{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:32:10Z","timestamp":1780705930231,"version":"3.54.1"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["IF160224"],"award-info":[{"award-number":["IF160224"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council\u00a0of\u00a0Scientific and Industrial Research, India","doi-asserted-by":"publisher","award":["MLP-0204"],"award-info":[{"award-number":["MLP-0204"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroscience Methods"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.jneumeth.2020.108916","type":"journal-article","created":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T21:52:54Z","timestamp":1597701174000},"page":"108916","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Development and validation of chemical kindling in adult zebrafish: A simple and improved chronic model for screening of antiepileptic agents"],"prefix":"10.1016","volume":"346","author":[{"given":"Savita","family":"Kumari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pallavi","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arindam Ghosh","family":"Mazumder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil Kumar","family":"Rana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supriya","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7998-5345","authenticated-orcid":false,"given":"Damanpreet","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jneumeth.2020.108916_bib0005","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.neuroscience.2004.11.031","article-title":"Pentylenetetrazole induced changes in zebrafish behavior, neural activity and c-fos expression","volume":"131","author":"Baraban","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0010","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a022863","article-title":"Glutamatergic mechanisms associated with seizures and epilepsy","volume":"5","author":"Barker-Haliski","year":"2015","journal-title":"Cold Spring Harbor Perspectives in Medicine"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0015","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nrd2997","article-title":"Key factors in the discovery and development of new antiepileptic drugs","volume":"9","author":"Bialer","year":"2010","journal-title":"Nature Reviews Drug Discovery"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0020","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.eplepsyres.2018.07.008","article-title":"In vitro and in vivo experimental models employed in the discovery and development of antiepileptic drugs for pharmacoresistant epilepsy","volume":"146","author":"Campos","year":"2018","journal-title":"Epilepsy Research"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0025","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1471-2202-11-9","article-title":"Levetiracetam attenuates hippocampal expression of synaptic plasticity-related immediate early and late response genes in amygdala-kindled rats","volume":"11","author":"Christensen","year":"2010","journal-title":"BMC Neuroscience"},{"issue":"6449","key":"10.1016\/j.jneumeth.2020.108916_bib0030","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/365855a0","article-title":"Phosphorylated CREB binds specifically to the nuclear protein CBP","volume":"365","author":"Chrivia","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0035","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.2174\/156802612800229215","article-title":"Recent progress in anticonvulsant drug research: strategies for anticonvulsant drug development and applications of antiepileptic drugs for non-epileptic central nervous system disorders","volume":"12","author":"Dalkara","year":"2012","journal-title":"Current Topics in Medicinal Chemistry"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2010.11.085","article-title":"Differential molecular regulation of glutamate in kindling resistant rats","volume":"1375","author":"Doi","year":"2011","journal-title":"Brain Research"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0045","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0006-8993(98)00159-0","article-title":"Pentylenetetrazole (PTZ)-induced c-fos expression in the hippocampus of kindled rats is suppressed by concomitant treatment with naloxone","volume":"792","author":"Erdtmann-Vourliotis","year":"1998","journal-title":"Brain Research"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0050","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.seizure.2016.11.022","article-title":"Drug development for refractory epilepsy: the past 25 years and beyond","volume":"44","author":"Golyala","year":"2017","journal-title":"Seizure"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0055","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/nn.3934","article-title":"Animal models in epilepsy research: legacies and new directions","volume":"18","author":"Grone","year":"2015","journal-title":"Nature Neuroscience"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0060","first-page":"157","article-title":"Effect of various antiepileptic drugs in zebrafish PTZ-seizure model","volume":"76","author":"Gupta","year":"2014","journal-title":"Indian Journal of Pharmaceutical Sciences"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0065","first-page":"48","article-title":"Effect of valproic acid on levels of GABA and glutamic acid in pentylenetetrazole-damaged rat brain","volume":"46","author":"Guzm\u00e1n","year":"2003","journal-title":"Proceedings of the Western Pharmacology Society"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0070","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1242\/dmm.002139","article-title":"Zebrafish as a model for studying genetic aspects of epilepsy","volume":"3","author":"Hortopan","year":"2010","journal-title":"Disease Models & Mechanisms"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0075","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0169-328X(93)90001-6","article-title":"Differences in c-fos immunoreactivity due to age and mode of seizure induction","volume":"17","author":"Jensen","year":"1993","journal-title":"Molecular Brain Research"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0080","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1093\/hmg\/ddg039","article-title":"Loss of CBP acetyltransferase activity by PHD finger mutations in Rubinstein\u2013Taybi syndrome","volume":"12","author":"Kalkhoven","year":"2003","journal-title":"Human Molecular Genetics"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0085","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.2147\/NDT.S50371","article-title":"Animal models of epilepsy: use and limitations","volume":"10","author":"Kandratavicius","year":"2014","journal-title":"Neuropsychiatric Disease and Treatment"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0090","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.plefa.2019.02.002","article-title":"Early \u03b1-linolenic acid exposure to embryo reduces pentylenetetrazol-induced seizures in zebrafish larva","volume":"143","author":"Kumari","year":"2019","journal-title":"Prostaglandins, Leukotrienes and Essential Fatty Acids"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0095","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3389\/fphar.2017.00515","article-title":"Zebrafish as a model for epilepsy-induced cognitive dysfunction: a pharmacological, biochemical and behavioral approach","volume":"8","author":"Kundap","year":"2017","journal-title":"Frontiers in Pharmacology"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0100","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3389\/fphar.2019.00315","article-title":"Embelin prevents seizure and associated cognitive impairments in a pentylenetetrazole-induced kindling zebrafish model","volume":"10","author":"Kundap","year":"2019","journal-title":"Frontiers in Pharmacology"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0105","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1523\/JNEUROSCI.13-02-00744.1993","article-title":"Induction of c-fos mRNA by kindled seizures: complex relationship with neuronal burst firing","volume":"13","author":"Labiner","year":"1993","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0110","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.nbd.2006.08.015","article-title":"CRE-mediated transcription and COX-2 expression in the pilocarpine model of status epilepticus","volume":"25","author":"Lee","year":"2007","journal-title":"Neurobiology of Disease"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0115","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0197-0186(03)00148-7","article-title":"Dynamic release of amino acid transmitters induced by valproate in PTZ-kindled epileptic rat hippocampus","volume":"44","author":"Li","year":"2004","journal-title":"Neurochemistry International"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0120","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0125","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0896-6273(02)00828-0","article-title":"Function and regulation of CREB family transcription factors in the nervous system","volume":"35","author":"Lonze","year":"2002","journal-title":"Neuron"},{"issue":"5","key":"10.1016\/j.jneumeth.2020.108916_bib0130","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.seizure.2011.01.003","article-title":"Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs","volume":"20","author":"L\u00f6scher","year":"2011","journal-title":"Seizure"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0135","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/876712","article-title":"Modulation of c-Fos and BDNF protein expression in pentylenetetrazole-kindled mice following the treatment with novel antiepileptic compound HHL-6","volume":"2014","author":"Malhi","year":"2014","journal-title":"BioMed Research International"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0140","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1111\/j.1528-1157.1972.tb04401.x","article-title":"A permanent change in convulsive threshold in normal and brain\u2010damaged rats with repeated small doses of pentylenetetrazol","volume":"13","author":"Manson","year":"1972","journal-title":"Epilepsia"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0145","doi-asserted-by":"crossref","first-page":"106207","DOI":"10.1016\/j.eplepsyres.2019.106207","article-title":"Anticonvulsant action of a selective phosphatidylinositol-3-kinase inhibitor LY294002 in pentylenetetrazole-mediated convulsions in Zebrafish","author":"Mazumder","year":"2019","journal-title":"Epilepsy Research"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0150","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/bcpt.12694","article-title":"Crocin Attenuates Kindling Development and Associated Cognitive Impairments in Mice via Inhibiting Reactive Oxygen Species\u2010Mediated NF\u2010\u03baB Activation","volume":"120","author":"Mazumder","year":"2017","journal-title":"Basic & Clinical Pharmacology & Toxicology"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0155","first-page":"14","article-title":"The role of glutamate in epilepsy and other CNS disorders","volume":"44","author":"Meldrum","year":"1994","journal-title":"Neurology"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0160","doi-asserted-by":"crossref","DOI":"10.4137\/JCNSD.S8315","article-title":"Pharmacotherapeutic and non-pharmacological options for refractory and difficult-to-treat seizures","volume":"4","author":"Mitchell","year":"2012","journal-title":"Journal of Central Nervous System Disease"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0165","first-page":"303","article-title":"Pro-and anticonvulsant effects of anesthetics (Part I)","volume":"70","author":"Modica","year":"1990","journal-title":"Anesthesia & Analgesia"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0170","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0165-6147(91)90594-I","article-title":"Proto-oncogene transcription factors and epilepsy","volume":"12","author":"Morgan","year":"1991","journal-title":"Trends in Pharmacological Sciences"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2004.03.009","article-title":"Kindling and status epilepticus models of epilepsy: rewiring the brain","volume":"73","author":"Morimoto","year":"2004","journal-title":"Progress in Neurobiology"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0180","doi-asserted-by":"crossref","first-page":"e54515","DOI":"10.1371\/journal.pone.0054515","article-title":"Seizures induced by pentylenetetrazole in the adult zebrafish: a detailed behavioral characterization","volume":"8","author":"Mussulini","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0185","series-title":"Models of Seizures and Epilepsy","year":"2017"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0190","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1002\/ana.20633","article-title":"A common pattern of persistent gene activation in human neocortical epileptic foci","volume":"58","author":"Rakhade","year":"2005","journal-title":"Annals of Neurology"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0195","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.34.2.182","article-title":"Biochemical and clinical effects of \u03b3\u2010vinyl GABA in patients with epilepsy","volume":"34","author":"Schechter","year":"1984","journal-title":"Neurology"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0200","first-page":"10508","article-title":"Interaction between carbenoxolone and valproic acid on pentylenetetrazole kindling model of epilepsy","volume":"8","author":"Sefil","year":"2015","journal-title":"International Journal of Clinical and Experimental Medicine"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0205","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.2174\/1570159X17666190809165549","article-title":"Dietary flavonoids interaction with CREB-BDNF pathway: An unconventional approach for comprehensive management of epilepsy","volume":"17","author":"Sharma","year":"2019","journal-title":"Current Neuropharmacology"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0210","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1080\/1028415X.2018.1478653","article-title":"Apigenin reverses behavioural impairments and cognitive decline in kindled mice via CREB-BDNF upregulation in the hippocampus","volume":"23","author":"Sharma","year":"2020","journal-title":"Nutritional Neuroscience"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0215","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.cqn.2014.11.002","article-title":"Zebrafish (Danio rerio): a potential model for nephroprotective drug screening","volume":"3","author":"Sharma","year":"2014","journal-title":"Clinical Queries: Nephrology"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0220","doi-asserted-by":"crossref","first-page":"288","DOI":"10.2174\/187152707781387251","article-title":"Extrasynaptic GABA and glutamate receptors in epilepsy","volume":"6","author":"Sierra-Paredes","year":"2007","journal-title":"CNS & Neurological Disorders-Drug Targets"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0225","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/ana.410290404","article-title":"Antiepileptogenic effects of conventional anticonvulsants in the kindling model of epilepsy","volume":"29","author":"Silver","year":"1991","journal-title":"Annals of Neurology"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0230","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.yebeh.2012.11.004","article-title":"Effect of saponin fraction from Ficus religiosa on memory deficit, and behavioral and biochemical impairments in pentylenetetrazol kindled mice","volume":"27","author":"Singh","year":"2013","journal-title":"Epilepsy & Behavior"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0235","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.yebeh.2014.10.002","article-title":"Ficus religiosa L. figs-a potential herbal adjuvant to phenytoin for improved management of epilepsy and associated behavioral comorbidities","volume":"41","author":"Singh","year":"2014","journal-title":"Epilepsy & Behavior"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0240","first-page":"1209","article-title":"Protective effect on phenytoin-induced cognition deficit in pentylenetetrazol kindled mice: a repertoire of Glycyrrhiza glabra flavonoid antioxidants","volume":"54","author":"Singh","year":"2016","journal-title":"Pharmaceutical Biology"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0245","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.brainresbull.2011.11.020","article-title":"Perspectives of zebrafish models of epilepsy: what, how and where next?","volume":"87","author":"Stewart","year":"2012","journal-title":"Brain Research Bulletin"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0250","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0014-2999(76)90140-0","article-title":"The anticonvulsant activity of ketamine against seizures induced by pentylenetetrazol and mercaptopropionic acid","volume":"39","author":"Taberner","year":"1976","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0255","doi-asserted-by":"crossref","first-page":"7904","DOI":"10.1038\/s41598-019-44264-6","article-title":"Target identification, screening and in vivo evaluation of pyrrolone-fused benzosuberene compounds against human epilepsy using Zebrafish model of pentylenetetrazol-induced seizures","volume":"9","author":"Tanwar","year":"2019","journal-title":"Scientific Reports"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0260","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1177\/000456329503200103","article-title":"Quantitative methods for amino acid analysis in biological fluids","volume":"32","author":"Walker","year":"1995","journal-title":"Annals of Clinical Biochemistry"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0265","doi-asserted-by":"crossref","first-page":"6581","DOI":"10.1038\/s41598-017-06646-6","article-title":"4-dimensional functional profiling in the convulsant-treated larval zebrafish brain","volume":"7","author":"Winter","year":"2017","journal-title":"Scientific Reports"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0270","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1101\/lm.86605","article-title":"Transgenic mice expressing a truncated form of CREB-binding protein (CBP) exhibit deficits in hippocampal synaptic plasticity and memory storage","volume":"12","author":"Wood","year":"2005","journal-title":"Learning & Memory"},{"key":"10.1016\/j.jneumeth.2020.108916_bib0275","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.nbd.2011.08.009","article-title":"Decreased CREB levels suppress epilepsy","volume":"45","author":"Zhu","year":"2012","journal-title":"Neurobiology of Disease"}],"container-title":["Journal of Neuroscience Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165027020303393?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165027020303393?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T11:03:59Z","timestamp":1778670239000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165027020303393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":55,"alternative-id":["S0165027020303393"],"URL":"https:\/\/doi.org\/10.1016\/j.jneumeth.2020.108916","relation":{},"ISSN":["0165-0270"],"issn-type":[{"value":"0165-0270","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development and validation of chemical kindling in adult zebrafish: A simple and improved chronic model for screening of antiepileptic agents","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroscience Methods","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneumeth.2020.108916","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108916"}}