{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T02:30:00Z","timestamp":1780108200777,"version":"3.54.0"},"reference-count":88,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001655","name":"DAAD","doi-asserted-by":"crossref","award":["57129429"],"award-info":[{"award-number":["57129429"]}],"id":[{"id":"10.13039\/501100001655","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100013278","name":"JPND","doi-asserted-by":"crossref","award":["01ED1501C"],"award-info":[{"award-number":["01ED1501C"]}],"id":[{"id":"10.13039\/100013278","id-type":"DOI","asserted-by":"crossref"}]},{"name":"DFG","award":["ES 434\/8-1"],"award-info":[{"award-number":["ES 434\/8-1"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroscience Methods"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.jneumeth.2019.108367","type":"journal-article","created":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T11:13:25Z","timestamp":1563966805000},"page":"108367","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Systematic data analysis and data mining in CatWalk gait analysis by heat mapping exemplified in rodent models for neurodegenerative diseases"],"prefix":"10.1016","volume":"326","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3923-9073","authenticated-orcid":false,"given":"Ivanna K.","family":"Timotius","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Canneva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Minakaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Moceri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Christine","family":"Plank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Casadei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Riess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Winkler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Klucken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjoern","family":"Eskofier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6409-0664","authenticated-orcid":false,"given":"Stephan","family":"von H\u00f6rsten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jneumeth.2019.108367_bib0005","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.bbr.2012.10.039","article-title":"Motor, emotional and cognitive deficits in adult BACHD mice: a model for Huntington\u2019s disease","volume":"238","author":"Abada","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0010","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0896-6273(00)80886-7","article-title":"Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system","volume":"25","author":"Abeliovich","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.jneumeth.2019.108367_bib0015","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.neuron.2014.09.005","article-title":"Toward a science of computational ethology","volume":"84","author":"Anderson","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.jneumeth.2019.108367_bib0020","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1046\/j.1475-1313.2000.00502.x","article-title":"An introduction to analysis of variance (ANOVA) with special reference to data from clinical experiments in optometry","volume":"20","author":"Armstrong","year":"2000","journal-title":"Ophthalmic Physiol. Opt."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0025","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s12883-017-0941-z","article-title":"Comprehensive catwalk gait analysis in a chronic model of multiple sclerosis subjected to treadmill exercise training","volume":"17","author":"Bernardes","year":"2017","journal-title":"BMC Neurol."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0030","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.neubiorev.2017.09.007","article-title":"Functional gait analysis in a spinal contusion rat model","volume":"83","author":"Bhimani","year":"2017","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0035","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.heliyon.2018.e00540","article-title":"Motor deficits following dorsal corticospinal tract transection in rats: voluntary versus skilled locomotion readouts","volume":"4","author":"Bieler","year":"2018","journal-title":"Heliyon"},{"key":"10.1016\/j.jneumeth.2019.108367_bib0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnbeh.2018.00039","article-title":"Gait analysis for early detection of motor symptoms in the 6-OHDA rat model of Parkinson\u2019s disease","volume":"12","author":"Boix","year":"2018","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0045","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1093\/hmg\/ddt467","article-title":"Overexpression of synphilin-1 promotes clearance of soluble and misfolded alpha-synuclein without restoring the motor phenotype in aged A30P transgenic mice","volume":"23","author":"Casadei","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0050","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jneumeth.2017.03.017","article-title":"Establishing a reliable gait evaluation method for rodent studies","volume":"283","author":"Chen","year":"2017","journal-title":"J. Neurosci. Methods"},{"issue":"62","key":"10.1016\/j.jneumeth.2019.108367_bib0055","article-title":"Detection of subtle neurological alterations by the Catwalk XT gait analysis system","volume":"11","author":"Chen","year":"2014","journal-title":"J. Neuroeng. Rehabil."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0060","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1038\/nn.2401","article-title":"Transformation of nonfunctional spinal circuits into functional states after the loss of brain input","volume":"12","author":"Courtine","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0065","doi-asserted-by":"crossref","DOI":"10.1186\/s12883-014-0161-8","article-title":"Gait in Huntington\u2019s disease and the stride length-cadence relationship","volume":"14","author":"Danoudis","year":"2014","journal-title":"BMC Neurol."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/6276348","article-title":"Use of the CatWalk gait device to assess differences in locomotion between genders in rats inherently and following spinal cord injury","volume":"2016","author":"Datto","year":"2016","journal-title":"Dataset Pap. Sci."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0075","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.bbr.2015.09.006","article-title":"Gait analysis in a mouse model resembling Leigh disease","volume":"296","author":"de Haas","year":"2016","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0080","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/0047-259X(71)90006-6","article-title":"An overview of multivariate data analysis","volume":"1","author":"Dempster","year":"1971","journal-title":"J. Multivar. Anal."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0085","first-page":"1","article-title":"The need for reporting negative results \u2013 a 90 year update","volume":"3","author":"Earp","year":"2017","journal-title":"J. Clin. Transl. Res."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0090","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1037\/a0015808","article-title":"An effect size primer: a guide for clinicians and researchers","volume":"40","author":"Ferguson","year":"2009","journal-title":"Prof. Psychol. Res. Pract."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0095","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1093\/ilar.43.4.244","article-title":"Guidelines for the design and statistical analysis of experiments using laboratory animals","volume":"43","author":"Festing","year":"2002","journal-title":"ILAR J."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0100","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1017\/S0021859600003750","article-title":"Studies in crop variation. I. An examination of the yield of dressed grain from broadbalk","volume":"11","author":"Fisher","year":"1921","journal-title":"J. Agric. Sci."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0105","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.bbr.2017.11.025","article-title":"Alpha-synuclein transgenic mice, h-alpha-synL62, display alpha-Syn aggregation and a dopaminergic phenotype reminiscent of Parkinson\u2019s disease","volume":"339","author":"Frahm","year":"2018","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0110","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1109\/TBME.2017.2701204","article-title":"A machine learning approach to automated gait analysis for the Noldus Catwalk system","volume":"65","author":"Fr\u00f6hlich","year":"2018","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0115","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1089\/neu.2013.3162","article-title":"Progesterone reduces secondary damage, preserves white matter, and improves locomotor outcome after spinal cord contusion","volume":"31","author":"Garcia-Ovejero","year":"2014","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.jneumeth.2019.108367_bib0120","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nmeth.1902","article-title":"Heat maps","volume":"9","author":"Gehlenborg","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jneumeth.2019.108367_bib0125","doi-asserted-by":"crossref","first-page":"6182","DOI":"10.1523\/JNEUROSCI.0857-08.2008","article-title":"Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD Mice","volume":"28","author":"Gray","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0130","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1089\/neu.2006.23.537","article-title":"CatWalk-assisted gait analysis in the assessment of spinal cord injury","volume":"23","author":"Hamers","year":"2006","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.jneumeth.2019.108367_bib0135","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1089\/08977150150502613","article-title":"Automated quantitative gait analysis during overground locomotion in the rat: its application to spinal cord contusion and transection injuries","volume":"18","author":"Hamers","year":"2001","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.jneumeth.2019.108367_bib0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2014.10.027","article-title":"Intrathecal injection of a therapeutic gene-containing polyplex to treat spinal cord injury","volume":"197","author":"Hayakawa","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jneumeth.2019.108367_bib0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pbio.1002106","article-title":"The extent and consequences of P-Hacking in science","volume":"13","author":"Head","year":"2015","journal-title":"PLoS Biol."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0150","article-title":"Fine motor kinematic analysis in R6\/2 mouse model of huntington\u2019 s disease : capturing dyskinesia-like movement as a component of progressive motor deficits","volume":"399","author":"Heikkinen","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.jneumeth.2019.108367_bib0155","first-page":"5","article-title":"Use of high precision kinematic analysis to assess pharmacologically- induced motor impairment in mice","volume":"399","author":"Heikkinen","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.jneumeth.2019.108367_bib0160","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1089\/neu.2006.23.18","article-title":"Profound differences in spontaneous long-term functional recovery after defined spinal tract lesions in the rat","volume":"23","author":"Hendriks","year":"2006","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.jneumeth.2019.108367_bib0165","doi-asserted-by":"crossref","DOI":"10.1186\/s12868-016-0317-0","article-title":"CatWalk gait analysis in a rat model of multiple sclerosis","volume":"17","author":"Herold","year":"2016","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0170","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/path.4511","article-title":"X-linked spinal muscular atrophy in mice caused by autonomous loss of ATP7A in the motor neuron","volume":"236","author":"Hodgkinson","year":"2015","journal-title":"J. Pathol."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0175","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jtcvs.2015.09.085","article-title":"A systematic approach to initial data analysis is good research practice","volume":"151","author":"Huebner","year":"2016","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0180","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ejphar.2014.05.048","article-title":"Efficacy of drugs with different mechanisms of action in relieving spontaneous pain at rest and during movement in a rat model of osteoarthritis","volume":"738","author":"Ishikawa","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0185","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1136\/jnnp.2007.131045","article-title":"Parkinson\u2019s disease: clinical features and diagnosis","volume":"79","author":"Jankovic","year":"2008","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jneumeth.2019.108367_bib0190","first-page":"151","article-title":"Contradicting\/negative results in clinical research: why (do we get these)? Why not (get these published)? Where (to publish)? Perspect","volume":"5","author":"Kannan","year":"2014","journal-title":"Clin. Res."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/brb3.723","article-title":"Validity and reliability of the CatWalk system as a static and dynamic gait analysis tool for the assessment of functional nerve recovery in small animal models","volume":"7","author":"Kappos","year":"2017","journal-title":"Brain Behav."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0200","first-page":"1","article-title":"Longitudinal assessment of deliberate mouse behavior in the home cage and attached environments: relevance to anxiety and mood disorders","volume":"2","author":"Kas","year":"2011","journal-title":"Neuromethods"},{"key":"10.1016\/j.jneumeth.2019.108367_bib0205","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.nbd.2015.10.021","article-title":"Severely impaired hippocampal neurogenesis associates with an early serotonergic deficit in a BAC \u03b1-synuclein transgenic rat model of Parkinson\u2019s disease","volume":"85","author":"Kohl","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0210","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.physbeh.2007.07.018","article-title":"Strain and locomotor speed affect over-ground locomotion in intact rats","volume":"92","author":"Koopmans","year":"2007","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0215","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jneumeth.2015.12.001","article-title":"Automated quantitative analysis to assess motor function in different rat models of impaired coordination and ataxia","volume":"268","author":"Kyriakou","year":"2016","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.jneumeth.2019.108367_bib0220","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1016\/j.joca.2016.03.008","article-title":"Gait analysis methods for rodent models of arthritic disorders: reviews and recommendations","volume":"24","author":"Lakes","year":"2016","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0225","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1016\/S0140-6736(09)60492-X","article-title":"Parkinson\u2019s disease","volume":"373","author":"Lees","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.jneumeth.2019.108367_bib0230","series-title":"Atlas statistique de la population de Paris","author":"Loua","year":"1873"},{"key":"10.1016\/j.jneumeth.2019.108367_bib0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.07892","article-title":"A quantitative framework for whole-body coordination reveals specific deficits in freely walking ataxic mice","volume":"4","author":"Machado","year":"2015","journal-title":"Elife"},{"key":"10.1016\/j.jneumeth.2019.108367_bib0240","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0093121","article-title":"Enriched housing enhances recovery of limb placement ability and reduces aggrecan-containing perineuronal nets in the rat somatosensory cortex after experimental stroke","volume":"9","author":"Madinier","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jneumeth.2019.108367_bib0245","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.3037-17.2018","article-title":"miR126-5p down-regulation facilitates axon degeneration and NMJ disruption via a non-cell-autonomous mechanism in ALS","author":"Maimon","year":"2018","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0250","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ejvs.2015.08.007","article-title":"Scientific methods and the reporting of negative results: critically important to patient safety","volume":"51","author":"Mastracci","year":"2016","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0255","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/ene.13413","article-title":"Huntington\u2019s disease: a clinical review","volume":"25","author":"McColgan","year":"2018","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0260","series-title":"Handbook of Biological Statistics","author":"Mcdonald","year":"2008"},{"key":"10.1016\/j.jneumeth.2019.108367_bib0265","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.bbr.2018.11.035","article-title":"Treadmill exercise intervention improves gait and postural control in alpha-synuclein mouse models without inducing cerebral autophagy","volume":"363","author":"Minakaki","year":"2019","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0270","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1097\/BRS.0b013e318299536a","article-title":"Assessment of pain behavior in a rat model of intervertebral disc injury using the catwalk gait analysis system","volume":"38","author":"Miyagi","year":"2013","journal-title":"Spine (Phila. Pa. 1976)"},{"key":"10.1016\/j.jneumeth.2019.108367_bib0275","series-title":"Advances in Alzheimer\u2019S and Parkinson\u2019S Therapies an AAT-AD\/PD Focus Meeting. Torino, Italy","article-title":"Association of early phenotypic behavioral alterations in human \u03b1-synuclein overexpressing transgenic rats with \u03b1-synuclein\/huntingtin\/amyloid-\u03b2 protein cross-seeding","author":"Moceri","year":"2018"},{"key":"10.1016\/j.jneumeth.2019.108367_bib0280","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1089\/neu.2014.3792","article-title":"A cervical hemi-contusion spinal cord injury model for the investigation of novel therapeutics targeting proximal and distal forelimb functional recovery","volume":"32","author":"Mondello","year":"2015","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.jneumeth.2019.108367_bib0285","series-title":"CatWalk XT Version 10.0. Reference Manual","author":"Noldus Information Technology b.v","year":"2012"},{"key":"10.1016\/j.jneumeth.2019.108367_bib0290","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/brain\/aws358","article-title":"A progressive dopaminergic phenotype associated with neurotoxic conversion of a-synuclein in BAC-transgenic rats","volume":"136","author":"Nuber","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.jneumeth.2019.108367_bib0295","article-title":"Assessment of gait deficiencies to provide a functional endpoint in the spinal nerve ligation model and spared nerve injury model in rats","volume":"63","author":"Nurmi","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.jneumeth.2019.108367_bib0300","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.gene.2013.11.091","article-title":"Pain assessment in animal models of osteoarthritis","volume":"537","author":"Piel","year":"2014","journal-title":"Gene"},{"key":"10.1016\/j.jneumeth.2019.108367_bib0305","doi-asserted-by":"crossref","first-page":"10710","DOI":"10.1523\/JNEUROSCI.0433-14.2014","article-title":"Knock-in of human BACE1 cleaves murine APP and teiterates Alzheimer-like phenotypes","volume":"34","author":"Pluci\u0144ska","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0310","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1523\/JNEUROSCI.4140-13.2014","article-title":"An adaptive role for BDNF Val66Met polymorphism in motor recovery in chronic stroke","volume":"34","author":"Qin","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0315","doi-asserted-by":"crossref","first-page":"633","DOI":"10.5005\/jp-journals-10024-2097","article-title":"P-hacking","volume":"18","author":"Raj","year":"2017","journal-title":"J. Contemp. Dent. Pract."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0320","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1750-1172-5-40","article-title":"Huntington\u2019s disease: a clinical review","volume":"5","author":"Roos","year":"2010","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0325","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1111\/jnc.12813","article-title":"Diet-induced obesity accelerates the onset of terminal phenotypes in \u03b1-synuclein transgenic mice","volume":"131","author":"Rotermund","year":"2014","journal-title":"J. Neurochem."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0330","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.nbd.2014.09.013","article-title":"AAV.shRNA-mediated downregulation of ROCK2 attenuates degeneration of dopaminergic neurons in toxin-induced models of Parkinson\u2019s disease in vitro and in vivo","volume":"73","author":"Saal","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0335","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.nbd.2014.04.005","article-title":"RNAi silencing of P\/Q-type calcium channels in Purkinje neurons of adult mouse leads to episodic ataxia type 2","volume":"68","author":"Salvi","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0340","doi-asserted-by":"crossref","first-page":"279","DOI":"10.4300\/JGME-D-12-00156.1","article-title":"Using effect size-or why the P value is not enough","author":"Sullivan","year":"2012","journal-title":"J. Grad. Med. Educ."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0345","article-title":"Fine motor kinematic analysis in the MDX mouse model of duchenne muscular dystrophy a longitudinal study of chronically exercised VS non-exercised MDX mice","volume":"339","author":"Sweeney","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.jneumeth.2019.108367_bib0350","doi-asserted-by":"crossref","DOI":"10.1186\/s40478-016-0310-y","article-title":"Fasudil attenuates aggregation of \u03b1-synuclein in models of Parkinson\u2019s disease","volume":"4","author":"Tatenhorst","year":"2016","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0355","first-page":"60","article-title":"Predicting receiver operating characteristic curve, Area under curve, and arithmetic means of accuracies based on the distribution of data samples","author":"Timotius","year":"2013","journal-title":"Int. Conf. on Control, Systems and Industrial Informatics (ICCSII)"},{"key":"10.1016\/j.jneumeth.2019.108367_bib0360","first-page":"43","article-title":"Systematic data analysis and data mining in gait analysis by heat mapping","author":"Timotius","year":"2018","journal-title":"11th International Conference on Methods and Techniques in Behavioral Research (Measuring Behavior 2018)"},{"key":"10.1016\/j.jneumeth.2019.108367_bib0365","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.dib.2017.12.067","article-title":"Dynamic footprints of \u03b1-synucleinopathic mice recorded by CatWalk gait analysis","volume":"17","author":"Timotius","year":"2018","journal-title":"Data Br."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0370","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneumeth.2017.12.004","article-title":"Dynamic footprint based locomotion sway assessment in \u03b1-synucleinopathic mice using Fast Fourier Transform and Low Pass Filter","volume":"296","author":"Timotius","year":"2018","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.jneumeth.2019.108367_bib0375","doi-asserted-by":"crossref","unstructured":"Timotius, I.K., Moceri, S., Plank, A.-C., Habermeyer, J., Canneva, F., Winkler, J., Klucken, J., Casadei, N., Riess, O., Eskofier, B., von H\u00f6rsten, S., 2019. Silhouette-length-scaled gait parameters for motor functional analysis in mice and rats. (submitted for publication).","DOI":"10.1523\/ENEURO.0100-19.2019"},{"key":"10.1016\/j.jneumeth.2019.108367_bib0380","article-title":"Using estimated arithmetic means of accuracies to select features for face-based gender classification","volume":"2013","author":"Timotius","year":"2013","journal-title":"Proceedings - 2013 International Conference on Information Technology and Electrical Engineering: \u201cIntelligent and Green Technologies for Sustainable Development\u201d"},{"key":"10.1016\/j.jneumeth.2019.108367_bib0385","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S1474-4422(05)70285-4","article-title":"The diagnosis of Parkinson\u2019s disease","volume":"5","author":"Tolosa","year":"2006","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0390","doi-asserted-by":"crossref","first-page":"e267","DOI":"10.1371\/journal.pmed.0020267","article-title":"Data cleaning: detecting, diagnosing, and editing data abnormalities","volume":"2","author":"Van den Broeck","year":"2005","journal-title":"PLoS Med."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0395","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2202-11-92","article-title":"Automated quantitative gait analysis in animal models of movement disorders","volume":"11","author":"Vandeputte","year":"2010","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0400","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.neuroscience.2007.06.043","article-title":"High frequency stimulation of the subthalamic nucleus improves speed of locomotion but impairs forelimb movement in Parkinsonian rats","volume":"148","author":"Vlamings","year":"2007","journal-title":"Neuroscience"},{"issue":"142","key":"10.1016\/j.jneumeth.2019.108367_bib0405","article-title":"Quantitative assessment of gait and neurochemical correlation in a classical murine model of Parkinson\u2019s disease","volume":"13","author":"Wang","year":"2012","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0410","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2018.00112","article-title":"Environmental enrichment prevents transcriptional disturbances induced by alpha-synuclein overexpression","volume":"12","author":"Wassouf","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0415","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1126\/science.1151888","article-title":"A postgenomic visual icon","volume":"319","author":"Weinstein","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.jneumeth.2019.108367_bib0420","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.bbr.2011.10.006","article-title":"Automated gait analysis in bilateral Parkinsonian rats and the role of l-DOPA therapy","volume":"226","author":"Westin","year":"2012","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0425","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1198\/tas.2009.0033","article-title":"The history of the cluster heat map","volume":"63","author":"Wilkinson","year":"2009","journal-title":"Am. Stat."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0430","article-title":"Behavioral characterization of the cuprizone model of demyelination in mice","author":"Zainana","year":"2015","journal-title":"45th annual meeting of the Society for Neuroscience (Neuroscience 2015)"},{"key":"10.1016\/j.jneumeth.2019.108367_bib0435","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.neulet.2014.10.032","article-title":"Gait analysis in three different 6-hydroxydopamine rat models of Parkinson\u2019s disease","volume":"584","author":"Zhou","year":"2015","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jneumeth.2019.108367_bib0440","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jneumeth.2017.05.005","article-title":"Analysis of locomotor behavior in the German mouse clinic","volume":"300","author":"Zimprich","year":"2018","journal-title":"J. Neurosci. Methods"}],"container-title":["Journal of Neuroscience Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165027019302249?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165027019302249?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T00:50:48Z","timestamp":1759020648000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165027019302249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":88,"alternative-id":["S0165027019302249"],"URL":"https:\/\/doi.org\/10.1016\/j.jneumeth.2019.108367","relation":{},"ISSN":["0165-0270"],"issn-type":[{"value":"0165-0270","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systematic data analysis and data mining in CatWalk gait analysis by heat mapping exemplified in rodent models for neurodegenerative diseases","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroscience Methods","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneumeth.2019.108367","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108367"}}