{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T05:12:31Z","timestamp":1780117951017,"version":"3.54.0"},"reference-count":96,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,9,7]],"date-time":"2015-09-07T00:00:00Z","timestamp":1441584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroscience Methods"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.jneumeth.2015.08.027","type":"journal-article","created":{"date-parts":[[2015,8,31]],"date-time":"2015-08-31T02:15:18Z","timestamp":1440987318000},"page":"2-12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Robust MR-based approaches to quantifying white matter structure and structure\/function alterations in Huntington's disease"],"prefix":"10.1016","volume":"265","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6400-3970","authenticated-orcid":false,"given":"Jessica J.","family":"Steventon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca C.","family":"Trueman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne E.","family":"Rosser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek K.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jneumeth.2015.08.027_bib0005","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1002\/mrm.1105","article-title":"Analysis of partial volume effects in diffusion-tensor MRI","volume":"45","author":"Alexander","year":"2001","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jneumeth.2015.08.027_bib0010","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1196\/annals.1340.018","article-title":"Multiple-fiber reconstruction algorithms for diffusion MRI","volume":"1064","author":"Alexander","year":"2005","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.jneumeth.2015.08.027_bib0015","series-title":"Non-linear registration, aka spatial normalisation","author":"Andersson","year":"2010"},{"issue":"4","key":"10.1016\/j.jneumeth.2015.08.027_bib0020","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1136\/jnnp.2010.208264","article-title":"Longitudinal change in regional brain volumes in prodromal Huntington disease","volume":"82","author":"Aylward","year":"2011","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"3","key":"10.1016\/j.jneumeth.2015.08.027_bib0025","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1002\/mrm.25226","article-title":"Acquisition strategy to reduce cerebrospinal fluid partial volume effects for improved DTI tractography","volume":"73","author":"Baron","year":"2015","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jneumeth.2015.08.027_bib0030","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1007\/s11064-007-9352-7","article-title":"Myelin breakdown and iron changes in Huntington's disease: pathogenesis and treatment implications","volume":"32","author":"Bartzokis","year":"2007","journal-title":"Neurochem Res"},{"key":"10.1016\/j.jneumeth.2015.08.027_bib0035","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1006\/jmrb.1994.1037","article-title":"Estimation of the effective self-diffusion tensor from the NMR spin echo","volume":"103","author":"Basser","year":"1994","journal-title":"J Magn Reson B"},{"key":"10.1016\/j.jneumeth.2015.08.027_bib0040","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1002\/1522-2594(200010)44:4<625::AID-MRM17>3.0.CO;2-O","article-title":"In vivo fiber tractography using DT-MRI data","volume":"44","author":"Basser","year":"2000","journal-title":"Magn Reson Med"},{"issue":"1","key":"10.1016\/j.jneumeth.2015.08.027_bib0045","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J Royal Stat Soc Ser B (Methodol)"},{"issue":"3","key":"10.1016\/j.jneumeth.2015.08.027_bib0050","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s11682-011-9121-8","article-title":"Diffusion tensor imaging in Huntington's disease reveals distinct patterns of white matter degeneration associated with motor and cognitive deficits","volume":"5","author":"Bohanna","year":"2011","journal-title":"Brain Imaging Behav"},{"issue":"3","key":"10.1016\/j.jneumeth.2015.08.027_bib0055","first-page":"263","article-title":"Triggering in quantitative diffusion imaging with single-shot EPI","volume":"40","author":"Brockstedt","year":"1999","journal-title":"Acta Radiol (Stockholm, Sweden: 1987)"},{"issue":"5","key":"10.1016\/j.jneumeth.2015.08.027_bib0060","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1002\/mrm.20426","article-title":"RESTORE: robust estimation of tensors by outlier rejection","volume":"53","author":"Chang","year":"2005","journal-title":"Magn Reson Med"},{"issue":"5","key":"10.1016\/j.jneumeth.2015.08.027_bib0065","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1002\/mrm.24173","article-title":"Informed RESTORE: a method for robust estimation of diffusion tensor from low redundancy datasets in the presence of physiological noise artifacts","volume":"68","author":"Chang","year":"2012","journal-title":"Magn Reson Med"},{"issue":"3","key":"10.1016\/j.jneumeth.2015.08.027_bib0070","first-page":"591","article-title":"FLAIR diffusion-tensor MR tractography: comparison of fiber tracking with conventional imaging","volume":"26","author":"Chou","year":"2005","journal-title":"AJNR Am J Neuroradiol"},{"issue":"18","key":"10.1016\/j.jneumeth.2015.08.027_bib0075","doi-asserted-by":"crossref","first-page":"10422","DOI":"10.1073\/pnas.96.18.10422","article-title":"Tracking neuronal fiber pathways in the living human brain","volume":"96","author":"Conturo","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jneumeth.2015.08.027_bib0080","series-title":"Proc. Annual Meet. ISMRM","article-title":"Camino: open-source diffusion \u2013 MRI reconstruction and processing","author":"Cook","year":"2006"},{"key":"10.1016\/j.jneumeth.2015.08.027_bib0085","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1002\/jmri.20905","article-title":"Optimal acquisition orders of diffusion-weighted MRI measurements","volume":"25","author":"Cook","year":"2007","journal-title":"J Magn Reson Imaging"},{"issue":"2","key":"10.1016\/j.jneumeth.2015.08.027_bib0090","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1016\/j.neuroimage.2009.09.033","article-title":"A modified damped Richardson\u2013Lucy algorithm to reduce isotropic background effects in spherical deconvolution","volume":"49","author":"Dell\u2019Acqua","year":"2010","journal-title":"Neuroimage"},{"issue":"12","key":"10.1016\/j.jneumeth.2015.08.027_bib0095","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1093\/cercor\/bhr360","article-title":"Multimodal MRI analysis of the corpus callosum reveals white matter differences in presymptomatic and early Huntington's disease","volume":"22","author":"Di Paola","year":"2012","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.jneumeth.2015.08.027_bib0100","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1002\/hbm.22391","article-title":"MRI measures of corpus callosum iron and myelin in early Huntington's disease","volume":"35","author":"Di Paola","year":"2014","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.jneumeth.2015.08.027_bib0105","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1194\/jlr.R400004-JLR200","article-title":"Thematic review series: brain lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal","volume":"45","author":"Dietschy","year":"2004","journal-title":"J Lipid Res"},{"issue":"1","key":"10.1016\/j.jneumeth.2015.08.027_bib0115","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/hbm.21205","article-title":"Early changes in white matter pathways of the sensorimotor cortex in premanifest Huntington's disease","volume":"33","author":"Dumas","year":"2012","journal-title":"Hum Brain Mapp"},{"issue":"6","key":"10.1016\/j.jneumeth.2015.08.027_bib0120","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1002\/mrm.10156","article-title":"Characterization of anisotropy in high angular resolution diffusion-weighted MRI","volume":"47","author":"Frank","year":"2002","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jneumeth.2015.08.027_bib0125","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/BF02289823","article-title":"On methods in the analysis of profile data","volume":"24","author":"Greenhouse","year":"1959","journal-title":"Psychometrika"},{"key":"10.1016\/j.jneumeth.2015.08.027_bib0130","series-title":"Proc. Annual Meet. ISMRM","first-page":"3133","article-title":"Relevance of cardiac-gating in longitudinal diffusion weighted MRI studies","author":"Habib","year":"2008"},{"key":"10.1016\/j.jneumeth.2015.08.027_bib0135","series-title":"Proc. Annual Meet. ISMRM","article-title":"Do we need cardiac gating in brain-DTI at high (3T) and ultra-high (7T) field strengths?","author":"Habib","year":"2009"},{"key":"10.1016\/j.jneumeth.2015.08.027_bib0140","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1118\/1.595711","article-title":"Measurement of signal intensities in the presence of noise in MR images","volume":"12","author":"Henkelman","year":"1985","journal-title":"Med Phys"},{"key":"10.1016\/j.jneumeth.2015.08.027_bib0145","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.neuroimage.2006.05.044","article-title":"Topography of the human corpus callosum revisited \u2013 comprehensive fiber tractography using diffusion tensor magnetic resonance imaging","volume":"32","author":"Hofer","year":"2006","journal-title":"Neuroimage"},{"issue":"11","key":"10.1016\/j.jneumeth.2015.08.027_bib0150","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1002\/hbm.22099","article-title":"Investigating the prevalence of complex fiber configurations in white matter tissue with diffusion magnetic resonance imaging","volume":"34","author":"Jeurissen","year":"2013","journal-title":"Hum Brain Mapp"},{"issue":"8","key":"10.1016\/j.jneumeth.2015.08.027_bib0155","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.cortex.2008.05.002","article-title":"Studying connections in the living human brain with diffusion MRI","volume":"44","author":"Jones","year":"2008","journal-title":"Cortex"},{"issue":"2","key":"10.1016\/j.jneumeth.2015.08.027_bib0160","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/RMR.0b013e31821e56ac","article-title":"Precision and accuracy in diffusion tensor magnetic resonance imaging","volume":"21","author":"Jones","year":"2010","journal-title":"Top Magn Reson Imaging"},{"issue":"7","key":"10.1016\/j.jneumeth.2015.08.027_bib0165","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1002\/nbm.1543","article-title":"Twenty-five pitfalls in the analysis of diffusion MRI data","volume":"23","author":"Jones","year":"2010","journal-title":"NMR Biomed"},{"issue":"3","key":"10.1016\/j.jneumeth.2015.08.027_bib0170","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/(SICI)1522-2594(199909)42:3<515::AID-MRM14>3.0.CO;2-Q","article-title":"Optimal strategies for measuring diffusion in anisotropic systems by magnetic resonance imaging","volume":"42","author":"Jones","year":"1999","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jneumeth.2015.08.027_bib0175","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/978-1-61737-992-5_6","article-title":"Diffusion tensor imaging","volume":"711","author":"Jones","year":"2011","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jneumeth.2015.08.027_bib0180","series-title":"Proc. Annual Meet. ISMRM","first-page":"222","article-title":"Contribution of cardiac pulsation to variability of tractography results","author":"Jones","year":"2005"},{"issue":"1","key":"10.1016\/j.jneumeth.2015.08.027_bib0185","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/(SICI)1522-2594(199907)42:1<37::AID-MRM7>3.0.CO;2-O","article-title":"Non-invasive assessment of axonal fiber connectivity in the human brain via diffusion tensor MRI","volume":"42","author":"Jones","year":"1999","journal-title":"Magn Reson Med"},{"issue":"6","key":"10.1016\/j.jneumeth.2015.08.027_bib0190","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1002\/mrm.20484","article-title":"PASTA: pointwise assessment of streamline tractography attributes","volume":"53","author":"Jones","year":"2005","journal-title":"Magn Reson Med"},{"issue":"11\u201312","key":"10.1016\/j.jneumeth.2015.08.027_bib0195","first-page":"399","article-title":"Diffusion MRI measured white matter microstructure as a biomarker of neurodegeneration in preclinical Huntington's disease","volume":"66","author":"Kincses","year":"2013","journal-title":"Ideggy\u00f3gy Szle"},{"key":"10.1016\/j.jneumeth.2015.08.027_bib0200","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1109\/TMI.2009.2035616","article-title":"elastix: a toolbox for intensity-based medical image registration","volume":"29","author":"Klein","year":"2010","journal-title":"IEEE Trans Med Imaging"},{"issue":"9","key":"10.1016\/j.jneumeth.2015.08.027_bib0205","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1093\/cercor\/bhl127","article-title":"Morphological, electrophysiological, and synaptic properties of corticocallosal pyramidal cells in the neonatal rat neocortex","volume":"17","author":"Le B\u00e9","year":"2007","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.jneumeth.2015.08.027_bib0210","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1002\/jmri.20683","article-title":"Artifacts and pitfalls in diffusion MRI","volume":"24","author":"Le Bihan","year":"2006","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.jneumeth.2015.08.027_bib0215","series-title":"Proc. Annual Meet. ISMRM","article-title":"ExploreDTI: a graphical toolbox for processing, analyzing, and visualizing diffusion MR data","author":"Leemans","year":"2009"},{"issue":"6","key":"10.1016\/j.jneumeth.2015.08.027_bib0220","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1002\/mrm.21890","article-title":"The B-matrix must be rotated when correcting for subject motion in DTI data","volume":"61","author":"Leemans","year":"2009","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jneumeth.2015.08.027_bib0225","doi-asserted-by":"crossref","first-page":"8473","DOI":"10.1523\/JNEUROSCI.21-21-08473.2001","article-title":"Huntingtin aggregate-associated axonal degeneration is an early pathological event in Huntington's disease mice","volume":"21","author":"Li","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.jneumeth.2015.08.027_bib0230","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.expneurol.2012.08.010","article-title":"Axonopathy in Huntington's disease","volume":"246","author":"Li","year":"2013","journal-title":"Exp Neurol"},{"key":"10.1016\/j.jneumeth.2015.08.027_bib0235","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/BF02742437","article-title":"The early cellular pathology of Huntington's disease","volume":"20","author":"Li","year":"1999","journal-title":"Mol Neurobiol"},{"issue":"1","key":"10.1016\/j.jneumeth.2015.08.027_bib0240","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s11682-008-9051-2","article-title":"Diffusion tensor imaging in preclinical Huntington's disease","volume":"3","author":"Magnotta","year":"2009","journal-title":"Brain Imaging Behav"},{"issue":"3","key":"10.1016\/j.jneumeth.2015.08.027_bib0245","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S1361-8415(02)00079-8","article-title":"Distortion correction and robust tensor estimation for MR diffusion imaging","volume":"6","author":"Mangin","year":"2002","journal-title":"Med Image Anal"},{"issue":"2","key":"10.1016\/j.jneumeth.2015.08.027_bib0250","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1016\/j.neuroimage.2011.08.043","article-title":"How and how not to correct for CSF-contamination in diffusion MRI","volume":"59","author":"Metzler-Baddeley","year":"2012","journal-title":"Neuroimage"},{"issue":"2","key":"10.1016\/j.jneumeth.2015.08.027_bib0255","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/1531-8249(199902)45:2<265::AID-ANA21>3.0.CO;2-3","article-title":"Three-dimensional tracking of axonal projections in the brain by magnetic resonance imaging","volume":"45","author":"Mori","year":"1999","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jneumeth.2015.08.027_bib0260","series-title":"MRI atlas of human white matter","author":"Mori","year":"2005"},{"issue":"1","key":"10.1016\/j.jneumeth.2015.08.027_bib0265","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/mrm.22786","article-title":"Preterm neonatal diffusion processing using detection and replacement of outliers prior to resampling","volume":"66","author":"Morris","year":"2011","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jneumeth.2015.08.027_bib0270","doi-asserted-by":"crossref","first-page":"RRN1232","DOI":"10.1371\/currents.RRN1232","article-title":"Stability of white matter changes related to Huntington's disease in the presence of imaging noise: a DTI study","volume":"3","author":"M\u00fcller","year":"2011","journal-title":"PLoS Curr"},{"issue":"2","key":"10.1016\/j.jneumeth.2015.08.027_bib0275","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.nicl.2012.12.005","article-title":"Evaluating multicenter DTI data in Huntington's disease on site specific effects: an ex post facto approach","volume":"3","author":"M\u00fcller","year":"2013","journal-title":"Neuroimage Clin"},{"issue":"9","key":"10.1016\/j.jneumeth.2015.08.027_bib0280","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1176\/appi.ajp.2007.06081266","article-title":"Morphology of the cerebral cortex in preclinical Huntington's disease","volume":"164","author":"Nopoulos","year":"2007","journal-title":"Am J Psychiatry"},{"issue":"1","key":"10.1016\/j.jneumeth.2015.08.027_bib0285","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.schres.2014.09.007","article-title":"Does diffusion MRI tell us anything about the white matter? An overview of methods and pitfalls","volume":"161","author":"O\u2019Donnell","year":"2014","journal-title":"Schizophr Res"},{"issue":"2","key":"10.1016\/j.jneumeth.2015.08.027_bib0290","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.neurobiolaging.2014.10.029","article-title":"Increased free water in the substantia nigra of Parkinson's disease: a single-site and multi-site study","volume":"36","author":"Ofori","year":"2015","journal-title":"Neurobiol Aging"},{"issue":"2","key":"10.1016\/j.jneumeth.2015.08.027_bib0295","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/mrm.10204","article-title":"Study of the effect of CSF suppression on white matter diffusion anisotropy mapping of healthy human brain","volume":"48","author":"Papadakis","year":"2002","journal-title":"Magn Reson Med"},{"issue":"4","key":"10.1016\/j.jneumeth.2015.08.027_bib0300","doi-asserted-by":"crossref","first-page":"873","DOI":"10.3171\/2013.12.JNS132090","article-title":"Hockey Concussion Education Project, Part 2. Microstructural white matter alterations in acutely concussed ice hockey players: a longitudinal free-water MRI study","volume":"120","author":"Pasternak","year":"2014","journal-title":"J Neurosurg"},{"issue":"3","key":"10.1016\/j.jneumeth.2015.08.027_bib0305","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/mrm.22055","article-title":"Free water elimination and mapping from diffusion MRI","volume":"62","author":"Pasternak","year":"2009","journal-title":"Magn Reson Med"},{"issue":"48","key":"10.1016\/j.jneumeth.2015.08.027_bib0310","doi-asserted-by":"crossref","first-page":"17365","DOI":"10.1523\/JNEUROSCI.2904-12.2012","article-title":"Excessive extracellular volume reveals a neurodegenerative pattern in schizophrenia onset","volume":"32","author":"Pasternak","year":"2012","journal-title":"J Neurosci"},{"issue":"6","key":"10.1016\/j.jneumeth.2015.08.027_bib0315","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1001\/archneur.63.6.883","article-title":"Preparing for preventive clinical trials: the predict-HD study","volume":"63","author":"Paulsen","year":"2006","journal-title":"Arch Neurol"},{"issue":"3\u20134","key":"10.1016\/j.jneumeth.2015.08.027_bib0320","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.brainresbull.2010.04.003","article-title":"Striatal and white matter predictors of estimated diagnosis for Huntington disease","volume":"82","author":"Paulsen","year":"2010","journal-title":"Brain Res Bull"},{"issue":"12","key":"10.1016\/j.jneumeth.2015.08.027_bib0325","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/S1474-4422(14)70238-8","article-title":"Prediction of manifest Huntington's disease with clinical and imaging measures: a prospective observational study","volume":"13","author":"Paulsen","year":"2014","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jneumeth.2015.08.027_bib0330","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1002\/ana.410410521","article-title":"CAG repeat number governs the development rate of pathology in Huntington's disease","volume":"41","author":"Penney","year":"1997","journal-title":"Ann Neurol"},{"issue":"9","key":"10.1016\/j.jneumeth.2015.08.027_bib0335","doi-asserted-by":"crossref","first-page":"e73280","DOI":"10.1371\/journal.pone.0073280","article-title":"Tractography of the corpus callosum in Huntington's disease","volume":"8","author":"Phillips","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.jneumeth.2015.08.027_bib0340","article-title":"The corticospinal tract in Huntington's disease","author":"Phillips","year":"2014","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.jneumeth.2015.08.027_bib0345","series-title":"Proc. Annual Meet. ISMRM","article-title":"Removing CSF contamination in brain DT-MRIs by using a two-compartment tensor model","author":"Pierpaoli","year":"2004"},{"key":"10.1016\/j.jneumeth.2015.08.027_bib0350","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.nbd.2014.01.013","article-title":"White matter connectivity reflects clinical and cognitive status in Huntington's disease","volume":"65","author":"Poudel","year":"2014","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.jneumeth.2015.08.027_bib0355","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.nbd.2014.12.009","article-title":"Longitudinal change in white matter microstructure in Huntington's disease: the IMAGE-HD study","volume":"74","author":"Poudel","year":"2015","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.jneumeth.2015.08.027_bib0360","series-title":"Manual for administration and scoring of the Halstead\u2013Reitan of neuropsychological test battery for adults and children","author":"Reitan","year":"1979"},{"issue":"4","key":"10.1016\/j.jneumeth.2015.08.027_bib0365","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1016\/j.neuroimage.2009.10.015","article-title":"Altered white matter microstructure in the corpus callosum in Huntington's disease: implications for cortical \u201cdisconnection\u201d","volume":"49","author":"Rosas","year":"2010","journal-title":"Neuroimage"},{"issue":"9","key":"10.1016\/j.jneumeth.2015.08.027_bib0370","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1002\/mds.23762","article-title":"A tale of two factors: what determines the rate of progression in Huntington's disease? A longitudinal MRI study","volume":"26","author":"Rosas","year":"2011","journal-title":"Mov Disord"},{"issue":"4","key":"10.1016\/j.jneumeth.2015.08.027_bib0375","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1093\/brain\/awn025","article-title":"Cerebral cortex and the clinical expression of Huntington's disease: complexity and heterogeneity","volume":"131","author":"Rosas","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.jneumeth.2015.08.027_bib0380","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1093\/brain\/awh041","article-title":"Diffusion tensor MRI of early upper motor neuron involvement in amyotrophic lateral sclerosis","volume":"127","author":"Sach","year":"2004","journal-title":"Brain"},{"key":"10.1016\/j.jneumeth.2015.08.027_bib0385","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/nn1426","article-title":"High cholesterol level is essential for myelin membrane growth","volume":"8","author":"Saher","year":"2005","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.jneumeth.2015.08.027_bib0390","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1212\/WNL.29.1.1","article-title":"Huntington disease: clinical care and evaluation","volume":"29","author":"Shoulson","year":"1979","journal-title":"Neurology"},{"key":"10.1016\/j.jneumeth.2015.08.027_bib0395","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.nbd.2009.02.012","article-title":"Live axonal transport disruption by mutant Huntingtin fragments in Drosophila motor neuron axons","volume":"34","author":"Sinadinos","year":"2009","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.jneumeth.2015.08.027_bib0400","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1016\/j.neuropsychologia.2009.03.004","article-title":"Cognitive reserve","volume":"47","author":"Stern","year":"2009","journal-title":"Neuropsychologia"},{"issue":"1","key":"10.1016\/j.jneumeth.2015.08.027_bib0405","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S1474-4422(11)70263-0","article-title":"Potential endpoints for clinical trials in premanifest and early Huntington's disease in the TRACK-HD study: analysis of 24 month observational data","volume":"11","author":"Tabrizi","year":"2012","journal-title":"Lancet Neurol"},{"issue":"1","key":"10.1016\/j.jneumeth.2015.08.027_bib0410","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1474-4422(10)70276-3","article-title":"Biological and clinical changes in premanifest and early stage Huntington's disease in the TRACK-HD study: the 12-month longitudinal analysis","volume":"10","author":"Tabrizi","year":"2011","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jneumeth.2015.08.027_bib0415","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/j.neuroimage.2007.02.016","article-title":"Robust determination of the fibre orientation distribution in diffusion MRI: non-negativity constrained super-resolved spherical deconvolution","volume":"35","author":"Tournier","year":"2007","journal-title":"Neuroimage"},{"issue":"6","key":"10.1016\/j.jneumeth.2015.08.027_bib0420","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1002\/mrm.22924","article-title":"Diffusion tensor imaging and beyond","volume":"65","author":"Tournier","year":"2011","journal-title":"Magn Reson Med"},{"issue":"4","key":"10.1016\/j.jneumeth.2015.08.027_bib0425","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/mrm.10268","article-title":"High angular resolution diffusion imaging reveals intravoxel white matter fiber heterogeneity","volume":"48","author":"Tuch","year":"2002","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jneumeth.2015.08.027_bib0430","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1093\/hmg\/ddm170","article-title":"Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by Huntingtin mutation","volume":"16","author":"Valenza","year":"2007","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jneumeth.2015.08.027_bib0435","doi-asserted-by":"crossref","first-page":"E143","DOI":"10.1073\/pnas.1006783107","article-title":"Neuroprotection and brain cholesterol biosynthesis in Huntington's disease","volume":"107","author":"Valenza","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jneumeth.2015.08.027_bib0440","doi-asserted-by":"crossref","first-page":"9932","DOI":"10.1523\/JNEUROSCI.3355-05.2005","article-title":"Dysfunction of the cholesterol biosynthetic pathway in Huntington's disease","volume":"25","author":"Valenza","year":"2005","journal-title":"J Neurosci"},{"issue":"6","key":"10.1016\/j.jneumeth.2015.08.027_bib0445","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/00005072-198511000-00003","article-title":"Neuropathological classification of Huntington's disease","volume":"44","author":"Vonsattel","year":"1985","journal-title":"J Neuropathol Exp Neurol"},{"issue":"4","key":"10.1016\/j.jneumeth.2015.08.027_bib0450","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1016\/j.neuroimage.2011.01.048","article-title":"Partial volume effect as a hidden covariate in DTI analyses","volume":"55","author":"Vos","year":"2011","journal-title":"Neuroimage"},{"issue":"2","key":"10.1016\/j.jneumeth.2015.08.027_bib0455","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/j.neuroimage.2010.08.048","article-title":"Effects of physiological noise in population analysis of diffusion tensor MRI data","volume":"54","author":"Walker","year":"2011","journal-title":"Neuroimage"},{"issue":"Pt. 12","key":"10.1016\/j.jneumeth.2015.08.027_bib0460","doi-asserted-by":"crossref","first-page":"3590","DOI":"10.1093\/brain\/awr307","article-title":"Quantification of increased cellularity during inflammatory demyelination","volume":"134","author":"Wang","year":"2011","journal-title":"Brain"},{"issue":"6","key":"10.1016\/j.jneumeth.2015.08.027_bib0465","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1002\/mrm.20642","article-title":"Mapping complex tissue architecture with diffusion spectrum magnetic resonance imaging","volume":"54","author":"Wedeen","year":"2005","journal-title":"Magn Reson Med"},{"issue":"Pt. 2","key":"10.1016\/j.jneumeth.2015.08.027_bib0470","first-page":"321","article-title":"Comparison of EPI distortion correction methods in diffusion tensor MRI using a novel framework","volume":"11","author":"Wu","year":"2008","journal-title":"Med Image Comput Comput Assist Interven"},{"issue":"26","key":"10.1016\/j.jneumeth.2015.08.027_bib0475","doi-asserted-by":"crossref","first-page":"9544","DOI":"10.1523\/JNEUROSCI.1291-11.2011","article-title":"Peroxisome-proliferator-activated receptor gamma coactivator 1\u03b1 contributes to dysmyelination in experimental models of Huntington's disease","volume":"31","author":"Xiang","year":"2011","journal-title":"J Neurosci"},{"issue":"2","key":"10.1016\/j.jneumeth.2015.08.027_bib0480","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.mri.2010.06.022","article-title":"Automated artifact detection and removal for improved tensor estimation in motion-corrupted DTI data sets using the combination of local binary patterns and 2D partial least squares","volume":"29","author":"Zhou","year":"2011","journal-title":"J Magn Reson Imaging"},{"issue":"2","key":"10.1016\/j.jneumeth.2015.08.027_bib0485","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.neuroimage.2010.06.014","article-title":"Patching cardiac and head motion artefacts in diffusion-weighted images","volume":"53","author":"Zwiers","year":"2010","journal-title":"Neuroimage"}],"container-title":["Journal of Neuroscience Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165027015003180?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165027015003180?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T00:39:28Z","timestamp":1759019968000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165027015003180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":96,"alternative-id":["S0165027015003180"],"URL":"https:\/\/doi.org\/10.1016\/j.jneumeth.2015.08.027","relation":{},"ISSN":["0165-0270"],"issn-type":[{"value":"0165-0270","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Robust MR-based approaches to quantifying white matter structure and structure\/function alterations in Huntington's disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroscience Methods","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneumeth.2015.08.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}