{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T12:34:43Z","timestamp":1793277283286,"version":"4.5.0"},"reference-count":94,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroscience Methods"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.jneumeth.2026.110924","type":"journal-article","created":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T09:44:10Z","timestamp":1792230250000},"page":"110924","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Use of the arousal-based individual screening model for studying post-traumatic stress disorder: Findings and future directions"],"prefix":"10.1016","volume":"438","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6920-439X","authenticated-orcid":false,"given":"Sebastiano A.","family":"Torrisi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7280-4871","authenticated-orcid":false,"given":"Gian Marco","family":"Leggio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jneumeth.2026.110924_bib1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3389\/fnsys.2019.00085","article-title":"Investigating Individual Pre-trauma Susceptibility to a PTSD-Like Phenotype in Animals","volume":"13","author":"Alexander","year":"2019","journal-title":"Front. Syst. Neurosci."},{"key":"10.1016\/j.jneumeth.2026.110924_bib2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.nbd.2016.01.012","article-title":"Behavioral profiling as a translational approach in an animal model of posttraumatic stress disorder","volume":"88","author":"Ardi","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.jneumeth.2026.110924_bib3","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.biopsycho.2018.01.005","article-title":"Veterans with PTSD demonstrate amygdala hyperactivity while viewing threatening faces: A MEG study","volume":"132","author":"Badura-Brack","year":"2018","journal-title":"Biol. Psychol."},{"key":"10.1016\/j.jneumeth.2026.110924_bib4","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.neuron.2016.04.015","article-title":"Circuit-wide Transcriptional Profiling Reveals Brain Region-Specific Gene Networks Regulating Depression Susceptibility","volume":"90","author":"Bagot","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.jneumeth.2026.110924_bib5","doi-asserted-by":"crossref","first-page":"G661","DOI":"10.1152\/ajpgi.00194.2019","article-title":"Posttraumatic stress disorder is associated with altered gut microbiota that modulates cognitive performance in veterans with cirrhosis","volume":"317","author":"Bajaj","year":"2019","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.jneumeth.2026.110924_bib6","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1038\/s41386-019-0405-9","article-title":"The critical importance of basic animal research for neuropsychiatric disorders","volume":"44","author":"Bale","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jneumeth.2026.110924_bib7","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cell.2018.03.006","article-title":"Metazoan MicroRNAs","volume":"173","author":"Bartel","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.jneumeth.2026.110924_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2020.105047","article-title":"Volatility as a Concept to Understand the Impact of Stress on the Microbiome","volume":"124","author":"Bastiaanssen","year":"2021","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jneumeth.2026.110924_bib9","doi-asserted-by":"crossref","DOI":"10.1080\/20008066.2026.2627060","article-title":"The microbiome and PTSD: a scoping review across preclinical and clinical studies","volume":"17","author":"Berendse","year":"2026","journal-title":"Eur. J. Psychotraumatol."},{"issue":"1","key":"10.1016\/j.jneumeth.2026.110924_bib10","doi-asserted-by":"crossref","first-page":"S186","DOI":"10.1016\/j.psyneuen.2009.05.021","article-title":"The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders","volume":"34","author":"Binder","year":"2009","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jneumeth.2026.110924_bib11","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1001\/jama.299.11.1291","article-title":"Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults","volume":"299","author":"Binder","year":"2008","journal-title":"JAMA"},{"key":"10.1016\/j.jneumeth.2026.110924_bib12","doi-asserted-by":"crossref","DOI":"10.1037\/tra0001949","article-title":"Development and evaluation of a centralized assessment hub for the clinician-administered PTSD Scale for the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (CAPS-5)","author":"Bovin","year":"2025","journal-title":"Psychol. Trauma."},{"key":"10.1016\/j.jneumeth.2026.110924_bib13","doi-asserted-by":"crossref","first-page":"445","DOI":"10.31887\/DCNS.2006.8.4\/jbremner","article-title":"Traumatic stress: effects on the brain","volume":"8","author":"Bremner","year":"2006","journal-title":"Dialog.-. Clin. Neurosci."},{"key":"10.1016\/j.jneumeth.2026.110924_bib14","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1176\/ajp.153.3.369","article-title":"Chronic PTSD in Vietnam combat veterans: course of illness and substance abuse","volume":"153","author":"Bremner","year":"1996","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jneumeth.2026.110924_bib15","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/nrn1909","article-title":"Why sex matters for neuroscience","volume":"7","author":"Cahill","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jneumeth.2026.110924_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneumeth.2025.110380","article-title":"A behavioral screening method for predicting PTSD-like phenotypes: Novel application to female rats","volume":"416","author":"Chiacchierini","year":"2025","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.jneumeth.2026.110924_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/srep32935","article-title":"24-hour-restraint stress induces long-term depressive-like phenotypes in mice","volume":"6","author":"Chu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jneumeth.2026.110924_bib18","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1196\/annals.1314.014","article-title":"An animal model of posttraumatic stress disorder: the use of cut-off behavioral criteria","volume":"1032","author":"Cohen","year":"2004","journal-title":"Ann. N. Y Acad. Sci."},{"key":"10.1016\/j.jneumeth.2026.110924_bib19","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/s41398-020-00929-9","article-title":"Predicting susceptibility and resilience in an animal model of post-traumatic stress disorder (PTSD)","volume":"10","author":"Colucci","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jneumeth.2026.110924_bib20","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1176\/appi.ajp.2020.20050653","article-title":"Impact of the KCNQ2\/3 Channel Opener Ezogabine on Reward Circuit Activity and Clinical Symptoms in Depression: Results From a Randomized Controlled Trial","volume":"178","author":"Costi","year":"2021","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jneumeth.2026.110924_bib21","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1152\/physrev.00018.2018","article-title":"The Microbiota-Gut-Brain Axis","volume":"99","author":"Cryan","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jneumeth.2026.110924_bib22","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.biopsych.2025.02.894","article-title":"Amygdala Hyperactivity in Posttraumatic Stress Disorder: Disentangling Predisposing From Consequential Factors Using a Prospective Longitudinal Design","volume":"98","author":"de Voogd","year":"2025","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jneumeth.2026.110924_bib23","doi-asserted-by":"crossref","first-page":"E14","DOI":"10.1097\/PHH.0000000000001837","article-title":"Symptoms of Posttraumatic Stress During the COVID-19 Pandemic in the Governmental Public Health Workforce and General Population","volume":"30","author":"Dewhurst","year":"2024","journal-title":"J. Public. Health Manag. Pract."},{"key":"10.1016\/j.jneumeth.2026.110924_bib24","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1097\/CM9.0000000000002647","article-title":"Psilocybin facilitates fear extinction in mice by promoting hippocampal neuroplasticity","volume":"136","author":"Du","year":"2023","journal-title":"Chin. Med. J. (Engl. )"},{"key":"10.1016\/j.jneumeth.2026.110924_bib25","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/sj.mp.4002054","article-title":"Reduced GABAA benzodiazepine receptor binding in veterans with post-traumatic stress disorder","volume":"13","author":"Geuze","year":"2008","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jneumeth.2026.110924_bib26","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s41593-020-00748-7","article-title":"Transcriptomic organization of the human brain in post-traumatic stress disorder","volume":"24","author":"Girgenti","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jneumeth.2026.110924_bib27","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jneumeth.2011.01.019","article-title":"Integrated behavioral z-scoring increases the sensitivity and reliability of behavioral phenotyping in mice: relevance to emotionality and sex","volume":"197","author":"Guilloux","year":"2011","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.jneumeth.2026.110924_bib28","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/s44220-024-00236-y","article-title":"Disentangling sex differences in PTSD risk factors","volume":"2","author":"Haering","year":"2024","journal-title":"Nat. Ment. Health"},{"key":"10.1016\/j.jneumeth.2026.110924_bib29","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1097\/PSY.0000000000000512","article-title":"The Microbiome in Posttraumatic Stress Disorder and Trauma-Exposed Controls: An Exploratory Study","volume":"79","author":"Hemmings","year":"2017","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.jneumeth.2026.110924_bib30","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.expneurol.2016.05.014","article-title":"Noradrenergic dysregulation in the pathophysiology of PTSD","volume":"284","author":"Hendrickson","year":"2016","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jneumeth.2026.110924_bib31","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/s41586-025-09083-y","article-title":"Single-cell transcriptomic and chromatin dynamics of the human brain in PTSD","volume":"643","author":"Hwang","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.jneumeth.2026.110924_bib32","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.janxdis.2010.09.004","article-title":"Gender differences in PTSD symptoms: an exploration of peritraumatic mechanisms","volume":"25","author":"Irish","year":"2011","journal-title":"J. Anxiety Disord."},{"key":"10.1016\/j.jneumeth.2026.110924_bib33","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/neu.10200","article-title":"Effects of neonatal gonadal steroids on adult CA3 pyramidal neuron dendritic morphology and spatial memory in rats","volume":"55","author":"Isgor","year":"2003","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.jneumeth.2026.110924_bib34","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jpsychires.2021.01.039","article-title":"Functional impairment in Posttraumatic Stress Disorder: A systematic review and meta-analysis","volume":"136","author":"Jellestad","year":"2021","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jneumeth.2026.110924_bib35","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1016\/j.psyneuen.2011.04.008","article-title":"Cortisol suppression by dexamethasone reduces exaggerated fear responses in posttraumatic stress disorder","volume":"36","author":"Jovanovic","year":"2011","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jneumeth.2026.110924_bib36","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.bbi.2023.09.005","article-title":"The emerging role of the gut microbiome in posttraumatic stress disorder","volume":"114","author":"Ke","year":"2023","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jneumeth.2026.110924_bib37","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nn.3275","article-title":"Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions","volume":"16","author":"Klengel","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jneumeth.2026.110924_bib38","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1017\/S0033291717000708","article-title":"Posttraumatic stress disorder in the World Mental Health Surveys","volume":"47","author":"Koenen","year":"2017","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jneumeth.2026.110924_bib39","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1002\/jts.20478","article-title":"A prospective study of sex differences in the lifetime risk of posttraumatic stress disorder among abused and neglected children grown up","volume":"22","author":"Koenen","year":"2009","journal-title":"J. Trauma. Stress."},{"key":"10.1016\/j.jneumeth.2026.110924_bib40","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/jnr.23864","article-title":"Sex differences in hippocampal function","volume":"95","author":"Koss","year":"2017","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.jneumeth.2026.110924_bib41","doi-asserted-by":"crossref","first-page":"12982","DOI":"10.1523\/JNEUROSCI.3059-09.2009","article-title":"Cytoskeletal changes underlie estrogen's acute effects on synaptic transmission and plasticity","volume":"29","author":"Kramar","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jneumeth.2026.110924_bib42","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.cell.2007.09.018","article-title":"Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions","volume":"131","author":"Krishnan","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.jneumeth.2026.110924_bib43","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s11920-017-0829-z","article-title":"Synaptic Loss and the Pathophysiology of PTSD: Implications for Ketamine as a Prototype Novel Therapeutic","volume":"19","author":"Krystal","year":"2017","journal-title":"Curr. Psychiatry Rep."},{"key":"10.1016\/j.jneumeth.2026.110924_bib44","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.brainres.2009.03.044","article-title":"Noradrenergic and serotonergic mechanisms in the neurobiology of posttraumatic stress disorder and resilience","volume":"1293","author":"Krystal","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.jneumeth.2026.110924_bib45","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.biopsych.2012.06.029","article-title":"Gray matter correlates of posttraumatic stress disorder: a quantitative meta-analysis","volume":"73","author":"Kuhn","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jneumeth.2026.110924_bib46","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.bbi.2022.11.004","article-title":"Gut microbiota alterations promote traumatic stress susceptibility associated with p-cresol-induced dopaminergic dysfunctions","volume":"107","author":"Laudani","year":"2023","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jneumeth.2026.110924_bib47","article-title":"Post traumatic stress disorder associated hypothalamic-pituitary-adrenal axis dysregulation and physical illness","volume":"41","author":"Lawrence","year":"2024","journal-title":"Brain Behav. Immun. Health"},{"issue":"1","key":"10.1016\/j.jneumeth.2026.110924_bib48","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.biopsych.2025.10.032","article-title":"Mapping DNA Methylation Signatures to Identify Epigenetic Variation Across Subcortical Regions of the Human Posttraumatic Stress Disorder Brain","volume":"100","author":"Li","year":"2026","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jneumeth.2026.110924_bib49","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.biopsych.2005.06.033","article-title":"Cortisol, learning, memory, and attention in relation to smaller hippocampal volume in police officers with posttraumatic stress disorder","volume":"59","author":"Lindauer","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jneumeth.2026.110924_bib50","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.biopsych.2017.09.006","article-title":"Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia","volume":"83","author":"Logue","year":"2018","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jneumeth.2026.110924_bib51","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2023.1182345","article-title":"Role of FKBP5 and its genetic mutations in stress-induced psychiatric disorders: an opportunity for drug discovery","volume":"14","author":"Malekpour","year":"2023","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.jneumeth.2026.110924_bib52","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s13293-025-00732-5","article-title":"Interindividual and sex differences in resilience and vulnerability to post-traumatic stress disorder (PTSD): insights from animal models","volume":"16","author":"Mancini","year":"2025","journal-title":"Biol. Sex. Differ."},{"key":"10.1016\/j.jneumeth.2026.110924_bib53","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22105157","article-title":"Dysregulation of miR-15a-5p, miR-497a-5p and miR-511-5p Is Associated with Modulation of BDNF and FKBP5 in Brain Areas of PTSD-Related Susceptible and Resilient Mice","volume":"22","author":"Maurel","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jneumeth.2026.110924_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.ynstr.2019.100169","article-title":"Effects of restraint stress on the regulation of hippocampal glutamate receptor and inflammation genes in female C57BL\/6 and BALB\/c mice","volume":"10","author":"McWhirt","year":"2019","journal-title":"Neurobiol. Stress."},{"key":"10.1016\/j.jneumeth.2026.110924_bib55","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1007\/s00213-014-3776-y","article-title":"Women with PTSD have a changed sensitivity to GABA-A receptor active substances","volume":"233","author":"Moller","year":"2016","journal-title":"Psychopharmacol. (Berl.)"},{"key":"10.1016\/j.jneumeth.2026.110924_bib56","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.biopsych.2011.07.003","article-title":"Reduced amygdala serotonin transporter binding in posttraumatic stress disorder","volume":"70","author":"Murrough","year":"2011","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jneumeth.2026.110924_bib57","doi-asserted-by":"crossref","first-page":"4977","DOI":"10.1038\/s41380-023-02139-3","article-title":"Stress, microRNAs, and stress-related psychiatric disorders: an overview","volume":"28","author":"Musazzi","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jneumeth.2026.110924_bib58","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1016\/j.neuron.2024.05.001","article-title":"Neurobiological basis of stress resilience","volume":"112","author":"Nestler","year":"2024","journal-title":"Neuron"},{"key":"10.1016\/j.jneumeth.2026.110924_bib59","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1152\/physrev.00025.2013","article-title":"The organic anion transporter (OAT) family: a systems biology perspective","volume":"95","author":"Nigam","year":"2015","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jneumeth.2026.110924_bib60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pscychresns.2015.01.002","article-title":"A systematic review and meta-analysis of magnetic resonance imaging measurement of structural volumes in posttraumatic stress disorder","volume":"232","author":"O'Doherty","year":"2015","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.jneumeth.2026.110924_bib61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000542696","article-title":"The saNeuroGut Initiative: Investigating the Gut Microbiome and Symptoms of Anxiety, Depression, and Posttraumatic Stress","volume":"32","author":"O'Hare","year":"2025","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.jneumeth.2026.110924_bib62","doi-asserted-by":"crossref","DOI":"10.1038\/s41386-026-02371-9","article-title":"Investigational drugs in PTSD","author":"Obi","year":"2026","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jneumeth.2026.110924_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2022.110512","article-title":"Long term effects of 24-h-restraint stress on the connectivity and structure of interneurons in the basolateral amygdala","volume":"115","author":"Pesarico","year":"2022","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jneumeth.2026.110924_bib64","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1038\/s41380-019-0383-7","article-title":"Resilience as a translational endpoint in the treatment of PTSD","volume":"24","author":"Rakesh","year":"2019","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jneumeth.2026.110924_bib65","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.biopsych.2017.11.016","article-title":"Mechanisms of Sex Differences in Fear and Posttraumatic Stress Disorder","volume":"83","author":"Ramikie","year":"2018","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jneumeth.2026.110924_bib66","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.biopsych.2006.06.004","article-title":"Neurocircuitry models of posttraumatic stress disorder and extinction: human neuroimaging research--past, present, and future","volume":"60","author":"Rauch","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jneumeth.2026.110924_bib67","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/s41582-022-00635-8","article-title":"Post-traumatic stress disorder: clinical and translational neuroscience from cells to circuits","volume":"18","author":"Ressler","year":"2022","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.jneumeth.2026.110924_bib68","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/s41398-021-01514-4","article-title":"Title: \"Labels Matter: Is it stress or is it Trauma?\"","volume":"11","author":"Richter-Levin","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jneumeth.2026.110924_bib69","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1038\/s41380-018-0272-5","article-title":"Animal models of PTSD: a challenge to be met","volume":"24","author":"Richter-Levin","year":"2019","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jneumeth.2026.110924_bib70","doi-asserted-by":"crossref","DOI":"10.1080\/20008066.2024.2448385","article-title":"Gender differences in early posttraumatic stress disorder symptoms: a network analysis","volume":"16","author":"Ronning","year":"2025","journal-title":"Eur. J. Psychotraumatol."},{"key":"10.1016\/j.jneumeth.2026.110924_bib71","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1038\/nn.3234","article-title":"Neurobiology of resilience","volume":"15","author":"Russo","year":"2012","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jneumeth.2026.110924_bib72","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/s41583-021-00540-x","article-title":"The stressed synapse 2.0: pathophysiological mechanisms in stress-related neuropsychiatric disorders","volume":"23","author":"Sanacora","year":"2022","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jneumeth.2026.110924_bib73","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1177\/070674371405900902","article-title":"Posttraumatic stress disorder in adults: impact, comorbidity, risk factors, and treatment","volume":"59","author":"Sareen","year":"2014","journal-title":"Can. J. Psychiatry"},{"key":"10.1016\/j.jneumeth.2026.110924_bib74","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1080\/03007995.2021.1978417","article-title":"Prevalence of post-traumatic stress disorder in the United States: a systematic literature review","volume":"37","author":"Schein","year":"2021","journal-title":"Curr. Med. Res. Opin."},{"key":"10.1016\/j.jneumeth.2026.110924_bib75","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1037\/0021-843X.113.2.189","article-title":"All symptoms are not created equal: the prominent role of hyperarousal in the natural course of posttraumatic psychological distress","volume":"113","author":"Schell","year":"2004","journal-title":"J. Abnorm. Psychol."},{"key":"10.1016\/j.jneumeth.2026.110924_bib76","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.ynstr.2014.09.005","article-title":"Sex differences in PTSD resilience and susceptibility: Challenges for animal models of fear learning","volume":"1","author":"Shansky","year":"2015","journal-title":"Neurobiol. Stress."},{"key":"10.1016\/j.jneumeth.2026.110924_bib77","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0033201","article-title":"MicroRNA expression is down-regulated and reorganized in prefrontal cortex of depressed suicide subjects","volume":"7","author":"Smalheiser","year":"2012","journal-title":"PLoS. One"},{"key":"10.1016\/j.jneumeth.2026.110924_bib78","doi-asserted-by":"crossref","first-page":"7780","DOI":"10.1523\/JNEUROSCI.0762-05.2005","article-title":"Estrogen-induced increase in the magnitude of long-term potentiation occurs only when the ratio of NMDA transmission to AMPA transmission is increased","volume":"25","author":"Smith","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jneumeth.2026.110924_bib79","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/0167-4838(90)90176-G","article-title":"Inactivation of dopamine beta-hydroxylase by p-cresol: evidence for a second, minor site of covalent modification at tyrosine 357","volume":"1037","author":"Southan","year":"1990","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jneumeth.2026.110924_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.ynstr.2019.100180","article-title":"HPA axis function and diurnal cortisol in post-traumatic stress disorder: A systematic review","volume":"11","author":"Speer","year":"2019","journal-title":"Neurobiol. Stress."},{"key":"10.1016\/j.jneumeth.2026.110924_bib81","doi-asserted-by":"crossref","first-page":"483","DOI":"10.3109\/08039488.2015.1005023","article-title":"The course of PTSD in naturalistic long-term studies: high variability of outcomes. A systematic review","volume":"69","author":"Steinert","year":"2015","journal-title":"Nord. J. Psychiatry"},{"key":"10.1016\/j.jneumeth.2026.110924_bib82","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1038\/s41380-018-0283-2","article-title":"Effects of the KCNQ channel opener ezogabine on functional connectivity of the ventral striatum and clinical symptoms in patients with major depressive disorder","volume":"25","author":"Tan","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jneumeth.2026.110924_bib83","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1037\/0033-2909.132.6.959","article-title":"Sex differences in trauma and posttraumatic stress disorder: a quantitative review of 25 years of research","volume":"132","author":"Tolin","year":"2006","journal-title":"Psychol. Bull."},{"key":"10.1016\/j.jneumeth.2026.110924_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.ynstr.2020.100286","article-title":"A novel arousal-based individual screening reveals susceptibility and resilience to PTSD-like phenotypes in mice","volume":"14","author":"Torrisi","year":"2021","journal-title":"Neurobiol. Stress."},{"key":"10.1016\/j.jneumeth.2026.110924_bib85","doi-asserted-by":"crossref","first-page":"404","DOI":"10.3389\/fphar.2019.00404","article-title":"Therapeutic Challenges of Post-traumatic Stress Disorder: Focus on the Dopaminergic System","volume":"10","author":"Torrisi","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jneumeth.2026.110924_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2025.108072","article-title":"Functional, synaptoproteomic and structural adaptations underlying sex-dependent traumatic stress susceptibility\/resilience in the hippocampus","volume":"223","author":"Torrisi","year":"2026","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jneumeth.2026.110924_bib87","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1475-2832-2-4","article-title":"Risk and resiliency factors in posttraumatic stress disorder","volume":"2","author":"Voges","year":"2003","journal-title":"Ann. Gen. Hosp. Psychiatry"},{"key":"10.1016\/j.jneumeth.2026.110924_bib88","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13073-025-01473-1","article-title":"A multi-omic approach implicates novel protein dysregulation in post-traumatic stress disorder","volume":"17","author":"Wang","year":"2025","journal-title":"Genome Med."},{"key":"10.1016\/j.jneumeth.2026.110924_bib89","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.neubiorev.2018.08.017","article-title":"Glucocorticoid receptor gene (NR3C1) DNA methylation in association with trauma, psychopathology, transcript expression, or genotypic variation: A systematic review","volume":"95","author":"Watkeys","year":"2018","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jneumeth.2026.110924_bib90","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3389\/fnbeh.2018.00258","article-title":"Treating PTSD: A Review of Evidence-Based Psychotherapy Interventions","volume":"12","author":"Watkins","year":"2018","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.jneumeth.2026.110924_bib91","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1080\/01677063.2024.2419098","article-title":"Clinical potential of epigenetic and microRNA biomarkers in PTSD","volume":"38","author":"Wellington","year":"2024","journal-title":"J. Neurogenet."},{"issue":"3","key":"10.1016\/j.jneumeth.2026.110924_bib92","article-title":"Pharmacotherapy for post traumatic stress disorder (PTSD)","author":"Williams","year":"2022","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.jneumeth.2026.110924_bib93","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.lfs.2003.12.004","article-title":"Sexual dimorphism in the induction of LTP: critical role of tetanizing stimulation","volume":"75","author":"Yang","year":"2004","journal-title":"Life Sci."},{"key":"10.1016\/j.jneumeth.2026.110924_bib94","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/s41398-023-02643-8","article-title":"Association between microbiome and the development of adverse posttraumatic neuropsychiatric sequelae after traumatic stress exposure","volume":"13","author":"Zeamer","year":"2023","journal-title":"Transl. Psychiatry"}],"container-title":["Journal of Neuroscience Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165027026002542?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165027026002542?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T12:01:20Z","timestamp":1793275280000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165027026002542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":94,"alternative-id":["S0165027026002542"],"URL":"https:\/\/doi.org\/10.1016\/j.jneumeth.2026.110924","relation":{},"ISSN":["0165-0270"],"issn-type":[{"value":"0165-0270","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Use of the arousal-based individual screening model for studying post-traumatic stress disorder: Findings and future directions","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroscience Methods","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneumeth.2026.110924","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"110924"}}