{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T05:51:21Z","timestamp":1783749081894,"version":"3.55.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004488","name":"Hrvatska Zaklada za Znanost","doi-asserted-by":"publisher","award":["IP-2019-04-3584"],"award-info":[{"award-number":["IP-2019-04-3584"]}],"id":[{"id":"10.13039\/501100004488","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004488","name":"Hrvatska Zaklada za Znanost","doi-asserted-by":"publisher","award":["IP-2014-09-9730"],"award-info":[{"award-number":["IP-2014-09-9730"]}],"id":[{"id":"10.13039\/501100004488","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["UTT-0002"],"award-info":[{"award-number":["UTT-0002"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008993","name":"Sveu\u010dili\u0161te u Zagrebu","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008993","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50 AG005138"],"award-info":[{"award-number":["P50 AG005138"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroscience Methods"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.jneumeth.2019.108547","type":"journal-article","created":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T04:46:29Z","timestamp":1575866789000},"page":"108547","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["A non-invasive hidden-goal test for spatial orientation deficit detection in subjects with suspected mild cognitive impairment"],"prefix":"10.1016","volume":"332","author":[{"given":"Danira","family":"Ba\u017eadona","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Fabek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjana","family":"Babi\u0107 Leko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela","family":"Bobi\u0107 Rasonja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dubravka","family":"Kalini\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ervina","family":"Bili\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakov Domagoj","family":"Ragu\u017e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ninoslav","family":"Mimica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran","family":"Borove\u010dki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick R.","family":"Hof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6339-9261","authenticated-orcid":false,"given":"Goran","family":"\u0160imi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jneumeth.2019.108547_bib0005","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1093\/brain\/122.9.1613","article-title":"Topographical disorientation: a synthesis and taxonomy","volume":"122","author":"Aguirre","year":"1999","journal-title":"Brain"},{"key":"10.1016\/j.jneumeth.2019.108547_bib0010","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.jalz.2011.03.008","article-title":"The diagnosis of mild cognitive impairment due to Alzheimer\u2019s disease: recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"Albert","year":"2011","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.jneumeth.2019.108547_bib0015","article-title":"Mini-Mental State Examination (MMSE) for the detection of Alzheimer\u2019s disease and other dementias in people with mild cognitive impairment (MCI)","volume":"3","author":"Arevalo-Rodriguez","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.jneumeth.2019.108547_bib0020","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0166-4328(01)00399-0","article-title":"Humans with hippocampus damage display severe spatial memory impairments in a virtual Morris water task","volume":"132","author":"Astur","year":"2002","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jneumeth.2019.108547_bib0025","doi-asserted-by":"crossref","first-page":"765","DOI":"10.3233\/JAD-150705","article-title":"Predictive value of cerebrospinal fluid visinin-like protein-1 levels for Alzheimer\u2019s disease early detection and differential diagnosis in patients with mild cognitive impairment","volume":"50","author":"Babi\u0107 Leko","year":"2016","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.jneumeth.2019.108547_bib0030","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1159\/000339596","article-title":"The reliability and validity of the Mini-Mental State Examination in the elderly Croatian population","volume":"33","author":"Boban","year":"2012","journal-title":"Dement. Geriatr. Cogn. Disord."},{"issue":"Suppl. 1","key":"10.1016\/j.jneumeth.2019.108547_bib0035","article-title":"Rat spatial memory tasks adapted for humans: characterization in subjects with intact brain and subjects with selective medial temporal lobe thermal lesions","volume":"51","author":"Bohbot","year":"2002","journal-title":"Physiol. Res."},{"issue":"36","key":"10.1016\/j.jneumeth.2019.108547_bib0040","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/S0028-3932(97)00161-9","article-title":"Spatial memory deficits in patients with lesions to the right hippocampus and to the right parahippocampal cortex","volume":"1998","author":"Bohbot","year":"1998","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.jneumeth.2019.108547_bib0045","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S0896-6273(02)00830-9","article-title":"The human hippocampus and spatial and episodic memory","volume":"35","author":"Burgess","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.jneumeth.2019.108547_bib0050","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/s41582-018-0031-x","article-title":"Spatial navigation deficits - overlooked cognitive marker for preclinical Alzheimer disease?","volume":"14","author":"Coughlan","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.jneumeth.2019.108547_bib0055","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1037\/0894-4105.18.3.462","article-title":"Allocentric versus egocentric spatial memory after unilateral temporal lobectomy in humans","volume":"18","author":"Feigenbaum","year":"2004","journal-title":"Neuropsychology"},{"key":"10.1016\/j.jneumeth.2019.108547_bib0060","doi-asserted-by":"crossref","first-page":"648","DOI":"10.3389\/fnhum.2015.00648","article-title":"Are all spatial reference frames egocentric? Reinterpreting evidence for allocentric, object-centered, or world-centered reference frames","volume":"9","author":"Filimon","year":"2015","journal-title":"Front. Hum. Neurosci."},{"key":"10.1016\/j.jneumeth.2019.108547_bib0065","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.pneurobio.2011.11.008","article-title":"The future of Alzheimer\u2019s disease: the next 10 years","volume":"95","author":"Hampel","year":"2011","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.jneumeth.2019.108547_bib0070","doi-asserted-by":"crossref","first-page":"4042","DOI":"10.1073\/pnas.0611314104","article-title":"Spatian navigation deficit in amnestic mild cognitive impairment","volume":"104","author":"Hort","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jneumeth.2019.108547_bib0075","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1093\/brain\/awz116","article-title":"Differentiation of mild cognitive impairment using an entorhinal cortex-based test of virtual reality navigation","volume":"142","author":"Howett","year":"2019","journal-title":"Brain"},{"key":"10.1016\/j.jneumeth.2019.108547_bib0080","doi-asserted-by":"crossref","first-page":"5945","DOI":"10.1523\/JNEUROSCI.23-13-05945.2003","article-title":"Cognitive strategies dependent on the hippocampus and caudate nucleus in human navigation: variability and change with practice","volume":"23","author":"Iaria","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jneumeth.2019.108547_bib0085","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.bbr.2008.12.029","article-title":"Cognitive map in patients with mild Alzheimer\u2019s disease: a computer-generated arena study","volume":"200","author":"Jheng","year":"2009","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jneumeth.2019.108547_bib0090","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1111\/cns.12814","article-title":"Evaluation of cerebrospinal fluid phosphorylated tau231 as a biomarker in the differential diagnosis of Alzheimer\u2019s disease and vascular dementia","volume":"24","author":"Ki\u0111emet-Piska\u010d","year":"2018","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.jneumeth.2019.108547_bib0095","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1111\/j.2044-8295.1998.tb02697.x","article-title":"Development of spatial memory and spatial orientation in preschoolers and primary school children","volume":"89","author":"Lehnung","year":"1998","journal-title":"Brit. J. Psychol."},{"key":"10.1016\/j.jneumeth.2019.108547_bib0100","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.280.5365.921","article-title":"Knowing where and getting there: a human navigation network","volume":"280","author":"Maguire","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.jneumeth.2019.108547_bib0105","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer\u2019s disease: recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.jneumeth.2019.108547_bib0110","doi-asserted-by":"crossref","first-page":"161","DOI":"10.2174\/156720506776383103","article-title":"Predictors of conversion to dementia of probable Alzheimer type in patients with mild cognitive impairment","volume":"3","author":"Modrego","year":"2006","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.jneumeth.2019.108547_bib0115","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1212\/WNL.61.11.1491","article-title":"Spatial disorientation in Alzheimer\u2019s disease: the remembrance of things passed","volume":"61","author":"Monacelli","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.jneumeth.2019.108547_bib0120","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/297681a0","article-title":"Place navigation impaired in rats with hippocampal lesions","volume":"297","author":"Morris","year":"1982","journal-title":"Nature"},{"key":"10.1016\/j.jneumeth.2019.108547_bib0125","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1212\/WNL.51.6.1546","article-title":"Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria","volume":"51","author":"Neary","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.jneumeth.2019.108547_bib0130","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1001\/archneur.65.7.963","article-title":"Detecting dementia with the Mini-Mental State Examination in highly educated individuals","volume":"65","author":"O\u2019Bryant","year":"2008","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.jneumeth.2019.108547_bib0135","series-title":"The Hippocampus As a Cognitive Map","author":"O\u2019Keefe","year":"1978"},{"key":"10.1016\/j.jneumeth.2019.108547_bib0140","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1037\/0735-7044.110.6.1205","article-title":"Ontogeny of place learning in children as measured in the radial arm maze, Morris search task, and open field task","volume":"110","author":"Overman","year":"1996","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.jneumeth.2019.108547_bib0145","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.actpsy.2004.10.006","article-title":"Allocentric spatial memory in humans with hippocampal lesions","volume":"118","author":"Parslow","year":"2005","journal-title":"Acta Psychol. (Amst)"},{"key":"10.1016\/j.jneumeth.2019.108547_bib0150","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1001\/archneur.56.3.303","article-title":"Mild cognitive impairment: clinical characterization and outcome","volume":"56","author":"Petersen","year":"1999","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.jneumeth.2019.108547_bib0155","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.cger.2013.07.003","article-title":"Classification and epidemiology of MCI","volume":"29","author":"Roberts","year":"2013","journal-title":"Clin. Geriatr. Med."},{"key":"10.1016\/j.jneumeth.2019.108547_bib0160","article-title":"The prevalence of mild cognitive impairment in diverse geographical and ethnocultural regions: the COSMIC collaboration","volume":"10","author":"Sachdev","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jneumeth.2019.108547_bib0165","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0166-4328(03)00141-4","article-title":"A battery of tests for quantitative examination of idiothetic and allothetic place navigation modes in humans","volume":"147","author":"St\u011bp\u00e1nkov\u00e1","year":"2003","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jneumeth.2019.108547_bib0170","first-page":"89","article-title":"Neural correlates of spatial navigation changes in mild cognitive impairment and Alzheimer\u2019s disease","volume":"8","author":"Vl\u010dek","year":"2014","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.jneumeth.2019.108547_bib0175","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.neuropsychologia.2010.12.031","article-title":"Egocentric and allocentric memory as assessed by virtual reality in individuals with amnestic mild cognitive impairment","volume":"49","author":"Weniger","year":"2011","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.jneumeth.2019.108547_bib0180","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.nlm.2009.08.003","article-title":"The human parahippocampal cortex subserves egocentric spatial learning during navigation in a virtual maze","volume":"93","author":"Weniger","year":"2010","journal-title":"Neurobiol. Learn. Mem."}],"container-title":["Journal of Neuroscience Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165027019304042?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165027019304042?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:15:14Z","timestamp":1777493714000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165027019304042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":36,"alternative-id":["S0165027019304042"],"URL":"https:\/\/doi.org\/10.1016\/j.jneumeth.2019.108547","relation":{},"ISSN":["0165-0270"],"issn-type":[{"value":"0165-0270","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A non-invasive hidden-goal test for spatial orientation deficit detection in subjects with suspected mild cognitive impairment","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroscience Methods","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneumeth.2019.108547","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108547"}}