{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T05:10:48Z","timestamp":1778044248343,"version":"3.51.4"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004242","name":"Princess Nourah Bint Abdulrahman University","doi-asserted-by":"publisher","award":["PNURSP2025R506"],"award-info":[{"award-number":["PNURSP2025R506"]}],"id":[{"id":"10.13039\/501100004242","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007446","name":"King Khalid University","doi-asserted-by":"publisher","award":["RGP.2\/275\/46"],"award-info":[{"award-number":["RGP.2\/275\/46"]}],"id":[{"id":"10.13039\/501100007446","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007446","name":"King Khalid University","doi-asserted-by":"publisher","award":["RGP.2\/379\/45"],"award-info":[{"award-number":["RGP.2\/379\/45"]}],"id":[{"id":"10.13039\/501100007446","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroscience Methods"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.jneumeth.2025.110433","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T10:16:46Z","timestamp":1742725006000},"page":"110433","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Integrating data mining with transcranial focused ultrasound to refine neuralgia treatment strategies"],"prefix":"10.1016","volume":"418","author":[{"given":"Muhammad Attique","family":"Khan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shrooq","family":"Alsenan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shabbab Ali","family":"Algamdi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haya","family":"Aldossary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. Narasimha","family":"Raju","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamel","family":"Baili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Asim","family":"Saleem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jneumeth.2025.110433_bib1","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1007\/s42600-023-00313-8","article-title":"Generation of Induced Wavefront Focalization in the Human Temporal Bone Using a Standard Focused Ultrasound Single-Element Transducer","volume":"39","author":"Andrade","year":"2023","journal-title":"Res. Biomed. Eng."},{"key":"10.1016\/j.jneumeth.2025.110433_bib2","unstructured":"Anon, \u3008https:\/\/zenodo.org\/records\/8330926\u3009, 2022."},{"issue":"12","key":"10.1016\/j.jneumeth.2025.110433_bib3","doi-asserted-by":"crossref","DOI":"10.1063\/5.0244356","article-title":"A deep learning-based method of acoustic holographic lens generation for transcranial focused ultrasound","volume":"14","author":"Bu","year":"2024","journal-title":"AIP Adv."},{"issue":"1","key":"10.1016\/j.jneumeth.2025.110433_bib4","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/mp.16090","article-title":"Numerical and experimental evaluation of low-intensity transcranial focused ultrasound wave propagation using human skulls for brain neuromodulation","volume":"50","author":"Chen","year":"2023","journal-title":"Med. Phys."},{"issue":"1","key":"10.1016\/j.jneumeth.2025.110433_bib5","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/mp.16090","article-title":"Numerical and experimental evaluation of low-intensity transcranial focused ultrasound wave propagation using human skulls for brain neuromodulation","volume":"50","author":"Chen","year":"2023","journal-title":"Med. Phys."},{"issue":"1","key":"10.1016\/j.jneumeth.2025.110433_bib6","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.brs.2023.01.120","article-title":"Mechanisms and optimal parameters for induction of cortical plasticity using transcranial focused ultrasound stimulation","volume":"16","author":"Chen","year":"2023","journal-title":"Brain Stimul.: Basic, Transl., Clin. Res. Neuromodulation"},{"key":"10.1016\/j.jneumeth.2025.110433_bib7","doi-asserted-by":"crossref","unstructured":"Compte, J., Tible, M., Cuadros, T., Romero-Gimenez, J., Laguna, A., Aubry, J.F., \u2026 & Vila, M. (2023). Non-ablative disease-modifying effects of magnetic resonance-guided focused ultrasound in neuromelanin-producing Parkinsonian rodents. bioRxiv, 2023-08.","DOI":"10.1101\/2023.08.08.552410"},{"key":"10.1016\/j.jneumeth.2025.110433_bib8","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.86190","article-title":"Transcranial focused ultrasound to human rIFG improves response inhibition through modulation of the P300 onset latency","volume":"12","author":"Fine","year":"2023","journal-title":"Elife"},{"key":"10.1016\/j.jneumeth.2025.110433_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneumeth.2023.110048","article-title":"A piezoelectric micromachined ultrasound transducer combined with recording electrodes for acute brain preparations in vitro","volume":"403","author":"Furukawa","year":"2024","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.jneumeth.2025.110433_bib10","article-title":"Transcranial focused ultrasound activates feedforward and feedback cortico-thalamo-cortical pathways by selectively activating excitatory neurons","author":"Gao","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.jneumeth.2025.110433_bib11","doi-asserted-by":"crossref","first-page":"1277906","DOI":"10.3389\/fnins.2023.1277906","article-title":"A transducer positioning method for transcranial focused ultrasound treatment of brain tumors","volume":"17","author":"Gao","year":"2023","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.jneumeth.2025.110433_bib12","doi-asserted-by":"crossref","first-page":"1277906","DOI":"10.3389\/fnins.2023.1277906","article-title":"A transducer positioning method for transcranial focused ultrasound treatment of brain tumors","volume":"17","author":"Gao","year":"2023","journal-title":"Front. Neurosci."},{"issue":"1","key":"10.1016\/j.jneumeth.2025.110433_bib13","doi-asserted-by":"crossref","DOI":"10.1088\/1741-2552\/acb104","article-title":"Simultaneous multi-target ultrasound neuromodulation in freely-moving mice based on a single-element ultrasound transducer","volume":"20","author":"He","year":"2023","journal-title":"J. Neural Eng."},{"key":"10.1016\/j.jneumeth.2025.110433_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneumeth.2023.109934","article-title":"Non-invasive central nervous system assessment of a porcine model of neuropathic pain demonstrates increased latency of somatosensory-evoked potentials","volume":"396","author":"Hilgart","year":"2023","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.jneumeth.2025.110433_bib15","doi-asserted-by":"crossref","first-page":"1117188","DOI":"10.3389\/fneur.2023.1117188","article-title":"Transcranial low-intensity ultrasound stimulation for treating central nervous system disorders: A promising therapeutic application","volume":"14","author":"Hu","year":"2023","journal-title":"Front. Neurol."},{"issue":"1","key":"10.1016\/j.jneumeth.2025.110433_bib16","doi-asserted-by":"crossref","first-page":"30240","DOI":"10.1038\/s41598-024-81243-y","article-title":"Non-invasive 4D transcranial functional ultrasound and ultrasound localization microscopy for multimodal imaging of neurovascular response","volume":"14","author":"Jones","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jneumeth.2025.110433_bib17","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jneumeth.2018.11.017","article-title":"A novel motor imagery hybrid brain computer interface using EEG and functional transcranial Doppler ultrasound","volume":"313","author":"Khalaf","year":"2019","journal-title":"J. Neurosci. Methods"},{"issue":"1","key":"10.1016\/j.jneumeth.2025.110433_bib18","doi-asserted-by":"crossref","first-page":"11876","DOI":"10.1038\/s41598-024-62500-6","article-title":"A novel transcranial MR Guided focused ultrasound method based on the ultrashort echo time skull acoustic model and phase retrieval techniques","volume":"14","author":"Kong","year":"2024","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.jneumeth.2025.110433_bib19","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41378-023-00513-3","article-title":"Multifocal skull-compensated transcranial focused ultrasound system for neuromodulation applications based on acoustic holography","volume":"9","author":"Kook","year":"2023","journal-title":"Microsyst. Nanoeng."},{"key":"10.1016\/j.jneumeth.2025.110433_bib20","doi-asserted-by":"crossref","first-page":"1120410","DOI":"10.3389\/fncir.2023.1120410","article-title":"Transcranial focused ultrasound selectively increases perfusion and modulates functional connectivity of deep brain regions in humans","volume":"17","author":"Kuhn","year":"2023","journal-title":"Front. Neural Circuits"},{"issue":"9","key":"10.1016\/j.jneumeth.2025.110433_bib21","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/s41928-024-01240-x","article-title":"A shape-morphing cortex-adhesive sensor for closed-loop transcranial ultrasound neurostimulation","volume":"7","author":"Lee","year":"2024","journal-title":"Nat. Electron."},{"issue":"5","key":"10.1016\/j.jneumeth.2025.110433_bib22","doi-asserted-by":"crossref","DOI":"10.1117\/1.JMI.10.5.055001","article-title":"Evaluation of synthetically generated computed tomography for use in transcranial focused ultrasound procedures","volume":"10","author":"Liu","year":"2023","journal-title":"J. Med. Imaging"},{"issue":"5","key":"10.1016\/j.jneumeth.2025.110433_bib23","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1016\/j.brs.2023.09.013","article-title":"Disrupting nociceptive information processing flow through transcranial focused ultrasound neuromodulation of thalamic nuclei","volume":"16","author":"Mishra","year":"2023","journal-title":"Brain Stimul."},{"key":"10.1016\/j.jneumeth.2025.110433_bib24","article-title":"An Investigation of Parameter-Dependent Cell-Type Specific Effects of Transcranial Focused Ultrasound Stimulation Using an Awake Head-Fixed Rodent Model","author":"Ramachandran","year":"2024","journal-title":"BioRxiv"},{"issue":"1","key":"10.1016\/j.jneumeth.2025.110433_bib25","doi-asserted-by":"crossref","DOI":"10.1088\/1741-2552\/acb50d","article-title":"Transcranial ultrasound stimulation modulates the interhemispheric balance of excitability in human motor cortex","volume":"20","author":"Ren","year":"2023","journal-title":"J. Neural Eng."},{"key":"10.1016\/j.jneumeth.2025.110433_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneumeth.2023.110009","article-title":"Activation of primate frontal eye fields with a CMUT phased array system","volume":"402","author":"Riley","year":"2024","journal-title":"J. Neurosci. Methods"},{"issue":"1","key":"10.1016\/j.jneumeth.2025.110433_bib27","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.brs.2023.01.121","article-title":"The emergence of transcranial focused ultrasound in human research and clinical applications","volume":"16","author":"Sanguinetti","year":"2023","journal-title":"Brain Stimul.: Basic, Transl., Clin. Res. Neuromodulation"},{"issue":"1","key":"10.1016\/j.jneumeth.2025.110433_bib28","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.neurom.2024.04.001","article-title":"Numerical investigation of layered homogeneous skull model for simulations of transcranial focused ultrasound","volume":"28","author":"Seo","year":"2025","journal-title":"Neuromodulation: Technol. Neural Interface"},{"key":"10.1016\/j.jneumeth.2025.110433_bib29","doi-asserted-by":"crossref","DOI":"10.1109\/OJUFFC.2023.3318560","article-title":"Generating Patient-Specific Acoustic Simulations for Transcranial Focused Ultrasound Procedures Based on Optical Tracking Information","author":"Sigona","year":"2023","journal-title":"IEEE Open J. Ultrason., Ferroelectr., Freq. Control"},{"issue":"3","key":"10.1016\/j.jneumeth.2025.110433_bib30","doi-asserted-by":"crossref","first-page":"218","DOI":"10.3390\/brainsci14030218","article-title":"Clinical Potential of Transcranial Focused Ultrasound for Neurorehabilitation in Pediatric Cancer Survivors","volume":"14","author":"VanGilder","year":"2024","journal-title":"Brain Sci."},{"issue":"4","key":"10.1016\/j.jneumeth.2025.110433_bib31","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s40846-023-00810-2","article-title":"Comparing transcranial direct current stimulation (tDCS) with other non-invasive brain stimulation (NIBS) in the treatment of Alzheimer\u2019s disease: A literature review","volume":"43","author":"Wang","year":"2023","journal-title":"J. Med. Biol. Eng."},{"issue":"1","key":"10.1016\/j.jneumeth.2025.110433_bib32","doi-asserted-by":"crossref","first-page":"13500","DOI":"10.1038\/s41598-023-40598-4","article-title":"Transcranial focused ultrasound-induced blood-brain barrier opening in mice without shaving hairs","volume":"13","author":"Xu","year":"2023","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.jneumeth.2025.110433_bib33","doi-asserted-by":"crossref","first-page":"12339","DOI":"10.1038\/s41598-023-39640-2","article-title":"Non-invasive enhancement of intracortical solute clearance using transcranial focused ultrasound","volume":"13","author":"Yoo","year":"2023","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.jneumeth.2025.110433_bib34","doi-asserted-by":"crossref","first-page":"12339","DOI":"10.1038\/s41598-023-39640-2","article-title":"Non-invasive enhancement of intracortical solute clearance using transcranial focused ultrasound","volume":"13","author":"Yoo","year":"2023","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.jneumeth.2025.110433_bib35","doi-asserted-by":"crossref","first-page":"3829","DOI":"10.1111\/cns.14303","article-title":"Excitatory-inhibitory modulation of transcranial focus ultrasound stimulation on human motor cortex","volume":"29","author":"Zhang","year":"2023","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.jneumeth.2025.110433_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneumeth.2021.109383","article-title":"Feasibility of ultrasound-induced blood-brain barrier disruption with a single-element transducer under three different frequencies in two non-human primates in vivo: Case report","volume":"365","author":"Zhou","year":"2022","journal-title":"J. Neurosci. Methods"}],"container-title":["Journal of Neuroscience Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165027025000743?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165027025000743?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T04:12:53Z","timestamp":1778040773000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165027025000743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":36,"alternative-id":["S0165027025000743"],"URL":"https:\/\/doi.org\/10.1016\/j.jneumeth.2025.110433","relation":{},"ISSN":["0165-0270"],"issn-type":[{"value":"0165-0270","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrating data mining with transcranial focused ultrasound to refine neuralgia treatment strategies","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroscience Methods","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneumeth.2025.110433","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110433"}}