{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T21:06:19Z","timestamp":1789938379553,"version":"4.0.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61527815"],"award-info":[{"award-number":["61527815"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61601435"],"award-info":[{"award-number":["61601435"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61501426"],"award-info":[{"award-number":["61501426"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31500800"],"award-info":[{"award-number":["31500800"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61471342"],"award-info":[{"award-number":["61471342"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61673024"],"award-info":[{"award-number":["61673024"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key R&D Program of China","award":["2017YFA0205900"],"award-info":[{"award-number":["2017YFA0205900"]}]},{"name":"Beijing Science and Technology Plan","award":["Z161100004916001"],"award-info":[{"award-number":["Z161100004916001"]}]},{"name":"Strategic Priority Research Program and Frontier Science Key Research Project of Chinese Academy of Sciences","award":["XDA16020902"],"award-info":[{"award-number":["XDA16020902"]}]},{"name":"Strategic Priority Research Program and Frontier Science Key Research Project of Chinese Academy of Sciences","award":["QYZDJ-SSW-SYS015"],"award-info":[{"award-number":["QYZDJ-SSW-SYS015"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroscience Methods"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.jneumeth.2018.04.015","type":"journal-article","created":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T13:07:32Z","timestamp":1524488852000},"page":"83-91","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["An integrated system for synchronous detection of neuron spikes and dopamine activities in the striatum of Parkinson monkey brain"],"prefix":"10.1016","volume":"304","author":[{"given":"Shengwei","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guihua","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mixia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilin","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5040-6696","authenticated-orcid":false,"given":"Ziyue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piu","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoxian","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxia","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jneumeth.2018.04.015_bib0005","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1152\/jn.1994.72.2.507","article-title":"The primate subthalamic nucleus. ii. neuronal activity in the mptp model of parkinsonism","volume":"72","author":"Bergman","year":"1994","journal-title":"J. Neurophysiol."},{"issue":"1","key":"10.1016\/j.jneumeth.2018.04.015_bib0010","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0306-4522(00)00546-7","article-title":"Pallidal border cells: an anatomical and electrophysiological study in the mptp-treated monkey","volume":"103","author":"Bezard","year":"2001","journal-title":"Neuroscience"},{"issue":"36","key":"10.1016\/j.jneumeth.2018.04.015_bib0015","doi-asserted-by":"crossref","first-page":"15927","DOI":"10.1073\/pnas.1010356107","article-title":"Neuron densities vary across and within cortical areas in primates","volume":"107","author":"Collins","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jneumeth.2018.04.015_bib0020","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jneumeth.2015.07.009","article-title":"A multi-site array for combined local electrochemistry and electrophysiology in the non-human primate brain","volume":"255","author":"Disney","year":"2015","journal-title":"J. Neurosci. Methods"},{"issue":"2","key":"10.1016\/j.jneumeth.2018.04.015_bib0025","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0306-4522(00)00060-9","article-title":"Neurochemical and electrophysiological studies on the functional significance of burst firing in serotonergic neurons","volume":"98","author":"Gartside","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.jneumeth.2018.04.015_bib0030","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0956-5663(01)00169-5","article-title":"General purpose, field-portable cell-based biosensor platform","volume":"16","author":"Gilchrist","year":"2001","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.jneumeth.2018.04.015_bib0035","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0956-5663(01)00167-1","article-title":"Design and demonstration of an automated cell-based biosensor","volume":"16","author":"Gray","year":"2001","journal-title":"Biosens. Bioelectron."},{"issue":"7","key":"10.1016\/j.jneumeth.2018.04.015_bib0040","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.tins.2007.05.004","article-title":"Pathological synchronization in parkinson\u2019s disease: networks, models and treatments","volume":"30","author":"Hammond","year":"2007","journal-title":"Trends Neurosci."},{"issue":"2","key":"10.1016\/j.jneumeth.2018.04.015_bib0045","article-title":"Movement disorders in 2016: progress in parkinson disease and other movement disorders","volume":"13","author":"Jankovic","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.jneumeth.2018.04.015_bib0050","first-page":"7325","article-title":"Neural probes for concurrent detection of neurochemical and electrophysiological signals in vivo","author":"Johnson","year":"2005","journal-title":"Conference Proceedings\u2014IEEE Engineering in Medicine and Biology Society"},{"issue":"1","key":"10.1016\/j.jneumeth.2018.04.015_bib0055","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jneumeth.2008.06.036","article-title":"Implantable microelectrode arrays for simultaneous electrophysiological and neurochemical recordings","volume":"174","author":"Johnson","year":"2008","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.jneumeth.2018.04.015_bib0060","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0924-4247(97)80221-X","article-title":"Plasmaetched neural probes","volume":"58","author":"Kewley","year":"1997","journal-title":"Sens. Actuators A"},{"issue":"19","key":"10.1016\/j.jneumeth.2018.04.015_bib0065","doi-asserted-by":"crossref","first-page":"11041","DOI":"10.1073\/pnas.1934665100","article-title":"Chronic, multisite, multielectrode recordings in macaque monkeys","volume":"100","author":"Miguel","year":"2003","journal-title":"Proc. Natl. Acad. Sci U. S. A."},{"key":"10.1016\/j.jneumeth.2018.04.015_bib0070","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0165-0270(94)00178-J","article-title":"Multi-electrode array for measuring evoked potentials from surface of ferret primary auditory cortex","volume":"58","author":"Owens","year":"1995","journal-title":"J. Neurosci. Methods"},{"issue":"11","key":"10.1016\/j.jneumeth.2018.04.015_bib0075","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/S0956-5663(03)00092-7","article-title":"A portable microelectrode array recording system incorporating cultured neuronal networks for neurotoxin detection","volume":"18","author":"Pancrazio","year":"2003","journal-title":"Biosens. Bioelectron."},{"issue":"2","key":"10.1016\/j.jneumeth.2018.04.015_bib0080","first-page":"111","article-title":"The dopaminergic nigropallidal projection in primates: distinct cellular origin and relative sparing in mptp-treated monkeys","volume":"53","author":"Parent","year":"1990","journal-title":"Adv. Neurol."},{"key":"10.1016\/j.jneumeth.2018.04.015_bib0085","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jcis.2016.10.024","article-title":"A simple preparation of graphite\/gelatin composite for electrochemical detection of dopamine","volume":"487","author":"Rajkumar","year":"2016","journal-title":"J. Colloid Interface Sci."},{"issue":"Pt 6","key":"10.1016\/j.jneumeth.2018.04.015_bib0090","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1093\/brain\/awh445","article-title":"Depression in parkinson\u2019s disease: loss of dopamine and noradrenaline innervation in the limbic system","volume":"128","author":"Remy","year":"2005","journal-title":"Brain J. Neurol."},{"issue":"2","key":"10.1016\/j.jneumeth.2018.04.015_bib0095","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/0006-8993(91)90318-P","article-title":"Relative sparing of the dopaminergic innervation of the globus pallidus in monkeys made hemi-parkinsonian by intracarotid mptp infusion","volume":"556","author":"Schneider","year":"1991","journal-title":"Brain Res."},{"issue":"6","key":"10.1016\/j.jneumeth.2018.04.015_bib0100","doi-asserted-by":"crossref","first-page":"3740","DOI":"10.1152\/jn.00544.2009","article-title":"The subthalamic nucleus in primary dystonia: single-unit discharge characteristics","volume":"102","author":"Schrock","year":"2009","journal-title":"J. Neurophysiol."},{"issue":"1","key":"10.1016\/j.jneumeth.2018.04.015_bib0105","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.snb.2006.05.013","article-title":"Design and construction of a low cost single-supply embedded telemetry system for amperometric biosensor applications","volume":"122","author":"Serra","year":"2007","journal-title":"Sens. Actuators B Chemical"},{"issue":"2012","key":"10.1016\/j.jneumeth.2018.04.015_bib0110","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.bios.2012.05.011","article-title":"A novel dual mode microelectrode array for neuroelectrical and neurochemical recording in vitro","volume":"38","author":"Song","year":"2012","journal-title":"Biosens. Bioelectron."},{"issue":"5","key":"10.1016\/j.jneumeth.2018.04.015_bib0115","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1152\/jn.90574.2008","article-title":"Neuronal activity of the human subthalamic nucleus in the parkinsonian and nonparkinsonian state","volume":"100","author":"Steigerwald","year":"2008","journal-title":"J. Neurophysiol."},{"issue":"185","key":"10.1016\/j.jneumeth.2018.04.015_bib0120","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.jneumeth.2009.10.008","article-title":"Real-time glutamate measurements in the putamen of awake rhesus monkeys using an enzyme-based human microelectrode array prototype","volume":"185","author":"Stephens","year":"2010","journal-title":"J. Neurosci. Methods"},{"issue":"4","key":"10.1016\/j.jneumeth.2018.04.015_bib0125","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1109\/TNSRE.2005.857687","article-title":"Reliability of signals from a chronically implanted, silicon-based electrode array in non-human primate primary motor cortex","volume":"13","author":"Suner","year":"2005","journal-title":"IEEE Trans. Neural Syst. Rehabil. Eng."},{"key":"10.1016\/j.jneumeth.2018.04.015_bib0130","doi-asserted-by":"crossref","first-page":"438","DOI":"10.3389\/fnins.2016.00438","article-title":"Trends and challenges in neuroengineering: toward intelligent neuroprostheses through brain- brain inspired systems communication","volume":"10","author":"Vassanelli","year":"2016","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.jneumeth.2018.04.015_bib0135","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jneumeth.2017.08.015","article-title":"A high-sensitive nano-modified biosensor for dynamic monitoring of glutamate and neural spike covariation from rat cortex to hippocampal sub-regions","volume":"291","author":"Xiao","year":"2017","journal-title":"J. Neurosci. Methods"},{"issue":"9","key":"10.1016\/j.jneumeth.2018.04.015_bib0140","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1016\/S1872-2040(16)60959-3","article-title":"Synchronous detection of rat neural spike firing and neurochemical signals based on dual-mode recording instrument","volume":"44","author":"Xu","year":"2016","journal-title":"Chin. J. Anal. Chem."},{"issue":"10","key":"10.1016\/j.jneumeth.2018.04.015_bib0145","doi-asserted-by":"crossref","first-page":"6227","DOI":"10.1073\/pnas.1034823100","article-title":"Behavioral, neurochemical, and electrophysiological characterization of a genetic mouse model of depression","volume":"100","author":"Yacoubi","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.jneumeth.2018.04.015_bib0150","first-page":"30","article-title":"Cell and neuron densities in the primary motor cortex of primates","volume":"7","author":"Young","year":"2013","journal-title":"Front. Neural Circuits"},{"key":"10.1016\/j.jneumeth.2018.04.015_bib0155","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.bios.2016.04.087","article-title":"A silicon based implantable microelectrode array for electrophysiological and dopamine recording from cortex to striatum in the non-human primate brain","volume":"85","author":"Zhang","year":"2016","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.jneumeth.2018.04.015_bib0160","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.brainres.2009.06.069","article-title":"Long term high frequency stimulation of stn increases dopamine in the corpus striatum of hemiparkinsonian rhesus monkey","volume":"1286","author":"Zhao","year":"2009","journal-title":"Brain Res."}],"container-title":["Journal of Neuroscience Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165027018301183?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165027018301183?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T00:45:28Z","timestamp":1759020328000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165027018301183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":32,"alternative-id":["S0165027018301183"],"URL":"https:\/\/doi.org\/10.1016\/j.jneumeth.2018.04.015","relation":{},"ISSN":["0165-0270"],"issn-type":[{"value":"0165-0270","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An integrated system for synchronous detection of neuron spikes and dopamine activities in the striatum of Parkinson monkey brain","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroscience Methods","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneumeth.2018.04.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}