{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T12:51:17Z","timestamp":1768740677682,"version":"3.49.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Arizona Alzheimer's Consortium","award":["AGR200737"],"award-info":[{"award-number":["AGR200737"]}]},{"DOI":"10.13039\/100002565","name":"Alzheimer's Drug Discovery Foundation","doi-asserted-by":"crossref","award":["291001"],"award-info":[{"award-number":["291001"]}],"id":[{"id":"10.13039\/100002565","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jni-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimmunology"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.jneuroim.2012.09.014","type":"journal-article","created":{"date-parts":[[2012,10,18]],"date-time":"2012-10-18T00:54:21Z","timestamp":1350521661000},"page":"154-160","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Feasibility of an early Alzheimer's disease immunosignature diagnostic test"],"prefix":"10.1016","volume":"254","author":[{"given":"Lucas","family":"Restrepo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip","family":"Stafford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen Albert","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jneuroim.2012.09.014_bb0005","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1038\/475S2a","article-title":"Dementia: a problem for our age","volume":"475","author":"Abbott","year":"2011","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.jneuroim.2012.09.014_bb0110","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. Ser. B (Methodol.)"},{"issue":"1","key":"10.1016\/j.jneuroim.2012.09.014_bb0095","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1186\/1471-2105-12-349","article-title":"Statistical methods for analyzing immunosignatures","volume":"12","author":"Brown","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.jneuroim.2012.09.014_bb0015","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1038\/475S8a","article-title":"In search of biomarkers","volume":"475","author":"Buckholtz","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jneuroim.2012.09.014_bb0160","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1586\/14789450.4.2.261","article-title":"Autoantibody microarrays for biomarker discovery","volume":"4","author":"Caiazzo","year":"2007","journal-title":"Expert Rev. Proteomics"},{"issue":"19","key":"10.1016\/j.jneuroim.2012.09.014_bb0175","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1016\/j.febslet.2007.04.031","article-title":"Managing and exploiting stress in the antibody factory","volume":"581","author":"Cenci","year":"2007","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jneuroim.2012.09.014_bb0010","series-title":"Evidence-based Demential Practice","first-page":"106","article-title":"Clinical criteria for demential subtypes","author":"Chui","year":"2002"},{"key":"10.1016\/j.jneuroim.2012.09.014_bb0180","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1634\/stemcells.22-6-1111","article-title":"Cell division rates of primary human precursor B cells in culture reflect in vivo rates","volume":"22","author":"Cooperman","year":"2004","journal-title":"Stem Cells"},{"issue":"8","key":"10.1016\/j.jneuroim.2012.09.014_bb0020","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.tins.2011.05.005","article-title":"Neuroimaging markers for the prediction and early diagnosis of Alzheimer's disease dementia","volume":"34","author":"Ewers","year":"2011","journal-title":"Trends Neurosci."},{"issue":"7","key":"10.1016\/j.jneuroim.2012.09.014_bb0115","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/nrn2420","article-title":"Animal models of Alzheimer's disease and frontotemporal dementia","volume":"9","author":"Gotz","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"issue":"1","key":"10.1016\/j.jneuroim.2012.09.014_bb0035","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1001\/archneur.61.1.59","article-title":"Mild cognitive impairment can be distinguished from Alzheimer's disease and normal aging for clinical trials","volume":"61","author":"Grundman","year":"2004","journal-title":"Arch. Neurol."},{"issue":"1","key":"10.1016\/j.jneuroim.2012.09.014_bb0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2105-13-1","article-title":"GuiTope: an application for mapping random-sequence peptides to protein sequences","volume":"13","author":"Halperin","year":"2012","journal-title":"BMC Bioinformatics"},{"issue":"7","key":"10.1016\/j.jneuroim.2012.09.014_bb0080","doi-asserted-by":"crossref","first-page":"e40201","DOI":"10.1371\/journal.pone.0040201","article-title":"Immunosignaturing can detect products from molecular markers in brain cancer","volume":"7","author":"Hughes","year":"2012","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.jneuroim.2012.09.014_bb0120","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/hmg\/ddh019","article-title":"Mutant presenilins specifically elevate the levels of the 42 residue \u03b2-amyloid peptide in vivo: evidence for augmentation of a 42-specific \u03b3 secretase","volume":"13","author":"Jankowsky","year":"2004","journal-title":"Hum. Mol. Genet."},{"issue":"11","key":"10.1016\/j.jneuroim.2012.09.014_bb0040","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1056\/NEJMcp022295","article-title":"Early Alzheimer's disease","volume":"349","author":"Kawas","year":"2003","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.jneuroim.2012.09.014_bb0085","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.yexmp.2012.03.002","article-title":"Autoreactive antibodies raised by self derived de novo peptides can identify unrelated antigens on protein microarrays. Are autoantibodies really autoantibodies?","volume":"92","author":"Kroening","year":"2012","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.jneuroim.2012.09.014_bb0055","first-page":"S6","article-title":"Immunosignaturing microarrays distinguish antibody profiles of related pancreatic diseases","author":"Kukreja","year":"2012","journal-title":"Proteomics Bioinformatics"},{"issue":"1","key":"10.1016\/j.jneuroim.2012.09.014_bb0105","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/1471-2105-13-139","article-title":"Comparative study of classification algorithms for immunosignaturing data","volume":"13","author":"Kukreja","year":"2012","journal-title":"BMC Bioinformatics"},{"issue":"28","key":"10.1016\/j.jneuroim.2012.09.014_bb0060","doi-asserted-by":"crossref","first-page":"4529","DOI":"10.1016\/j.vaccine.2010.04.061","article-title":"A general method for characterization of humoral immunity induced by a vaccine or infection","volume":"28","author":"Legutki","year":"2010","journal-title":"Vaccine"},{"issue":"3","key":"10.1016\/j.jneuroim.2012.09.014_bb0045","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1001\/archneur.58.3.397","article-title":"Mild cognitive impairment represents early-stage Alzheimer's disease","volume":"58","author":"Morris","year":"2001","journal-title":"Arch. Neurol."},{"issue":"12","key":"10.1016\/j.jneuroim.2012.09.014_bb0130","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1001\/archneur.61.12.1859","article-title":"Gene vaccination to bias the immune response to amyloid-beta peptide as therapy for Alzheimer disease","volume":"61","author":"Qu","year":"2004","journal-title":"Arch. Neurol."},{"issue":"1\u20132","key":"10.1016\/j.jneuroim.2012.09.014_bb0125","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jns.2006.02.006","article-title":"Abeta42 gene vaccination reduces brain amyloid plaque burden in transgenic mice","volume":"244","author":"Qu","year":"2006","journal-title":"J. Neurol. Sci."},{"issue":"1\u20132","key":"10.1016\/j.jneuroim.2012.09.014_bb0135","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.jns.2007.05.012","article-title":"Abeta42 gene vaccine prevents Abeta42 deposition in brain of double transgenic mice","volume":"260","author":"Qu","year":"2007","journal-title":"J. Neurol. Sci."},{"issue":"11","key":"10.1016\/j.jneuroim.2012.09.014_bb0150","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1038\/nm1653","article-title":"Classification and prediction of clinical Alzheimer's diagnosis based on plasma signalling proteins","volume":"13","author":"Ray","year":"2007","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.jneuroim.2012.09.014_bb0155","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.cell.2010.11.054","article-title":"Identification of candidate IgG biomarkers for Alzheimer's disease via combinatorial library screening","volume":"144","author":"Reddy","year":"2011","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.jneuroim.2012.09.014_bb0140","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1601-183X.2006.00221.x","article-title":"Impaired spatial learning in the APPSwe+PSEN1DeltaE9 bigenic mouse model of Alzheimer's disease","volume":"6","author":"Reiserer","year":"2007","journal-title":"Genes Brain Behav."},{"issue":"2","key":"10.1016\/j.jneuroim.2012.09.014_bb0145","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/ana.22405","article-title":"Application of immunosignatures to the assessment of Alzheimer's disease","volume":"70","author":"Restrepo","year":"2011","journal-title":"Ann. Neurol."},{"issue":"1\u20132","key":"10.1016\/j.jneuroim.2012.09.014_bb0165","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jim.2008.07.002","article-title":"Autoantibody profiling on high-density protein microarrays for biomarker discovery in the cerebrospinal fluid","volume":"338","author":"Roche","year":"2008","journal-title":"J. Immunol. Methods"},{"issue":"4","key":"10.1016\/j.jneuroim.2012.09.014_bb0025","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nrd2176","article-title":"Biomarkers of neurodegeneration for diagnosis and monitoring therapeutics","volume":"6","author":"Shaw","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"issue":"4","key":"10.1016\/j.jneuroim.2012.09.014_bb0030","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/ana.21610","article-title":"Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects","volume":"65","author":"Shaw","year":"2009","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jneuroim.2012.09.014_bb0070","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M111.011593","article-title":"Physical characterization of the \u2018Immunosignaturing Effect\u2018","author":"Stafford","year":"2012","journal-title":"Mol. Cell. Proteomics"},{"issue":"6","key":"10.1016\/j.jneuroim.2012.09.014_bb0185","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/S0092-8240(05)80168-5","article-title":"Memory in idiotypic networks due to competition between proliferation and differentiation","volume":"55","author":"Sulzer","year":"1993","journal-title":"Bull. Math. Biol."},{"key":"10.1016\/j.jneuroim.2012.09.014_bb0170","series-title":"Bioinformatic Analysis of Humoral Immune Response and Protein Microarray for Biomarker Discovery","author":"Vuong","year":"2011"}],"container-title":["Journal of Neuroimmunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572812003037?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572812003037?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T08:20:35Z","timestamp":1759047635000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165572812003037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":33,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S0165572812003037"],"URL":"https:\/\/doi.org\/10.1016\/j.jneuroim.2012.09.014","relation":{},"ISSN":["0165-5728"],"issn-type":[{"value":"0165-5728","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Feasibility of an early Alzheimer's disease immunosignature diagnostic test","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroimmunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneuroim.2012.09.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}