{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T11:27:22Z","timestamp":1791026842638,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T00:00:00Z","timestamp":1078099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T00:00:00Z","timestamp":1078099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jni-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimmunology"],"published-print":{"date-parts":[[2004,3]]},"DOI":"10.1016\/j.jneuroim.2003.10.056","type":"journal-article","created":{"date-parts":[[2004,1,15]],"date-time":"2004-01-15T05:19:27Z","timestamp":1074143967000},"page":"11-23","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":275,"title":["Intracerebral expression of CXCL13 and BAFF is accompanied by formation of lymphoid follicle-like structures in the meninges of mice with relapsing experimental autoimmune encephalomyelitis"],"prefix":"10.1016","volume":"148","author":[{"given":"Roberta","family":"Magliozzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Columba-Cabezas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Serafini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Aloisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jneuroim.2003.10.056_BIB1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/1521-4141(200208)32:8<2133::AID-IMMU2133>3.0.CO;2-W","volume":"32","author":"Alt","year":"2002","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB2","doi-asserted-by":"crossref","first-page":"4497","DOI":"10.4049\/jimmunol.170.9.4497","article-title":"Determinants of human B cell migration across brain endothelial cells","volume":"170","author":"Alter","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB3","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/S0952-7915(00)00201-6","article-title":"Chemokines in lymphopoiesis and lymphoid organ development","volume":"13","author":"Ansel","year":"2001","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB4","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1002\/1531-8249(200006)47:6<694::AID-ANA2>3.0.CO;2-W","article-title":"The role of B cells and autoantibodies in multiple sclerosis","volume":"47","author":"Archelos","year":"2000","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB5","doi-asserted-by":"crossref","first-page":"5133","DOI":"10.4049\/jimmunol.163.9.5133","article-title":"B cell repertoire diversity and clonal expansion in multiple sclerosis brain lesions","volume":"163","author":"Baranzini","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB6","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S0002-9440(10)65615-5","article-title":"T-cell apoptosis in inflammatory brain lesions: destruction of T cells does not depend on antigen recognition","volume":"153","author":"Bauer","year":"1998","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB7","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/1529-0131(200106)44:6<1313::AID-ART223>3.0.CO;2-S","article-title":"Elevated serum B lymphocyte stimulator levels in patients with systemic immune-based rheumatic diseases","volume":"44","author":"Cheema","year":"2001","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB8","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.4049\/jimmunol.164.5.2782","article-title":"Accumulation of clonally related B lymphocytes in the cerebrospinal fluid of multiple sclerosis patients","volume":"164","author":"Colombo","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB9","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1750-3639.2003.tb00005.x","article-title":"Lymphoid chemokines CCL19 and CCL21 are expressed in the central nervous system during experimental autoimmune encephalomyelitis: implications for the maintenance of chronic neuroinflammation","volume":"13","author":"Columba-Cabezas","year":"2003","journal-title":"Brain Pathol."},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-5728(00)00409-4","article-title":"B cells and antibodies in CNS demyelinating disease","volume":"112","author":"Cross","year":"2001","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB11","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1126\/science.286.5447.2098","article-title":"Chemokines and cell migration in secondary lymphoid organs","volume":"286","author":"Cyster","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB12","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1034\/j.1600-065X.2000.00618.x","article-title":"Follicular stromal cells and lymphocyte homing to follicles","volume":"176","author":"Cyster","year":"2000","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB13","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1093\/intimm\/12.5.711","article-title":"Short-lived immunization site inflammation in self-limited active experimental allergic encephalomyelitis","volume":"12","author":"Di Rosa","year":"2000","journal-title":"Int. Immunol."},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB14","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1084\/jem.189.1.159","article-title":"Mature follicular dendritic cell networks depend on expression of lymphotoxin beta receptor by radioresistant stromal cells and of lymphotoxin beta and tumor necrosis factor by B cells","volume":"189","author":"Endres","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB15","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/S0140-6736(77)91603-8","article-title":"Immunoglobulin-containing cells in multiple sclerosis plaques","volume":"2","author":"Esiri","year":"1977","journal-title":"Lancet"},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB16","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.4049\/jimmunol.163.5.2403","article-title":"Caspase-1 regulates the inflammatory process leading to autoimmune demyelination","volume":"163","author":"Furlan","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB17","doi-asserted-by":"crossref","first-page":"2966","DOI":"10.1172\/JCI118368","article-title":"Antibody facilitation of multiple sclerosis-like lesions in a nonhuman primate","volume":"96","author":"Genain","year":"1995","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB18","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/5532","article-title":"Identification of autoantibodies associated with myelin damage in multiple sclerosis","volume":"5","author":"Genain","year":"1999","journal-title":"Nat. Med."},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB19","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1189\/jlb.1202598","article-title":"Phenotypic and functional analysis of T cells homing into the CSF of subjects with inflammatory diseases of the CNS","volume":"73","author":"Giunti","year":"2003","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB20","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1172\/JCI0214121","article-title":"Association of BAFF\/BLys overexpression and altered B cell differentiation with Sj\u00f6gren's syndrome","volume":"109","author":"Groom","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB21","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1189\/jlb.69.3.331","article-title":"Lymphoid neogenesis: de novo formation of lymphoid tissue in chronic inflammation through expression of homing chemokines","volume":"69","author":"Hjelmstr\u00f6m","year":"2001","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB22","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1084\/jem.193.12.1393","article-title":"Aberrant high expression of B lymphocyte chemokine (BLC\/CXCL13) by C11b+CD11c+ dendritic cells in murine lupus and preferential chemotaxis of B1 cells towards BLC","volume":"193","author":"Ishikawa","year":"2001","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB23","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.4049\/jimmunol.148.8.2331","article-title":"Follicular dendritic cell-dependent adhesion and proliferation of B cells in vitro","volume":"15","author":"Kosco","year":"1992","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB24","first-page":"69","article-title":"Follicular dendritic cells: antigen retention, B cell activation and cytokine production","volume":"201","author":"Kosco-Vilbois","year":"1995","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB25","first-page":"443","article-title":"Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin\/oligodendrocyte glycoprotein","volume":"130","author":"Linington","year":"1988","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB26","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1084\/jem.188.1.169","article-title":"B lymphocytes producing demyelinating autoantibodies: development and function in gene-targeted transgenic mice","volume":"188","author":"Litzenburger","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB27","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S1471-4906(01)02063-4","article-title":"Immunology of viral-vector-mediated gene transfer into the brain: an evolutionary and developmental perspective","volume":"23","author":"Lowenstein","year":"2002","journal-title":"Trends Immunol."},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB28","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S1074-7613(00)80199-5","article-title":"BLC expression in pancreatic islets causes B cell recruitment and lymphotoxin-dependent lymphoid neogenesis","volume":"12","author":"Luther","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB29","doi-asserted-by":"crossref","first-page":"424","DOI":"10.4049\/jimmunol.169.1.424","article-title":"Differing activities of homeostatic chemokines CCL19, CCL21 and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis","volume":"169","author":"Luther","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB30","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1002\/1521-4141(200207)32:7<1905::AID-IMMU1905>3.0.CO;2-L","article-title":"Critical role of antigen-specific antibody in experimental autoimmune encephalomyelitis induced by recombinant myelin oligodendrocyte glycoprotein","volume":"32","author":"Lyons","year":"2002","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB31","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nri844","article-title":"BAFF: a fundamental survival factor for B cells","volume":"2","author":"Mackay","year":"2002","journal-title":"Nat. Rev., Immunol."},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB32","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1084\/jem.190.11.1697","article-title":"Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations","volume":"190","author":"Mackay","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB48","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1002\/1521-4141(200002)30:2<498::AID-IMMU498>3.0.CO;2-Q","article-title":"Inhibition of Th1 development and treatment of chronic-relapsing experimental allergic encephalomyelitis by a non-hypercalcemic analogue of 1,25-dihydroxyvitamin D3","volume":"30","author":"Mattner","year":"2000","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB33","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1084\/jem.189.2.403","article-title":"Lymphotoxin alpha\/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen","volume":"189","author":"Ngo","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB34","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S0165-5728(02)00441-1","article-title":"Secondary lymphoid organ chemokines are elevated in the cerebrospinal fluid during central nervous system inflammation","volume":"135","author":"Pashenkov","year":"2003","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB35","first-page":"409","article-title":"Macrophages, lymphocytes, and plasma cells in the perivascular compartment in chronic multiple sclerosis","volume":"38","author":"Prineas","year":"1978","journal-title":"Lab. Invest."},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB49","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1126\/science.424741","article-title":"Multiple sclerosis: presence of lymphatic capillaries and lymphoid tissue in the brain and spinal cord","volume":"203","author":"Prineas","year":"1979","journal-title":"Science"},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB36","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1172\/JCI3568","article-title":"Clonal expansion and somatic hypermutation of V(H) genes of B cells from cerebrospinal fluid in multiple sclerosis lesions","volume":"102","author":"Qin","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB37","first-page":"534","article-title":"Adoptively transferred chronic relapsing experimental autoimmune encephalomyelitis in the mouse. Neuropathologic analysis","volume":"51","author":"Raine","year":"1984","journal-title":"Lab. Invest."},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB38","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/1531-8249(199908)46:2<144::AID-ANA3>3.0.CO;2-K","article-title":"Demyelination in primate autoimmune encephalomyelitis and acute multiple sclerosis lesions: a case for antigen-specific antibody mediation","volume":"46","author":"Raine","year":"1999","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB39","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/S0952-7915(02)00332-1","article-title":"BAFFled B cells survive and thrive: roles of BAFF in B-cell development","volume":"14","author":"Rolink","year":"2002","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB41","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0165-5728(94)00144-D","article-title":"The subarachnoid space as a site for precursor T cell proliferation and effector T cell selection in experimental autoimmune encephalomyelitis","volume":"56","author":"Shin","year":"1995","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB42","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1182\/blood-2002-05-1576","article-title":"Expression of B-cell-attracting chemokine 1 (CXCL13) by malignant lymphocytes and vascular endothelium in primary central nervous system lymphoma","volume":"101","author":"Smith","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB43","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1002\/1521-4141(200207)32:7<1939::AID-IMMU1939>3.0.CO;2-S","article-title":"A comparative analysis of B cell-mediated myelin oligodendrocyte glycoprotein-experimental autoimmune encephalomyelitis pathogenesis in B cell-deficient mice reveals an effect on demyelination","volume":"32","author":"Svensson","year":"2002","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB44","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S1471-4906(01)01942-1","article-title":"Follicular dendritic cells: beyond the necessity of T-cell help","volume":"22","author":"Tew","year":"2001","journal-title":"Trends Immunol."},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB45","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1749-6632.1984.tb14775.x","article-title":"The current status of multiple sclerosis intra-blood\u2013brain-barrier IgG synthesis","volume":"436","author":"Tourtellotte","year":"1984","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB46","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1126\/science.7029715","article-title":"Autoimmune encephalomyelitis: simultaneous identification of T and B cells in the target organ","volume":"214","author":"Traugott","year":"1981","journal-title":"Science"},{"key":"10.1016\/j.jneuroim.2003.10.056_BIB47","first-page":"420","article-title":"Identification of CD4-CD8-alpha beta T cells in the subarachnoid space of rats with experimental autoimmune encephalomyelitis. A possible route by which effector cells invade the lesions","volume":"81","author":"Tsuchida","year":"1994","journal-title":"Immunology"}],"container-title":["Journal of Neuroimmunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572803004983?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572803004983?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T07:57:34Z","timestamp":1759046254000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165572803004983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3]]},"references-count":48,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2004,3]]}},"alternative-id":["S0165572803004983"],"URL":"https:\/\/doi.org\/10.1016\/j.jneuroim.2003.10.056","relation":{},"ISSN":["0165-5728"],"issn-type":[{"value":"0165-5728","type":"print"}],"subject":[],"published":{"date-parts":[[2004,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intracerebral expression of CXCL13 and BAFF is accompanied by formation of lymphoid follicle-like structures in the meninges of mice with relapsing experimental autoimmune encephalomyelitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroimmunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneuroim.2003.10.056","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}