{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T08:09:03Z","timestamp":1779350943261,"version":"3.51.4"},"reference-count":35,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jni-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimmunology"],"published-print":{"date-parts":[[2006,3]]},"DOI":"10.1016\/j.jneuroim.2005.10.012","type":"journal-article","created":{"date-parts":[[2006,1,11]],"date-time":"2006-01-11T09:36:36Z","timestamp":1136972196000},"page":"1-8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Endogenous T lymphocytes and microglial reactivity in the axotomized facial motor nucleus of mice: Effect of genetic background and the RAG2 gene"],"prefix":"10.1016","volume":"172","author":[{"given":"Grace K.","family":"Ha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang J.","family":"Streit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Petitto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jneuroim.2005.10.012_bib1","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.4049\/jimmunol.164.4.1705","article-title":"Functional maturation of adult mouse resting microglia into an APC is promoted by granulocyte-macrophage colony-stimulating factor and interaction with Th1 cells","volume":"164","author":"Aloisi","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2005.10.012_bib2","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1523\/JNEUROSCI.19-05-01708.1999","article-title":"Activated macrophages and microglia induce dopaminergic sprouting in the injured striatum and express brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor","volume":"19","author":"Batchelor","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jneuroim.2005.10.012_bib3","doi-asserted-by":"crossref","first-page":"4333","DOI":"10.1523\/JNEUROSCI.5276-03.2004","article-title":"CD4-positive T cell-mediated neuroprotection requires dual compartment antigen presentation","volume":"24","author":"Byram","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jneuroim.2005.10.012_bib4","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/glia.10145","article-title":"Microglia as liaisons between the immune and central nervous systems: functional implications for multiple sclerosis","volume":"40","author":"Carson","year":"2002","journal-title":"Glia"},{"key":"10.1016\/j.jneuroim.2005.10.012_bib5","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0165-5728(90)90061-Q","article-title":"New expression of myelomonocytic antigens by microglia and perivascular cells following lethal motor neuron injury","volume":"27","author":"Graeber","year":"1990","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2005.10.012_bib6","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0006-8993(98)00859-2","article-title":"The microglia\/macrophage response in the neonatal rat facial nucleus following axotomy","volume":"813","author":"Graeber","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.jneuroim.2005.10.012_bib7","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.bbi.2004.05.004","article-title":"Role of the immune system in the maintenance of mouse facial motoneuron viability after nerve injury","volume":"19","author":"Jones","year":"2005","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jneuroim.2005.10.012_bib8","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1097\/00001756-200209160-00003","article-title":"Facial nerve lesion response; strain differences but no involvement of IFN-gamma, STAT4 or STAT6","volume":"13","author":"Lidman","year":"2002","journal-title":"NeuroReport"},{"key":"10.1016\/j.jneuroim.2005.10.012_bib9","doi-asserted-by":"crossref","first-page":"9817","DOI":"10.1523\/JNEUROSCI.23-30-09817.2003","article-title":"Discrete gene loci regulate neurodegeneration, lymphocyte infiltration, and major histocompatibility complex class II expression in the CNS","volume":"23","author":"Lidman","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jneuroim.2005.10.012_bib10","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.neuroscience.2004.10.043","article-title":"Major histocompatibility complex (MHC2+) perivascular macrophages in the axotomized facial motor nucleus are regulated by receptors for interferon-gamma (IFNgamma) and tumor necrosis factor (TNF)","volume":"131","author":"Liu","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.jneuroim.2005.10.012_bib11","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.expneurol.2004.04.010","article-title":"Axonal reinjury reveals the survival and re-expression of regeneration-associated genes in chronically axotomized adult mouse motoneurons","volume":"188","author":"McPhail","year":"2004","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jneuroim.2005.10.012_bib12","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/(SICI)1098-1136(199606)17:2<121::AID-GLIA4>3.0.CO;2-5","article-title":"Regulation of thrombospondin in the regenerating mouse facial motor nucleus","volume":"17","author":"Moller","year":"1996","journal-title":"Glia"},{"key":"10.1016\/j.jneuroim.2005.10.012_bib13","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.brainresrev.2003.11.004","article-title":"The facial nerve axotomy model","volume":"44","author":"Moran","year":"2004","journal-title":"Brain Res. Brain Res. Rev."},{"key":"10.1016\/j.jneuroim.2005.10.012_bib14","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1749-6632.2000.tb05383.x","article-title":"Genetic regulation of nerve avulsion-induced spinal cord inflammation","volume":"917","author":"Olsson","year":"2000","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.jneuroim.2005.10.012_bib15","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0165-5728(02)00422-8","article-title":"IL-2 gene knockout affects T lymphocyte trafficking and the microglial response to regenerating facial motor neurons","volume":"134","author":"Petitto","year":"2003","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2005.10.012_bib16","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0165-5728(99)00136-8","article-title":"Non-MHC gene regulation of nerve root injury induced spinal cord inflammation and neuron death","volume":"101","author":"Piehl","year":"1999","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2005.10.012_bib17","doi-asserted-by":"crossref","first-page":"5804","DOI":"10.1523\/JNEUROSCI.18-15-05804.1998","article-title":"Immune surveillance in the injured nervous system: T-lymphocytes invade the axotomized mouse facial motor nucleus and aggregate around sites of neuronal degeneration","volume":"18","author":"Raivich","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jneuroim.2005.10.012_bib18","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1006\/exnr.2002.8024","article-title":"Cytotoxic potential of proinflammatory cytokines: combined deletion of TNF receptors TNFR1 and TNFR2 prevents motoneuron cell death after facial axotomy in adult mouse","volume":"178","author":"Raivich","year":"2002","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jneuroim.2005.10.012_bib19","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1002\/jnr.10621","article-title":"Lymphocyte infiltration in the injured brain: role of proinflammatory cytokines","volume":"72","author":"Raivich","year":"2003","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.jneuroim.2005.10.012_bib20","doi-asserted-by":"crossref","first-page":"5320","DOI":"10.4049\/jimmunol.160.11.5320","article-title":"Central nervous system microglial cell activation and proliferation follows direct interaction with tissue-infiltrating T cell blasts","volume":"160","author":"Sedgwick","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2005.10.012_bib21","doi-asserted-by":"crossref","first-page":"RC7","DOI":"10.1523\/JNEUROSCI.19-11-j0004.1999","article-title":"Exacerbation of facial motoneuron loss after facial nerve transection in severe combined immunodeficient (scid) mice","volume":"19","author":"Serpe","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jneuroim.2005.10.012_bib22","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/1097-4547(20001015)62:2<273::AID-JNR11>3.0.CO;2-C","article-title":"Kinetics of facial motoneuron loss following facial nerve transection in severe combined immunodeficient mice","volume":"62","author":"Serpe","year":"2000","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.jneuroim.2005.10.012_bib23","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0889-1591(03)00028-X","article-title":"CD4+ T, but not CD8+ or B, lymphocytes mediate facial motoneuron survival after facial nerve transection","volume":"17","author":"Serpe","year":"2003","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jneuroim.2005.10.012_bib24","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.bbi.2004.07.005","article-title":"Brain-derived neurotrophic factor supports facial motoneuron survival after facial nerve transection in immunodeficient mice","volume":"19","author":"Serpe","year":"2005","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jneuroim.2005.10.012_bib25","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/0092-8674(92)90029-C","article-title":"RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement","volume":"68","author":"Shinkai","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.jneuroim.2005.10.012_bib35","series-title":"Mouse Genetics","author":"Silver","year":"1995"},{"key":"10.1016\/j.jneuroim.2005.10.012_bib26","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/glia.10154","article-title":"Microglia as neuroprotective, immunocompetent cells of the CNS","volume":"40","author":"Streit","year":"2002","journal-title":"Glia"},{"key":"10.1016\/j.jneuroim.2005.10.012_bib27","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/cne.902680209","article-title":"Response of endogenous glial cells to motor neuron degeneration induced by toxic ricin","volume":"268","author":"Streit","year":"1988","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.jneuroim.2005.10.012_bib28","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/glia.440010502","article-title":"Functional plasticity of microglia: a review","volume":"1","author":"Streit","year":"1988","journal-title":"Glia"},{"key":"10.1016\/j.jneuroim.2005.10.012_bib29","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0301-0082(98)00069-0","article-title":"Reactive microgliosis","volume":"57","author":"Streit","year":"1999","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.jneuroim.2005.10.012_bib30","doi-asserted-by":"crossref","first-page":"8526","DOI":"10.1523\/JNEUROSCI.23-24-08526.2003","article-title":"Fas\/tumor necrosis factor receptor death signaling is required for axotomy-induced death of motoneurons in vivo","volume":"23","author":"Ugolini","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jneuroim.2005.10.012_bib31","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/sj.cdd.4400806","article-title":"Elevated DNA double strand breaks and apoptosis in the CNS of scid mutant mice","volume":"8","author":"Vemuri","year":"2001","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.jneuroim.2005.10.012_bib32","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1097\/00129492-200205000-00029","article-title":"Apoptosis and expression of BCL-2 in facial motoneurons after facial nerve injury","volume":"23","author":"Wang","year":"2002","journal-title":"Otol. Neurotol."},{"key":"10.1016\/j.jneuroim.2005.10.012_bib33","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s004410100393","article-title":"Leukocyte recruitment and neuroglial activation during facial nerve regeneration in ICAM-1-deficient mice: effects of breeding strategy","volume":"305","author":"Werner","year":"2001","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.jneuroim.2005.10.012_bib34","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1006\/jmcc.1997.0614","article-title":"Staurosporine-induced apoptosis in cardiomyocytes: a potential role of caspase-3","volume":"30","author":"Yue","year":"1998","journal-title":"J. Mol. Cell. Cardiol."}],"container-title":["Journal of Neuroimmunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572805004546?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572805004546?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T08:02:23Z","timestamp":1759046543000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165572805004546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":35,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["S0165572805004546"],"URL":"https:\/\/doi.org\/10.1016\/j.jneuroim.2005.10.012","relation":{},"ISSN":["0165-5728"],"issn-type":[{"value":"0165-5728","type":"print"}],"subject":[],"published":{"date-parts":[[2006,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endogenous T lymphocytes and microglial reactivity in the axotomized facial motor nucleus of mice: Effect of genetic background and the RAG2 gene","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroimmunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneuroim.2005.10.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}