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(Lond.)"},{"key":"10.1016\/j.jneuroim.2008.06.031_bib83","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1046\/j.1460-9568.2002.02015.x","article-title":"Differential Ca2+-dependence of transmitter release mediated by P\/Q and N-type calcium channels at neonatal rat neuromuscular junctions","volume":"15","author":"Rosato-Siri","year":"2002","journal-title":"Eur. J. 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