamp":1411832891000},"page":"94-99","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Regional and tissue-specific differences in brain glutamate concentration measured by in vivo single voxel MRS"],"prefix":"10.1016","volume":"239","author":[{"given":"Yan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jneumeth.2014.09.021_bib0005","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1006\/nimg.1997.0290","article-title":"Multimodal image coregistration and partitioning \u2013 a unified framework","volume":"6","author":"Ashburner","year":"1997","journal-title":"Neuroimage"},{"key":"10.1016\/j.jneumeth.2014.09.021_bib0010","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/jmri.21285","article-title":"Regional apparent metabolite concentrations in young adult brain measured by 1H MR spectroscopy at 3 Tesla","volume":"27","author":"Baker","year":"2008","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.jneumeth.2014.09.021_bib0015","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/nbm.701","article-title":"Cramer\u2013Rao bounds: an evaluation tool for quantitation","volume":"14","author":"Cavassila","year":"2001","journal-title":"NMR Biomed"},{"key":"10.1016\/j.jneumeth.2014.09.021_bib0020","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1002\/mrm.21055","article-title":"T2 measurement and quantification of glutamate in human brain in vivo","volume":"56","author":"Choi","year":"2006","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jneumeth.2014.09.021_bib0025","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0301-0082(90)90013-7","article-title":"Metabolism and role of glutamate in mammalian brain","volume":"35","author":"Erecinska","year":"1990","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.jneumeth.2014.09.021_bib0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/jmrb.1993.1055","article-title":"Absolute quantitation of water and metabolites in human brain. I. Compartments and water","volume":"102","author":"Ernst","year":"1993","journal-title":"J Magn Reson B"},{"key":"10.1016\/j.jneumeth.2014.09.021_bib0035","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1002\/mrm.10640","article-title":"Comparison of longitudinal metabolite relaxation times in different regions of the human brain at 1.5 and 3 Tesla","volume":"50","author":"Ethofer","year":"2003","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jneumeth.2014.09.021_bib0040","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1002\/nbm.1662","article-title":"Reproducibility of prefrontal \u03b3-aminobutyric acid measurements with J-edited spectroscopy","volume":"24","author":"Geramita","year":"2011","journal-title":"NMR Biomed"},{"key":"10.1016\/j.jneumeth.2014.09.021_bib0045","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/1099-1492(200005)13:3<129::AID-NBM619>3.0.CO;2-V","article-title":"Proton NMR chemical shifts and coupling constants for brain metabolites","volume":"13","author":"Govindaraju","year":"2000","journal-title":"NMR Biomed"},{"key":"10.1016\/j.jneumeth.2014.09.021_bib0050","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.neuint.2003.08.016","article-title":"Intercellular metabolic compartmentation in the brain: past, present and future","volume":"45","author":"Hertz","year":"2004","journal-title":"Neurochem Int"},{"key":"10.1016\/j.jneumeth.2014.09.021_bib0055","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/mrm.20007","article-title":"Measurement of brain glutamate using TE-averaged PRESS at 3 T","volume":"51","author":"Hurd","year":"2004","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jneumeth.2014.09.021_bib0060","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1002\/mrm.10443","article-title":"Quantitative proton short-echo-time LASER spectroscopy of normal human white matter and hippocampus at 4 Tesla incorporating macromolecule subtraction","volume":"49","author":"Kassem","year":"2003","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jneumeth.2014.09.021_bib0065","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1148\/radiol.09091015","article-title":"Brain metabolite proton T2 mapping at 3.0 T in relapsing-remitting multiple sclerosis","volume":"254","author":"Kirov","year":"2010","journal-title":"Radiology"},{"key":"10.1016\/j.jneumeth.2014.09.021_bib0070","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1038\/npp.2012.126","article-title":"Regional decoupling of N-acetyl-aspartate and glutamate in schizophrenia","volume":"37","author":"Kraguljac","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jneumeth.2014.09.021_bib0075","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1002\/mrm.21875","article-title":"Mapping of brain metabolite distributions by volumetric proton MR spectroscopic imaging (MRSI)","volume":"61","author":"Maudsley","year":"2009","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jneumeth.2014.09.021_bib0080","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/1522-2594(200009)44:3<401::AID-MRM10>3.0.CO;2-W","article-title":"Quantitative analysis of short echo time 1H MRSI of cerebral gray and white matter","volume":"44","author":"McLean","year":"2000","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jneumeth.2014.09.021_bib0085","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0304-3940(93)90291-R","article-title":"Phospholipid metabolite levels are altered in cerebral cortex of patients with dominantly inherited olivopontocerebellar atrophy","volume":"161","author":"Nitsch","year":"1993","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jneumeth.2014.09.021_bib0090","doi-asserted-by":"crossref","first-page":"179","DOI":"10.2460\/ajvr.75.2.179","article-title":"Regional variations and age-related changes detected with magnetic resonance spectroscopy in the brain of healthy dogs","volume":"75","author":"Ono","year":"2014","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.jneumeth.2014.09.021_bib0095","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/mrm.1910360103","article-title":"Spectroscopic imaging of human brain glutamate by water-suppressed J-refocused coherence transfer at 4.1 T","volume":"36","author":"Pan","year":"1996","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jneumeth.2014.09.021_bib0100","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1002\/mrm.21897","article-title":"Functional changes in CSF volume estimated using measurement of water T2 relaxation","volume":"61","author":"Piechnik","year":"2009","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jneumeth.2014.09.021_bib0105","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.pnpbp.2007.11.023","article-title":"High-field MRS study of GABA, glutamate and glutamine in social anxiety disorder: response to treatment with levetiracetam","volume":"32","author":"Pollack","year":"2008","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.jneumeth.2014.09.021_bib0110","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1002\/jmri.23945","article-title":"MR spectroscopic imaging: principles and recent advances","volume":"37","author":"Posse","year":"2013","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.jneumeth.2014.09.021_bib0115","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/mrm.1910390110","article-title":"Regional metabolite concentrations in human brain as determined by quantitative localized proton MRS","volume":"39","author":"Pouwels","year":"1998","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jneumeth.2014.09.021_bib0120","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0010-4655(82)90173-4","article-title":"A constrained regularization method for inverting data represented by linear algebraic or integral equations","volume":"27","author":"Provencher","year":"1982","journal-title":"Comput Phys Commun"},{"key":"10.1016\/j.jneumeth.2014.09.021_bib0125","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/mrm.1910300604","article-title":"Estimation of metabolite concentrations from localized in vivo proton NMR spectra","volume":"30","author":"Provencher","year":"1993","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jneumeth.2014.09.021_bib0130","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.mri.2007.06.007","article-title":"Regional variations and the effects of age and gender on glutamate concentrations in the human brain","volume":"26","author":"Sailasuta","year":"2008","journal-title":"Magn Reson Imaging"},{"key":"10.1016\/j.jneumeth.2014.09.021_bib0135","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1002\/mrm.1119","article-title":"Region and tissue differences of metabolites in normally aged brain using 1H magnetic resonance spectroscopic imaging","volume":"45","author":"Schuff","year":"2001","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jneumeth.2014.09.021_bib0140","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.neuroimage.2005.10.048","article-title":"TE-averaged two dimensional proton spectroscopic imaging of glutamate at 3 T","volume":"30","author":"Srinivasan","year":"2006","journal-title":"Neuroimage"},{"key":"10.1016\/j.jneumeth.2014.09.021_bib0145","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/mrm.20605","article-title":"T1, T2 relaxation and magnetization transfer in tissue at 3 T","volume":"54","author":"Stanisz","year":"2005","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jneumeth.2014.09.021_bib0150","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/jmri.20053","article-title":"1H metabolite relaxation times at 3.0 Tesla: measurements of T1 and T2 values in normal brain and determination of regional differences in transverse relaxation","volume":"19","author":"Traber","year":"2004","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.jneumeth.2014.09.021_bib0155","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1002\/mrm.21225","article-title":"Fast mapping of the T2 relaxation time of cerebral metabolites using proton echo-planar spectroscopic imaging (PEPSI)","volume":"57","author":"Tsai","year":"2007","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jneumeth.2014.09.021_bib0160","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1002\/jmri.24009","article-title":"Regional difference in GABA levels between medial prefrontal and occipital cortices","volume":"38","author":"van der Veen","year":"2013","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.jneumeth.2014.09.021_bib0165","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/S0730-725X(01)00441-6","article-title":"Short echo time multislice proton magnetic resonance spectroscopic imaging in human brain: metabolite distributions and reliability","volume":"19","author":"Wiedermann","year":"2001","journal-title":"Magn Reson Imaging"},{"key":"10.1016\/j.jneumeth.2014.09.021_bib0170","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1002\/mrm.24337","article-title":"Soft constraints in nonlinear spectral fitting with regularized lineshape deconvolution","volume":"69","author":"Zhang","year":"2013","journal-title":"Magn Reson Med"},{"issue":"4","key":"10.1016\/j.jneumeth.2014.09.021_bib0175","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1002\/mrm.25013","article-title":"Smoothness of in vivo spectral baseline determined by mean-square error","volume":"72","author":"Zhang","year":"2014","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jneumeth.2014.09.021_bib0180","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/mrm.23029","article-title":"Quantitative measurement of N-acetyl-aspartyl-glutamate at 3 T using TE-averaged PRESS spectroscopy and regularized lineshape deconvolution","volume":"66","author":"Zhang","year":"2011","journal-title":"Magn Reson Med"}],"container-title":["Journal of Neuroscience Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016502701400346X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016502701400346X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T00:35:04Z","timestamp":1759019704000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016502701400346X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":36,"alternative-id":["S016502701400346X"],"URL":"https:\/\/doi.org\/10.1016\/j.jneumeth.2014.09.021","relation":{},"ISSN":["0165-0270"],"issn-type":[{"value":"0165-0270","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regional and tissue-specific differences in brain glutamate concentration measured by in vivo single voxel MRS","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroscience Methods","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneumeth.2014.09.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}