{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:21:21Z","timestamp":1790223681933,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jni-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimmunology"],"published-print":{"date-parts":[[2008,2]]},"DOI":"10.1016\/j.jneuroim.2007.11.012","type":"journal-article","created":{"date-parts":[[2008,1,7]],"date-time":"2008-01-07T07:17:33Z","timestamp":1199690253000},"page":"34-43","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Differential effects of decoy chemokine (7ND) gene therapy on acute, biphasic and chronic autoimmune encephalomyelitis: Implication for pathomechanisms of lesion formation"],"prefix":"10.1016","volume":"194","author":[{"given":"Il-Kwon","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Hiraki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuniko","family":"Kohyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoh","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jneuroim.2007.11.012_bib1","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1111\/j.1471-4159.1972.tb05118.x","article-title":"Partial characterization of a new myelin protein component","volume":"19","author":"Agrawal","year":"1972","journal-title":"J. Neurochem."},{"key":"10.1016\/j.jneuroim.2007.11.012_bib2","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S0165-5728(99)00193-9","article-title":"Molecular pathogenesis of multiple sclerosis","volume":"100","author":"Bar-Or","year":"1999","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2007.11.012_bib3","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1111\/j.0300-9475.2004.01440.x","article-title":"Utility of the housekeeping genes 18S rRNA, beta-actin and glyceraldehyde-3-phosphate-dehydrogenase for normalization in real-time quantitative reverse transcriptase-polymerase chain reaction analysis of gene expression in human T lymphocytes","volume":"59","author":"Bas","year":"2004","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.jneuroim.2007.11.012_bib4","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/BF00972485","article-title":"Isolation and characterization of bovine brain myelin distribution of 5\u2032-nucleotidase","volume":"13","author":"Casado","year":"1988","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.jneuroim.2007.11.012_bib5","first-page":"139","article-title":"Large scale preparation of myelin basic protein from central nervous tissue of several mammalian species","volume":"2","author":"Deibler","year":"1972","journal-title":"Prep. Biochem."},{"key":"10.1016\/j.jneuroim.2007.11.012_bib6","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1161\/01.HYP.0000051642.65283.36","article-title":"Molecular mechanisms mediating inflammation in vascular disease: special reference to monocyte chemoattractant protein-1","volume":"41","author":"Egashira","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.jneuroim.2007.11.012_bib7","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1096\/fj.00-0141com","article-title":"Anti-monocyte chemoattractant protein-1 gene therapy inhibits vascular remodeling in rats: blockade of MCP-1 activity after intramuscular transfer of a mutant gene inhibits vascular remodeling induced by chronic blockade of NO synthesis","volume":"14","author":"Egashira","year":"2000","journal-title":"FASEB J."},{"key":"10.1016\/j.jneuroim.2007.11.012_bib8","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1084\/jem.186.1.131","article-title":"An antagonisit of monocyte chemoattractant protein 1 (MCP-1) inhibits arthritis in the MRL-lpr mouse model","volume":"186","author":"Gong","year":"1997","journal-title":"J Exp. Med."},{"key":"10.1016\/j.jneuroim.2007.11.012_bib9","doi-asserted-by":"crossref","first-page":"3400","DOI":"10.1161\/CIRCULATIONAHA.105.572396","article-title":"Critical role for monocyte chemoattractant protein-1 and macrophage inflammatory protein-1alpha in induction of experimental autoimmune myocarditis and effective anti-monocyte chemoattractant protein-1 gene therapy","volume":"112","author":"Goser","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jneuroim.2007.11.012_bib10","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1084\/jem.193.6.713","article-title":"Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis","volume":"193","author":"Huang","year":"2001","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jneuroim.2007.11.012_bib11","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1084\/jem.172.4.1025","article-title":"Suppression of experimental allergic encephalomyelitis in Lewis rats after elimination of macrophages","volume":"172","author":"Huitinga","year":"1990","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jneuroim.2007.11.012_bib12","doi-asserted-by":"crossref","first-page":"H2021","DOI":"10.1152\/ajpheart.00919.2001","article-title":"Anti-monocyte chemoattractant protein-1 gene therapy attenuates pulmonary hypertension in rats","volume":"283","author":"Ikeda","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.jneuroim.2007.11.012_bib13","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0165-5728(02)00147-9","article-title":"Upregulation of monocyte chemoattractant protein-1 and CC chemokine receptor 2 in the central nervous system is closely associated with relapse of autoimmune encephalomyelitis in Lewis rats","volume":"128","author":"Jee","year":"2002","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2007.11.012_bib14","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S0165-5728(98)00187-8","article-title":"Acute and relapsing experimental encephalomyelitis are regulated by differential expression of the CC chemokines macrophage inflammatory protein-1\u03b1 and monocyte chemotactic protein-1","volume":"92","author":"Kennedy","year":"1998","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2007.11.012_bib15","doi-asserted-by":"crossref","first-page":"509","DOI":"10.4049\/jimmunol.160.1.509","article-title":"CDR3 size spectratyping and sequencing of spectratype-derived T cell receptor of spinal cord T cells in autoimmune encephalomyelitis","volume":"160","author":"Kim","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2007.11.012_bib16","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1073\/pnas.0510672103","article-title":"Antibodies to native myelin oligodendrocyte glycoprotein are serologic markers of early inflammation in multiple sclerosis","volume":"103","author":"Lalive","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.jneuroim.2007.11.012_bib17","first-page":"IV\/2","article-title":"Recent neuropathological findings in MS-implication for diagnosis and therapy","volume":"4","author":"Lassmann","year":"2004","journal-title":"J. Neurol. Suppl."},{"key":"10.1016\/j.jneuroim.2007.11.012_bib18","doi-asserted-by":"crossref","first-page":"22294","DOI":"10.1074\/jbc.M311224200","article-title":"Identification of the glycosaminoglycan binding site of the CC chemokine, MCP-1: implications for structure and function in vivo","volume":"279","author":"Lau","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jneuroim.2007.11.012_bib19","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1212\/WNL.46.4.907","article-title":"Defining the clinical course of multiple sclerosis: results of an international survey","volume":"46","author":"Lublin","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.jneuroim.2007.11.012_bib20","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1002\/1531-8249(200006)47:6<707::AID-ANA3>3.0.CO;2-Q","article-title":"Heterogeity of multiple sclerosis lesions: implication for the pathogenesis of demyelination","volume":"47","author":"Lucchinetti","year":"2000","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jneuroim.2007.11.012_bib21","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0022-510X(87)90204-8","article-title":"The immunopathology of adoptively transferred experimental allergic encephalomyelitis (EAE) in Lewis rats. Part 1. Immunohistochemical examination of developing lesion of EAE","volume":"77","author":"Matsumoto","year":"1987","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.jneuroim.2007.11.012_bib22","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.4049\/jimmunol.173.5.3535","article-title":"C protein-induced myocarditis and subsequent dilated cardiomyopathy: rescue from death and prevention of dilated cardiomyopathy by chemokine receptor DNA therapy","volume":"173","author":"Matsumoto","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2007.11.012_bib23","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jneuroim.2005.08.022","article-title":"Characterization of relapsing autoimmune encephalomyelitis and its treatment with decoy chemokine receptor gene","volume":"170","author":"Matsumoto","year":"2005","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2007.11.012_bib24","first-page":"54","article-title":"In situ demonstration of proliferating cells in the rat central nervous system during experimental autoimmune encephalomyelitis. Evidence suggesting that most infiltrating T cells do not proliferate in the target organ","volume":"66","author":"Ohmori","year":"1992","journal-title":"Lab. Invest."},{"key":"10.1016\/j.jneuroim.2007.11.012_bib25","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1073\/pnas.0334864100","article-title":"Glycosaminoglycan binding and oligomerization are essential for the in vivo activity of certain chemokines","volume":"100","author":"Proudfoot","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.jneuroim.2007.11.012_bib26","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1093\/brain\/awh260","article-title":"Clinicopathological study of a myelin oligodendrocyte glycoprotein-induced demyelinating disease in LEW.1AV1 rats","volume":"127","author":"Sakuma","year":"2004","journal-title":"Brain"},{"key":"10.1016\/j.jneuroim.2007.11.012_bib27","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1146\/annurev.immunol.23.021704.115707","article-title":"Immunology of multipel sclerosis","volume":"23","author":"Sospendra","year":"2005","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jneuroim.2007.11.012_bib28","doi-asserted-by":"crossref","first-page":"3767","DOI":"10.4049\/jimmunol.161.7.3767","article-title":"Immune invasion of the central nervous system parenchyma and experimental allergic encephalomyelitis, but not leukocyte extravasation from blood, are prevented in macrophage-depleted mice","volume":"161","author":"Tran","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2007.11.012_bib29","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jneuroim.2004.12.010","article-title":"Determination of the sequential degradation of myelin protein by macrophages","volume":"161","author":"van der Goes","year":"2005","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2007.11.012_bib30","doi-asserted-by":"crossref","first-page":"8207","DOI":"10.1073\/pnas.122092499","article-title":"Molecular characterization of antibody specificities against myelin\/oligodendrocyte glycoprotein in autoimmune demyelination","volume":"99","author":"von Budingen","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.jneuroim.2007.11.012_bib31","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.1128\/MCB.15.9.4851","article-title":"A dominant negative inhibitor indicates that monocyte chemoattractant protein 1 functions as a dimer","volume":"15","author":"Zhang","year":"1995","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.jneuroim.2007.11.012_bib32","doi-asserted-by":"crossref","first-page":"15918","DOI":"10.1016\/S0021-9258(17)40768-X","article-title":"Structure\/activity analysis of human monocyte chemoattractant protein-1 (MCP-1) by mutagenesis. Identification of a mutated protein that inhibits MCP-1-mediated monocyte chemotaxis","volume":"269","author":"Zhang","year":"1994","journal-title":"J. Biol. Chem."}],"container-title":["Journal of Neuroimmunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572807004250?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572807004250?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T08:12:34Z","timestamp":1759047154000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165572807004250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2]]},"references-count":32,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["S0165572807004250"],"URL":"https:\/\/doi.org\/10.1016\/j.jneuroim.2007.11.012","relation":{},"ISSN":["0165-5728"],"issn-type":[{"value":"0165-5728","type":"print"}],"subject":[],"published":{"date-parts":[[2008,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential effects of decoy chemokine (7ND) gene therapy on acute, biphasic and chronic autoimmune encephalomyelitis: Implication for pathomechanisms of lesion formation","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroimmunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneuroim.2007.11.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}