{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T22:55:28Z","timestamp":1789167328680,"version":"build-2803163510"},"reference-count":39,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jni-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimmunology"],"published-print":{"date-parts":[[2008,2]]},"DOI":"10.1016\/j.jneuroim.2007.11.018","type":"journal-article","created":{"date-parts":[[2008,3,6]],"date-time":"2008-03-06T18:38:55Z","timestamp":1204828735000},"page":"70-82","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":70,"title":["Lymphocytic Choriomeningitis Virus (LCMV) infection of CNS glial cells results in TLR2-MyD88\/Mal-dependent inflammatory responses"],"prefix":"10.1016","volume":"194","author":[{"given":"Shenghua","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annett","family":"Halle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn A.","family":"Kurt-Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna M.","family":"Cerny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ermelinda","family":"Porpiglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Rogers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas T.","family":"Golenbock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Finberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jneuroim.2007.11.018_bib1","first-page":"131","article-title":"Nature of the inflammatory process in the central nervous system of mice infected with lymphocytic choriomeningitis virus","volume":"134","author":"Allan","year":"1987","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.jneuroim.2007.11.018_bib2","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1097\/01.jnen.0000173893.01929.fc","article-title":"Astrocytes produce dendritic cell-attracting chemokines in vitro and in multiple sclerosis lesions","volume":"64","author":"Ambrosini","year":"2005","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.jneuroim.2007.11.018_bib3","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0165-5728(91)90021-X","article-title":"Breakdown of blood\u2013brain barrier function in the murine lymphocytic choriomeningitis virus infection mediated by virus-specific CD8+ T cells","volume":"31","author":"Andersen","year":"1991","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2007.11.018_bib4","doi-asserted-by":"crossref","first-page":"7832","DOI":"10.1128\/jvi.71.10.7832-7840.1997","article-title":"Chemokine gene expression in the brains of mice with lymphocytic choriomeningitis","volume":"71","author":"Asensio","year":"1997","journal-title":"J. Virol."},{"key":"10.1016\/j.jneuroim.2007.11.018_bib5","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1046\/j.1471-4159.2002.01091.x","article-title":"Characterization of chemokines and their receptors in the central nervous system: physiopathological implications","volume":"82","author":"Bajetto","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.jneuroim.2007.11.018_bib6","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0166-0934(91)90018-U","article-title":"Quantification of lymphocytic choriomeningitis virus with an immunological focus assay in 24-or 96-well plates","volume":"33","author":"Battegay","year":"1991","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.jneuroim.2007.11.018_bib7","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0165-5728(90)90073-V","article-title":"Immortalization of murine microglial cells by a v-raf\/v-myc carrying retrovirus","volume":"27","author":"Blasi","year":"1990","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2007.11.018_bib8","doi-asserted-by":"crossref","first-page":"6618","DOI":"10.1128\/JVI.76.13.6618-6635.2002","article-title":"Critical role for glial cells in the propagation and spread of lymphocytic choriomeningitis virus in the developing rat brain","volume":"76","author":"Bonthius","year":"2002","journal-title":"J. Virol."},{"key":"10.1016\/j.jneuroim.2007.11.018_bib9","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/glia.10256","article-title":"Cultured astrocytes express toll-like receptors for bacterial products","volume":"43","author":"Bowman","year":"2003","journal-title":"Glia"},{"key":"10.1016\/j.jneuroim.2007.11.018_bib10","doi-asserted-by":"crossref","first-page":"716","DOI":"10.4049\/jimmunol.152.2.716","article-title":"Cerebral expression of multiple cytokine genes in mice with lymphocytic choriomeningitis","volume":"152","author":"Campbell","year":"1994","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2007.11.018_bib11","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.virol.2005.12.004","article-title":"Novel pathway of human immunodeficiency virus type 1 uptake and release in astrocytes","volume":"348","author":"Clarke","year":"2006","journal-title":"Virology"},{"key":"10.1016\/j.jneuroim.2007.11.018_bib12","doi-asserted-by":"crossref","first-page":"4588","DOI":"10.1128\/JVI.77.8.4588-4596.2003","article-title":"Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2","volume":"77","author":"Compton","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.jneuroim.2007.11.018_bib13","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1038\/nm1477","article-title":"Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia","volume":"12","author":"de Jong","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.jneuroim.2007.11.018_bib14","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/glia.1107","article-title":"Immune function of astrocytes","volume":"36","author":"Dong","year":"2001","journal-title":"Glia"},{"key":"10.1016\/j.jneuroim.2007.11.018_bib15","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jneuroim.2004.10.005","article-title":"Dose-dependent activation of microglial cells by toll-like receptor agonists alone and in combination","volume":"159","author":"Ebert","year":"2005","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2007.11.018_bib16","doi-asserted-by":"crossref","first-page":"6802","DOI":"10.4049\/jimmunol.176.11.6802","article-title":"Central role for MyD88 in the responses of microglia to pathogen-associated molecular patterns","volume":"176","author":"Esen","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2007.11.018_bib17","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jneuroim.2004.09.009","article-title":"Preferential expression and function of toll-like receptor 3 in human astrocytes","volume":"159","author":"Farina","year":"2005","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2007.11.018_bib18","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/j.micinf.2004.08.013","article-title":"Viruses and toll-like receptors","volume":"6","author":"Finberg","year":"2004","journal-title":"Microbes. Infect."},{"key":"10.1016\/j.jneuroim.2007.11.018_bib19","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.4049\/jimmunol.152.6.2720","article-title":"Antigen presentation in the central nervous system. The inhibitory effect of IL-10 on MHC class II expression and production of cytokines depends on the inducing signals and the type of cell analyzed","volume":"152","author":"Frei","year":"1994","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2007.11.018_bib20","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1002\/eji.1830190418","article-title":"On the cellular source and function of interleukin 6 produced in the central nervous system in viral diseases","volume":"19","author":"Frei","year":"1989","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jneuroim.2007.11.018_bib21","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0167-5699(90)90106-J","article-title":"Astrocytes: auxiliary cells for immune responses in the central nervous system?","volume":"11","author":"Hertz","year":"1990","journal-title":"Immunol. Today"},{"key":"10.1016\/j.jneuroim.2007.11.018_bib22","doi-asserted-by":"crossref","first-page":"4320","DOI":"10.4049\/jimmunol.175.7.4320","article-title":"TLR signaling tailors innate immune responses in human microglia and astrocytes","volume":"175","author":"Jack","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2007.11.018_bib23","doi-asserted-by":"crossref","first-page":"340","DOI":"10.4049\/jimmunol.169.1.340","article-title":"The role of proinflammatory cytokines in wasting disease during lymphocytic choriomeningitis virus infection","volume":"169","author":"Kamperschroer","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2007.11.018_bib24","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/jb\/mvm032","article-title":"Antiviral signaling through pattern recognition receptors","volume":"141","author":"Kawai","year":"2007","journal-title":"J. Biochem. (Tokyo)"},{"key":"10.1016\/j.jneuroim.2007.11.018_bib25","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1172\/JCI28349","article-title":"Immunoprivileged status of the liver is controlled by toll-like receptor 3 signaling","volume":"116","author":"Lang","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jneuroim.2007.11.018_bib26","doi-asserted-by":"crossref","first-page":"583","DOI":"10.4049\/jimmunol.177.1.583","article-title":"A mechanism for neurodegeneration induced by group B streptococci through activation of the TLR2\/MyD88 pathway in microglia","volume":"177","author":"Lehnardt","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2007.11.018_bib27","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jneuroim.2005.08.006","article-title":"In response to pathogens, glial cells dynamically and differentially regulate toll-like receptor gene expression","volume":"169","author":"McKimmie","year":"2005","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2007.11.018_bib28","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/35100529","article-title":"Toll-like receptors and innate immunity","volume":"1","author":"Medzhitov","year":"2001","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jneuroim.2007.11.018_bib29","first-page":"83","article-title":"Biology and pathogenesis of lymphocytic choriomeningitis virus infection","volume":"263","author":"Oldstone","year":"2002","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.jneuroim.2007.11.018_bib30","doi-asserted-by":"crossref","first-page":"3916","DOI":"10.4049\/jimmunol.173.6.3916","article-title":"Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs","volume":"173","author":"Olson","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2007.11.018_bib31","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.4049\/jimmunol.172.6.3415","article-title":"Myeloid differentiation factor 88 is required for cross-priming in vivo","volume":"172","author":"Palliser","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2007.11.018_bib32","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.immuni.2004.10.006","article-title":"Toll-dependent control mechanisms of CD4 T cell activation","volume":"21","author":"Pasare","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.jneuroim.2007.11.018_bib33","doi-asserted-by":"crossref","first-page":"220","DOI":"10.4049\/jimmunol.153.1.220","article-title":"Altered tissue distribution of viral replication and T cell spreading is pivotal in the protection against fatal lymphocytic choriomeningitis in mice after neutralization of IFN-alpha\/beta","volume":"153","author":"Sandberg","year":"1994","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2007.11.018_bib34","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/ni712","article-title":"Toll-like receptors control activation of adaptive immune responses","volume":"2","author":"Schnare","year":"2001","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jneuroim.2007.11.018_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/intimm\/dxh186","article-title":"Toll-like receptors in innate immunity","volume":"17","author":"Takeda","year":"2005","journal-title":"Int. Immunol."},{"key":"10.1016\/j.jneuroim.2007.11.018_bib36","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1128\/JVI.01167-06","article-title":"Coordinated regulation and widespread cellular expression of interferon-stimulated genes (ISG) ISG-49, ISG-54, and ISG-56 in the central nervous system after infection with distinct viruses","volume":"81","author":"Wacher","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.jneuroim.2007.11.018_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1074-7613(00)80583-X","article-title":"Chemokines and T lymphocytes: more than an attraction","volume":"9","author":"Ward","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/j.jneuroim.2007.11.018_bib38","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1002\/eji.200425730","article-title":"MyD88 is critical for the development of innate and adaptive immunity during acute lymphocytic choriomeningitis virus infection","volume":"35","author":"Zhou","year":"2005","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jneuroim.2007.11.018_bib39","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/316814a0","article-title":"Susceptibility to murine lymphocytic choriomeningitis maps to class I MHC genes\u2014a model for MHC\/disease associations","volume":"316","author":"Zinkernagel","year":"1985","journal-title":"Nature"}],"container-title":["Journal of Neuroimmunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572807004304?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572807004304?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T08:11:49Z","timestamp":1759047109000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165572807004304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2]]},"references-count":39,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["S0165572807004304"],"URL":"https:\/\/doi.org\/10.1016\/j.jneuroim.2007.11.018","relation":{},"ISSN":["0165-5728"],"issn-type":[{"value":"0165-5728","type":"print"}],"subject":[],"published":{"date-parts":[[2008,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lymphocytic Choriomeningitis Virus (LCMV) infection of CNS glial cells results in TLR2-MyD88\/Mal-dependent inflammatory responses","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroimmunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneuroim.2007.11.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}