{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T17:43:18Z","timestamp":1789148598003,"version":"build-2803163510"},"reference-count":31,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2011,3,3]],"date-time":"2011-03-03T00:00:00Z","timestamp":1299110400000},"content-version":"vor","delay-in-days":336,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100005667","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e Inova\u00e7\u00e3o do Estado de Santa Catarina","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005667","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013360","name":"Universidade do Extremo Sul Catarinense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013360","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013379","name":"Instituto Mente e C\u00e9rebro - Neuroci\u00eancia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013379","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jni-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimmunology"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1016\/j.jneuroim.2010.02.009","type":"journal-article","created":{"date-parts":[[2010,3,5]],"date-time":"2010-03-05T04:41:17Z","timestamp":1267764077000},"page":"42-45","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":67,"title":["TNF-\u03b1, IL-1\u03b2, IL-6, and cinc-1 levels in rat brain after meningitis induced by Streptococcus pneumoniae"],"prefix":"10.1016","volume":"221","author":[{"given":"Tatiana","family":"Barichello","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivonete","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geovana D.","family":"Savi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutiana R.","family":"Sim\u00f5es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago","family":"Silvestre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarissa M.","family":"Comim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Sachs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro M.","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio L.","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Quevedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jneuroim.2010.02.009_bib1","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/35094583","article-title":"Cytokines and acute neurodegeneration","volume":"2","author":"Allan","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jneuroim.2010.02.009_bib2","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.neulet.2009.10.039","article-title":"Tumor necrosis factor alpha (TNF-alpha) levels in the brain and cerebrospinal fluid after meningitis induced by Streptococcus pneumoniae","volume":"467","author":"Barichello","year":"2009","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jneuroim.2010.02.009_bib3","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.brainresbull.2009.04.011","article-title":"Brain creatine kinase activity after meningitis induced by Streptococcus pneumoniae","volume":"80","author":"Barichello","year":"2009","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.jneuroim.2010.02.009_bib4","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.neulet.2009.08.072","article-title":"Early antibiotic administration prevents cognitive impairment induced by meningitis in rats","volume":"465","author":"Barichello","year":"2009","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jneuroim.2010.02.009_bib5","first-page":"106","article-title":"Cytokines: influence on glial cell gene expression and function","volume":"52","author":"Benveniste","year":"1992","journal-title":"Chem. Immunol."},{"key":"10.1016\/j.jneuroim.2010.02.009_bib7","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1086\/322688","article-title":"Bacterial meningitis in aging adults","volume":"33","author":"Choi","year":"2001","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.jneuroim.2010.02.009_bib8","first-page":"113","article-title":"Inflammatory cytokines IL-1beta and TNF-alpha regulate p75NTR expression in CNS neurons and astrocytes by distinct cell-type-specific signalling mechanisms","volume":"20","author":"Choi","year":"2009","journal-title":"ASN Neuro"},{"key":"10.1016\/j.jneuroim.2010.02.009_bib9","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1097\/01.CCM.0000185500.11080.91","article-title":"The cytokines interleukin-1\u03b2","volume":"33","author":"Dinarello","year":"2005","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.jneuroim.2010.02.009_bib10","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1056\/NEJMra010462","article-title":"The prevention of pneumococcal disease in children","volume":"345","author":"Giebink","year":"2001","journal-title":"N. England J. Med."},{"key":"10.1016\/j.jneuroim.2010.02.009_bib11","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1128\/AAC.01014-06","article-title":"Prevention of brain injury by the nonbacteriolytic antibiotic daptomycin in experimental pneumococcal meningitis","volume":"51","author":"Grandgirard","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jneuroim.2010.02.009_bib12","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s00401-007-0304-8","article-title":"An infant mouse model of brain damage in pneumococcal meningitis","volume":"114","author":"Grandgirard","year":"2007","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.jneuroim.2010.02.009_bib13","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1136\/adc.83.2.111","article-title":"Twelve year outcomes following bacterial meningitis: further evidence for persisting effects","volume":"83","author":"Grimwood","year":"2000","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.jneuroim.2010.02.009_bib14","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1084\/jem.170.2.607","article-title":"Tumor necrosis factor identified in multiple sclerosis brain","volume":"170","author":"Hofman","year":"1989","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jneuroim.2010.02.009_bib15","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1136\/jnnp.2006.110023","article-title":"Cognitive outcome in adults after bacterial meningitis","volume":"78","author":"Hoogman","year":"2007","journal-title":"J. Neurol. Neurosurg. Psychiatr."},{"key":"10.1016\/j.jneuroim.2010.02.009_bib16","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1097\/00003246-200211000-00025","article-title":"Modulation of nuclear factor-kB activation and decreased markers of neurological injury associated with hypothermic therapy in experimental bacterial meningitis","volume":"30","author":"Irazuzta","year":"2002","journal-title":"Crit Care Med."},{"key":"10.1016\/j.jneuroim.2010.02.009_bib17","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1097\/CCM.0b013e318170ab08","article-title":"Caspases inhibition decreases neurological sequelae in meningitis","volume":"5","author":"Irazuzta","year":"2008","journal-title":"Neurol. Crit. Care"},{"key":"10.1016\/j.jneuroim.2010.02.009_bib18","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1128\/IAI.68.2.615-620.2000","article-title":"Matrix metalloproteinases contribuite to brain damage in experimental pneumococcal meningitis","volume":"68","author":"Leib","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jneuroim.2010.02.009_bib19","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0891-5520(05)70093-3","article-title":"Pathogenesis of bacterial meningitis","volume":"13","author":"Leib","year":"1999","journal-title":"Infect. Dis. Clin. North Am."},{"key":"10.1016\/j.jneuroim.2010.02.009_bib20","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1086\/313922","article-title":"Atrix metalloproteinase (MMP)-8 and MMP-9 in cerebrospinal fluid during bacterial meningitis: association with blood\u2013brain barrier damage and neurological sequelae","volume":"31","author":"Leppert","year":"2000","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.jneuroim.2010.02.009_bib21","doi-asserted-by":"crossref","first-page":"6348","DOI":"10.1073\/pnas.86.16.6348","article-title":"Production of tumor necrosis factor and other cytokines by astrocytes stimulated with lipopolysaccharide or a neurotropic virus","volume":"86","author":"Lieberman","year":"1989","journal-title":"Proc. Natl Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.jneuroim.2010.02.009_bib31","doi-asserted-by":"crossref","first-page":"438","DOI":"10.4049\/jimmunol.170.1.438","article-title":"Toll-like receptor 2 participates in mediation of immune response in experimental pneumococcal meningitis","volume":"170","author":"Koedel","year":"2003","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.jneuroim.2010.02.009_bib32","doi-asserted-by":"crossref","first-page":"907","DOI":"10.3171\/jns.2003.99.5.0907","article-title":"Interleukin-1beta and adverse effects on cerebral blood flow during long-term global hypoperfusion","volume":"99","author":"Maher","year":"2003","journal-title":"J Neurosurg."},{"key":"10.1016\/j.jneuroim.2010.02.009_bib22","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0166-2236(96)10047-3","article-title":"Cytokines in inflammatory brain lesion: helpful and harmful","volume":"19","author":"Merril","year":"1996","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.jneuroim.2010.02.009_bib23","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1152\/ajpheart.2001.280.4.H1448","article-title":"Role of nitricoxide in the cerebrovascular and thermoregulatory response to interleukin-1b","volume":"280","author":"Monroy","year":"2001","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.jneuroim.2010.02.009_bib24","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/1743-422X-6-122","article-title":"A rat model of picornavirus-induced airway infection and inflammation","volume":"vol. 11","author":"Rosenthal","year":"2009","journal-title":"Virol J"},{"key":"10.1016\/j.jneuroim.2010.02.009_bib25","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.emc.2008.07.004","article-title":"Central nervous system infections","volume":"27","author":"Somand","year":"2009","journal-title":"Emerg. Med. Clin. N. Am."},{"key":"10.1016\/j.jneuroim.2010.02.009_bib26","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0165-5728(93)90008-M","article-title":"Increase in IL-6, IL-1 and TNF levels in rat brain following traumatic lesion. Influence of pre- and post-traumatic treatment with Ro5 4864, a peripheral-type (p site) benzodiazepine ligand","volume":"42","author":"Taupin","year":"1993","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2010.02.009_bib27","first-page":"339","article-title":"Modulation of inflammation in bacterial meningitis","volume":"30","author":"Tuomanen","year":"1994","journal-title":"Isr. J. Med. Sci."},{"key":"10.1016\/j.jneuroim.2010.02.009_bib28","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.medmal.2009.02.033","article-title":"Corticosteroids for acute adult bacterial meningitis","volume":"39","author":"van de Beek","year":"2009","journal-title":"Mal. Infect."},{"key":"10.1016\/j.jneuroim.2010.02.009_bib29","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1084\/jem.170.6.1859","article-title":"Local production of tumor necrosis factor alpha, interleukin 1, and interlukin 6 in meningococcal meningitis. Relation to the inflammatory response","volume":"170","author":"Waage","year":"1989","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jneuroim.2010.02.009_bib30","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.mri.2008.06.010","article-title":"Correlation of CSF neuroinflammatory molecules with leptomeningeal cortical subcortical white matter fractional anisotropy in neonatal meningitis","volume":"27","author":"Yadav","year":"2009","journal-title":"Magnet. Reson. Imag."}],"container-title":["Journal of Neuroimmunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572810000585?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572810000585?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T08:13:28Z","timestamp":1759047208000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165572810000585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":31,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["S0165572810000585"],"URL":"https:\/\/doi.org\/10.1016\/j.jneuroim.2010.02.009","relation":{},"ISSN":["0165-5728"],"issn-type":[{"value":"0165-5728","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TNF-\u03b1, IL-1\u03b2, IL-6, and cinc-1 levels in rat brain after meningitis induced by Streptococcus pneumoniae","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroimmunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneuroim.2010.02.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}