{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:29:31Z","timestamp":1769732971310,"version":"3.49.0"},"reference-count":98,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T00:00:00Z","timestamp":1501200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"University of Minnesota Foundation"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroscience Methods"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.jneumeth.2017.07.025","type":"journal-article","created":{"date-parts":[[2017,7,26]],"date-time":"2017-07-26T12:45:19Z","timestamp":1501073119000},"page":"2-11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Back to the Future: Circuit-testing TS &amp; OCD"],"prefix":"10.1016","volume":"292","author":[{"given":"Frank H.","family":"Burton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"7168","key":"10.1016\/j.jneumeth.2017.07.025_bib0005","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/nature06310","article-title":"Neural substrates of awakening probed with optogenetic control of hypocretin neurons","volume":"450","author":"Adamantidis","year":"2007","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.jneumeth.2017.07.025_bib0010","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1002\/da.22367","article-title":"Dissecting OCD circuits: from animal models to targeted treatments","volume":"32","author":"Ahmari","year":"2015","journal-title":"Depress. Anxiety"},{"issue":"5","key":"10.1016\/j.jneumeth.2017.07.025_bib0015","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1038\/npp.2011.308","article-title":"Impaired sensorimotor gating in unmedicated adults with obsessive-compulsive disorder","volume":"37","author":"Ahmari","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0020","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1126\/science.1234733","article-title":"Repeated cortico-striatal stimulation generates persistent OCD-like behavior","volume":"340","author":"Ahmari","year":"2013","journal-title":"Science"},{"issue":"7241","key":"10.1016\/j.jneumeth.2017.07.025_bib0025","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1038\/nature07926","article-title":"Temporally precise in vivo control of intracellular signalling","volume":"458","author":"Airan","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0030","series-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"2013"},{"issue":"5","key":"10.1016\/j.jneumeth.2017.07.025_bib0035","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/nn.3369","article-title":"Strengthening the accumbal indirect pathway promotes resilience to compulsive cocaine use","volume":"16","author":"Bock","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0040","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1093\/brain\/awl050","article-title":"Neural correlates of tic generation in Tourette syndrome: an event-related functional MRI study","volume":"129","author":"Bohlhalter","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0045","first-page":"30049","article-title":"Modeling tics in rodents: conceptual challenges and paths forward","author":"Bortolato","year":"2017","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0050","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1176\/appi.ajp.2007.07060978","article-title":"Treatment of Tourette's syndrome with finasteride","volume":"164","author":"Bortolato","year":"2007","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0055","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.1038\/npp.2008.39","article-title":"Antipsychotic-like properties of 5-alpha-reductase inhibitors","volume":"33","author":"Bortolato","year":"2008","journal-title":"Neuropsychopharmacology"},{"issue":"13","key":"10.1016\/j.jneumeth.2017.07.025_bib0060","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1038\/npp.2011.157","article-title":"Social deficits and perseverative behaviors, but not overt aggression, in MAO-A hypomorphic mice","volume":"36","author":"Bortolato","year":"2011","journal-title":"Neuropsychopharmacology"},{"issue":"7","key":"10.1016\/j.jneumeth.2017.07.025_bib0065","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1001\/archpsyc.1996.01830070041008","article-title":"Functional magnetic resonance imaging of symptom provocation in obsessive-compulsive disorder","volume":"53","author":"Breiter","year":"1996","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0070","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1126\/science.1232380","article-title":"Optogenetic stimulation of lateral orbitofronto-striatal pathway suppresses compulsive behaviors","volume":"340","author":"Burguiere","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0075","series-title":"Animal Models of Movement Disorders","first-page":"441","article-title":"Animal models of Tourette syndrome","author":"Burke","year":"2004"},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0080","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/350074a0","article-title":"Pituitary hyperplasia and gigantism in mice caused by a cholera toxin transgene","volume":"350","author":"Burton","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0085","first-page":"249","article-title":"Lethal psychomotor abnormalities in mice caused by a neural cholera toxin transgene","volume":"2","author":"Burton","year":"1998","journal-title":"Transgenics"},{"issue":"12","key":"10.1016\/j.jneumeth.2017.07.025_bib0090","doi-asserted-by":"crossref","first-page":"5044","DOI":"10.1523\/JNEUROSCI.19-12-05044.1999","article-title":"OCD-Like behaviors caused by a neuropotentiating transgene targeted to cortical and limbic D1+ neurons","volume":"19","author":"Campbell","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0095","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0014-2999(99)00184-3","article-title":"Differential response of cortical-limbic neuropotentiated compulsive mice to D1 and D2 antagonists","volume":"371","author":"Campbell","year":"1999","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0100","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0006-8993(99)01544-9","article-title":"Behavioral effects of cocaine on a transgenic mouse model of cortical-limbic compulsion","volume":"833","author":"Campbell","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0105","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1097\/00001756-200007140-00053","article-title":"TS+OCD-like neuropotentiated mice are supersensitive to seizure induction","volume":"11","author":"Campbell","year":"2000","journal-title":"Neuroreport"},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0110","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1034\/j.1600-0447.2000.102006401.x","article-title":"On the role of cortical glutamate in obsessive-compulsive disorder and attention-deficit hyperactivity disorder, two phenomenologically antithetical conditions","volume":"102","author":"Carlsson","year":"2000","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0115","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.neuron.2013.10.052","article-title":"Histidine decarboxylase deficiency causes Tourette syndrome: parallel findings in humans and mice","volume":"81","author":"Castellan Baldan","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0120","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1038\/sj.npp.1300733","article-title":"Glutamatergic dysfunction in OCD","volume":"30","author":"Chakrabarty","year":"2005","journal-title":"Neuropsychopharmacol"},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0125","first-page":"386","article-title":"Pediatric Tourette syndrome: insights from recent neuroimaging studies","volume":"3","author":"Church","year":"2014","journal-title":"J. Obsess. Compul. Relat. Disord."},{"issue":"12","key":"10.1016\/j.jneumeth.2017.07.025_bib0130","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1038\/nn.4430","article-title":"A viral strategy for tarteing and manipulating interneurons across vertebrate species","volume":"19","author":"Dimidschstein","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0135","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/j.1469-7793.1999.00565.x","article-title":"Experiments using transcranial magnetic brain stimulation in man could reveal important new mechanisms in motor control","volume":"521","author":"Edgley","year":"1999","journal-title":"J. Physiol. (Lond.)"},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0140","doi-asserted-by":"crossref","first-page":"15340","DOI":"10.1523\/JNEUROSCI.3144-11.2011","article-title":"Differential modulation of excitatory and inhibitory striatal synaptic transmission by histamine","volume":"31","author":"Ellender","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0145","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1056\/NEJMoa0907006","article-title":"L-histidine decarboxylase and Tourette's syndrome","volume":"362","author":"Ercan-Sencicek","year":"2010","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.jneumeth.2017.07.025_bib0150","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/npp.2012.251","article-title":"A G(s DREADD mouse for selective modulation of cAMP production in striatopallidal neurons","volume":"38","author":"Farrell","year":"2013","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/j.jneumeth.2017.07.025_bib0155","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nn.2703","article-title":"Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitization","volume":"14","author":"Ferguson","year":"2011","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0160","doi-asserted-by":"crossref","first-page":"11668","DOI":"10.1523\/JNEUROSCI.4783-12.2013","article-title":"Direct-pathway striatal neurons regulate the retention of decision-making strategies","volume":"33","author":"Ferguson","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0165","first-page":"30015","article-title":"Assessment of gait and sensorimotor deficits in the D1CT-7 mouse model of Tourette syndrome","author":"Fowler","year":"2017","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0170","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s00213-013-2988-x","article-title":"An evaluation of the serotonin system and perseverative, compulsive, stereotypical, and hyperactive behaviors in dopamine transporter (DAT) knockout mice","volume":"227","author":"Fox","year":"2013","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0175","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.psyneuen.2012.07.014","article-title":"Inhibition of 5\u03b1-reductase attenuates behavioral effects of D1-, but not D2-like receptor agonists in C57BL\/6 mice","volume":"38","author":"Frau","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0180","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.psyneuen.2015.09.014","article-title":"The neurosteroidogenic enzyme 5\u03b1-reductase modulates the role of D1 dopamine receptors in rat sensorimotor gating","volume":"63","author":"Frau","year":"2016","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0185","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev-neuro-061010-113641","article-title":"Modulation of striatal projection systems by dopamine","volume":"34","author":"Gerfen","year":"2011","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0190","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1002\/mds.20044","article-title":"Association of cortical disinhibition with tic, ADHD and OCD severity in Tourette Syndrome","volume":"19","author":"Gilbert","year":"2004","journal-title":"Mov. Disord."},{"issue":"1","key":"10.1016\/j.jneumeth.2017.07.025_bib0195","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/WNF.0000000000000017","article-title":"A D1 receptor antagonist, ecopipam, for treatment of tics in Tourette syndrome","volume":"37","author":"Gilbert","year":"2014","journal-title":"Clin. Neuropharmacol."},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0200","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.neubiorev.2016.10.003","article-title":"What makes you tic? Translational approaches to study the role of stress and contextual triggers in Tourette syndrome","volume":"76","author":"Godar","year":"2017","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0205","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1111\/bph.13243","article-title":"The D1CT-7 mouse model of Tourette syndrome displays sensorimotor gating deficits in response to spatial confinement","volume":"173","author":"Godar","year":"2016","journal-title":"Br. J. Pharmacol."},{"issue":"5925","key":"10.1016\/j.jneumeth.2017.07.025_bib0210","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1126\/science.1167093","article-title":"Optical deconstruction of parkinsonian neural circuitry","volume":"324","author":"Gradinaru","year":"2009","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.jneumeth.2017.07.025_bib0215","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1089\/cap.2007.0021","article-title":"An open-label trial of riluzole, a glutamate antagonist, in children with treatment-resistant obsessive-compulsive disorder","volume":"17","author":"Grant","year":"2007","journal-title":"J. Child Adolesc. Psychopharmacol."},{"issue":"7","key":"10.1016\/j.jneumeth.2017.07.025_bib0220","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1001\/archgenpsychiatry.2009.60","article-title":"N-acetylcysteine, a glutamate modulator, in the treatment of trichotillomania: a double-blind, placebo-controlled study","volume":"66","author":"Grant","year":"2009","journal-title":"Arch. Gen. Psychiatry"},{"issue":"3","key":"10.1016\/j.jneumeth.2017.07.025_bib0225","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1177\/104012371402600304","article-title":"A single-blind study of \u2018as-needed' ecopipam for gambling disorder","volume":"26","author":"Grant","year":"2014","journal-title":"Ann. Clin. Psychiatry"},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0230","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1038\/ncomms3264","article-title":"Orbitofrontal and striatal circuits dynamically encode the shift between goal-directed and habitual actions","volume":"4","author":"Gremel","year":"2013","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.jneumeth.2017.07.025_bib0235","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.cell.2014.06.025","article-title":"State-dependent architecture of thalamic reticular subnetworks","volume":"158","author":"Halassa","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0240","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.neuron.2010.05.011","article-title":"Distinct roles of synaptic transmission in direct and indirect striatal pathways to reward and aversive behavior","volume":"66","author":"Hikida","year":"2010","journal-title":"Neuron"},{"issue":"June (6)","key":"10.1016\/j.jneumeth.2017.07.025_bib0245","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.neuron.2017.06.010","article-title":"Rare copy number variants in NRXN1 and CNTN6 increase risk for Tourette Syndrome","volume":"94","author":"Huang","year":"2017","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.jneumeth.2017.07.025_bib0250","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.pnpbp.2005.11.006","article-title":"Current animal models of obsessive compulsive disorder: a critical review","volume":"30","author":"Joel","year":"2006","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry."},{"issue":"37","key":"10.1016\/j.jneumeth.2017.07.025_bib0255","doi-asserted-by":"crossref","first-page":"13307","DOI":"10.1073\/pnas.0502624102","article-title":"Altered parvalbumin-positive neuron distribution in basal ganglia of individuals with Tourette syndrome","volume":"102","author":"Kalanithi","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0260","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1136\/jmedgenet-2013-101637","article-title":"Support of the histaminergic hypothesis in Tourette syndrome: association of the histamine decarboxylase gene in a large sample of families","volume":"50","author":"Karagiannidis","year":"2013","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0265","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/cne.22206","article-title":"Decreased number of parvalbumin and cholinergic interneurons in the striatum of individuals with Tourette syndrome","volume":"518","author":"Kataoka","year":"2010","journal-title":"J. Comp. Neurol."},{"issue":"9","key":"10.1016\/j.jneumeth.2017.07.025_bib0270","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/nmeth.2559","article-title":"Functional labeling of neurons and their projections using the synthetic activity-dependent promoter E-SARE","volume":"10","author":"Kawashima","year":"2013","journal-title":"Nat. Methods"},{"issue":"7306","key":"10.1016\/j.jneumeth.2017.07.025_bib0275","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/nature09159","article-title":"Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry","volume":"466","author":"Kravitz","year":"2010","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.jneumeth.2017.07.025_bib0280","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/s00213-005-0246-6","article-title":"N-acetylcysteine augmentation in serotonin reuptake inhibitor refractory obsessive-compulsive disorder","volume":"184","author":"Lafleur","year":"2006","journal-title":"Psychopharmacology (Berl.)"},{"issue":"1","key":"10.1016\/j.jneumeth.2017.07.025_bib0285","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1017\/S1461145705005729","article-title":"Repetitive transcranial magnetic stimulation (rTMS) in the treatment of obsessive-compulsive disorder (OCD) and Tourette's syndrome (TS)","volume":"9","author":"Mantovani","year":"2006","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0290","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1097\/00008877-199909000-00001","article-title":"Anxiety in a transgenic mouse model of cortical-limbic neuropotentiated compulsive behavior","volume":"10","author":"McGrath","year":"1999","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0295","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1037\/0735-7044.113.6.1249","article-title":"The role of cognitive and affective processing in a transgenic mouse model of cortical-limbic neuropotentiated compulsive behavior","volume":"113","author":"McGrath","year":"1999","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0300","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0006-8993(00)02646-9","article-title":"Glutamatergic drugs exacerbate symptomatic behavior in a transgenic model of comorbid Tourette's syndrome and obsessive-compulsive disorder","volume":"877","author":"McGrath","year":"2000","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.jneumeth.2017.07.025_bib0305","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.tics.2011.11.003","article-title":"Obsessive-compulsive disorder: beyond segregated cortico-striatal pathways","volume":"16","author":"Milad","year":"2012","journal-title":"Trends Cogn. Sci."},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0310","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jns.2003.12.006","article-title":"Increased prefrontal D2 protein in Tourette syndrome: a postmortem analysis of frontal cortex and striatum","volume":"219","author":"Minzer","year":"2004","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0315","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1002\/mds.23810","article-title":"A preliminary study of finasteride in Tourette syndrome","volume":"26","author":"Muroni","year":"2011","journal-title":"Mov. Disord."},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0320","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/sj.mp.4001144","article-title":"A transgenic model of comorbid Tourette's syndrome and obsessive-compulsive disorder circuitry","volume":"7","author":"Nordstrom","year":"2002","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0325","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.brainres.2015.09.032","article-title":"Hyperglutamatergic cortico-striato-thalamo-cortical circuit breaker drugs alleviate tics in a transgenic circuit model of Tourette's syndrome","volume":"1629","author":"Nordstrom","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0330","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.cell.2011.08.040","article-title":"Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits","volume":"147","author":"Penagarikano","year":"2011","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.jneumeth.2017.07.025_bib0335","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.pharmthera.2011.09.006","article-title":"Glutamate abnormalities in obsessive compulsive disorder: neurobiology, pathophysiology, and treatment","volume":"132","author":"Pittenger","year":"2011","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0340","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.expneurol.2015.01.001","article-title":"Corticostriatal interactions in the generation of tic-like behaviors after local striatal disinhibition","volume":"265","author":"Pogorelov","year":"2015","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0345","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1016\/j.euroneuro.2014.10.007","article-title":"Dysregulated intracellular signaling in the striatum in a pathophysiologically grounded model of Tourette syndrome","volume":"24","author":"Rapanelli","year":"2014","journal-title":"Eur. Neuropsychopharmacol."},{"issue":"January (1)","key":"10.1016\/j.jneumeth.2017.07.025_bib0350","doi-asserted-by":"crossref","first-page":"e1013","DOI":"10.1038\/tp.2016.290","article-title":"Histamine H3R receptor activation in the dorsal striatum triggers stereotypies in a mouse model of tic disorders","volume":"7","author":"Rapanelli","year":"2017","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0355","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1704547114","article-title":"Histamine modulation of the basal ganglia circuitry in the development of pathological grooming","author":"Rapanelli","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0360","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1093\/brain\/123.3.425","article-title":"Tourette syndrome, associated conditions and the complexities of treatment","volume":"123","author":"Robertson","year":"2000","journal-title":"Brain"},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0365","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1124\/pr.110.003020","article-title":"Remote control of neuronal signaling","volume":"63","author":"Rogan","year":"2011","journal-title":"Pharmacol. Rev."},{"issue":"9","key":"10.1016\/j.jneumeth.2017.07.025_bib0370","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1097\/00004583-200009000-00008","article-title":"Decrease in caudate glutamatergic concentrations in pediatric obsessive-compulsive disorder patients taking paroxetine","volume":"39","author":"Rosenberg","year":"2000","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"issue":"53","key":"10.1016\/j.jneumeth.2017.07.025_bib0375","doi-asserted-by":"crossref","first-page":"41501","DOI":"10.1074\/jbc.M110.177600","article-title":"Natural and engineered photoactivated nucleotidyl cyclases for optogenetic applications","volume":"285","author":"Ryu","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0380","series-title":"Dopamine Receptors and Transporters: Function, Imaging, and Clinical Implication","first-page":"369","article-title":"Dopaminergic neurotransmission in Tourette\u2019s syndrome: a current update","author":"Sah","year":"2002"},{"issue":"5","key":"10.1016\/j.jneumeth.2017.07.025_bib0385","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/nm.2125","article-title":"Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive-like behaviors in mice","volume":"16","author":"Shmelkov","year":"2010","journal-title":"Nat. Med."},{"issue":"5","key":"10.1016\/j.jneumeth.2017.07.025_bib0390","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.mehy.2009.11.028","article-title":"Glutamatergic modulatory therapy for Tourette syndrome","volume":"74","author":"Singer","year":"2010","journal-title":"Med. Hypotheses"},{"issue":"2","key":"10.1016\/j.jneumeth.2017.07.025_bib0395","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.neuron.2013.05.038","article-title":"A dual operator view of habitual behavior reflecting cortical and striatal dynamics","volume":"79","author":"Smith","year":"2013","journal-title":"Neuron"},{"issue":"46","key":"10.1016\/j.jneumeth.2017.07.025_bib0400","doi-asserted-by":"crossref","first-page":"18932","DOI":"10.1073\/pnas.1216264109","article-title":"Reversible online control of habitual behavior by optogenetic perturbation of medial prefrontal cortex","volume":"109","author":"Smith","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0405","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1146\/annurev-neuro-071013-014048","article-title":"Chemogenetic tools to interrogate brain functions","volume":"37","author":"Sternson","year":"2014","journal-title":"Annu. Rev. Neurosci."},{"issue":"2","key":"10.1016\/j.jneumeth.2017.07.025_bib0410","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1074\/jbc.M110.185496","article-title":"Light modulation of cellular cAMP by a small bacterial photoactivated adenylyl cyclase, bPAC, of the soil bacterium Beggiatoa","volume":"286","author":"Stierl","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0415","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1001\/archpsyc.1992.01820090018003","article-title":"Cerebral glucose metabolism in childhood-onset obsessive-compulsive disorder. Revisualization during pharmacotherapy","volume":"49","author":"Swedo","year":"1992","journal-title":"Arch. Gen. Psychiatry"},{"issue":"3","key":"10.1016\/j.jneumeth.2017.07.025_bib0420","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.pharmthera.2005.05.003","article-title":"Using animal models to develop therapeutics for Tourette Syndrome","volume":"108","author":"Swerdlow","year":"2005","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0425","first-page":"69","article-title":"Preclinical models relevant to Tourette syndrome","volume":"99","author":"Swerdlow","year":"2006","journal-title":"Adv. Neurol."},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0430","doi-asserted-by":"crossref","first-page":"62","DOI":"10.2174\/1875397300802010062","article-title":"Glutamatergic synaptic dysfunction and obsessive-compulsive disorder","volume":"2","author":"Ting","year":"2008","journal-title":"Curr. Chem. Genom."},{"issue":"5930","key":"10.1016\/j.jneumeth.2017.07.025_bib0435","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1126\/science.1168878","article-title":"Phasic firing in dopaminergic neurons is sufficient for behavioral conditioning","volume":"324","author":"Tsai","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0440","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0888-7543(03)00097-1","article-title":"Tourette Syndrome Association International Consortium for Genetics. CNTNAP2 is disrupted in a family with Gilles de la Tourette syndrome and obsessive compulsive disorder","volume":"82","author":"Verkerk","year":"2003","journal-title":"Genomics"},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0445","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.biopsych.2013.01.008","article-title":"Circuit-selective striatal synaptic dysfunction in the Sapap3 knockout mouse model of obsessive-compulsive disorder","volume":"75","author":"Wan","year":"2014","journal-title":"Biol. Psychiatry"},{"issue":"2","key":"10.1016\/j.jneumeth.2017.07.025_bib0450","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/FBP.0b013e32832a80ad","article-title":"Assessing the validity of current mouse genetic models of obsessive\u2013compulsive disorder","volume":"20","author":"Wang","year":"2009","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0455","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1176\/appi.ajp.2011.09111692","article-title":"The neural circuits that generate tics in Tourette's syndrome","volume":"168","author":"Wang","year":"2011","journal-title":"Am. J. Psychiatry"},{"issue":"7156","key":"10.1016\/j.jneumeth.2017.07.025_bib0460","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nature06104","article-title":"Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice","volume":"448","author":"Welch","year":"2007","journal-title":"Nature"},{"issue":"6011","key":"10.1016\/j.jneumeth.2017.07.025_bib0465","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1126\/science.1193771","article-title":"Cholinergic interneurons control local circuit activity and cocaine conditioning","volume":"330","author":"Witten","year":"2010","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.jneumeth.2017.07.025_bib0470","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.pbb.2011.10.007","article-title":"The role of glutamate signaling in the pathogenesis and treatment of obsessive-compulsive disorder","volume":"100","author":"Wu","year":"2012","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0475","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1073\/pnas.1419533112","article-title":"Targeted ablation of cholinergic interneurons in the dorsolateral striatum produces behavioral manifestations of Tourette syndrome","volume":"112","author":"Xu","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0480","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.neulet.2015.03.067","article-title":"Histidine decarboxylase knockout mice, a genetic model of Tourette syndrome, show repetitive grooming after induced fear","volume":"595","author":"Xu","year":"2015","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0485","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.1210\/endo.138.8.5347","article-title":"Thyroid-specific expression of cholera toxin A1 subunit causes thyroid hyperplasia and hyperthyroidism in transgenic mice","volume":"138","author":"Zeiger","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.jneumeth.2017.07.025_bib0490","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1176\/ajp.154.9.1277","article-title":"Decreased motor inhibition in Tourette's disorder: evidence from transcranial magnetic stimulation","volume":"154","author":"Ziemann","year":"1997","journal-title":"Am. J. Psychiatry"}],"container-title":["Journal of Neuroscience Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165027017302698?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165027017302698?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T00:42:49Z","timestamp":1759020169000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165027017302698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":98,"alternative-id":["S0165027017302698"],"URL":"https:\/\/doi.org\/10.1016\/j.jneumeth.2017.07.025","relation":{},"ISSN":["0165-0270"],"issn-type":[{"value":"0165-0270","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Back to the Future: Circuit-testing TS & OCD","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroscience Methods","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneumeth.2017.07.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Author. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}