{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T23:46:32Z","timestamp":1793490392021,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jni-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimmunology"],"published-print":{"date-parts":[[2005,11]]},"DOI":"10.1016\/j.jneuroim.2005.07.002","type":"journal-article","created":{"date-parts":[[2005,8,9]],"date-time":"2005-08-09T07:30:18Z","timestamp":1123572618000},"page":"154-163","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":76,"title":["Cerebrospinal fluid interferon-\u03b3-inducible protein 10 (IP-10, CXCL10) in HIV-1 infection"],"prefix":"10.1016","volume":"168","author":[{"given":"Paola","family":"Cinque","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arabella","family":"Bestetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Marenzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Sala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Gisslen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Hagberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard W.","family":"Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jneuroim.2005.07.002_bib1","first-page":"1","article-title":"1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults","volume":"41","year":"1992","journal-title":"MMWR, Recomm. Rep."},{"key":"10.1016\/j.jneuroim.2005.07.002_bib2","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1189\/jlb.70.3.465","article-title":"Chemokine\/chemokine receptor nomenclature","volume":"70","year":"2001","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.jneuroim.2005.07.002_bib3","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/infdis\/158.1.193","article-title":"Cerebrospinal fluid abnormalities in patients without AIDS who are seropositive for the human immunodeficiency virus","volume":"158","author":"Appleman","year":"1988","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jneuroim.2005.07.002_bib4","doi-asserted-by":"crossref","first-page":"7067","DOI":"10.1128\/JVI.75.15.7067-7077.2001","article-title":"Interferon-independent, human immunodeficiency virus type 1 gp120-mediated induction of CXCL10\/IP-10 gene expression by astrocytes in vivo and in vitro","volume":"75","author":"Asensio","year":"2001","journal-title":"J. Virol."},{"key":"10.1016\/j.jneuroim.2005.07.002_bib5","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1046\/j.1471-4159.2002.01091.x","article-title":"Characterization of chemokines and their receptors in the central nervous system: physiopathological implications","volume":"82","author":"Bajetto","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.jneuroim.2005.07.002_bib6","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jneuroim.2004.08.034","article-title":"Investigations on four host response factors whose expression is enhanced in X4 SHIV encephalitis","volume":"157","author":"Buch","year":"2004","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2005.07.002_bib7","doi-asserted-by":"crossref","first-page":"4502","DOI":"10.1128\/JVI.77.8.4502-4515.2003","article-title":"CXCL10 production from cytomegalovirus-stimulated microglia is regulated by both human and viral interleukin-10","volume":"77","author":"Cheeran","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.jneuroim.2005.07.002_bib8","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3109\/13550289809113490","article-title":"Diagnosis and clinical management of neurological disorders caused by cytomegalovirus in AIDS patients. European Union Concerted Action on Virus Meningitis and Encephalitis","volume":"4","author":"Cinque","year":"1998","journal-title":"J. Neurovirology"},{"key":"10.1016\/j.jneuroim.2005.07.002_bib9","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1080\/13550280490279807","article-title":"Expression of chemokines by human fetal microglia after treatment with the human immunodeficiency virus type 1 protein Tat","volume":"10","author":"D'Aversa","year":"2004","journal-title":"J. Neurovirology"},{"key":"10.1016\/j.jneuroim.2005.07.002_bib10","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1056\/NEJM200102153440702","article-title":"Virologic and immunologic consequences of discontinuing combination antiretroviral-drug therapy in HIV-infected patients with detectable viremia","volume":"344","author":"Deeks","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jneuroim.2005.07.002_bib11","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1212\/WNL.54.4.927","article-title":"Cerebrospinal fluid HIV RNA originates from both local CNS and systemic sources","volume":"54","author":"Ellis","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.jneuroim.2005.07.002_bib12","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1046\/j.1365-2990.2001.00312.x","article-title":"CXCR3 expression in human central nervous system diseases","volume":"27","author":"Goldberg","year":"2001","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.jneuroim.2005.07.002_bib13","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nm822","article-title":"HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages","volume":"9","author":"Izmailova","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.jneuroim.2005.07.002_bib14","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1046\/j.1365-2249.2002.01947.x","article-title":"T-cells in the cerebrospinal fluid express a similar repertoire of inflammatory chemokine receptors in the absence or presence of CNS inflammation: implications for CNS trafficking","volume":"129","author":"Kivisakk","year":"2002","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jneuroim.2005.07.002_bib15","doi-asserted-by":"crossref","first-page":"8389","DOI":"10.1073\/pnas.1433000100","article-title":"Human cerebrospinal fluid central memory CD4+T cells: evidence for trafficking through choroid plexus and meninges via P-selectin","volume":"100","author":"Kivisakk","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jneuroim.2005.07.002_bib16","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/S0165-5728(98)00223-9","article-title":"Identification of a T cell chemotactic factor in the cerebrospinal fluid of HIV-1-infected individuals as interferon-gamma inducible protein 10","volume":"93","author":"Kolb","year":"1999","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2005.07.002_bib17","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1002\/eji.1830271004","article-title":"Chemotactic activity on mononuclear cells in the cerebrospinal fluid of patients with viral meningitis is mediated by interferon-gamma inducible protein-10 and monocyte chemotactic protein-1","volume":"27","author":"Lahrtz","year":"1997","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jneuroim.2005.07.002_bib18","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0165-5728(97)00267-1","article-title":"Chemokines and chemotaxis of leukocytes in infectious meningitis","volume":"85","author":"Lahrtz","year":"1998","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2005.07.002_bib19","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S0042-6822(02)00045-4","article-title":"The C-X-C chemokine IP-10 stimulates HIV-1 replication","volume":"307","author":"Lane","year":"2003","journal-title":"Virology"},{"key":"10.1016\/j.jneuroim.2005.07.002_bib20","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.4049\/jimmunol.167.7.4091","article-title":"Neutralization of the chemokine CXCL10 reduces inflammatory cell invasion and demyelination and improves neurological function in a viral model of multiple sclerosis","volume":"167","author":"Liu","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2005.07.002_bib21","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1084\/jem.184.3.963","article-title":"Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes","volume":"184","author":"Loetscher","year":"1996","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jneuroim.2005.07.002_bib22","doi-asserted-by":"crossref","first-page":"3696","DOI":"10.1002\/(SICI)1521-4141(199811)28:11<3696::AID-IMMU3696>3.0.CO;2-W","article-title":"Lymphocyte-specific chemokine receptor CXCR3: regulation, chemokine binding and gene localization","volume":"28","author":"Loetscher","year":"1998","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jneuroim.2005.07.002_bib23","doi-asserted-by":"crossref","first-page":"S34","DOI":"10.1002\/ana.410230712","article-title":"Cerebrospinal fluid abnormalities in homosexual men with and without neuropsychiatric findings","volume":"23","author":"McArthur","year":"1988","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jneuroim.2005.07.002_bib24","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1189\/jlb.1102577","article-title":"Expression and function of chemokines during viral infections: from molecular mechanisms to in vivo function","volume":"74","author":"Melchjorsen","year":"2003","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.jneuroim.2005.07.002_bib25","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0966-842X(00)01821-7","article-title":"The two faces of cerebrospinal fluid (CSF) HIV infection","volume":"8","author":"Price","year":"2000","journal-title":"Trends Microbiol."},{"issue":"Suppl. 1","key":"10.1016\/j.jneuroim.2005.07.002_bib26","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1080\/jnv.10.s1.44.51","article-title":"Antiretroviral drug treatment interruption in human immunodeficiency virus-infected adults: clinical and pathogenetic implications for the central nervous system","volume":"10","author":"Price","year":"2004","journal-title":"J. Neurovirology"},{"key":"10.1016\/j.jneuroim.2005.07.002_bib27","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1002\/ana.410420502","article-title":"Measuring the \u201cviral load\u201d in cerebrospinal fluid in human immunodeficiency virus infection: window into brain infection?","volume":"42","author":"Price","year":"1997","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jneuroim.2005.07.002_bib28","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1097\/00002030-200107060-00006","article-title":"Cerebrospinal fluid response to structured treatment interruption after virological failure","volume":"15","author":"Price","year":"2001","journal-title":"AIDS"},{"key":"10.1016\/j.jneuroim.2005.07.002_bib29","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1172\/JCI1422","article-title":"The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions","volume":"101","author":"Qin","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jneuroim.2005.07.002_bib30","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S1471-4906(03)00163-7","article-title":"Chemokine induction by HIV-1: recruitment to the cause","volume":"24","author":"Reinhart","year":"2003","journal-title":"Trends Immunol."},{"key":"10.1016\/j.jneuroim.2005.07.002_bib31","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1097\/00002030-199809000-00009","article-title":"Chemokines and receptors in HIV encephalitis","volume":"12","author":"Sanders","year":"1998","journal-title":"AIDS"},{"key":"10.1016\/j.jneuroim.2005.07.002_bib32","first-page":"1459","article-title":"Chemokine expression in simian immunodeficiency virus-induced AIDS encephalitis","volume":"149","author":"Sasseville","year":"1996","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jneuroim.2005.07.002_bib33","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1086\/421244","article-title":"Increased adhesion molecule and chemokine receptor expression on CD8+ T cells trafficking to cerebrospinal fluid in HIV-1 infection","volume":"189","author":"Shacklett","year":"2004","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jneuroim.2005.07.002_bib34","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1097\/00002030-199906180-00008","article-title":"Time course of cerebrospinal fluid responses to antiretroviral therapy: evidence for variable compartmentalization of infection","volume":"13","author":"Staprans","year":"1999","journal-title":"AIDS"},{"key":"10.1016\/j.jneuroim.2005.07.002_bib35","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1016\/S0002-9440(10)63714-5","article-title":"Neuronal apoptosis is mediated by CXCL10 overexpression in simian human immunodeficiency virus encephalitis","volume":"164","author":"Sui","year":"2004","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jneuroim.2005.07.002_bib36","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1084\/jem.177.6.1809","article-title":"Recombinant human interferon-inducible protein 10 is a chemoattractant for human monocytes and T lymphocytes and promotes T cell adhesion to endothelial cells","volume":"177","author":"Taub","year":"1993","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jneuroim.2005.07.002_bib37","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1046\/j.0305-1846.2003.00507.x","article-title":"Chemokine receptors on infiltrating leucocytes in inflammatory pathologies of the central nervous system (CNS)","volume":"29","author":"Trebst","year":"2003","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.jneuroim.2005.07.002_bib38","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1093\/brain\/awh130","article-title":"CSF quinolinic acid levels are determined by local HIV infection: cross-sectional analysis and modelling of dynamics following antiretroviral therapy","volume":"127","author":"Valle","year":"2004","journal-title":"Brain"},{"key":"10.1016\/j.jneuroim.2005.07.002_bib39","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.virol.2004.08.024","article-title":"Human immunodeficiency virus type 1 Nef protein mediates neural cell death: a neurotoxic role for IP-10","volume":"329","author":"van Marle","year":"2004","journal-title":"Virology"},{"key":"10.1016\/j.jneuroim.2005.07.002_bib40","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0166-0934(97)00152-3","article-title":"Polymerase chain reaction for detection of JC virus DNA in cerebrospinal fluid: a quality control study. European Union Concerted Action on Viral Meningitis and Encephalitis","volume":"69","author":"Weber","year":"1997","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.jneuroim.2005.07.002_bib41","first-page":"659","article-title":"Chemokine receptor expression on resident and inflammatory cells in the brain of macaques with simian immunodeficiency virus encephalitis","volume":"152","author":"Westmoreland","year":"1998","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jneuroim.2005.07.002_bib42","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1006\/viro.2001.1249","article-title":"The effect of X4 and R5 HIV-1 on C, C-C, and C-X-C chemokines during the early stages of infection in human PBMCs","volume":"292","author":"Wetzel","year":"2002","journal-title":"Virology"},{"key":"10.1016\/j.jneuroim.2005.07.002_bib43","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1084\/jem.193.8.905","article-title":"Perivascular macrophages are the primary cell type productively infected by simian immunodeficiency virus in the brains of macaques: implications for the neuropathogenesis of AIDS","volume":"193","author":"Williams","year":"2001","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jneuroim.2005.07.002_bib44","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3109\/13550289909029743","article-title":"Chemokines\/chemokine receptors in the central nervous system and Alzheimer's disease","volume":"5","author":"Xia","year":"1999","journal-title":"J. Neurovirology"},{"key":"10.1016\/j.jneuroim.2005.07.002_bib45","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0165-5728(00)00285-X","article-title":"Expression of the chemokine receptor CXCR3 on neurons and the elevated expression of its ligand IP-10 in reactive astrocytes: in vitro ERK1\/2 activation and role in Alzheimer's disease","volume":"108","author":"Xia","year":"2000","journal-title":"J. Neuroimmunol."}],"container-title":["Journal of Neuroimmunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016557280500281X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016557280500281X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T08:02:50Z","timestamp":1759046570000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016557280500281X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11]]},"references-count":45,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["S016557280500281X"],"URL":"https:\/\/doi.org\/10.1016\/j.jneuroim.2005.07.002","relation":{},"ISSN":["0165-5728"],"issn-type":[{"value":"0165-5728","type":"print"}],"subject":[],"published":{"date-parts":[[2005,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cerebrospinal fluid interferon-\u03b3-inducible protein 10 (IP-10, CXCL10) in HIV-1 infection","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroimmunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneuroim.2005.07.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}