{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:03:16Z","timestamp":1759104196047,"version":"3.44.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jni-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimmunology"],"published-print":{"date-parts":[[2007,8]]},"DOI":"10.1016\/j.jneuroim.2007.05.010","type":"journal-article","created":{"date-parts":[[2007,6,19]],"date-time":"2007-06-19T07:09:18Z","timestamp":1182236958000},"page":"39-47","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Intraperitoneal inoculation of Sandhoff mouse neonates with an HIV-1 based lentiviral vector exacerbates the attendant neuroinflammation and disease phenotype"],"prefix":"10.1016","volume":"188","author":[{"given":"Stephanos","family":"Kyrkanides","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jen-nie H.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ross H.","family":"Tallents","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine M.","family":"Brouxhon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gina M.","family":"Centola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Olschowka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jneuroim.2007.05.010_bib1","first-page":"769","article-title":"Restoration of hexosaminidase A activity in human Tay-Sachs fibriblasts via adenoviral vector mediated gene transfer","volume":"3","author":"Akli","year":"1996","journal-title":"Gene Ther."},{"key":"10.1016\/j.jneuroim.2007.05.010_bib2","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1038\/sj.gt.3302094","article-title":"Optimized lentiviral vector production and purification procedure prevents immune response after transduction of mouse brain","volume":"10","author":"Baekelandt","year":"2003","journal-title":"Gene Ther."},{"key":"10.1016\/j.jneuroim.2007.05.010_bib3","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1038\/sj.gt.3301420","article-title":"Prevention of systemic clinical disease in MPS VII mice following AAV-mediated neonatal gene transfer","volume":"8","author":"Daly","year":"2001","journal-title":"Gene Ther."},{"key":"10.1016\/j.jneuroim.2007.05.010_bib4","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/j.1749-6632.1986.tb27151.x","article-title":"In vitro studies of the blood-brain barrier using isolated brain capillaries and cultured endothelial cells","volume":"481","author":"Goldstein","year":"1986","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.jneuroim.2007.05.010_bib5","doi-asserted-by":"crossref","first-page":"713-626","DOI":"10.1084\/jem.193.6.713","article-title":"Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis","volume":"193","author":"Huang","year":"2001","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jneuroim.2007.05.010_bib6","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/nrn1725","article-title":"Storage solutions: Treating lysosomal disorders of the brain","volume":"6","author":"Jeyakumar","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jneuroim.2007.05.010_bib7","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1093\/brain\/awg089","article-title":"Central nervous system inflammation is a hallmark of pathogenesis in mouse models of GM1 and GM2 gangliosidosis","volume":"126","author":"Jeyakumar","year":"2003","journal-title":"Brain"},{"key":"10.1016\/j.jneuroim.2007.05.010_bib8","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/sj.gt.3302464","article-title":"HIV-1-derived lentiviral vectors and fetal route of administration on transgene biodistribution and expression in rhesus monkeys","volume":"12","author":"Jimenez","year":"2005","journal-title":"Gene Ther."},{"key":"10.1016\/j.jneuroim.2007.05.010_bib9","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/ng1197-314","article-title":"Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors","volume":"17","author":"Kafri","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jneuroim.2007.05.010_bib10","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S1525-0016(03)00073-X","article-title":"Efficient production of human FVIII in hemophilic mice using lentiviral vectors","volume":"7","author":"Kootstra","year":"2003","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jneuroim.2007.05.010_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/exnr.1999.7178","article-title":"Lentiviral gene transfer to the nonhuman primate brain","volume":"160","author":"Kordower","year":"1999","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jneuroim.2007.05.010_bib12","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.ymthe.2003.07.005","article-title":"Transcriptional and post-translational regulation of Cre recombinase by RU486 as the basis for an enhanced inducible expression system","volume":"8","author":"Kyrkanides","year":"2003","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jneuroim.2007.05.010_bib13","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.molbrainres.2004.10.026","article-title":"\u03b2-hexosaminidase lentiviral vectors: transfer into the CNS via systemic administration","volume":"133","author":"Kyrkanides","year":"2005","journal-title":"Mol. Brain Res."},{"key":"10.1016\/j.jneuroim.2007.05.010_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molbrainres.2003.08.016","article-title":"Systemic FIV vector administration: transduction of CNS immune cells and Purkinje neurons","volume":"119","author":"Kyrkanides","year":"2003","journal-title":"Mol. Brain Res."},{"key":"10.1016\/j.jneuroim.2007.05.010_bib15","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/nm0496-424","article-title":"Expression of human beta-hexosaminidase alpha-subunit gene (the gene defect of Tay-Sachs disease) in mouse brains upon engraftment of transduced progenitor cells","volume":"2","author":"Lacorazza","year":"1996","journal-title":"Nat. Med."},{"key":"10.1016\/j.jneuroim.2007.05.010_bib16","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1172\/JCI5542","article-title":"A genetic model of substrate deprivation therapy for a glycosphingolipid storage disorder","volume":"103","author":"Liu","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jneuroim.2007.05.010_bib17","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1042\/bst0240133","article-title":"Function of the two mannose 6-phosphate receptors in lysosomal enzyme transport","volume":"24","author":"Munier-Lehmann","year":"1996","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.jneuroim.2007.05.010_bib18","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1093\/hmg\/11.11.1343","article-title":"Molecular pathophysiology in Tay-Sachs and Sandhoff diseases as revealed by gene expression profiling","volume":"11","author":"Myerowitz","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.jneuroim.2007.05.010_bib19","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1172\/JCI2127","article-title":"Bone marrow transplantation prolongs life span and ameliorates neurologic manifestations in Sandhoff disease mice","volume":"101","author":"Norflus","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jneuroim.2007.05.010_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/hmg\/5.1.1","article-title":"Dramatically different phenotypes in mouse models of human Tay-Sachs and Sandhoff diseases","volume":"5","author":"Phaneuf","year":"1996","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.jneuroim.2007.05.010_bib22","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1038\/nm1201-1356","article-title":"Targeting gene-modified hematopoietic cells to the central nervous system: use of green fluorescent protein uncovers microglial engraftment","volume":"7","author":"Priller","year":"2001","journal-title":"Nat. Med."},{"key":"10.1016\/j.jneuroim.2007.05.010_bib23","doi-asserted-by":"crossref","first-page":"3350","DOI":"10.1016\/S0021-9258(17)43301-1","article-title":"Association of a- and b-subunits during the biosynthesis of b-hexosaminidase in cultured human fibroblasts","volume":"259","author":"Proia","year":"1984","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jneuroim.2007.05.010_bib24","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/0012-1606(86)90321-0","article-title":"Differentiation-dependent expression of proteins in brain endothelium during development of the blood-brain barrier","volume":"117","author":"Risau","year":"1986","journal-title":"Dev. Biol."},{"key":"10.1016\/j.jneuroim.2007.05.010_bib25","first-page":"174","article-title":"Development of blood-brain barrier","volume":"13","author":"Risau","year":"1990","journal-title":"TINS"},{"key":"10.1016\/j.jneuroim.2007.05.010_bib26","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.ymthe.2006.01.006","article-title":"Gene therapy for lysosomal storage diseases","volume":"13","author":"Sands","year":"2006","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jneuroim.2007.05.010_bib27","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/ng1196-348","article-title":"Mice lacking both subunits of lysosomal \u03b2-hexosaminidase display gangliosidosis and mucopolysaccharidosis","volume":"14","author":"Sango","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jneuroim.2007.05.010_bib28","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/ng1095-170","article-title":"Mouse models of Tay-Sachs and Sandhoff diseases differ in neurologic phenotype and ganglioside metabolism","volume":"11","author":"Sango","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jneuroim.2007.05.010_bib29","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/j.1749-6632.1995.tb55834.x","article-title":"Developmental regulation of the human antibody repertoire","volume":"764","author":"Schroeder","year":"1995","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.jneuroim.2007.05.010_bib30","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1097\/00005072-199706000-00007","article-title":"Mice deficient in all forms of lysosomal \u03b2-hexosaminidase show mucopolysaccharosis-like pathology","volume":"56","author":"Suzuki","year":"1997","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.jneuroim.2007.05.010_bib31","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1212\/WNL.29.6.848","article-title":"Enzyme replacement therapy for Tay-Sachs disease","volume":"29","author":"von Specht","year":"1979","journal-title":"Neurol."},{"key":"10.1016\/j.jneuroim.2007.05.010_bib32","doi-asserted-by":"crossref","first-page":"10954","DOI":"10.1073\/pnas.97.20.10954","article-title":"Microglial activation precedes acute neurodegeneration in Sandhoff disease and is suppressed by bone marrow transplantation","volume":"97","author":"Wada","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jneuroim.2007.05.010_bib33","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1073\/pnas.0337659100","article-title":"Contribution of transplanted bone marrow cells to Purkinje neurons in human adult brain","volume":"100","author":"Weinmann","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jneuroim.2007.05.010_bib34","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1006\/mthe.2002.0590","article-title":"Endostatin gene transfer inhibits joint angiogenesis and pannus formation in inflammatory arthritis","volume":"5","author":"Yin","year":"2002","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jneuroim.2007.05.010_bib35","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/glia.10195","article-title":"Lentiviral vectors for gene delivery to normal and demyelinated white matter","volume":"42","author":"Zhao","year":"2003","journal-title":"GLIA"}],"container-title":["Journal of Neuroimmunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572807001610?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572807001610?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T08:06:44Z","timestamp":1759046804000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165572807001610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8]]},"references-count":34,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["S0165572807001610"],"URL":"https:\/\/doi.org\/10.1016\/j.jneuroim.2007.05.010","relation":{},"ISSN":["0165-5728"],"issn-type":[{"type":"print","value":"0165-5728"}],"subject":[],"published":{"date-parts":[[2007,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intraperitoneal inoculation of Sandhoff mouse neonates with an HIV-1 based lentiviral vector exacerbates the attendant neuroinflammation and disease phenotype","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroimmunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneuroim.2007.05.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}