{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:19:04Z","timestamp":1790713144009,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T00:00:00Z","timestamp":1651622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004411","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","award":["G-16-00012613"],"award-info":[{"award-number":["G-16-00012613"]}],"id":[{"id":"10.13039\/100004411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroscience Methods"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.jneumeth.2022.109612","type":"journal-article","created":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T11:24:18Z","timestamp":1650972258000},"page":"109612","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["A comparison of lesion-overlap approaches to quantify corticospinal tract involvement in chronic stroke"],"prefix":"10.1016","volume":"376","author":[{"given":"Clarissa Pedrini","family":"Schuch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy K.","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mindy F.","family":"Levin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven C.","family":"Cramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard H.","family":"Swartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Thiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce L.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jneumeth.2022.109612_bib1","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1093\/cercor\/bhx066","article-title":"A template and probabilistic atlas of the human sensorimotor tracts using diffusion MRI","volume":"28","author":"Archer","year":"2018","journal-title":"Cereb. Cortex"},{"issue":"4","key":"10.1016\/j.jneumeth.2022.109612_bib2","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1177\/1747493016643851","article-title":"Moving rehabilitation research forward: developing consensus statements for rehabilitation and recovery research","volume":"11","author":"Bernhardt","year":"2016","journal-title":"Int. J. Stroke"},{"issue":"5","key":"10.1016\/j.jneumeth.2022.109612_bib3","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1177\/1747493017714176","article-title":"Biomarkers of stroke recovery: consensus-based core recommendations from the Stroke Recovery and Rehabilitation Roundtable","volume":"12","author":"Boyd","year":"2017","journal-title":"Int. J. Stroke"},{"issue":"6","key":"10.1016\/j.jneumeth.2022.109612_bib4","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1007\/s00415-014-7341-8","article-title":"A multimodal approach to understanding motor impairment and disability after stroke","volume":"261","author":"Burke","year":"2014","journal-title":"J. Neurol."},{"issue":"1","key":"10.1016\/j.jneumeth.2022.109612_bib5","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/ana.24309","article-title":"Neural function, injury, and stroke subtype predict treatment gains after stroke","volume":"77","author":"Burke Quinlan","year":"2015","journal-title":"Ann. Neurol."},{"issue":"6","key":"10.1016\/j.jneumeth.2022.109612_bib6","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1002\/ana.24472","article-title":"Proportional recovery after stroke depends on corticomotor integrity","volume":"78","author":"Byblow","year":"2015","journal-title":"Ann. Neurol."},{"issue":"2","key":"10.1016\/j.jneumeth.2022.109612_bib7","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1161\/STROKEAHA.120.033227","article-title":"Under-enrollment of women in stroke clinical trials","volume":"52","author":"Carcel","year":"2021","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.jneumeth.2022.109612_bib8","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1177\/1545968311411054","article-title":"Upstream dysfunction of somatomotor functional connectivity after corticospinal damage in stroke","volume":"26","author":"Carter","year":"2012","journal-title":"Neurorehabil. Neural Repair"},{"issue":"2","key":"10.1016\/j.jneumeth.2022.109612_bib9","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1161\/STROKEAHA.117.018844","article-title":"Neuroimaging identifies patients most likely to respond to a restorative stroke therapy","volume":"49","author":"Cassidy","year":"2018","journal-title":"Stroke"},{"issue":"1\u20132","key":"10.1016\/j.jneumeth.2022.109612_bib10","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jns.2010.08.051","article-title":"The Montreal Cognitive Assessment (MoCA) is superior to the Mini-Mental State Examination (MMSE) for the detection of vascular cognitive impairment after acute stroke","volume":"299","author":"Dong","year":"2010","journal-title":"J. Neurol. Sci."},{"issue":"2","key":"10.1016\/j.jneumeth.2022.109612_bib11","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1161\/STROKEAHA.119.028205","article-title":"Neuroimaging in ischemic stroke is different between men and women in the DEFUSE 3 cohort","volume":"51","author":"Dula","year":"2020","journal-title":"Stroke"},{"issue":"6","key":"10.1016\/j.jneumeth.2022.109612_bib12","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1002\/ana.24510","article-title":"Corticospinal tract lesion load: An imaging biomarker for stroke motor outcomes","volume":"78","author":"Feng","year":"2015","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jneumeth.2022.109612_bib13","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.nicl.2018.10.003","article-title":"Lesion locations associated with persistent proprioceptive impairment in the upper limbs after stroke","volume":"20","author":"Findlater","year":"2018","journal-title":"NeuroImage: Clin."},{"issue":"10","key":"10.1016\/j.jneumeth.2022.109612_bib14","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1177\/1545968319868714","article-title":"Comparing CST Lesion Metrics as Biomarkers for Recovery of Motor and Proprioceptive Impairments After Stroke","volume":"33","author":"Findlater","year":"2019","journal-title":"Neurorehabil. Neural Repair"},{"issue":"3","key":"10.1016\/j.jneumeth.2022.109612_bib15","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1177\/154596802401105171","article-title":"The fugl-meyer assessment of motor recovery after stroke: a critical review of its measurement properties","volume":"16","author":"Gladstone","year":"2002","journal-title":"Neurorehabil. Neural Repair"},{"issue":"8","key":"10.1016\/j.jneumeth.2022.109612_bib16","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1177\/1545968320935811","article-title":"Assessment of sex differences in recovery of motor and sensory impairments poststroke","volume":"34","author":"Hawe","year":"2020","journal-title":"Neurorehabil. Neural Repair"},{"key":"10.1016\/j.jneumeth.2022.109612_bib17","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.nicl.2016.09.015","article-title":"Are we armed with the right data? Pooled individual data review of biomarkers in people with severe upper limb impairment after stroke","volume":"13","author":"Hayward","year":"2017","journal-title":"NeuroImage: Clin."},{"issue":"1","key":"10.1016\/j.jneumeth.2022.109612_bib18","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.neuroimage.2007.07.053","article-title":"Tract probability maps in stereotaxic spaces: analyses of white matter anatomy and tract-specific quantification","volume":"39","author":"Hua","year":"2008","journal-title":"NeuroImage"},{"issue":"10","key":"10.1016\/j.jneumeth.2022.109612_bib19","doi-asserted-by":"crossref","first-page":"E1098","DOI":"10.1212\/WNL.0000000000007041","article-title":"Somatosensory system integrity explains differences in treatment response after stroke","volume":"92","author":"Ingemanson","year":"2019","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.jneumeth.2022.109612_bib20","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.neuroimage.2011.09.015","article-title":"FSL","volume":"62","author":"Jenkinson","year":"2012","journal-title":"NeuroImage"},{"issue":"1","key":"10.1016\/j.jneumeth.2022.109612_bib21","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/1545968316662708","article-title":"Can neurological biomarkers of brain impairment be used to predict poststroke motor recovery? A systematic review","volume":"31","author":"Kim","year":"2017","journal-title":"Neurorehabil. Neural Repair"},{"issue":"5","key":"10.1016\/j.jneumeth.2022.109612_bib22","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1177\/1747493017711813","article-title":"Standardized measurement of sensorimotor recovery in stroke trials: consensus-based core recommendations from the Stroke Recovery and Rehabilitation Roundtable","volume":"12","author":"Kwakkel","year":"2017","journal-title":"Int. J. Stroke"},{"issue":"1","key":"10.1016\/j.jneumeth.2022.109612_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-27541-8","article-title":"Variability in stroke motor outcome is explained by structural and functional integrity of the motor system","volume":"8","author":"Lam","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jneumeth.2022.109612_bib24","first-page":"1","article-title":"Determining corticospinal tract injury from stroke using computed tomography","author":"Lam","year":"2020","journal-title":"Can. J. Neurol. Sci. J. Can. Des. Sci. Neurol."},{"issue":"4","key":"10.1016\/j.jneumeth.2022.109612_bib25","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1080\/13803395.2011.645016","article-title":"A short bedside battery for visuoconstructive hemispatial neglect: sunnybrook Neglect Assessment Procedure (SNAP)","volume":"34","author":"Leibovitch","year":"2012","journal-title":"J. Clin. Exp. Neuropsychol."},{"issue":"4","key":"10.1016\/j.jneumeth.2022.109612_bib26","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1177\/1545968308328727","article-title":"What do motor \u201crecovery\u201d and \u201ccompensation\u201d mean in patients following stroke?","volume":"23","author":"Levin","year":"2009","journal-title":"Neurorehabilitation Neural Repair"},{"issue":"12","key":"10.1016\/j.jneumeth.2022.109612_bib27","doi-asserted-by":"crossref","first-page":"3569","DOI":"10.1161\/STROKEAHA.119.025898","article-title":"Corticospinal tract injury estimated from acute stroke imaging predicts upper extremity motor recovery after stroke","volume":"50","author":"Lin","year":"2019","journal-title":"Stroke"},{"issue":"7","key":"10.1016\/j.jneumeth.2022.109612_bib28","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.03.017","article-title":"Analysis of gender differences in knowledge of stroke warning signs","volume":"24","author":"Madsen","year":"2015","journal-title":"J. Stroke Cerebrovasc. Dis."},{"issue":"3","key":"10.1016\/j.jneumeth.2022.109612_bib29","first-page":"389","article-title":"Emerging evidence of the association between cognitive deficits and arm motor recovery after stroke: a meta-analysis","volume":"33","author":"Mullick","year":"2015","journal-title":"Restor. Neurol. Neurosci."},{"issue":"12","key":"10.1016\/j.jneumeth.2022.109612_bib30","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1136\/jnnp-2015-312738","article-title":"The contribution of lesion location to upper limb deficit after stroke","volume":"87","author":"Park","year":"2016","journal-title":"J. Neurol., Neurosurg. Psychiatry"},{"issue":"3","key":"10.1016\/j.jneumeth.2022.109612_bib31","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1161\/01.STR.31.3.672","article-title":"Relating MRI changes to motor deficit after ischemic stroke by segmentation of functional motor pathways","volume":"31","author":"Pineiro","year":"2000","journal-title":"Stroke"},{"issue":"7","key":"10.1016\/j.jneumeth.2022.109612_bib32","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.3174\/ajnr.A2038","article-title":"Wallerian degeneration in the corticospinal tract evaluated by diffusion tensor imaging correlates with motor deficit 30 days after middle cerebral artery ischemic stroke","volume":"31","author":"Puig","year":"2010","journal-title":"Am. J. Neuroradiol."},{"issue":"2","key":"10.1016\/j.jneumeth.2022.109612_bib33","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1161\/STROKEAHA.110.599340","article-title":"Anatomy of stroke injury predicts gains from therapy","volume":"42","author":"Riley","year":"2011","journal-title":"Stroke"},{"issue":"9","key":"10.1016\/j.jneumeth.2022.109612_bib34","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1136\/jnnp-2016-315030","article-title":"Brain regions important for recovery after severe post-stroke upper limb paresis","volume":"88","author":"Rondina","year":"2017","journal-title":"J. Neurol., Neurosurg. Psychiatry"},{"issue":"6","key":"10.1016\/j.jneumeth.2022.109612_bib35","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1152\/japplphysiol.01063.2003","article-title":"Hand function: peripheral and central constraints on performance","volume":"96","author":"Schieber","year":"2004","journal-title":"J. Appl. Physiol."},{"issue":"1","key":"10.1016\/j.jneumeth.2022.109612_bib36","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.bandc.2012.03.009","article-title":"An update on the Conceptual\u2013Production Systems model of apraxia: evidence from stroke","volume":"80","author":"Stamenova","year":"2012","journal-title":"Brain Cogn."},{"issue":"10","key":"10.1016\/j.jneumeth.2022.109612_bib37","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/S1474-4422(17)30283-1","article-title":"Prediction of motor recovery after stroke: advances in biomarkers","volume":"16","author":"Stinear","year":"2017","journal-title":"Lancet Neurol."},{"issue":"4","key":"10.1016\/j.jneumeth.2022.109612_bib38","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1161\/STROKEAHA.116.015790","article-title":"Predicting recovery potential for individual stroke patients increases rehabilitation efficiency","volume":"48","author":"Stinear","year":"2017","journal-title":"Stroke"},{"issue":"11","key":"10.1016\/j.jneumeth.2022.109612_bib39","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1002\/acn3.488","article-title":"PREP2: a biomarker-based algorithm for predicting upper limb function after stroke","volume":"4","author":"Stinear","year":"2017","journal-title":"Ann. Clin. Transl. Neurol."},{"issue":"4","key":"10.1016\/j.jneumeth.2022.109612_bib40","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1249\/MSS.0b013e31827a0169","article-title":"Cognition and motor impairment correlates with exercise test performance after stroke","volume":"45","author":"Tang","year":"2013","journal-title":"Med. Sci. Sports Exerc."},{"issue":"2","key":"10.1016\/j.jneumeth.2022.109612_bib41","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1136\/jnnp.2004.046375","article-title":"Time course of wallerian degeneration after ischaemic stroke revealed by diffusion tensor imaging","volume":"76","author":"Thomalla","year":"2005","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"3","key":"10.1016\/j.jneumeth.2022.109612_bib42","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/ana.25679","article-title":"Predicting upper limb motor impairment recovery after stroke: a mixture model","volume":"87","author":"Vliet","year":"2020","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jneumeth.2022.109612_bib43","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/7092496","article-title":"White matter biomarkers associated with motor change in individuals with stroke: a continuous theta burst stimulation study","volume":"2019","author":"Wadden","year":"2019","journal-title":"Neural Plast."},{"key":"10.1016\/j.jneumeth.2022.109612_bib44","unstructured":"Wakana, S., Jiang, H., Zijl, P.C. M.Van., 2003. Fiber Tract Based Atlas of Human Brain, 21\u201329."},{"issue":"7","key":"10.1016\/j.jneumeth.2022.109612_bib45","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1177\/1545968314562115","article-title":"Generalizability of the proportional recovery model for the upper extremity after an ischemic stroke","volume":"29","author":"Winters","year":"2015","journal-title":"Neurorehabil. Neural Repair"},{"issue":"4","key":"10.1016\/j.jneumeth.2022.109612_bib46","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.clinph.2018.01.057","article-title":"Finger strength, individuation, and their interaction: relationship to hand function and corticospinal tract injury after stroke","volume":"129","author":"Wolbrecht","year":"2018","journal-title":"Clin. Neurophysiol."},{"issue":"5","key":"10.1016\/j.jneumeth.2022.109612_bib47","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1161\/STROKEAHA.109.577023","article-title":"Lesion load of the corticospinal tract predicts motor impairment in chronic stroke","volume":"41","author":"Zhu","year":"2010","journal-title":"Stroke"}],"container-title":["Journal of Neuroscience Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016502702200139X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016502702200139X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T01:02:25Z","timestamp":1759021345000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016502702200139X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":47,"alternative-id":["S016502702200139X"],"URL":"https:\/\/doi.org\/10.1016\/j.jneumeth.2022.109612","relation":{},"ISSN":["0165-0270"],"issn-type":[{"value":"0165-0270","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A comparison of lesion-overlap approaches to quantify corticospinal tract involvement in chronic stroke","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroscience Methods","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneumeth.2022.109612","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"109612"}}