{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:40:33Z","timestamp":1777405233543,"version":"3.51.4"},"reference-count":16,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jni-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimmunology"],"published-print":{"date-parts":[[2009,4]]},"DOI":"10.1016\/j.jneuroim.2009.02.006","type":"journal-article","created":{"date-parts":[[2009,3,11]],"date-time":"2009-03-11T04:40:22Z","timestamp":1236746422000},"page":"139-142","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["The trigeminal retrograde transfer pathway in the treatment of neurodegeneration"],"prefix":"10.1016","volume":"209","author":[{"given":"Stephanos","family":"Kyrkanides","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meixiang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ross H.","family":"Tallents","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jen-nie H.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine M.","family":"Brouxhon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Olschowka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jneuroim.2009.02.006_bib1","first-page":"769","article-title":"Restoration of hexosaminidase A activity in human Tay\u2013Sachs fibriblasts via adenoviral vector mediated gene transfer","volume":"3","author":"Akli","year":"1996","journal-title":"Gene Ther."},{"key":"10.1016\/j.jneuroim.2009.02.006_bib2","doi-asserted-by":"crossref","first-page":"6216","DOI":"10.1073\/pnas.082011999","article-title":"Functional correction of established central nervous system deficits in an animal model of lysosomal storage disease with feline immunodeficiency virus-based vectors","volume":"99","author":"Brooks","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jneuroim.2009.02.006_bib21","doi-asserted-by":"crossref","first-page":"10373","DOI":"10.1073\/pnas.0603765103","article-title":"Effective gene therapy in an authentic model of Tay-Sachs-related diseases","volume":"103","author":"Cachon-Gonzalez","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jneuroim.2009.02.006_bib3","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ymgme.2006.12.012","article-title":"Intrathecal enzyme replacement therapy: successful treatment of brain disease via the cerebrospinal fluid","volume":"91","author":"Dickson","year":"2007","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.jneuroim.2009.02.006_bib4","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.ymthe.2005.04.018","article-title":"AAV2-mediated ocular gene therapy for infantile neuronal ceroid lipofuscinosis","volume":"12","author":"Griffey","year":"2005","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jneuroim.2009.02.006_bib5","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.ymgme.2006.10.005","article-title":"Injection of recombinant human sulfamidase into the CSF via the cerebellomedullary cistern in MPS IIIA mice","volume":"90","author":"Hemsley","year":"2007","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.jneuroim.2009.02.006_bib8","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1177\/154405910408300113","article-title":"Non-primate lentiviral vector administration in the TMJ","volume":"83","author":"Kyrkanides","year":"2004","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.jneuroim.2009.02.006_bib9","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.molbrainres.2004.10.026","article-title":"\u03b2-hexosaminidase lentiviral vectors: transfer into the CNS via systemic administration","volume":"133","author":"Kyrkanides","year":"2005","journal-title":"Mol. Brain Res."},{"key":"10.1016\/j.jneuroim.2009.02.006_bib10","first-page":"39","article-title":"Intraperitoneal inoculation of Sandhoff mouse neonates with an HIV-1 based lentiviral vector exacerbates the attendant neuroinflammation and disease phenotype","volume":"188","author":"Kyrkanides","year":"2007","journal-title":"J. Neuroinflam."},{"key":"10.1016\/j.jneuroim.2009.02.006_bib6","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1002\/art.22635","article-title":"Amelioration of pain and histopathologic joint abnormalities in the Col1-IL-1beta(XAT) mouse model of arthritis by intraarticular induction of mu-opioid receptor into the temporomandibular joint","volume":"56","author":"Kyrkanides","year":"2007","journal-title":"Arthr. Rheum."},{"key":"10.1016\/j.jneuroim.2009.02.006_bib7","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jneuroim.2008.06.024","article-title":"Peripheral blood mononuclear cell infiltration and neuroinflammation in the HexB\u2212\/\u2212 mouse model of neurodegeneration","volume":"203","author":"Kyrkanides","year":"2008","journal-title":"J. Neuroimmunol"},{"key":"10.1016\/j.jneuroim.2009.02.006_bib11","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/nm0496-424","article-title":"Expression of human beta-hexosaminidase alpha-subunit gene (the gene defect of Tay\u2013Sachs disease) in mouse brains upon engraftment of transduced progenitor cells","volume":"2","author":"Lacorazza","year":"1996","journal-title":"Nat. Med."},{"key":"10.1016\/j.jneuroim.2009.02.006_bib14","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S1525-0016(02)00036-9","article-title":"Helper-free HSV-1 amplicons elicit a markedly less robust innate immune response in the CNS","volume":"7","author":"Olschowka","year":"2003","journal-title":"Molec. Ther."},{"key":"10.1016\/j.jneuroim.2009.02.006_bib16","doi-asserted-by":"crossref","first-page":"3350","DOI":"10.1016\/S0021-9258(17)43301-1","article-title":"Association of a- and b-subunits during the biosynthesis of b-hexosaminidase in cultured human fibroblasts","volume":"259","author":"Proia","year":"1984","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jneuroim.2009.02.006_bib18","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/ng1095-170","article-title":"Mouse models of Tay\u2013Sachs and Sandhoff diseases differ in neurologic phenotype and ganglioside metabolism","volume":"11","author":"Sango","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jneuroim.2009.02.006_bib19","doi-asserted-by":"crossref","first-page":"9975","DOI":"10.1073\/pnas.91.21.9975","article-title":"Targeted disruption of the Hexa gene results in mice with biochemical and pathologic features of Tay\u00adSachs disease","volume":"91","author":"Yamanaka","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Journal of Neuroimmunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572809000599?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572809000599?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T08:11:54Z","timestamp":1759047114000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165572809000599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4]]},"references-count":16,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["S0165572809000599"],"URL":"https:\/\/doi.org\/10.1016\/j.jneuroim.2009.02.006","relation":{},"ISSN":["0165-5728"],"issn-type":[{"value":"0165-5728","type":"print"}],"subject":[],"published":{"date-parts":[[2009,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The trigeminal retrograde transfer pathway in the treatment of neurodegeneration","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroimmunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneuroim.2009.02.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}