{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:03:09Z","timestamp":1759104189660,"version":"3.44.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jni-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimmunology"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1016\/j.jneuroim.2011.11.002","type":"journal-article","created":{"date-parts":[[2011,12,6]],"date-time":"2011-12-06T00:38:50Z","timestamp":1323131930000},"page":"47-51","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["The role of the Epstein\u2013Barr Virus receptor CD21 in Multiple Sclerosis"],"prefix":"10.1016","volume":"242","author":[{"given":"Nicole","family":"Toepfner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Cepok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Verena","family":"Grummel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Hemmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jneuroim.2011.11.002_bb0005","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/ana.21117","article-title":"Environmental risk factors for multiple sclerosis. Part I: the role of infection","volume":"61","author":"Ascherio","year":"2007","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jneuroim.2011.11.002_bb0015","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.1001\/jama.286.24.3083","article-title":"Epstein\u2013Barr virus antibodies and risk of multiple sclerosis \u2014 a prospective study","volume":"286","author":"Ascherio","year":"2001","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.jneuroim.2011.11.002_bb0020","doi-asserted-by":"crossref","first-page":"383","DOI":"10.4049\/jimmunol.177.1.383","article-title":"Characterization of human complement receptor type 2 (CR2\/CD21) as a receptor for IFN-alpha: a potential role in systemic lupus erythematosus","volume":"177","author":"Asokan","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2011.11.002_bb0025","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/hmg\/ddp120","article-title":"Pathway and network-based analysis of genome-wide association studies in multiple sclerosis","volume":"18","author":"Baranzini","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.jneuroim.2011.11.002_bb0200","first-page":"1","article-title":"Genome-wide association study of severity in multiple sclerosis","author":"Briggs","year":"2011","journal-title":"Genes Immun."},{"key":"10.1016\/j.jneuroim.2011.11.002_bb0035","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1093\/brain\/awf098","article-title":"Prospective study on the relationship between infections and multiple sclerosis exacerbations","volume":"125","author":"Buljevac","year":"2002","journal-title":"Brain"},{"key":"10.1016\/j.jneuroim.2011.11.002_bb0040","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.ajhg.2010.02.027","article-title":"Evidence for polygenic susceptibility to multiple sclerosis\u2014the shape of things to come","volume":"86","author":"Bush","year":"2010","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.jneuroim.2011.11.002_bb0045","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1172\/JCI200523661","article-title":"Identification of Epstein\u2013Barr virus proteins as putative targets of the immune response in multiple sclerosis","volume":"115","author":"Cepok","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jneuroim.2011.11.002_bb0050","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/S0140-6736(08)61620-7","article-title":"Multiple sclerosis","volume":"372","author":"Compston","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.jneuroim.2011.11.002_bb0060","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1146\/annurev.immunol.18.1.393","article-title":"Regulation of B lymphocyte responses to foreign and self-antigens by the CD19\/CD21 complex","volume":"18","author":"Fearon","year":"2000","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jneuroim.2011.11.002_bb0065","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/ana.21092","article-title":"The hygiene hypothesis and multiple sclerosis","volume":"61","author":"Fleming","year":"2007","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jneuroim.2011.11.002_bb0070","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0162-3109(99)00026-0","article-title":"Functional properties of soluble CD21","volume":"42","author":"Fremeaux-Bacchi","year":"1999","journal-title":"Immunopharmacology"},{"key":"10.1016\/j.jneuroim.2011.11.002_bb0075","first-page":"568","article-title":"When is the absence of evidence, evidence of absence? Use of equivalence-based analyses in genetic epidemiology and a conclusion for the KIF1B rs10492972*C allelic association in multiple sclerosis","volume":"35","author":"Gourraud","year":"2011","journal-title":"Genet. Epidemiol."},{"key":"10.1016\/j.jneuroim.2011.11.002_bb0080","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1056\/NEJMoa073493","article-title":"Risk alleles for multiple sclerosis identified by a genomewide study","volume":"357","author":"Hafler","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jneuroim.2011.11.002_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.febslet.2011.04.006","article-title":"Environmental triggers of multiple sclerosis","author":"Kakalacheva","year":"2011","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jneuroim.2011.11.002_bb0090","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/bfgp\/elr004","article-title":"Genome-wide association studies in multiple sclerosis: lessons and future prospects","volume":"10","author":"Kemppinen","year":"2011","journal-title":"Brief. Funct. Genomics"},{"key":"10.1016\/j.jneuroim.2011.11.002_bb0095","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1002\/eji.1830250634","article-title":"Expression of Epstein\u2013Barr-Virus Nuclear Antigen-2 (Ebna2) induces Cd21\/Cr2 on B-cell and T-cell lines and shedding of soluble Cd21","volume":"25","author":"Larcher","year":"1995","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jneuroim.2011.11.002_bb0100","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0171-2985(11)80656-X","article-title":"Properties of soluble Cr-2 in human serum","volume":"185","author":"Ling","year":"1992","journal-title":"Immunobiology"},{"key":"10.1016\/j.jneuroim.2011.11.002_bb0105","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1046\/j.1365-2249.1998.00668.x","article-title":"Origin and properties of soluble CD21 (CR2) in human blood","volume":"113","author":"Ling","year":"1998","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jneuroim.2011.11.002_bb0110","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1084\/jem.170.6.1931","article-title":"Mapping of the Epstein\u2013Barr Virus and C3dg binding-sites to a common domain on complement receptor type-2","volume":"170","author":"Lowell","year":"1989","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jneuroim.2011.11.002_bb0205","unstructured":"Masilamani, M., 2002. Dissertation \"Immunological investigation of human complement receptor type II (CR2\/CD21). Serum soluble CD21 in health and disease\", Universit\u00e4t Konstanz."},{"key":"10.1016\/j.jneuroim.2011.11.002_bb0120","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1002\/eji.200323843","article-title":"B cell activation leads to shedding of complement receptor type II (CR2\/CD21)","volume":"33","author":"Masilamani","year":"2003","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jneuroim.2011.11.002_bb0125","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/j.0300-9475.2004.01494.x","article-title":"Reduction of soluble complement receptor 2\/CD21 in systemic lupus erythomatosus and Sjogren's Syndrome but not juvenile arthritis","volume":"60","author":"Masilamani","year":"2004","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.jneuroim.2011.11.002_bb0130","doi-asserted-by":"crossref","first-page":"3559","DOI":"10.1128\/jvi.65.7.3559-3565.1991","article-title":"Inhibition of Epstein\u2013Barr Virus Infection in vitro and in vivo by soluble Cr-2 (Cd21) containing 2 short consensus repeats","volume":"65","author":"Moore","year":"1991","journal-title":"J. Virol."},{"key":"10.1016\/j.jneuroim.2011.11.002_bb0135","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.4049\/jimmunol.135.5.3068","article-title":"Binding of monoclonal-antibody to the Epstein\u2013Barr Virus (Ebv)\/Cr2 receptor induces activation and differentiation of human lymphocytes-B","volume":"135","author":"Nemerow","year":"1985","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2011.11.002_bb0140","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/nrg2395","article-title":"The genetics of multiple sclerosis: SNPs to pathways to pathogenesis","volume":"9","author":"Oksenberg","year":"2008","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.jneuroim.2011.11.002_bb0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1399-0039.1991.tb02029.x","article-title":"HLA class II-associated genetic susceptibility in multiple sclerosis: a critical evaluation","volume":"38","author":"Olerup","year":"1991","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.jneuroim.2011.11.002_bb0145","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.4049\/jimmunol.135.4.2687","article-title":"Human follicular dendritic cells express Cr-1, Cr-2, and Cr3 complement receptor antigens","volume":"135","author":"Reynes","year":"1985","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2011.11.002_bb0150","doi-asserted-by":"crossref","first-page":"4377","DOI":"10.4049\/jimmunol.162.8.4377","article-title":"Cutting edge: recruitment of the CD19\/CD21 coreceptor to B cell antigen receptor is required for antigen-mediated expression of Bcl-2 by resting and cycling hen egg lysozyme transgenic B cells","volume":"162","author":"Roberts","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2011.11.002_bb0155","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/WCO.0b013e32832b4c8d","article-title":"Epstein\u2013Barr virus and multiple sclerosis","volume":"22","author":"Salvetti","year":"2009","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.jneuroim.2011.11.002_bb0210","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nature10251","article-title":"Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis","volume":"476","author":"Sawcer","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jneuroim.2011.11.002_bb0165","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/S0165-5728(01)00347-2","article-title":"No association of three polymorphisms in the alpha-2-macroglobulin and lipoprotein related receptor genes with multiple sclerosis","volume":"118","author":"Schweer","year":"2001","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2011.11.002_bb0170","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1084\/jem.20071030","article-title":"Dysregulated Epstein\u2013Barr virus infection in the multiple sclerosis brain","volume":"204","author":"Serafini","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jneuroim.2011.11.002_bb0175","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1172\/JCI17348","article-title":"Complement receptor 2-mediated targeting of complement inhibitors to sites of complement activation","volume":"111","author":"Song","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jneuroim.2011.11.002_bb0180","doi-asserted-by":"crossref","first-page":"678","DOI":"10.4049\/jimmunol.133.2.678","article-title":"Expression of C3d receptors during human B-cell differentiation \u2014 immunofluorescence analysis with the Hb-5 monoclonal-antibody","volume":"133","author":"Tedder","year":"1984","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2011.11.002_bb0185","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1385\/IR:36:1:197","article-title":"Complement-mediated activation of the adaptive immune responses \u2014 role of C3d in linking the innate and adaptive immunity","volume":"36","author":"Toapanta","year":"2006","journal-title":"Immunol. Res."},{"key":"10.1016\/j.jneuroim.2011.11.002_bb0190","doi-asserted-by":"crossref","first-page":"5926","DOI":"10.1073\/pnas.81.19.5926","article-title":"Expression of Epstein\u2013Barr Virus (Ebv) DNA and cloned DNA fragments in human-lymphocytes following Sendai Virus envelope-mediated gene-transfer","volume":"81","author":"Volsky","year":"1984","journal-title":"Proc. Natl. Acad. Sci. U.S.A.-Biol. Sci."},{"key":"10.1016\/j.jneuroim.2011.11.002_bb0195","doi-asserted-by":"crossref","first-page":"3824","DOI":"10.1016\/S0021-9258(17)38799-9","article-title":"The identification of N-linked oligosaccharides on the human Cr2\/Epstein\u2013Barr virus receptor and their function in receptor metabolism, plasma-membrane expression, and ligand-binding","volume":"260","author":"Weis","year":"1985","journal-title":"J. Biol. Chem."}],"container-title":["Journal of Neuroimmunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016557281100302X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016557281100302X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T08:18:11Z","timestamp":1759047491000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016557281100302X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":38,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["S016557281100302X"],"URL":"https:\/\/doi.org\/10.1016\/j.jneuroim.2011.11.002","relation":{},"ISSN":["0165-5728"],"issn-type":[{"type":"print","value":"0165-5728"}],"subject":[],"published":{"date-parts":[[2012,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of the Epstein\u2013Barr Virus receptor CD21 in Multiple Sclerosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroimmunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneuroim.2011.11.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}