{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T06:35:56Z","timestamp":1781850956242,"version":"3.54.5"},"reference-count":52,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jni-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimmunology"],"published-print":{"date-parts":[[2006,6]]},"DOI":"10.1016\/j.jneuroim.2006.03.008","type":"journal-article","created":{"date-parts":[[2006,4,27]],"date-time":"2006-04-27T11:37:09Z","timestamp":1146137829000},"page":"118-127","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["BDNF: A missing link between sympathetic dysfunction and inflammatory disease?"],"prefix":"10.1016","volume":"175","author":[{"given":"Lora J.","family":"Kasselman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Sideris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal","family":"Bruno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamee N.","family":"Nicoletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley J.","family":"Wiegand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan D.","family":"Croll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jneuroim.2006.03.008_bib1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S1566-0702(00)00247-2","article-title":"Evidence that nerve growth factor promotes the recovery of peripheral neuropathy induced in mice by cisplatin: behavioral, structural and biochemical analysis","volume":"86","author":"Aloe","year":"2000","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.jneuroim.2006.03.008_bib2","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1002\/neu.480251107","article-title":"The Trk family of neurotrophin receptors","volume":"25","author":"Barbacid","year":"1994","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.jneuroim.2006.03.008_bib3","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0304-3940(02)01152-7","article-title":"Modulation of cytokine mRNA expression by brain-derived neurotrophic factor and nerve growth factor in human immune cells","volume":"335","author":"Bayas","year":"2003","journal-title":"Neurosci. Lett."},{"issue":"8","key":"10.1016\/j.jneuroim.2006.03.008_bib4","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1111\/j.1460-9568.1994.tb00325.x","article-title":"Regulation of neuropeptides in adult rat forebrain by the neurotrophins BDNF and NGF","volume":"6","author":"Croll","year":"1994","journal-title":"Eur. J. Neurosci."},{"issue":"1","key":"10.1016\/j.jneuroim.2006.03.008_bib5","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1006\/exnr.1998.6836","article-title":"Co-infusion with a TrkB-Fc receptor body carrier enhances BDNF distribution in the adult rat brain","volume":"152","author":"Croll","year":"1998","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jneuroim.2006.03.008_bib6","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.expneurol.2004.02.010","article-title":"VEGF-mediated inflammation precedes angiogenesis in adult brain","volume":"187","author":"Croll","year":"2004","journal-title":"Exp. Neurol."},{"issue":"4","key":"10.1016\/j.jneuroim.2006.03.008_bib51","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0031-6997(24)01470-4","article-title":"The sympathetic nerve\u2014an integrative interface between two supersystems: the brain and the immune system","volume":"52","author":"Elenkov","year":"2000","journal-title":"Pharmacol Rev."},{"key":"10.1016\/j.jneuroim.2006.03.008_bib7","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s004010000268","article-title":"Brain-derived neurotrophic factor reduces cortical cell death by ischemia after middle cerebral artery occlusion in the rat","volume":"101","author":"Ferrer","year":"2001","journal-title":"Acta Neuropathol. (Berl.)."},{"key":"10.1016\/j.jneuroim.2006.03.008_bib8","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1002\/1529-0131(200008)43:8<1886::AID-ANR27>3.0.CO;2-S","article-title":"Increased alpha2-adrenergic constriction of isolated arterioles in diffuse scleroderma","volume":"43","author":"Flavahan","year":"2000","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jneuroim.2006.03.008_bib9","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0166-2236(96)01007-7","article-title":"The role of neurotrophic factors in regulating the development of inner ear innervation","volume":"20","author":"Fritzsch","year":"1997","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.jneuroim.2006.03.008_bib10","first-page":"125","article-title":"Raynaud's phenomenon and systemic sclerosis","volume":"11","author":"Generini","year":"1996","journal-title":"Ann. Ital. Med. Int."},{"key":"10.1016\/j.jneuroim.2006.03.008_bib11","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1523\/JNEUROSCI.4523-03.2004","article-title":"Heterogeneous requirement of NGF for sympathetic target innervation in vivo","volume":"24","author":"Glebova","year":"2004","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.jneuroim.2006.03.008_bib12","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1038\/jcbfm.1989.123","article-title":"Direct evidence for acute and massive norepinephrine release in the hippocampus during transient ischemia","volume":"9","author":"Globus","year":"1989","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"2","key":"10.1016\/j.jneuroim.2006.03.008_bib13","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.expneurol.2004.03.011","article-title":"Differential change in mRNA expression of p75 and Trk neurotrophin receptors in nucleus gracilis after spinal nerve ligation in the rat","volume":"187","author":"Goettl","year":"2004","journal-title":"Exp. Neurol."},{"issue":"1","key":"10.1016\/j.jneuroim.2006.03.008_bib14","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s00418-002-0426-y","article-title":"Expression of neurotrophins and their receptors in peripheral lung cells of mice","volume":"118","author":"Hikawa","year":"2002","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.jneuroim.2006.03.008_bib15","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1080\/03009749850154311","article-title":"Raynaud's phenomenon: state of the art 1998","volume":"27","author":"Ho","year":"1998","journal-title":"Scand. J. Rheumatol."},{"key":"10.1016\/j.jneuroim.2006.03.008_bib16","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0889-857X(21)01040-1","article-title":"Vascular disease in scleroderma. Endothelial T lymphocyte\u2013fibroblast interactions","volume":"16","author":"Kahaleh","year":"1990","journal-title":"Rheum. Dis. Clin. North Am."},{"key":"10.1016\/j.jneuroim.2006.03.008_bib17","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1084\/jem.189.5.865","article-title":"Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation","volume":"189","author":"Kerschensteiner","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jneuroim.2006.03.008_bib18","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1093\/rheumatology\/31.6.375","article-title":"Further evidence of increased polymorphonuclear cell activity in patients with Raynaud's phenomenon","volume":"31","author":"Lau","year":"1992","journal-title":"Br. J. Rheumatol."},{"key":"10.1016\/j.jneuroim.2006.03.008_bib19","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1136\/ard.51.2.249","article-title":"White blood cell activation in Raynaud's phenomenon of systemic sclerosis and vibration induced white finger syndrome","volume":"51","author":"Lau","year":"1992","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jneuroim.2006.03.008_bib20","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0301-0082(03)00019-4","article-title":"Neurotrophin secretion: current facts and future prospects","volume":"69","author":"Lessmann","year":"2003","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.jneuroim.2006.03.008_bib21","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev.ne.19.030196.001445","article-title":"Physiology of the neurotrophins","volume":"19","author":"Lewin","year":"1996","journal-title":"Annu. Rev. Neurosci."},{"issue":"5","key":"10.1016\/j.jneuroim.2006.03.008_bib22","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1136\/ard.60.5.487","article-title":"Nerve growth factor and neuropeptides circulating levels in systemic sclerosis (scleroderma)","volume":"60","author":"Matucci-Cerinic","year":"2001","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jneuroim.2006.03.008_bib23","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/S0006-8993(02)02420-4","article-title":"Alterations in hippocampal GAP-43, BDNF, and L1 following sustained cerebral ischemia","volume":"935","author":"Miyake","year":"2002","journal-title":"Brain. Res."},{"issue":"9","key":"10.1016\/j.jneuroim.2006.03.008_bib24","doi-asserted-by":"crossref","first-page":"4029","DOI":"10.1523\/JNEUROSCI.13-09-04029.1993","article-title":"Neurotrophin receptor genes are expressed in distinct patterns in developing dorsal root ganglia","volume":"13","author":"Mu","year":"1993","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jneuroim.2006.03.008_bib25","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1046\/j.1365-2745.2002.01442.x","article-title":"Activation of the specific neurotrophin receptors TrkA, TrkB and TrkC influences the function of eosinophils","volume":"32","author":"Noga","year":"2002","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.jneuroim.2006.03.008_bib26","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0304-3940(01)02001-8","article-title":"The upregulation of nerve growth factor receptors in reactive astrocytes of rat spinal cord during experimental autoimmune encephalomyelitis","volume":"308","author":"Oderfeld-Nowak","year":"2001","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jneuroim.2006.03.008_bib27","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1136\/bmj.294.6581.1186","article-title":"Exaggerated postural vasoconstrictor reflex in Raynaud's phenomenon","volume":"294","author":"Olsen","year":"1987","journal-title":"Br. Med. J. (Clin. Res. Ed.)"},{"key":"10.1016\/j.jneuroim.2006.03.008_bib52","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1986"},{"issue":"2","key":"10.1016\/j.jneuroim.2006.03.008_bib28","doi-asserted-by":"crossref","first-page":"E331","DOI":"10.1152\/ajpendo.00076.2004","article-title":"NGF gene expression and secretion in white adipose tissue: regulation in 3T3-L1 adipocytes by hormones and inflammatory cytokines","volume":"287","author":"Peeraully","year":"2004","journal-title":"Am. J. Physiol., Endocrinol. Metabol."},{"key":"10.1016\/j.jneuroim.2006.03.008_bib29","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1191\/1352458503ms869oa","article-title":"Effect of immunomodulatory drugs on in vitro production of brain-derived neurotrophic factor","volume":"9","author":"Petereit","year":"2003","journal-title":"Mult. Scler."},{"issue":"11","key":"10.1016\/j.jneuroim.2006.03.008_bib30","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1136\/ard.2004.032599","article-title":"Involvement of neurotrophins and their receptors in spondyloarthritis synovitis: relation to inflammation and response to treatment","volume":"64","author":"Rihl","year":"2005","journal-title":"Ann. Rheum. Dis."},{"issue":"8","key":"10.1016\/j.jneuroim.2006.03.008_bib31","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1097\/00004872-200018080-00008","article-title":"Enhanced vascular reactivity in the sympathetcomized rat: studies in vivo and in small isolated resistance arteries","volume":"18","author":"Rizzoni","year":"2000","journal-title":"J. Hypertens."},{"issue":"1","key":"10.1016\/j.jneuroim.2006.03.008_bib32","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/00005344-200301000-00014","article-title":"Ouabain changes arterial blood pressure and vascular reactivity to phenylephrine in l-NAME-induced hypertension","volume":"41","author":"Rossoni","year":"2003","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.jneuroim.2006.03.008_bib33","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1440-1681.1997.tb02089.x","article-title":"Neurotrophic factors are required by mature sympathetic neurons for survival, transmission, and connectivity","volume":"24","author":"Rush","year":"1997","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.jneuroim.2006.03.008_bib34","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1046\/j.1523-1747.2003.12023.x","article-title":"Endothelium-dependent regulation of cutaneous microcirculation in patients with systemic scleroderma","volume":"120","author":"Schlez","year":"2003","journal-title":"J. Invest. Dermatol."},{"issue":"4","key":"10.1016\/j.jneuroim.2006.03.008_bib35","first-page":"569","article-title":"Distribution of neurotrophin receptors in the mouse neuromuscular system","volume":"46","author":"Sheard","year":"2002","journal-title":"Int. J. Dev. Biol."},{"issue":"4","key":"10.1016\/j.jneuroim.2006.03.008_bib36","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/S1044-7431(03)00102-7","article-title":"BDNF and CNTF regulate cholinergic properties of sympathetic neurons through independent mechanisms","volume":"23","author":"Slonimsky","year":"2003","journal-title":"Mol. Cell. Neurosci."},{"issue":"2","key":"10.1016\/j.jneuroim.2006.03.008_bib37","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.cardiores.2003.12.024","article-title":"Increased vascular sensitivity and connexin-43 expression after sympathetic denervation","volume":"62","author":"Slovut","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.jneuroim.2006.03.008_bib38","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1093\/brain\/awf015","article-title":"BDNF and gp145trkB in multiple sclerosis brain lesions: neuroprotective interactions between immune and neuronal cells?","volume":"125","author":"Stadelmann","year":"2002","journal-title":"Brain"},{"key":"10.1016\/j.jneuroim.2006.03.008_bib39","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s00018-003-3099-3","article-title":"Neurotrophins and their receptors: signaling trios in complex biological systems","volume":"61","author":"Teng","year":"2004","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.jneuroim.2006.03.008_bib40","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/jnr.10760","article-title":"Changes in spinal GDNF, BDNF, and NT-3 expression after transient spinal cord ischemia in the rat","volume":"74","author":"Tokumine","year":"2003","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.jneuroim.2006.03.008_bib41","doi-asserted-by":"crossref","unstructured":"van Laar. J.M., Tyndall. A. Intense immunosuppression and stem-cell transplantation for patients with severe rheumatic autoimmune disease: a review. Cancer Control; 10: 57\u201365.","DOI":"10.1177\/107327480301000107"},{"key":"10.1016\/j.jneuroim.2006.03.008_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1469-7580.2003.00203.x","article-title":"Neurotrophins and the immune system","volume":"203","author":"Vega","year":"2003","journal-title":"J. Anat."},{"key":"10.1016\/j.jneuroim.2006.03.008_bib43","series-title":"The Lupus Book","author":"Wallace","year":"1995"},{"key":"10.1016\/j.jneuroim.2006.03.008_bib44","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0196-9781(86)90076-8","article-title":"Use of cryoprotectant to maintain long-term peptide immunoreactivity and tissue morphology","volume":"7","author":"Watson","year":"1986","journal-title":"Peptides"},{"issue":"1","key":"10.1016\/j.jneuroim.2006.03.008_bib45","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1136\/ard.2003.016154","article-title":"Low density of sympathetic nerve fibres and increased density of brain derived neurotrophic factor positive cells in RA synovium","volume":"64","author":"Weidler","year":"2005","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jneuroim.2006.03.008_bib46","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1097\/00002281-199611000-00011","article-title":"Raynaud's phenomenon and other features of scleroderma, including pulmonary hypertension","volume":"8","author":"Wigley","year":"1996","journal-title":"Curr. Opin. Rheumatol."},{"issue":"6","key":"10.1016\/j.jneuroim.2006.03.008_bib47","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/nn0602-853","article-title":"A rapid switch in sympathetic neurotransmitter release properties mediated by the p75 receptor","volume":"5","author":"Yang","year":"2002","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jneuroim.2006.03.008_bib48","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s100670050141","article-title":"Sympathetic skin response in scleroderma, scleroderma overlap syndromes and inflammatory myopathies","volume":"18","author":"Zakrzewska-Pniewska","year":"1999","journal-title":"Clin. Rheumatol."},{"key":"10.1016\/j.jneuroim.2006.03.008_bib49","first-page":"216","article-title":"The change of nerve growth factor and brain derived neurotrophic factor in neurons of cerebral cortex of adult rat following local ischemia","volume":"32","author":"Zeng","year":"2001","journal-title":"Hua Xi Yi Ke Da Xue Xue Bao"},{"issue":"2","key":"10.1016\/j.jneuroim.2006.03.008_bib50","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1139\/y03-006","article-title":"Neuropeptide Y: a new mediator linking sympathetic nerves, blood vessels and immune system","volume":"81","author":"Zukowska","year":"2003","journal-title":"Can. J. Physiol. Pharm."}],"container-title":["Journal of Neuroimmunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572806000877?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572806000877?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T08:03:39Z","timestamp":1759046619000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165572806000877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6]]},"references-count":52,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["S0165572806000877"],"URL":"https:\/\/doi.org\/10.1016\/j.jneuroim.2006.03.008","relation":{},"ISSN":["0165-5728"],"issn-type":[{"value":"0165-5728","type":"print"}],"subject":[],"published":{"date-parts":[[2006,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"BDNF: A missing link between sympathetic dysfunction and inflammatory disease?","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroimmunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneuroim.2006.03.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}