{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:09:57Z","timestamp":1790665797085,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jni-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimmunology"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1016\/j.jneuroim.2013.09.010","type":"journal-article","created":{"date-parts":[[2013,9,18]],"date-time":"2013-09-18T02:00:20Z","timestamp":1379469620000},"page":"106-113","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":55,"title":["Anti-streptococcal, tubulin, and dopamine receptor 2 antibodies in children with PANDAS and Tourette syndrome: Single-point and longitudinal assessments"],"prefix":"10.1016","volume":"264","author":[{"given":"C.M.","family":"Morris-Berry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Pollard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.S.","family":"Singer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jneuroim.2013.09.010_bb0005","series-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"2000"},{"key":"10.1016\/j.jneuroim.2013.09.010_bb0010","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1056\/NEJMoa021933","article-title":"Development of autoantibodies before the clinical onset of systemic lupus erythematosus","volume":"349","author":"Arbuckle","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jneuroim.2013.09.010_bb0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0073516","article-title":"Dopamine receptor autoantibodies correlate with symptoms in Sydenham's chorea","author":"Ben-Pazi","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jneuroim.2013.09.010_bb0020","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1212\/WNL.0b013e3182181090","article-title":"Antibody binding to neuronal surface in Sydenham chorea, but not in PANDAS or Tourette syndrome","volume":"76","author":"Brilot","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.jneuroim.2013.09.010_bb0025","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1038\/npp.2012.56","article-title":"Behavioral, pharmacological, and immunological abnormalities after streptococcal exposure: a novel rat model of Sydenham chorea and related neuropsychiatric disorders","volume":"37","author":"Brimberg","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jneuroim.2013.09.010_bb0030","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1067\/mpd.2001.110325","article-title":"Group A streptococcal infections and tic disorders in an Italian pediatric population","volume":"138","author":"Cardona","year":"2001","journal-title":"J. Pediatr."},{"key":"10.1016\/j.jneuroim.2013.09.010_bb0035","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1136\/jnnp.74.5.602","article-title":"Tourette's syndrome: a cross sectional study to examine the PANDAS hypothesis","volume":"74","author":"Church","year":"2003","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jneuroim.2013.09.010_bb0040","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jneuroim.2005.10.014","article-title":"Neuronal surface glycolytic enzymes are autoantigen targets in post-streptococcal autoimmune CNS disease","volume":"172","author":"Dale","year":"2006","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2013.09.010_bb0045","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1212\/01.wnl.0000226832.36908.4c","article-title":"Serum autoantibodies do not differentiate PANDAS and Tourette syndrome from controls","volume":"66","author":"Dale","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.jneuroim.2013.09.010_bb0050","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.1093\/brain\/aws256","article-title":"Antibodies to surface dopamine-2 receptor in autoimmune movement and psychiatric disorders","volume":"135","author":"Dale","year":"2012","journal-title":"Brain"},{"key":"10.1016\/j.jneuroim.2013.09.010_bb0055","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jneuroim.2009.06.015","article-title":"Antineuronal antibodies in OCD: comparisons in children with OCD-only, OCD+chronic tics and OCD+PANDAS","volume":"214","author":"Gause","year":"2009","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2013.09.010_bb0060","series-title":"Laboratory Diagnosis of Group A Streptococcal Infections","author":"Johnson","year":"1998"},{"key":"10.1016\/j.jneuroim.2013.09.010_bb0065","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1086\/650167","article-title":"The human immune response to streptococcal extracellular antigens: clinical, diagnostic, and potential pathogenetic implications","volume":"50","author":"Johnson","year":"2010","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.jneuroim.2013.09.010_bb0070","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.biopsych.2006.06.012","article-title":"Decreased numbers of regulatory T cells suggest impaired immune tolerance in children with Tourette syndrome: a preliminary study","volume":"61","author":"Kawikova","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jneuroim.2013.09.010_bb0080","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/nm892","article-title":"Mimicry and autoantibody-mediated neuronal cell signaling in Sydenham chorea","volume":"9","author":"Kirvan","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.jneuroim.2013.09.010_bb0085","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1080\/08916930500484757","article-title":"Streptococcal mimicry and antibody-mediated cell signaling in the pathogenesis of Sydenham's chorea","volume":"39","author":"Kirvan","year":"2006","journal-title":"Autoimmunity"},{"key":"10.1016\/j.jneuroim.2013.09.010_bb0090","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jneuroim.2006.06.017","article-title":"Antibody-mediated neuronal cell signaling in behavior and movement disorders","volume":"179","author":"Kirvan","year":"2006","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2013.09.010_bb0075","doi-asserted-by":"crossref","first-page":"7412","DOI":"10.4049\/jimmunol.178.11.7412","article-title":"Tubulin is a neuronal target of autoantibodies in Sydenham's chorea","volume":"178","author":"Kirvan","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2013.09.010_bb0100","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1542\/peds.113.4.883","article-title":"The pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS) etiology for tics and obsessive\u2013compulsive symptoms: hypothesis or entity? Practical considerations for the clinician","volume":"113","author":"Kurlan","year":"2004","journal-title":"Pediatrics"},{"key":"10.1016\/j.jneuroim.2013.09.010_bb0095","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1542\/peds.2007-2657","article-title":"Streptococcal infection and exacerbations of childhood tics and obsessive\u2013compulsive symptoms: a prospective blinded cohort study","volume":"121","author":"Kurlan","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.jneuroim.2013.09.010_bb0105","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.biopsych.2004.12.004","article-title":"Increased serum levels of interleukin-12 and tumor necrosis factor-alpha in Tourette's syndrome","volume":"57","author":"Leckman","year":"2005","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jneuroim.2013.09.010_bb0110","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jaac.2010.10.011","article-title":"Streptococcal upper respiratory tract infections and exacerbations of tic and obsessive\u2013compulsive symptoms: a prospective longitudinal study","volume":"50","author":"Leckman","year":"2011","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"10.1016\/j.jneuroim.2013.09.010_bb0115","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.biopsych.2009.08.020","article-title":"Streptococcal upper respiratory tract infections and psychosocial stress predict future tic and obsessive\u2013compulsive symptom severity in children and adolescents with Tourette syndrome and obsessive\u2013compulsive disorder","volume":"67","author":"Lin","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jneuroim.2013.09.010_bb0120","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0076-6879(06)17015-9","article-title":"Determination of glycolipid-protein interaction specificity","volume":"417","author":"Lopez","year":"2006","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.jneuroim.2013.09.010_bb0125","doi-asserted-by":"crossref","first-page":"e578","DOI":"10.1542\/peds.113.6.e578","article-title":"Prospective longitudinal study of children with tic disorders and\/or obsessive\u2013compulsive disorder: relationship of symptom exacerbations to newly acquired streptococcal infections","volume":"113","author":"Luo","year":"2004","journal-title":"Pediatrics"},{"key":"10.1016\/j.jneuroim.2013.09.010_bb0130","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1002\/mds.22504","article-title":"Immunopathogenic mechanisms in Tourette syndrome: a critical review","volume":"24","author":"Martino","year":"2009","journal-title":"Mov. Disord."},{"key":"10.1016\/j.jneuroim.2013.09.010_bb0135","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1590\/S1516-44462005000100006","article-title":"Secondary tics and tourettism","volume":"27","author":"Mejia","year":"2005","journal-title":"Rev. Bras. Psiquiatr."},{"key":"10.1016\/j.jneuroim.2013.09.010_bb0140","first-page":"109","article-title":"A correction: the use of ranks to avoid the assumption of normality implicit in the analysis of variance","volume":"34","author":"Milton","year":"1939","journal-title":"J. Am. Stat. Assoc."},{"key":"10.1016\/j.jneuroim.2013.09.010_bb0145","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1111\/j.1468-1331.2008.02159.x","article-title":"Immunophenotyping in Tourette syndrome\u2014a pilot study","volume":"15","author":"Moller","year":"2008","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.jneuroim.2013.09.010_bb0150","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jns.2008.08.032","article-title":"Serum autoantibodies measured by immunofluorescence confirm a failure to differentiate PANDAS and Tourette syndrome from controls","volume":"276","author":"Morris","year":"2009","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.jneuroim.2013.09.010_bb0155","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0165-1781(00)00125-6","article-title":"Increased anti-streptococcal antibodies in patients with Tourette's syndrome","volume":"94","author":"Muller","year":"2000","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.jneuroim.2013.09.010_bb0160","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0887-8994(03)00413-2","article-title":"Anti-brain antibodies in PANDAS versus uncomplicated streptococcal infection","volume":"30","author":"Pavone","year":"2004","journal-title":"Pediatr. Neurol."},{"key":"10.1016\/j.jneuroim.2013.09.010_bb0165","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1177\/08830738060210091001","article-title":"Increased antistreptococcal antibody titers and anti-basal ganglia antibodies in patients with Tourette syndrome: controlled cross-sectional study","volume":"21","author":"Rizzo","year":"2006","journal-title":"J. Child Neurol."},{"key":"10.1016\/j.jneuroim.2013.09.010_bb0170","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/mp.2012.69","article-title":"Genome-wide association study of Tourette's syndrome","volume":"18","author":"Scharf","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jneuroim.2013.09.010_bb0175","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S1474-4422(05)70018-1","article-title":"Tourette's syndrome: from behaviour to biology","volume":"4","author":"Singer","year":"2005","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jneuroim.2013.09.010_bb0190","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1212\/01.wnl.0000183223.69946.f1","article-title":"Serum autoantibodies do not differentiate PANDAS and Tourette syndrome from controls","volume":"65","author":"Singer","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.jneuroim.2013.09.010_bb0180","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1542\/peds.2007-2658","article-title":"Serial immune markers do not correlate with clinical exacerbations in pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections","volume":"121","author":"Singer","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.jneuroim.2013.09.010_bb0185","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.jpeds.2011.11.040","article-title":"Moving from PANDAS to CANS","volume":"160","author":"Singer","year":"2012","journal-title":"J. Pediatr."},{"key":"10.1016\/j.jneuroim.2013.09.010_bb0195","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1176\/ajp.155.2.264","article-title":"Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: clinical description of the first 50 cases","volume":"155","author":"Swedo","year":"1998","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jneuroim.2013.09.010_bb0205","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1542\/peds.113.4.907","article-title":"The pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS) subgroup: separating fact from fiction","volume":"113","author":"Swedo","year":"2004","journal-title":"Pediatrics"},{"key":"10.1016\/j.jneuroim.2013.09.010_bb0210","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s11373-005-9033-y","article-title":"Antineural antibody in patients with Tourette's syndrome and their family members","volume":"13","author":"Yeh","year":"2006","journal-title":"J. Biomed. Sci."}],"container-title":["Journal of Neuroimmunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016557281300252X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016557281300252X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T08:21:20Z","timestamp":1759047680000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016557281300252X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":41,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["S016557281300252X"],"URL":"https:\/\/doi.org\/10.1016\/j.jneuroim.2013.09.010","relation":{},"ISSN":["0165-5728"],"issn-type":[{"value":"0165-5728","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-streptococcal, tubulin, and dopamine receptor 2 antibodies in children with PANDAS and Tourette syndrome: Single-point and longitudinal assessments","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroimmunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneuroim.2013.09.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}