{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T12:34:29Z","timestamp":1793277269730,"version":"4.5.0"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:00:00Z","timestamp":1792713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroscience Methods"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.jneumeth.2026.110940","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T16:14:24Z","timestamp":1792772064000},"page":"110940","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Baseline adjustment and normalisation in neurite outgrowth assays: A simulation-based comparison of analytical methods"],"prefix":"10.1016","volume":"438","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5027-1528","authenticated-orcid":false,"given":"Kyle","family":"Hewitt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu-Feng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jneumeth.2026.110940_bib1","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.cct.2004.06.001","article-title":"Adjustment for baseline measurement error in randomized controlled trials induces bias","volume":"25","author":"Chan","year":"2004","journal-title":"Control. Clin. Trials"},{"key":"10.1016\/j.jneumeth.2026.110940_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2023.1108715","article-title":"Methods for the isolation and analysis of Abeta from postmortem brain","volume":"17","author":"Hong","year":"2023","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.jneumeth.2026.110940_bib3","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s13024-022-00558-4","article-title":"Elevated ganglioside GM2 activator (GM2A) in human brain tissue reduces neurite integrity and spontaneous neuronal activity","volume":"17","author":"Hsieh","year":"2022","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.jneumeth.2026.110940_bib4","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.1038\/s41467-018-05068-w","article-title":"An in vitro paradigm to assess potential anti-Abeta antibodies for Alzheimer's disease","volume":"9","author":"Jin","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jneumeth.2026.110940_bib5","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1258\/la.2012.012003","article-title":"The fallacy of ratio correction to address confounding factors","volume":"46","author":"Karp","year":"2012","journal-title":"Lab. Anim."},{"key":"10.1016\/j.jneumeth.2026.110940_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.2005282","article-title":"What exactly is 'N' in cell culture and animal experiments?","volume":"16","author":"Lazic","year":"2018","journal-title":"PLoS. Biol."},{"key":"10.1016\/j.jneumeth.2026.110940_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.719636","article-title":"Pharmacological Modulation of Neurite Outgrowth in Human Neural Progenitor Cells by Inhibiting Non-muscle Myosin II","volume":"9","author":"Lilienberg","year":"2021","journal-title":"Front. Cell. Dev. Biol."},{"key":"10.1016\/j.jneumeth.2026.110940_bib8","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1037\/h0025105","article-title":"A paradox in the interpretation of group comparisons","volume":"68","author":"Lord","year":"1967","journal-title":"Psychol. Bull."},{"key":"10.1016\/j.jneumeth.2026.110940_bib9","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202001064","article-title":"SuperPlots: Communicating reproducibility and variability in cell biology","volume":"219","author":"Lord","year":"2020","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.jneumeth.2026.110940_bib10","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.48175","article-title":"Ten common statistical mistakes to watch out for when writing or reviewing a manuscript","volume":"8","author":"Makin","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.jneumeth.2026.110940_bib11","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1002\/sim.8086","article-title":"Using simulation studies to evaluate statistical methods","volume":"38","author":"Morris","year":"2019","journal-title":"Stat. Med."},{"key":"10.1016\/j.jneumeth.2026.110940_bib12","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1038\/nn.2886","article-title":"Erroneous analyses of interactions in neuroscience: a problem of significance","volume":"14","author":"Nieuwenhuis","year":"2011","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jneumeth.2026.110940_bib13","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1007\/s00204-024-03708-3","article-title":"Effects of the nerve agent VX on hiPSC-derived motor neurons","volume":"98","author":"Schaefers","year":"2024","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.jneumeth.2026.110940_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/cells10040931","article-title":"A Propagated Skeleton Approach to High Throughput Screening of Neurite Outgrowth for In Vitro Parkinson's Disease Modelling","volume":"10","author":"Schikora","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.jneumeth.2026.110940_bib15","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1002\/sim.4780131703","article-title":"Testing for baseline balance in clinical trials","volume":"13","author":"Senn","year":"1994","journal-title":"Stat. Med."},{"key":"10.1016\/j.jneumeth.2026.110940_bib16","doi-asserted-by":"crossref","first-page":"4334","DOI":"10.1002\/sim.2682","article-title":"Change from baseline and analysis of covariance revisited","volume":"25","author":"Senn","year":"2006","journal-title":"Stat. Med."},{"key":"10.1016\/j.jneumeth.2026.110940_bib17","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.jclinepi.2006.02.007","article-title":"ANCOVA versus change from baseline: more power in randomized studies, more bias in nonrandomized studies [corrected]","volume":"59","author":"Van Breukelen","year":"2006","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.jneumeth.2026.110940_bib18","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-2288-1-6","article-title":"The use of percentage change from baseline as an outcome in a controlled trial is statistically inefficient: a simulation study","volume":"1","author":"Vickers","year":"2001","journal-title":"BMC Med. Res. Methodol."},{"key":"10.1016\/j.jneumeth.2026.110940_bib19","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1136\/bmj.323.7321.1123","article-title":"Statistics notes: Analysing controlled trials with baseline and follow up measurements","volume":"323","author":"Vickers","year":"2001","journal-title":"BMJ"},{"key":"10.1016\/j.jneumeth.2026.110940_bib20","article-title":"High-Throughput Neurite Outgrowth Assay Using GFP-Labeled iPSC-Derived Neurons","volume":"2","author":"Zhang","year":"2022","journal-title":"Curr. Protoc."}],"container-title":["Journal of Neuroscience Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165027026002700?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165027026002700?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T12:00:42Z","timestamp":1793275242000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165027026002700"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":20,"alternative-id":["S0165027026002700"],"URL":"https:\/\/doi.org\/10.1016\/j.jneumeth.2026.110940","relation":{},"ISSN":["0165-0270"],"issn-type":[{"value":"0165-0270","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Baseline adjustment and normalisation in neurite outgrowth assays: A simulation-based comparison of analytical methods","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroscience Methods","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneumeth.2026.110940","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"110940"}}